Sperm gene expression regulation developmental. Medical search. Frequent questions

Detlef Weigel received his PhD in 1988 from the Max Planck Institute for Developmental Biology. (elifesciences.org)
Since 2002, he has been director of the Department of Molecular Biology at the Max Planck Institute for Developmental Biology. (elifesciences.org)
He serves on the Editorial Boards of Annual Review of Cell and Developmental Biology and Genome Biology. (elifesciences.org)
She is currently a Senior Investigator leading the Chromosome Structure and Epigenetics Mechanism Unit within the Laboratory of Receptor Biology and Gene Expression at the Center for Cancer Research of the NCI/NIH in Bethesda. (elifesciences.org)
These elements are involved in control of gene expression which governs the phenotype and also plays role in disease biology. (researchgate.net)
However, understanding the consequence of this regulation at the level of entire networks remains one of the most important, yet elusive, dimensions in miRNA biology. (ox.ac.uk)
Tong's administrative and scientific leadership in the fields of marine, cellular, and developmental biology contributed to China's experimental embryology research programs. (asu.edu)
Published in Nature Genetics , this discovery is a milestone for developmental biology. (news-medical.net)
Frontiers in cell and developmental biology 2022 6 10 903612. (cdc.gov)

The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
The generation of a zygote through fertilization marks the onset of development for the offspring, and requires the proper completion of sperm and oocyte development in the respective parents. (elifesciences.org)
Spermatogenesis produces haploid sperm capable of penetrating the oocyte, whereas oogenesis produces differentiated oocytes that are stockpiled with maternal nutrients, proteins, and mRNAs, and have outer layers that protect the embryo and enable fertilization. (elifesciences.org)
In most animals the oocyte is arrested in meiosis, and fertilization leads to initiation of mitosis as the oocyte nucleus completes meiosis and fuses with the haploid sperm nucleus. (elifesciences.org)
The production of viable offspring requires three key developmental events: oocyte maturation, the oocyte-to-embryo transition (OET), and the maternal-to-zygotic transition (MZT) ( Figure 1A ). (elifesciences.org)
Fertilization is the ultimate reprograming experiment where two highly differentiated cells (oocyte and sperm) fuse to form a zygote with totipotent potential. (nih.gov)
Consequently, we anti cipated that sperm mitophagy may very well be reconstituted in a cell-free system consisting of permeabilized mammalian spermatozoa co-incubated with porcine oocyte extracts. (eqalix.com)
We discovered that SQSTM1 was detected within the midpiece/mitochondrial sheath of the sperm tail after, however not earlier than, co-incubation with oocyte extracts. (eqalix.com)
As well as, it was noticed that sperm head enlargement mimicked the early levels of paternal pronucleus growth in a zygote throughout extended sperm-oocyte extract co-incubation. (eqalix.com)
Even in an interspecific mobile setting encompassing bull spermatozoa and porcine oocyte extract, ooplasmic SQSTM1 was recruited to heterospecific sperm mitochondria. (eqalix.com)
We used our knowledge of sperm/oocyte regulators to chemically reprogram germlines. (wisc.edu)
The formation of a human embryo starts with the fertilization of the oocyte by the sperm cell. (news-medical.net)

Numerous genes transcribed in oocytes are involved in multiple aspects of cell maintenance and protection, including metabolism, signal perception and transduction, RNA processing, cell cycle, defense against pathogens and DNA damage. (biomedcentral.com)
This study was conducted to evaluate in vivo and in vitro development of in vitro-matured equine oocytes fertilized by intracytoplasmic sperm injection. (bioone.org)
Oocytes were collected from slaughterhouse-derived ovaries, matured in vitro, and injected with frozen-thawed stallion sperm. (bioone.org)
Complementary with the binding of SQSTM1 and VCP to sperm mitochondria, two sperm-borne pro-mitophagy proteins, parkin co-regulated gene product (PACRG) and spermatogenesis related 18, underwent localization modifications after extract coincubation, which had been according to their degradation noticed inside fertilized porcine oocytes. (eqalix.com)
Our focus is the germ line, which is composed of totipotent cells that generate sperm or oocytes to launch the next generation. (wisc.edu)
Animal germ cells differentiate as sperm in males and as oocytes in females. (wisc.edu)
Recent epigenomic studies have revealed the extraordinary chromatin landscapes found in oocytes, sperm, and early preimplantation embryos, including atypical histone modification patterns and differences in chromosome organization and accessibility. (fsu.edu)
The final piece of evidence came when the EPFL scientists removed the DUX gene from fertilized mouse oocytes using CRISPR/Cas9 genome editing. (news-medical.net)

