Specific t lymphocytes cytotoxic. Medical search. Frequent questions

Using tetrameric complexes of human histocompatibility leukocyte antigen (HLA) class I to identify antigen-specific T cells ex vivo, we observed high frequencies of circulating MelanA-specific, A*0201-restricted cytotoxic T lymphocytes (A2-MelanA tetramer+ CTLs) in seven of nine HLA-A*0201-positive individuals with vitiligo. (ox.ac.uk)
Finally, we observed that the A2-MelanA tetramer+ CTLs isolated from vitiligo patients expressed high levels of the skin homing receptor, cutaneous lymphocyte-associated antigen, which was absent from the CTLs seen in the single A*0201-positive normal control. (ox.ac.uk)
These data are consistent with a role of skin-homing autoreactive melanocyte-specific CTLs in causing the destruction of melanocytes seen in autoimmune vitiligo. (ox.ac.uk)
In this study, we investigated whether high avidity MDM2-specific CTLs can mediate tumor protection without causing damage to normal tissues in mice. (birmingham.ac.uk)
We show that tumor growth occurred despite the continued presence of MDM2-specific CTLs and the continued susceptibility of tumor cells to CTL killing. (birmingham.ac.uk)
However, analysis of the CTLs revealed that they had been rendered unresponsive in vivo because they did not produce interferon gamma in response to antigen-specific stimulation. (birmingham.ac.uk)
In this study, four amino acid residues that were predicted to potentially interact with the T-cell receptor of CAP1-specific CTLs were systematically replaced. (aacrjournals.org)
An analogue peptide was identified that was capable of sensitizing CAP1-specific CTLs 10 2 -10 3 times more efficiently than the native CAP1 peptide. (aacrjournals.org)
The cytotoxic T lymphocytes (CTLs) typically susceptible to antigenic variation. (cdc.gov)
The role of uncultured melanoma cells in the proliferation of autologous tumor-specific cytotoxic T lymphocytes (CTLs) was investigated. (johnshopkins.edu)
These results demonstrate that administration of EBV-specific CTLs to patients with advanced NPC is feasible, appears to be safe, and can be associated with significant antitumor activity. (nih.gov)
The highly sensitive quantitation of virus-specific CD8(+) T cells using major histocompatibility complex-peptide tetramer assays has revealed higher levels of cytotoxic T lymphocytes (CTLs) in acute and chronic virus infections than were recognized previously. (ox.ac.uk)
Allogeneic virus-specific cytotoxic T lymphocytes (CTLs) have a long track record of safety and efficacy in treating viral infections occurring after allogeneic stem cell transplantation. (aai.org)
Covid-19 specific CTLs were produced by priming and enriching T cells from convalescent patients using COVID-19 peptides predicted or demonstrated to bind to specific HLA alleles. (aai.org)
Epstein-Barr virus (EBV) is usually maintained in an asymptomatic and latent form by the host immune system, and primarily by EBV-specific cytotoxic T cells (CTLs). (researchgate.net)
Immunotherapy is emerging as a new form to treat cancer by harnessing the activity of cytotoxic CD8 + T lymphocytes (CTLs) that specifically recognize tumor-associated antigens. (lifeboat.com)
Transfusion of autologous tumor-specific CTLs 1-4 and blockade of T cell inhibitory receptors 5-7 have demonstrated to elicit durable clinical benefit in a significant proportion of patients with melanoma, leukemia, lymphoma and other cancers, who failed to respond to conventional treatments. (lifeboat.com)
As vaccine -induced non- neutralizing antibodies may cause antibody-dependent enhancement of Zika virus ( ZIKV ) infection , we test a vaccine that induces only specific cytotoxic T lymphocytes (CTLs) without specific antibodies . (bvsalud.org)
Cytotoxic T lymphocytes (CTLs) recognize antigens on target cells and lyse these cells. (msdmanuals.com)

Lack of strong immune selection pressure by the immunodominant, HLA-A 0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection. (anaspec.com)

