AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Cyclin-Dependent KinasesCyclin-Dependent Kinase 2Cyclin D1Cyclin ACyclin ECyclinsCyclin-Dependent Kinase 4Cyclin-Dependent Kinase Inhibitor p27CDC2-CDC28 KinasesCell CycleCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase 5Cell Cycle ProteinsCyclin BCyclin CProtein-Serine-Threonine KinasesCDC2 Protein KinaseCyclin DG1 PhaseCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor ProteinsCyclin D3Cyclin B1PhosphorylationRetinoblastoma ProteinCyclin-Dependent Kinase 6Cyclin-Dependent Kinase Inhibitor p57Tumor Suppressor ProteinsS PhaseProtein Kinase InhibitorsCyclin D2Cyclin A1Microtubule-Associated ProteinsProtein KinasesCell ProliferationPurinesCell DivisionProto-Oncogene ProteinsApoptosisSubstrate SpecificityE2F1 Transcription FactorMolecular Sequence DataCyclin A2Phosphatidylinositol 3-KinasesCell Line, TumorSensitivity and SpecificityCyclin GTumor Cells, CulturedTumor Suppressor Protein p53MitosisSignal TransductionCyclin G1Cells, CulturedBlotting, WesternMAP Kinase Signaling SystemEnzyme InhibitorsTranscription Factor DP1G2 PhaseMutationTransfectionCell LineBase SequenceE2F Transcription FactorsCalcium-Calmodulin-Dependent Protein KinasesDNA-Binding ProteinsProliferating Cell Nuclear AntigenAmino Acid SequenceCarrier ProteinsNuclear ProteinsRNA, MessengerTranscription FactorsProtein Kinase CProtein Bindingsrc-Family KinasesImmunohistochemistryReverse Transcriptase Polymerase Chain ReactionDNA DamageAntineoplastic AgentsKineticsp38 Mitogen-Activated Protein KinasesCyclic AMP-Dependent Protein KinasesMitogen-Activated Protein Kinase 1Enzyme ActivationCyclin B2Gene Expression RegulationBinding SitesTranscription, GeneticMitogen-Activated Protein Kinase KinasesCyclin TProtein-Tyrosine KinasesJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein Kinase 3Recombinant Fusion Proteinsp21-Activated KinasesCyclin HCyclin G2Models, BiologicalTime Factors3T3 CellsMAP Kinase Kinase Kinases
CdksCdk2Dual-specificity phosphataseInhibitorsPhosphorylationCdk1SerineTyrosine kinaseTumorInhibitor 1bCDKN2AProteinsBiolEukaryoticDifferentiallySubstrateCDC2ProgressionSensitivityResiduesRegulatesGeneInhibitsMitoticSubtypeInhibitionCellularModulate2001RTKsMRNA expressionReplicationActivatorMalignantDrosophilaActivityComplexesCellsPotencySpeciesOverexpressionHydrophobicCompoundsHUMAN2000Monoclonal
Cdks10
Cdk224
  • Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. (wikipedia.org)
  • This protein associates with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. (wikipedia.org)
  • Cdk2 is capable of binding to many different cyclins, including cyclins A, B, E, and possibly C. Recent studies suggest Cdk2 binds preferentially to cyclins A and E, while Cdk1 prefers cyclins A and B. Cdk2 becomes active when a cyclin protein (either A or E) binds at the active site located between the N and C lobes of the kinase. (wikipedia.org)
  • Due to the location of the active site, partner cyclins interact with both lobes of Cdk2. (wikipedia.org)
  • Cdk2 contains an important alpha helix located in the C lobe of the kinase, called the C-helix or the PSTAIRE-helix. (wikipedia.org)
  • It is important to note that throughout this activation process, cyclins binding to Cdk2 do not undergo any conformational change. (wikipedia.org)
  • Prior to G1 phase, levels of Cdk4 and Cdk6 increase along with cyclin D. This allows for the partial phosphorylation of Rb, and partial activation of E2F at the beginning of G1 phase, which promotes cyclin E synthesis and increased Cdk2 activity. (wikipedia.org)
  • Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. (nature.com)
  • Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. (proteopedia.org)
  • NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. (proteopedia.org)
  • Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. (proteopedia.org)
  • Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. (proteopedia.org)
  • and 3) to explore the mechanism by which Cdk2 kinase activity regulates Cdc25A protein turnover. (pitt.edu)