Epigenetics refers to the modulation on gene expression and on DNA structure that are not related to alterations of base sequence. (fapesp.br)
Sperm epigenetics landscape: correlation with embryo quality, reproductive outcomes and offspring's health. (ivi-rmainnovation.com)
The concept of epigenetics refers nowadays to the long-lasting and inheritable gene expression states that are established in the absence of a change in the DNA sequence itself. (benthamscience.com)

Among gene families with a significant expansion, four of them exhibit overexpression on fertile males and they are linked to male spermatogenesis or cellular division: Kelch-like proteins 10 (KLHL10) and Seven-in-abstenia (SINA). (wikipedia.org)
The MBD5 gene provides instructions for a protein that likely regulates the activity (expression) of genes, controlling the production of proteins that are involved in neurological functions such as learning, memory, and behavior. (medlineplus.gov)
It is likely that any changes in MBD5 protein levels impair its regulation of gene expression, leading to the uncontrolled production of certain proteins. (medlineplus.gov)
Genomic DNA contains genes: these include fragments that encode instructions for producing proteins as well as non-coding regions with regulatory functions that comprise it's structure. (keydifference.info)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
2020). Higher expression of dynein proteins over the course of spermatogeneisis in C. gigas (Dheilly et al. (github.io)
What remain unknown are the mechanisms whereby Polycomb proteins regulate gene expression during spermatogenesis. (grantome.com)
Our central hypothesis is that Polycomb proteins cooperate to preprogram the epigenome in undifferentiated spermatogonia, thus regulating the subsequent dynamic genome-wide expression profile and programmed differentiation necessary for spermatogenesis. (grantome.com)
These studies will reveal novel epigenetic mechanisms by which interplay between Polycomb proteins regulates the dynamic gene expression during spermatogenesis. (grantome.com)
There is strong evidence that the epigenetic regulation of gene transcription, by way of covalent modifications of DNA and DNA-associated proteins, and through microRNAs, is an essential process underlying neuronal plasticity and memory. (benthamscience.com)
EPFL scientists have just found that members of the DUX family of proteins are responsible for igniting the gene expression program of the nascent embryo. (news-medical.net)
The study points to DUX4, and by extension the DUX family of proteins, as the master regulator responsible for kick-starting genome expression at the earliest stage of embryonic life in humans, mouse and probably all placental mammals. (news-medical.net)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

Transcriptomic analyses provide an efficient approach to explore the temporal gene expression profiles in embryos and to search for the developmental regulators. (biomedcentral.com)
Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences. (ivi-rmainnovation.com)
Haploid androgenetic axolotl embryos develop devoid of the 8S DNA-ligase characteristic of control embryos ( Fig. 1A,B ). The paternal gene for DNA-ligase I is in a repressed state. (silverchair.com)
2021). Examination of the C. gigas kinome found several serine/threonine-protein kinases in eggs and embryos, with some gene expression changes in response to abiotic stress (Epelboin et al. (github.io)
When in culture, a small fraction of these cells exhibit at any given time the gene expression pattern of 2-cell stage embryos, before cycling back to the features of more advanced embryonic cells. (news-medical.net)

Dynein heavy chain 5, axonemal: Associated with sperm (flagellar and cillar) motility). (github.io)
2012). Dynein does not have strict functions relating to sperm motility. (github.io)
During their passage through the epididymis to the vas deferens, sperm acquire their motility. (jci.org)

2022). Brain-wide bidirectional neuropeptide modulation of individual neuron classes regulates a developmental decision. (caltech.edu)
Genomic DNA regulates gene expression by activating or inactivating certain genes depending on cell types or developmental stages, providing critical regulation of proper cell functioning and specialization. (keydifference.info)
Deciphering the Role of Histone Modifications in Uterine Leiomyoma: Acetylation of H3K27 Regulates the Expression of Genes Involved in Proliferation, Cell Signaling, Cell Transport, Angiogenesis and Extracellular Matrix Formation. (ivi-rmainnovation.com)