Emerging evidence indicates that findings from from PR8 that are processed to generate peptides recog- mouse studies are pertinent to immunopathology in human nized by influenza-specific CD8+ T cells. (cdc.gov)
Successful recognition of antigenic peptides bound to Major Histocompatibility Complexes (pMHCs) requires specific binding of the TCR to these complexes ( 5 - 7 ), which in turn modulates the cell's fitness, clonal expansion, and acquisition of effector properties ( 7 ). (frontiersin.org)
Following specific binding of T cell receptors to viral and bacterial-derived peptides bound to MHC ( 5 ), or from neo-antigens ( 8 - 10 ), the appropriate T cells expand, resulting in the increased frequency of T cells carrying such receptors. (frontiersin.org)
the TB2 tube contains an additional set of peptides targeted to the induction of CMI responses from CD8+ cytotoxic T lymphocytes. (cdc.gov)

Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. (jci.org)
Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. (jci.org)

Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. (jci.org)
Three type-specific epitopes were identified, two of them in highly variable regions of envelope. (jci.org)
Most influenza A virus-specific memory cytotoxic T lymphocytes react with antigenic epitopes associated with internal virus determinants. (rupress.org)
Thus, the predominant reactivity of influenza A virus-specific CTL differs from that of anti-influenza A antibodies, which are primarily directed towards epitopes on the virus surface glycoproteins. (rupress.org)
Influenza-specific CD8+ T cells recognize multiple of reagents and genetically modified mouse models has viral epitopes on target cells and antigen-presenting cells. (cdc.gov)
Sub-Saharan Africans and C clade infection have been relatively neglected in terms of the HIV-specific CTL epitopes that have been defined to date. (ox.ac.uk)

Specific adsorption of cytotoxic thymus-processed lymphocytes (t cells" by P Golstein, E A. Svedmyr et al. (jax.org)
Specific adsorption of cytotoxic thymus-processed lymphocytes (t cells) on glutaraldehyde-fixed fibroblast monolayers. (jax.org)
They not only help activate B cells to secrete antibodies and macrophages to destroy ingested microbes, but they also help activate cytotoxic T cells to kill infected target cells. (nih.gov)
B lymphocytes may become infected through exposure to these cells or may be directly infected in the tonsillar crypts. (medscape.com)
In the immunocompetent patient, the proliferation of infected B cells results in massive activation and proliferation of cytotoxic T lymphocytes, leading to the characteristic lymphoid hyperplasia. (medscape.com)
These atypical lymphocytes (ie, Downey cells) actually are CD8 cytotoxic T cells. (medscape.com)
T lymphocytes (T cells) are pivotal in the cellular immune response ( 1 , 2 ). (frontiersin.org)
Consideration of the genetic identity of both the Dengue and Zika flaviviruses as well as the cross-reactivity of relevant T cells along with the actions of CD4+ cytotoxic cells in these infections are also presented. (frontiersin.org)
It is strongly recommended that when using a reagent for the first time, users compare the spillover on cells and BD CompBeads to ensure that BD® CompBeads are appropriate for your specific cellular application. (bdbiosciences.com)
Background: Tumor-specific cytotoxic T lymphocytes (CTL) can be activated in vivo by vaccination with dendritic cells (DC). (uni-muenchen.de)
It is now clear that tumours co-opt certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumour antigens. (nih.gov)
Here, we demonstrated that intradermal administration of clinically relevant vaccines efficiently induces Trm cells specific for tumor-specific and self-antigens that accumulate in vaccinated and non-vaccinated skin. (lifeboat.com)
However, the specific contribution of Trm cells to anti-tumor immunity is incompletely understood. (lifeboat.com)
It may have a specific function in the mechanism or regulation of cytolytic activity of immune cells. (bvsalud.org)
Macrophages can kill specific tumor cells when activated by a combination of factors, including lymphokines (soluble factors produced by T cells) and interferon. (msdmanuals.com)
Under certain circumstances, macrophages may present TAAs to T cells and stimulate tumor-specific immune response. (msdmanuals.com)
Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)
In states of immune dysfunction in which the number of EBV-specific cytotoxic T lymphocytes is decreased, there is an increase in the number of circulating EBV-infected B cells. (medscape.com)
Correspondence with low molecular weight chemicals that results in the priming of chemical-specific, Prof. Dr. Stefan F. Martin, Allergy Research skin-homing CD8+ Tc1/Tc17 and CD4+ Th1/Th17 cells. (cdc.gov)