  • The results of our studies revealed that Cdc25A protein half-life in non-stressed interphase cells is regulated, in part, by Cdk2 kinase activity, and that Cdk2 does not regulate Cdc25A turnover by affecting several known signal transduction pathways that control Cdc25A protein stability. (pitt.edu)
  • The kinase(s) responsible for phosphorylating these serine residues remain to be identified, although Cdk2 could be one prime candidate. (pitt.edu)
  • The increased potency arises primarily from the formation of two additional hydrogen bonds between the inhibitor and Asp 86 of CDK2, which facilitate optimum hydrophobic packing of the anilino group with the specificity surface of CDK2. (rcsb.org)
  • Cellular studies with O(6)-cyclohexylmethyl-2-(4'- sulfamoylanilino) purine demonstrated inhibition of MCF-7 cell growth and target protein phosphorylation, consistent with CDK1 and CDK2 inhibition. (rcsb.org)
  • The work represents the first successful iterative synthesis of a potent CDK inhibitor based on the structure of fully activated CDK2-cyclin A. Furthermore, the potency of O(6)-cyclohexylmethyl-2-(4'- sulfamoylanilino)purine was both predicted and fully rationalized on the basis of protein-ligand interactions. (rcsb.org)
  • CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. (rockland.com)
  • CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. (rockland.com)
  • CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B) (1). (rockland.com)
  • CDK2 Protein is ideal for investigators involved in Signaling Proteins, Cell Cycle Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research. (rockland.com)
  • Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway. (nih.gov)
  • Fig. 2: p38γ compensates for the loss of CDK1 or CDK2. (nature.com)
Dual-specificity phosphatase1
Inhibitors14
  • Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases. (proteopedia.org)
  • Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers. (koreamed.org)
  • Here, we generated knockout mouse models for each of these three cyclin-dependent kinase inhibitors using engineered nucleases. (koreamed.org)
  • Studies with bortezomib (VELCADE, formerly known as PS-341) and other proteasome inhibitors indicate that cancer cells are especially dependent on the proteasome for survival, and several mechanisms used by prostate cancer cells require proteasome function. (aacrjournals.org)
  • The recent identification of associations between protein kinases and AD pathology has spurred interest in tyrosine kinase inhibitors (TKIs) as potential strategic therapeutic agents for AD. (biomedcentral.com)
  • These findings suggest that tyrosine kinase inhibitors (TKIs) could be leveraged as therapeutic agents for AD. (biomedcentral.com)
  • Kinase inhibitors are now one of the major categories of chemotherapy medicine. (callaix.com)
  • Over 50 kinase inhibitors are approved in the US for cancer treatment with more under development. (callaix.com)
  • Of the 69 new drugs approved by the FDA for cancer from 2015 to 2020, 26 were kinase inhibitors. (callaix.com)
  • Most kinase inhibitors work on tyrosine kinases . (callaix.com)
  • As oncology drugs, kinase inhibitors were created out of modern genetics- the understanding of DNA, the cell cycle, and molecular signaling pathways- and thus represent a change from general to molecular methods of cancer treatment. (callaix.com)
  • An article published in the journal Molecular Cancer in 2018 claimed that over 10,000 patents had been filed in the US for kinase inhibitors since 2001. (callaix.com)
  • Tyrosine kinase inhibitors (TKIs) are a class of chemotherapy medications that inhibit, or block, one or more of the enzyme tyrosine kinases. (callaix.com)
  • Tyrosine kinase inhibitors treat cancer by correcting this deregulation. (callaix.com)
Phosphorylation19
  • hPTTG phosphorylation is mediated by cyclin-dependent kinase 2 (CDC2) and expression is regulated by specificity protein 1 (SP1). (endocrine-abstracts.org)
  • Here we compare the specificity of two budding yeast cyclins, the S-phase cyclin Clb5 and the M-phase cyclin Clb2, in the phosphorylation of 150 Cdk1 (Cdc28) substrates. (nature.com)
