• Zurück zum Zitat Villiger PM, Caliezi G, Cottin V et al (2010) Effects of TNF antagonists on sperm characteristics in patients with spondyloarthritis. (springermedizin.at)
  • Zurück zum Zitat La montagna GL, Malesci D, Buono R, Valenti G (2005) Asthenoazoopermia in patients receiving anti-tumour necrosis factor α agents. (springermedizin.at)
  • Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart failure, or diabetic kidney disease). (guidelinecentral.com)
  • Penis enlargement surgery can be expected to have a double effect in patients with irritable premature ejaculation as it slightly slows the sensitive nerves. (jivaka.care)
  • Catecholamine-depleting drugs may have an additive effect when given with beta-blocking agents. (nih.gov)
  • Infertility in men can result from deficiencies in sperm formation, concentration, or transportation. (medscape.com)
  • Infertile men may have deficiencies in sperm formation, concentration (eg, oligospermia [too few sperm], azoospermia [no sperm in the ejaculate]), or transportation. (medscape.com)
  • Using a newly developed ex vivo system simulating sympathetic effects on the most relevant structures for the emission phase of ejaculation, that is seminal vesicles, prostate and the most distal part of the cauda epididymidis, we elucidated that tamsulosin fundamentally disturbed the obligatory noradrenaline-induced contractions in each of these structures which differed to an alternative pharmacotherapy, the PDE5 inhibitor tadalafil. (bvsalud.org)
  • Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation. (theodora.com)
  • In vitro studies have shown that the effect of tadalafil is more potent on PDE5 than on other phosphodiesterases. (theodora.com)
  • Our Stendra Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Severe bradycardia, greater than first degree heart block, or sick sinus syndrome without a pacemaker. (nih.gov)
  • Viagra, Cialis and Levitra are three drugs that have a similar effect and are highly sought after by men all over the world. (healthcaremall4you.com)
  • By blocking PDE-5 and stabilizing cGMP drugs of this group enhance nitrogen oxide effect, that activates guanylate cyclase, which leads to cGMP level increase, relaxing cavernous bodies smooth muscles and blood flow to them. (healthcaremall4you.com)
  • BYSTOLIC is a beta-adrenergic blocking agent indicated for the treatment of hypertension, to lower blood pressure. (guidelinecentral.com)
  • By focusing on promoting the formation of new blood vessels and increasing the rate of tissue engraftment, the treatment effect is enhanced and the duration is prolonged. (jivaka.care)
  • Studies on the antifertility effect of bis-trichloromethyl sulfone and its reversibility in male rats]. (harvard.edu)
  • Zurück zum Zitat Puchner R, Danninger K, Puchner A et al (2012) Impact of TNF-blocking agents on male sperm characteristics and pregnancy outcomes in fathers exposed to TNF-blocking agents at time of conception. (springermedizin.at)
  • This graph shows the total number of publications written about "Antispermatogenic Agents" by people in Harvard Catalyst Profiles by year, and whether "Antispermatogenic Agents" was a major or minor topic of these publication. (harvard.edu)
  • Testicular biopsy is indicated in azoospermic men with a normal-sized testis and normal findings on hormonal studies to evaluate for ductal obstruction, to further evaluate idiopathic infertility, and to retrieve sperm. (medscape.com)
  • If concomitant use of CYP3A4 inhibitor is necessary, consider dosage reduction of acetaminophen and codeine phosphate tablets until stable drug effects are achieved. (medlibrary.org)
  • GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
  • After stopping a CYP3A4 inducer, as the effects of the inducer decline, codeine plasma concentrations may increase, with subsequently greater metabolism by cytochrome CYP2D6, resulting in greater morphine levels (see CLINICAL PHARMACOLOGY ), which could increase or prolong both the therapeutic effects and adverse reactions, and may cause serious respiratory depression. (medlibrary.org)
  • Indications for performing a postcoital test include semen hyperviscosity, increased or decreased semen volume with good sperm density, or unexplained infertility. (medscape.com)
  • What Are Side Effects of Stendra? (rxlist.com)
  • This document does not contain all possible side effects and others may occur. (rxlist.com)
  • Check with your physician for additional information about side effects. (rxlist.com)
  • This method can reduce the side effect of 'lowering angle during erection' of the existing ligament resection. (jivaka.care)
  • Ovarian spermatogenesis and suppressed ovarian maturation were observed in the females that exhibited imposex, although no histopathological abnormalities were found in males. (nih.gov)
  • Given the lack of any evidence that these drugs improve survival, antiarrhythmic agents should generally be avoided in patients with non-life-threatening ventricular arrhythmias, even if the patients are experiencing unpleasant, but not life-threatening, symptoms or signs. (nih.gov)
  • Avoid use with other antiarrhythmic agents or drugs that prolong the QT interval. (nih.gov)
  • Consistent with this expression pattern, male mice lacking A-Myb are infer-tile because of a block in spermatogenesis, and A-myb null females have underdeveloped breast tissue after pregnancy [19]. (123dok.net)
  • The results revealed remarkable differences in sperm parameters, testosterone and oxidative stress biomarkers levels, and histomorphometrical indices, between the control and treatment groups. (ijfs.ir)
  • In 30-40% of cases, no male-associated factor is found to explain the underlying impairment of sperm parameters and historically was referred to as idiopathic male infertility. (uroweb.org)
  • Unexplained male infertility is defined as infertility of unknown origin with normal sperm parameters and partner evaluation. (uroweb.org)
  • This document does not contain all possible side effects and others may occur. (order-cialis.com)
  • Based on these data, spermatogenesis appears to occur between late May to early July with peak sperm production occurring in June and July. (elasmollet.org)