Suboptimal Stimulation by Weak Agonist Epitope Variants Does Not Drive Dysfunction of HIV-1-Specific Cytotoxic T Lymphocyte Clones. (aidshealth.org)
This paper shows that most murine (C57BL/6) influenza A virus-specific memory cytotoxic T lymphocyte (CTL) clones tested in limiting dilution did not react with the influenza A virus surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA). (rupress.org)
Eight HLA B27-restricted influenza A virus nucleoprotein 383-391-specific cytotoxic T lymphocyte (CTL) clones were obtained from three unrelated donors following natural infection. (ox.ac.uk)
beta-chain variable-region usage was also conserved, with V beta 7 being used by five clones despite contributing less than 2% of peripheral blood lymphocyte V beta sequences of one individual studied. (ox.ac.uk)
We previously reported cytotoxic activity of dengue virus-specific CD4+ CD8- T cell clones established in long-term in vitro culture. (umassmed.edu)

Identification of type-specific cytotoxic T lymphocyte responses to homologous viral proteins in laboratory workers accidentally infected with HIV-1. (jci.org)

Adaptive immune mechanisms recognize and neutralize foreign molecules or microorganisms in a specific manner. (lu.se)
Individuals infected with M. tuberculosis complex organisms (M. tuberculosis, M. bovis, M. africanum, M. microti, M. canetti) usually have lymphocytes in their blood that recognize these and other mycobacterial antigens. (cdc.gov)

Current vaccine strategies against influenza focus on Antigen-specific ligation of T-cell receptors induces generating robust antibody responses. (cdc.gov)

This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. (jci.org)
Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. (jci.org)
Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class I-restricted responses. (ox.ac.uk)
This study shows that peptide-specific HLA B27-restricted CTL following influenza virus infection use very similar TcR and, when considered with previous studies, suggests a pattern of TcR conservation for major histocompatibility complex class I-restricted responses. (ox.ac.uk)
Rapid characterization of HIV clade C-specific cytotoxic T lymphocyte responses in infected African children and adults. (ox.ac.uk)
Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. (lifeboat.com)
Vaccination strategies eliciting CTL responses specific for tumor-specific and self-antigens have shown promising results in recent clinical trials. (lifeboat.com)
Subchronic exposure to EA for 28 days in drinking water caused significant suppression of specific IgM antibody responses in the 2.0 mg/kg EA treatment group and suppressed cytotoxic T-cell function in the 0.5 and 1.0 mg/kg EA treatment groups. (cdc.gov)

Co-administration of a clinically relevant dexamethasone dosage with ablative radiotherapy reduces peripheral lymphocytes but does not alter in vivo intratumoral lymphocyte phenotype or inhibit efficacy of radiotherapy in a murine colorectal tumor model. (rochester.edu)

Antibodies against specific EBV antigens and a number of autoantibodies also are produced. (medscape.com)
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) antibodies were the first of this class of immunotherapeutics to achieve US Food and Drug Administration (FDA) approval. (nih.gov)

However, nothing is known about the ability of the N-specific CD8 + T cell immunity in controlling viral replication in the lungs, a major pathogenic signature of severe disease in humans. (nature.com)

Results: Prophylactic DC-based vaccination completely prevented subcutaneous and orthotopic tumor development and induced immunological memory as well as tumor antigen-specific CTL. (uni-muenchen.de)

This finding may be relevant for the role of influenza A virus-specific CTL in recurrent infections with different influenza A viruses. (rupress.org)

Lymphocytes in lungs are maintained separately from the pool of circulating lymphocytes, and their continuous loss through intraepithelial migration toward the airways is constantly replenished by homeostatic proliferation 9 . (nature.com)

The T-cell response is largely responsible for the rise in the absolute lymphocyte count and for the finding of atypical lymphocytes. (medscape.com)

These results indicate that dengue virus-specific CD4+ CD8- CTL are generated in short-term bulk cultures as well as in long-term-cultured cell lines, and support the concept that CD4+ CTL may be generated in vivo during infection. (umassmed.edu)

The antiviral effect appeared similarly strong when the viral challenge was carried out 3 months after boosting, and associated with the persistence of N-specific CD8 + T-resident memory lymphocytes. (nature.com)