  • Phosphorylation of Clb5-specific targets during S phase was reduced by replacing Clb5 with Clb2 or by mutating the substrate RXL motif, confirming the importance of Clb5 specificity in vivo . (nature.com)
  • Although we did not identify any highly Clb2-specific substrates, we found that Clb2-Cdk1 possessed higher intrinsic kinase activity than Clb5-Cdk1, enabling efficient phosphorylation of a broad range of mitotic Cdk1 targets. (nature.com)
  • controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. (proteopedia.org)
  • regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. (proteopedia.org)
  • Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
  • To fully understand this complex and essential regulatory process, the kinases and phosphatases mediating the changes in cellular phosphorylation must be identified and characterized. (rupress.org)
  • Phosphorylation of FOXO1 leads to its inhibition (2). (rockland.com)
  • Here DARPP-32 phosphorylation by protein kinase A (PKA), DARPP-32 into a powerful protein phosphatase 1 (PP1) inhibitor. (pp1a.com)
  • DARPP-32 can itself inhibit the following PKA DARPP-32 phosphorylation by cyclin-dependent kinase 5 (Cdk5). (pp1a.com)
  • Mechanistic investigations revealed reduce GR-Ser211 phosphorylation following PP1α silencing and provide the first indication of the involvement of glycogen synthase kinase 3 (GSK-3). (pp1a.com)
  • An in vitro binding kinetic analysis revealed that these phosphorylation-dependent events were attributable to a decrease in the affinity of phosphorylated Homer3 for its ligand. (jneurosci.org)
  • In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
  • This process leads to the activation of each receptors' tyrosine kinase and the subsequent phosphorylation of tyrosine residues located on their C-terminal tails. (plos.org)
  • Kinases are a class of enzyme that promote phosphorylation. (callaix.com)
  • Imatinib, for example, blocks a kinase receptor from binding to ATP, preventing the phosphorylation that would benefit the cancerous cell and promote cell division. (callaix.com)
  • 2001). Temporal regulation of herpes simplex virus type 2 VP22 expression and phosphorylation. (geneticsmr.com)
  • 2005). Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity. (geneticsmr.com)
Cdk13
  • This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans. (wikipedia.org)
  • Targets of the cyclin-dependent kinase Cdk1. (nature.com)
  • Cyclin A degradation employs preferentially used lysines and a cyclin box function other than Cdk1 binding. (nih.gov)
Serine2
Tyrosine kinase3
  • Results from these analyses demonstrated that the C-terminal domain of HER3 (CTD, amino acids distal to the tyrosine kinase domain) contained potent transactivation potential. (plos.org)
  • Brand TM, Iida M, Luthar N, Wleklinski MJ, Starr MM, Wheeler DL (2013) Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3. (plos.org)
  • There are three primary growth factors that relate to tyrosine kinase. (callaix.com)
Tumor4
  • Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)
  • Membrane-bound HER receptors activate numerous tumor promoting signaling cascades via this mechanism, including the PI3K/AKT, Ras/Raf/Mek/Erk, PLCγ/PKC, and signal transducer and activator of transcription (STAT) pathways [1] , [2] . (plos.org)
  • Mice lacking the tumor suppressors p16(Ink4a) (Cdkn2a, cyclin-dependent kinase inhibitor 2a), p19(Arf) (an alternative reading frame product of Cdkn2a,), and p27(Kip1) (Cdkn1b, cyclin-dependent kinase inhibitor 1b) result in malignant progression of epithelial cancers, sarcomas, and melanomas, respectively. (koreamed.org)
  • The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
Inhibitor 1b1
  • In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
CDKN2A2
  • METHODS: Cervical samples from women in Cape Town, South Africa, ages 30-65 years, were collected and tested with Xpert HPV and with real-time PCR to detect mRNA for cyclin-dependent kinase inhibitor 2A (CDKN2A), topoisomerase 2 alpha (TOP2A), and Ki67 (MKi67). (bvsalud.org)