One report describes a 46,XX/46,XY infertile chimeric male who fathered a child with sperm obtained from his testicular tissue through intracytoplasmic sperm injection. (medscape.com)

This includes, 1) how small RNAs regulate gene expression in the male germline to support spermatogenesis and fertility, 2) how small RNAs are packaged into mature sperm, 3) how RNAs transmitted during fertilization are able to regulate early embryonic gene expression and development, and 4) how this regulation can alter developmental programs to produce a non-genetically inherited phenotype. (upenn.edu)
Catenins form functional networks in the nucleus to regulate gene expression and determine cell fate. (bvsalud.org)
Recently, pol III and core components of the pol III complex such as TFIIIC have been demonstrated to establish boundaries between genomic domains, and regulate gene expression within those domains. (yale.edu)

There are other gene families which are not expanded but shows a differential expression pattern among developmental stages and castes. (wikipedia.org)
Additionally, the characteristics and marks of active and inactive chromatin exhibit a distinct radial profile across developmental stages and the genome. (fsu.edu)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)

It has approximately 280 functional chemoreceptor genes. (wikipedia.org)
MBD5 gene mutations and deletions prevent one copy of the MBD5 gene in each cell from producing any functional protein, which reduces the total amount of this protein in cells. (medlineplus.gov)
Here, we aimed at identifying a β-catenin-independent Wnt target gene signature in order to understand the functional significance of non-canonical signaling in colon cancer cells. (nature.com)
We demonstrate that, despite the functional mono-allelicism of imprinted genes and their unique mechanisms of epigenetic dosage control, imprinted genes as a class are neither more susceptible nor protected from expression perturbation induced by maternal undernutrition in either the F1 or the F2 generation compared to other genes. (prolekarniky.cz)
Furthermore, a functional analysis of differentially expressed genes revealed enriched gene ontology terms involved in the regulation of circadian rhythm, histone modification, meiotic nuclear division, and others. (biomedcentral.com)
We wish to understand how germ cells protect their DNA, while turning different genes on and off at the right times to make functional sperm and eggs. (yale.edu)
Functional disomy of Xp including duplication of DAX1 gene with sex reversal due to t(X;Y)(p21.2;p11.3). (medscape.com)

Prezygotic transcripts included multiple regulators that are most likely involved in developmental processes that take place long after fertilization, such as components of ErbB, hedgehog, notch, retinoid, TGFb, VEGF and Wnt signaling pathways, as well as transcripts involved in the development of nervous system. (biomedcentral.com)
Following fertilization and within a few cell divisions, the first cell lineages are established, and different gene-expression programs are put into action. (nih.gov)
Instead, male germ cells retain a unique cellular identity that is passed on to sperm and gives rise to a totipotent zygote after fertilization. (grantome.com)
Propagation of paternal sperm-contributed mitochondrial genes, leading to heteroplasmy, is seldom noticed in mammals attributable to post-fertilization degradation of sperm mitochondria, known as sperm mitophagy. (eqalix.com)
post-fertilization sperm mitophagy depend on the ubiquitin -binding autophagy receptor, sequestosome 1 (SQSTM1), and the proteasome-interacting ubiquitin ated protein dislocase, valosin-containing protein (VCP). (eqalix.com)
These outcomes reveal that the early developmental occasions of post-fertilization sperm mitophagy noticed in porcine zygote will be reconstituted in a cell-free system, which may grow to be a useful gizmo for figuring out extra molecules that regulate mitochondrial inheritance in mammals. (eqalix.com)
We integrate chromosome organization with allelic expression states and chromatin marks and demonstrate that after fertilization, higher-order chromatin structure is associated with an allele specific enrichment of histone H3 lysine 27 methylation. (fsu.edu)