  • Experiments with a monocistronic positive feedback configuration in transgenic animals also showed no detrimental effects (Shockett et al, 1995). (allindianpatents.com)
  • Expression or transient expression of cell cycle arresting genes is described for "metabolic engineering", i.e. regulating expression of desirable proteins, and it is mentioned that a transcriptional "squelching" effect by the VP16 transactivator domain may be lethal for the host cell, even at moderate expression levels (Berger et al. (allindianpatents.com)
  • tion and a conserved region (CR) which has variously been associated with positive and negative effects on transcriptional activity [5 - 9]. (123dok.net)
  • Nebivolol Tablets are a beta-adrenergic blocking agent indicated for the treatment of hypertension, to lower blood pressure. (nih.gov)
  • Considering the fact that the majority of these chaperone families are cell stress responders or heat shock proteins (HSPs), chaperones have important roles in raising the cellular resistance against environmental stressors, although the HSPs are known to be involved in regulating spermatogenesis ( 8 , 9 ). (ijfs.ir)
  • In fact, the testicular temperature must be 2-4°C lower than the rest of the body for maintaining optimal sperm quality. (ijfs.ir)
  • Even a slight increase in temperature could lead to rapid disrupts in spermatogenesis due to inducing protein denaturation ( 8 ). (ijfs.ir)
  • The preservative effects of low temperature on biological materials have been long recognised, and cryopreservation is now widely used in biomedicine, including in organ transplantation, regenerative medicine and drug discovery. (biomedcentral.com)
  • Agents, either mechanical or chemical, which destroy spermatozoa in the male genitalia and block spermatogenesis. (nih.gov)
  • Developing a drug for any purpose is difficult but one that blocks sperm function is a particular challenge as spermatozoa don't divide, transcribe or translate, have specialized organelles, are highly motile and continually produced in large numbers (~100 million per day). (elifesciences.org)
  • Many reports of endocrine disruption describe changes in the normal development of organs and tissues that are consistent with genetic damage, and recent studies confirm that many chemicals classified to have hormone-modulating effects also possess carcinogenic and mutagenic potential. (nih.gov)
  • To date, however, there have been no conclusive examples linking genetic damage with perturbation of endocrine function and adverse effects in vivo . (nih.gov)
  • It is now believed that idiopathic male infertility may be associated with several previously unidentified pathological factors, which include but are not limited to endocrine disruption as a result of environmental pollution, generation of reactive oxygen species (ROS)/sperm DNA damage, or genetic and epigenetic abnormalities [ 1753 ]. (uroweb.org)
  • To address this deficit, we developed a fully-automated robotic screening platform that provided quantitative evaluation of compound activity against two key attributes of human sperm function: motility and acrosome reaction. (elifesciences.org)
  • Hence, a male contraceptive could work in a number of different ways - it could completely halt spermatogenesis, block an essential function of the spermatozoon (such a motility) or perturb a cellular process that results in a non-productive interaction with the oocyte (such as prematurely triggering the acrosome reaction, and/or by blocking exocytosis or inhibiting receptor binding). (elifesciences.org)
  • However, substantial differences in the mechanism of action, glucose-lowering efficacy and effects on body weight and other cardiovascular risk factors of each drug may explain a potential variable impact on erectile function. (encyclopedia.pub)
  • This review sought to report on the selective effects demonstrated by glucose-lowering medications on erectile function and explore the potential mechanisms involved. (encyclopedia.pub)
  • Sodium Iodide I-131 is a radioactive therapeutic agent indicated for the treatment of hyperthyroidism and selected cases of carcinoma of the thyroid. (nih.gov)
  • The most commonly reported adverse events with propafenone (greater than 5%) included: unusual taste, nausea and/or vomiting, dizziness, constipation, headache, fatigue, first-degree AV block, and intraventricular conduction delay. (nih.gov)
  • Surprisingly, it has now been found that it is possible to employ a positive feedback mechanism both to enhance the effect of an insect promoter, as well as to control its expression. (allindianpatents.com)
  • One of the genes regulated through this mechanism en-codes the B-Myb transcription factor, which has been shown to be critically required for early embryonal de-velopment in the mouse. (123dok.net)
  • The preservative effect of cold was also a topic of interest to the early experimentalists of the seventeenth century, most notably Boyle [ 2 ], who commented on the ability of ice to preserve human bodies and made several attempts to freeze and revive live animals, discovering species of frogs and fish that could survive encasement in ice. (biomedcentral.com)
  • Lidocaine may increase central nervous system side effects. (nih.gov)
  • during embryogenesis and in the developing central ner-vous system, sperm cell precursors, female breast ductal epithelium and B lymphocytes [18]. (123dok.net)
  • Because of proarrhythmic effects, use with lesser ventricular arrhythmias is not recommended, even if patients are symptomatic. (nih.gov)
  • Consider reducing the dose in patients with hepatic impairment, significant widening of the QRS complex, or second- or third-degree AV block. (nih.gov)
  • Promoters active in insects can be enhanced by positive feedback mechanisms and associated with repressible lethal effects. (allindianpatents.com)
  • Before discussing the medical applications and opportunities of cryopreservation, we should first consider the physiological effects of low temperatures, and the challenges they present. (biomedcentral.com)