  • Specifically, the Glio-DNA panel targets specific genetic and chromosomal alterations involving ATRX chromatin remodeler (ATRX), cyclin dependent kinase inhibitor 2A (CDKN2A), isocitrate dehydrogenase (NADP+) 1 (IDH1) and the telomerase reverse transcriptase (TERT) promoter while also recognizing the co-deletion of 1p/19q, loss of chromosome 10 and gain of chromosome 7. (figshare.com)
Proteins9
  • It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, where cells make proteins necessary for mitosis and replicate their DNA. (wikipedia.org)
  • In chapter 2, by using CRISPR/Cas9 gene editing, genetic analysis and biochemical assays, I identified the differential pairings of typical NLR receptor SOC3 with atypical NLR proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1. (ubc.ca)
  • Further characterization showed that susa2-2 only suppresses the autoimmunity mediated by either CHS1-SOC3 or TN2-SOC3 paired NLR proteins, indicating that SUSA2 is specifically involved in NLR protein SOC3-mediated immunity. (ubc.ca)
  • CA is caused by the epithelial-associated proteins found in the genomes of each subtype ( 2 , 3 ). (spandidos-publications.com)
  • The capsid and tegument of the alphaherpesviruses are linked by an interaction between the UL25 and VP1/2 proteins. (geneticsmr.com)
  • We looked into whether modulating cyclin-dependent kinase (CDK) activity could alter matrix proteins and cytokine creation by SSc fibroblasts. (antiviralbiologic.com)
  • The foundation recognition complicated (ORC), a six-subunit initiator proteins (2), exists in both pre- and post-RCs (10), and among its functions is definitely to mark the positioning of replication roots in the genome. (pkc-inhibitor.com)
  • Predicated on series commonalities between Cdc6p, replication aspect C, and various other AAA+ family and on the characterization of the dominant-negative mutant, it's been suggested that fungus Cdc6p might work as an ATP-dependent MCM proteins loader (45, 63). (pkc-inhibitor.com)
  • It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes [ 1 , 2 ]. (archivesofmedicalscience.com)
Biol1
Eukaryotic2
  • The significance of this movement is that it brings the side chain of Glu 51, which belongs to a triad of catalytic site residues conserved in all eukaryotic kinases, into the catalytic site. (wikipedia.org)
  • Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis. (nature.com)
Differentially1
Substrate5
  • Clb5 specificity depended on an interaction between a hydrophobic patch in Clb5 and a short sequence in the substrate (the RXL or Cy motif). (nature.com)
  • Figure 2: Clb5 specificity depends on an interaction between the Clb5 hydrophobic patch and an RXL motif in the substrate. (nature.com)
  • Brown, N. R., Noble, M. E., Endicott, J. A. & Johnson, L. N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. (nature.com)
  • Schulman, B. A., Lindstrom, D. L. & Harlow, E. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. (nature.com)
  • p38γ shares high sequence homology, inhibition sensitivity and substrate specificity with CDK family members. (nature.com)
CDC21
Progression2
  • This family of RTKs has been highly implicated in the formation and progression of various cancers via aberrant overexpression, kinase activation, and mutation [1] , [2] . (plos.org)
  • Loss of vitamin D-dependent homeostatic mechanisms may promote disease progression. (springer.com)
Sensitivity2
  • BACKGROUND: Human papillomavirus (HPV) testing is the cornerstone of cervical cancer screening, with outstanding sensitivity but only moderate specificity. (bvsalud.org)
  • We evaluated whether reflex testing for cancer biomarkers improves the sensitivity/specificity balance of screening. (bvsalud.org)
Residues1
  • Phosphorylated tyrosine residues recruit various intracellular adaptor and effector molecules that result in the propagation of growth promoting signal transduction cascades [1] , [2] . (plos.org)
Regulates1
  • By acting as a ligand-dependent transcription factor of the glucocorticoid receptor (GR) mediates the action of glucocorticoids and regulates many physiological processes. (pp1a.com)
Gene4
  • The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. (wikipedia.org)