Collectively, the data suggest an expanded role around spermatogenesis regulation and termite evolution. (wikipedia.org)
The goal of this study is to elucidate the epigenetic mechanisms underlying dynamic genome-wide gene expression during spermatogenesis. (grantome.com)
Our recent RNA-seq analysis showed that about three thousand spermatogenesis-specific genes are activated, while approximately three thousand genes expressed in both somatic lineages and progenitor cells of the male germline (termed somatic/progenitor genes) are largely suppressed during late spermatogenesis, i.e., in meiosis and in postmeiotic spermatids. (grantome.com)
both for subsequent genome-wide gene silencing and activation during spermatogenesis (termed ?programmed differentiation? (grantome.com)
In Aim 1, we will elucidate how PRC1 defines heritable gene activation and silencing during spermatogenesis. (grantome.com)
The proposed research is relevant to public health because dysregulation of gene expression in spermatogenesis is associated with testicular cancers and male infertility. (grantome.com)
The study potentially identifies fundamental mechanisms for dynamic and coordinated regulation of genome-wide gene expression necessary for spermatogenesis. (grantome.com)
Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm production. (jci.org)

Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)
Our lab is interested in understanding cell-lineage differentiation, gene regulation, and how non-coding DNA elements and the 3D architecture of chromosomes contribute to these processes during development and disease. (nih.gov)
Na(+) influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation. (nih.gov)
Developmental expression of DAX1 in the European sea bass, Dicentrarchus labrax: lack of evidence for sexual dimorphism during sex differentiation. (ualg.pt)
They are intimately related to cell differentiation and developmental plasticity and relay environmental influences to the cell nucleus, thus bridging the gap between lifestyle and the genome. (benthamscience.com)
the gene expression profile during B lymphoid differentiation. (lu.se)

Maternal to zygotic transition (MZT) is the key event during embryogenesis marked by the switch of control from the maternal and possibly paternal transcripts to the newly synthesized embryonic gene products [ 9 - 11 ]. (biomedcentral.com)
Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes. (nature.com)
However, robust and large-scale genome-wide reprogramming of DNA methylome occurs during two critical developmental processes: (1) development of primordial germ cells and (2) pre-implantation embryogenesis. (nature.com)
This week, I spent a lot of time playing gene librarian and understanding the functions of each of these genes in the gonad or during embryogenesis, probable responses to low pH stress, and overlaps between other studies. (github.io)
Changes in methylation of this gene could impact progression of gametogenesis or embryogenesis. (github.io)

Characterization of the growth rate of adult wolffishes Anarhichas minor and A. lupus: Is avoidance of paternal care at the origin of the expression of a sexual size dimorphism? (uit.no)
Finally, we discover that these domains are lost as genes are silenced on the paternal X chromosome but persist in regions that are not inactivated by the X chromosome. (fsu.edu)
Epigenetic changes in sperm are associated with paternal and child quantitative autistic traits in an autism-enriched cohort. (cdc.gov)

2022). Interneuron control of C. elegans developmental decision-making. (caltech.edu)

Because mutations in the MBD5 gene and changes on chromosome 2 that involve this gene both cause MAND, researchers believe that MBD5 gene changes underlie most of the signs and symptoms of the condition. (medlineplus.gov)
It is also unknown whether the loss or gain of other genes in chromosome 2 deletions or duplications contributes to the variable features of MAND. (medlineplus.gov)

The neurons, the NPC and the sperm will be submitted to RNA extraction and the sncRNA will be analyzed through next generation sequencing the sncRNA that show differential expression and that show relevance for this study will be validated by RT-qPCR. (fapesp.br)
Transcriptomes from the tissues of the brain-pituitary-gonad (BPG) axis of T10 samples revealed a differential gene expression profile compared to the other experimental groups, with clustering in a principal component analysis and in heat maps of all differentially expressed genes. (biomedcentral.com)

The MZT marks the transfer of control of development from the mother to the zygote as maternal mRNAs are degraded, transcription from the zygotic genome begins, and embryonic development becomes dependent on zygotic gene products ( Tadros and Lipshitz, 2009 ). (elifesciences.org)
Such patterns are according to our earlier commentary of SQSTM1 and VCP associating with sperm mitochondria contained in the porcine zygote. (eqalix.com)

We are particularly interested in how RNAs present in sperm are capable of transmitting non-genetic information to their progeny, influencing offspring phenotype. (upenn.edu)
These type of modulation of gene expression include DNA methylation and regulation through short non-coding RNAs (sncRNA). (fapesp.br)
The molecular mechanisms that mediate epigenetic regulation are principally DNA methylation, the post-translational modifications of the histones and the regulation by non-coding RNAs. (benthamscience.com)