  • A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
  • The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. (nih.gov)
  • CDKL5 deficiency is a severe neurological disorder caused by mutations in the X-linked Cyclin-Dependent Kinase-Like 5 gene (CDKL5). (nih.gov)
Inhibits2
Mitotic1
  • Donaldson, A. D. The yeast mitotic cyclin Clb2 cannot substitute for S phase cyclins in replication origin firing. (nature.com)
Subtype1
Inhibition1
  • Scientists are looking the possibility of kinase inhibition for other diseases including hypertension and Parkinson's disease but here we focus on cancer medicines. (callaix.com)
Cellular2
  • The success of the cell division process is dependent on the precise regulation of processes at both cellular and tissue levels. (wikipedia.org)
  • When these kinases go wrong, normal cellular function can go awry. (callaix.com)
Modulate1
  • Furthermore, kinases and phosphatases may work together to modulate the strength of a signal. (rupress.org)
20011
  • The first kinase inhibitor introduced for cancer was imatinib, which the FDA approved in 2001. (callaix.com)
RTKs2
MRNA expression1
  • Further, the overexpression of HER3 enhanced cyclin D1 mRNA expression, while HER3 deleted of its identified TADs was hindered at doing so. (plos.org)
Replication1
Activator1
  • Thus, the ability for HER3 to function as a transcriptional co-activator may be dependent on specific C-terminal TADs. (plos.org)
Malignant1
  • Drugs given to stop kinases can slow the proliferation of malignant cells and angiogenesis (growth of blood vessels). (callaix.com)
Drosophila2
  • Drosophila Jumonji/Jarid2 (dJmj) has been identified as a component of Polycomb repressive complex 2. (sdbonline.org)
  • Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis. (nih.gov)
Activity1
  • The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. (thermofisher.com)
Complexes1
  • Lundberg, A. S. & Weinberg, R. A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. (nature.com)
Cells3
  • We found that Homer3, the predominant isoform in Purkinje cells, is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) both in vitro and in vivo . (jneurosci.org)
  • Androgens are necessary for normal prostate cell growth (1) , and in animal models, androgen ablation causes cell atrophy and death of prostate epithelial cells (2) . (aacrjournals.org)
  • Likewise, in the early stages of prostate cancer, the growth of cancerous prostatic epithelial cells is often androgen dependent (3) . (aacrjournals.org)
Potency1
  • Protein drugs are increasingly important in drug development worldwide due their high specificity, potency, and low toxicity. (lu.se)
Species1
  • Among the biological agents re- because species specificity limits the causes lymphoproliferative diseas- viewed in Volume 100B of the IARC feasibility of this approach for most of es in New World monkeys and in Monographs (IARC, 2012) are sever- these viruses. (who.int)
Overexpression1
  • To investigate the clinical role of nm23 expression in identifying both high‐risk human papillomavirus (HR‐HPV) and high‐grade cervical lesions or carcinomas [cervical intraepithelial neoplasia 2 + (CIN2 + )], and to compare it with p16 overexpression, as this latter biomarker has already been reported widely in HR‐HPV infected cervical lesions. (mcmaster.ca)
Hydrophobic1
  • Hydrophobic interactions cause the C-helix to associate with another helix in the activating cyclin. (wikipedia.org)
Compounds1
  • M any kinase inhibitor compounds have been found. (callaix.com)
HUMAN3
  • Orthologous to several human genes including CCNB1 (cyclin B1). (nih.gov)
  • The protein interaction landscape of the human CMGC kinase group. (nature.com)
  • There are many kinases (over 500 in the human body ). (callaix.com)
20001
  • 2000). The response of pigs inoculated with a thymidine kinase-negative (TK-) pseudorabies virus to challenge infection with virulent virus. (geneticsmr.com)
Monoclonal1
  • Open up in another screen FIG. 1 Specificities of brand-new monoclonal anti-hCdc6p antibodies (Ab). (pkc-inhibitor.com)