SCML2 is a germline-specific subunit of the Polycomb repressive complex 1 (PRC1), a regulator of heritable gene repression during development. (grantome.com)
DNA methylation is the most commonly studied epigenetic mark in humans, as it is well recognised as a stable, heritable mark that can affect genome function and influence gene expression. (frontiersin.org)
Epigenetic marks are heritable DNA modifications that can influence gene expression without changing the DNA sequence. (frontiersin.org)
Genes are molecular, heritable instructions for how an organism develops. (asu.edu)

Most people with MAND have features similar to autism spectrum disorder , a developmental condition that affects communication and social interaction. (medlineplus.gov)
The Autism Spectrum Disorder (ASD) is developmental neurologic disorder that involves a broad spectrum of phenotypes and that show complex genetic contribution. (fapesp.br)

In Xenopus, zebrafish, and Drosophila the major activation of zygotic transcription occurs as the cell cycle lengthens and gastrulation begins, a developmental period referred to as the midblastula transition. (elifesciences.org)
β-catenin then translocates to the nucleus where it forms a complex with TCF/LEF transcription factors and activates Wnt target gene expression 28 , 29 . (nature.com)
Control of gene expression at transcription and translation level: Regulation of phages, viruses, prokaryotic and eukaryotic gene expression, role of chromatin in regulating gene expression and gene silencing. (pathfinderacademy.in)

There were found all the vias related to immunity in Drosophila and other insects, including pattern recognition receptors, signaling pathways and regulatory genes. (wikipedia.org)
We are also interested in early mammalian development as a system in which decipher how cells make lineage decisions and how gene-regulatory networks are established. (nih.gov)
Changes in DNA methylation and histone modifications at putative regulatory regions correlating with the altered expression of genes implicated in phenotypic development have been observed in a number of animal models of early life compromise [3] - [8] . (prolekarniky.cz)
This information is embedded at multiple levels - in the regulatory information of individual genes, in the partitioning of that sequence into chromatin domains, and in the spatial segregation of these domains into functionally distinct regions of the nucleus. (yale.edu)
Most experimental techniques to analyse gene expression regulatory networks rely on deletion of a particular component, akin to closure of a station. (ox.ac.uk)
The Oxford team used this technology to understand the activity of microRNAs, small RNA molecules that form an important regulatory layer of gene expression. (ox.ac.uk)
In line with this lead, the scientists could show that the DUX4 protein binds to the regulatory region of genes that are induced during zygotic genome activation, stimulating their expression. (news-medical.net)

The switch from maternal to zygotic developmental programs is associated with large-scale modification of chromosomes. (biomedcentral.com)
These cells guard their DNA very carefully to allow the production of sperm and eggs with the right number of chromosomes and no mutations. (yale.edu)

The major event of MBT was the activation of a large group of histones and other genes that modify chromatin structure preceding massive gene expression changes. (biomedcentral.com)
Potential methylation regulation of chromatin structure. (github.io)

5 signaling pathway genes related to immune system are overexpressed in reproductive females. (wikipedia.org)
Gene expression profiling was performed after silencing of key components of Wnt signaling pathway and an iterative signature algorithm was applied to predict pathway-dependent gene signatures. (nature.com)

Our long-term goal is understand how such processes occur in vivo and how their regulation dictates cell identity and cell-fate decisions in mammals. (nih.gov)

The presented results support our hypothesis that a low temperature seawater treatment induces an early sexual developmental stage in European eels. (biomedcentral.com)
There are mechanisms by which environmental exposures induces epigenetic changes by affecting regulation and gene expression. (cloudfront.net)

Retrospective studies of the survivors of famines, such as those exposed to the Dutch Hunger Winter of 1944-45, have linked exposures around conception to later disease outcomes, some of which correlate with DNA methylation changes at certain genes. (frontiersin.org)

This thermoception may have caused the observed effects through epigenetic mechanisms, since all analysed tissues further revealed differentially expressed genes involved in histone modification. (biomedcentral.com)
In this introductory chapter we offer a general vision of the well-documented effects of lifestyle choices and environmental impact on gene expression and present the reader with a general overview of the better known epigenetic mechanisms and the techniques most often used to study them. (benthamscience.com)

Research Interests: Mechanisms involved in the production of normal sperm and eggs. (csuohio.edu)
The epigenetic code is determined by several mechanisms that affect gene expression, the most well-known of which is DNA methylation (See Figure 1). (cdc.gov)

Independent experiments confirmed several target genes, including PLOD2 , HADH , LCOR and REEP1 as non-canonical target genes in various colon cancer cells. (nature.com)
Moreover, non-canonical Wnt target genes are regulated via RoR2, Dvl2, ATF2 and ATF4. (nature.com)
We are currently identifying additional Notch target genes in GSCs and mapping the landscape of Notch signaling in the GSC pool. (wisc.edu)

The pleiotropic harmful effects of EDCs act through hormone-dependent downstream signaling pathways responsible for gonad development either through direct interaction with steroid hormone receptor or via epigenetic regulation. (intechopen.com)
Elucidating the function of the mutated gene, ALMS1 , is critical for the development of specific treatments and may uncover pathways relevant to a range of other disorders including common forms of obesity and type 2 diabetes. (springer.com)
We will build on decades of lineage-fate experiments and precisely characterized signaling pathways known to regulate early mouse development to understand the contribution of nuclear organization to gene regulation during these early cell fate decisions. (nih.gov)
Cell signaling: Hormones and their receptors, cell surface receptor, signaling through G-protein coupled receptors, signal transduction pathways, second messengers, regulation of signaling pathways, bacterial and plant two-component signaling systems, bacterial chemotaxis and quorum sensing. (pathfinderacademy.in)

How extensively does genome organization contribute to coordinated expression of functionally related genes? (yale.edu)
How does genome organization stabilize and instruct tissue-specific gene expression? (yale.edu)
These findings highlight the complexities of three-dimensional genome organization and gene expression dynamics during early development. (fsu.edu)

Developmental cell 50(1): 7-8, July 2019. (upenn.edu)
Outlier SNP loci were found in this gene in O. lurida , potentailly related to immune or stress response (Silliman 2019). (github.io)

We are studying germ cell regulation primarily using the model organism C. elegans, a nematode, because of the large number of germ cells it contains, and because of the many experimental advantages it offers. (yale.edu)
Because the genes in C. elegans are related to those in higher organisms, the results from our studies should help us to understand how germ cells function in humans as well. (yale.edu)
We address these questions in vivo with unprecedented cell specificity and comprehensiveness, utilizing innovative methods to investigate how genome structure and organization influences gene expression specifically in the C. elegans germ line. (yale.edu)
C. elegans gamete specification relies on master RNA regulators FOG-1/CPEB and FOG-3/Tob, which function at the end of the sex determination pathway to drive the sperm fate. (wisc.edu)

Intra-sample heterogeneity of sperm DNA methylation. (ivi-rmainnovation.com)

Imprinted genes, a class of functionally mono-allelic genes critical for early growth and metabolic axis development, have been proposed to be uniquely susceptible to environmental change. (prolekarniky.cz)

B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)

the FOG-1/CPEB RNA binding protein together with the FOG-3/Tob RNA regulator specify the sperm fate at the expense of oogenesis. (wisc.edu)

Developmental Cell 55(6): 677-678, December 2020. (upenn.edu)
2020. I also looked at the C. gigas -specific reproduction and gene expression papers: Dheilly et al. (github.io)

Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix and vesicles. (ivi-rmainnovation.com)

Placenta-associated pregnancy complications, such as preeclampsia and intrauterine growth restriction, are all associated with aberrant patterns of DNA methylation and expression which are only now being linked to disease risk later in life. (frontiersin.org)
Ankylosing Spondylitis Patients Display Aberrant ERAP1 Gene DNA Methylation and Expression. (cdc.gov)

It cannot be detected in the unfertilized egg, sperm or differentiated tissues such as liver or muscle. (silverchair.com)
We therefore analyse the role of imprinted genes in multiple tissues in two affected generations of an established murine model of the developmental origins of health and disease using microarrays and quantitative RT-PCR. (prolekarniky.cz)

Cell division and cell cycle: Mitosis and meiosis, their regulation, steps in cell cycle, and control of cell cycle. (pathfinderacademy.in)

Early ontogeny is associated with dramatic gene expression changes that underlie and determine the developmental processes. (biomedcentral.com)
Methyalation of this gene could promote homeostasis by regulating gonad development processes. (github.io)
The results of such research suggest that the processes are tightly controlled and are themselves critical components of gene regulation. (nih.gov)

De Iaco also found that when DUX4 is forcibly produced in muscle cells, it turns on a whole set of genes that are expressed during zygotic genome activation. (news-medical.net)
They found that DUX4 is one of the very first genes expressed at this stage, releasing a high concentration of its protein product just before zygotic genome activation. (news-medical.net)

Cellular communication: Regulation of hematopoiesis, general principles of cell communication, cell adhesion and roles of different adhesion molecules, gap junctions, extracellular matrix, integrins, neurotransmission and its regulation. (pathfinderacademy.in)

Less frequently, MAND is caused by mutations that affect only the MBD5 gene. (medlineplus.gov)
Multiple mutations affecting embryonic development have been induced by chemical and insertional mutagenesis resulting in the identification of genes with important roles in development in Drosophila [ 23 - 25 ]. (biomedcentral.com)
Whithout mutations we would know very little about inheritance and the existence of genes. (intechopen.com)

piRNA clustering is evolutionarily conserved, indicating that physical proximity is a key feature for coordinated expression, yet how germline-specific expression is implemented is a mystery. (yale.edu)

Amazingly, these piRNAs exhibit synchronized expression in the germ line, despite being interspersed among hundreds of coding genes with diverse expression patterns. (yale.edu)
We have found that SNPC-4 preferentially binds across both piRNA clusters only in the germ line and promotes piRNA expression. (yale.edu)

During the twentieth century in the United States, Alfred Day Hershey studied phages, or viruses that infect bacteria, and experimentally verified that genes were made of deoxyribonucleic acid, or DNA. (asu.edu)
When Hershey started to study phages, scientists did not know if phages contained genes, or whether genes were made of DNA or protein. (asu.edu)

Aside from the physical and emotional consequences associated with genital ambiguity, patients with ovotesticular disorder of sexual development usually do not possess other developmental malformations. (medscape.com)

This feature means that this kind of genes were expanded early within the evolution of this species. (wikipedia.org)
can be unambiguously characterized and the advantages offered by the early amphibian embryo have made possible the identification of some basic features of their regulation. (silverchair.com)
Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture? (uit.no)
These early parental-specific domains are associated with gene repression and contribute to parentally biased gene expression-including newly described transiently imprinted loci. (fsu.edu)
According to the Developmental Origins of Health and Disease hypothesis, environmental exposures in early life affects later life risk. (frontiersin.org)
The early steps of this developmental formation process. (lu.se)

tures and gene expression patterns. (lu.se)

VCP was distinguished within the sperm mitochondrial sheath each earlier than and after the extract co-incubation and was additionally detected within the acrosome and postacrosomal sheath and the subacrosomal layer of the spermatozoa co-incubated with extraction buffer as management. (eqalix.com)

Regulation of gene expression plays a central role in embryonic development. (biomedcentral.com)
However in recent years with the development of epigenesis, genomic imprinting and the horizontal transferences of the genes, Lamarck's ideas have resurfaced. (intechopen.com)
Genomic DNA is essential to human development, inheritance, and gene regulation while plasmid DNA - while not found naturally within humans - may play an essential role in antibiotic resistance as well as genetic engineering and bacterial adaptation. (keydifference.info)
Increased expression of this gene in Artemia sinica can suppress cell division and macromolecule synthesis (Jiang 2011), so methylation may be regulating gonad development. (github.io)
Ultimately, candidates identified this way will be fully characterized in vivo to stringently determine their impact on gene regulation during mammalian development. (nih.gov)
We and others have hypothesised that a compromised in utero environment may impinge upon the epigenetic apparatus with lasting consequences for gene expression and development. (prolekarniky.cz)
Development of an oligo DNA microarray for the European sea bass and its application to expression profiling of jaw deformity. (ualg.pt)

Peak Campbell, KL (1985) Monitoring ovarian function and predicting ovulation: summary of a meeting, Research Frontiers in Fertility Regulation 3:1-16. (slideserve.com)

Anatomy30

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Progenitor cells1

Oogenesis1

20202

Methylome1

Methylation and expression2

Tissues2

Mitosis1

Processes3

Zygotic2

Extracellular matrix1

Mutations3

Germline-specific1

Germ line2

Phages2

Malformations1

Early6

Patterns1

Mitochondrial1

Development7

Frontiers1