To fill the gap, we investigated the immunity generated in the lungs by N-engineered EVs in terms of induction of N-specific effectors and resident memory CD8 + T lymphocytes before and after virus challenge carried out three weeks and three months after boosting. (nature.com)
The impaired viral replication matched with a reduced induction of Spike-specific CD8 + T lymphocytes. (nature.com)
Cell-mediated immunity triggered by activated macrophages and the induction of a T-cell population capable of direct lymphocyte-mediated cytotoxicity are necessary to kill Nocardia . (medscape.com)

IM represents the immunopathologic expression that occurs under a specific set of circumstances and in response to infection with the Epstein-Barr virus (EBV). (medscape.com)
Disseminated and fulminant disease mainly occurs in immunocompromised hosts (among persons with deficient cell-mediated immunity) with underlying illnesses, such as chronic granulomatous disease or human immunodeficiency virus (HIV) infection, and in children undergoing cytotoxic chemotherapy, bone marrow transplantation, or prolonged glucocorticoid treatment. (medscape.com)
A vaccine inducing solely cytotoxic T lymphocytes fully prevents Zika virus infection and fetal damage. (bvsalud.org)
The pathogenesis of hairy leukoplakia is clearly complex, potentially requiring a convergence of factors including EBV co-infection, productive EBV replication, EBV genetic evolution, expression of specific EBV "latent" genes, and immune escape. (medscape.com)
Cytotoxic T lymphocytes cannot eliminate EBV from the body, but they are essential in maintaining the latent state of the infection. (medscape.com)
et 20 témoins en bonne santé ne présentant pas d'infection par le virus de l'hépatite C. Une réduction importante de la fréquence des cellules tueuses naturelles totales dans le groupe des patients porteurs d'une infection chronique a été observée par rapport au groupe des témoins ( P = 0,001) ou au groupe des patients dont l'infection a connu une résolution spontanée ( P = 0,01). (who.int)

To activate a cytotoxic or helper T cell to proliferate and differentiate into an effector cell , an antigen-presenting cell provides two kinds of signals. (nih.gov)

The high level of Toxoplasma -specific IgG was maintained, with mixed IgG1/IgG2a levels. (nature.com)

We now demonstrate that EBV-specific cytotoxic T-cell (CTL) lines can readily be generated from individuals with NPC, notwithstanding the patients' prior exposure to chemotherapy/radiation. (nih.gov)
Subchronic exposure to ellagic acid impairs cytotoxic T-cell function and suppresses humoral immunity in mice. (cdc.gov)
During the development of toxicological profiles, Minimal Risk Levels (MRLs) are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration for a given route of exposure. (cdc.gov)

PBMC were incubated with noninfectious dengue 1 antigen (Ag)3 for 7 days, and were examined for dengue 1-specific cytotoxic activity. (umassmed.edu)
Treatment of cultured PBMC with monoclonal antibody to CD3 or CD4 and complement abrogated the cytotoxic activity but treatment with a monoclonal antibody to CD8 and complement did not. (umassmed.edu)
Immunological parameters assessed included natural killer (NK) cell activity, cytotoxic T lymphocyte (CTL) activity, IgM antibody plaque forming cell (PFC) response, thymus, spleen, kidney, and liver mass, and total cellularity for the thymus and spleen. (cdc.gov)
Their tumoricidal activity is termed natural because it is not induced by a specific antigen. (msdmanuals.com)

We combined large-scale TCR-peptide dictionaries with deep learning methods to produce ERGO (pEptide tcR matchinG predictiOn), a highly specific and generic TCR-peptide binding predictor. (frontiersin.org)

Our results showed that ME49Δ cdpk3 vaccination triggered a strong immune response marked by significantly elevated proinflammatory cytokine levels, such as IFN-γ, IL-12, and TNF-α, and increased the percentage of CD4 + and CD8 + T-lymphocytes. (nature.com)
This work led us to the conclusion that both the form and the method of delivery of specific antigens strongly affect the produced immune response. (cancer.gov)

The virtual absence of Spike-specific cell immunity in lungs of vaccinees is not surprising given that the vaccine is administrated intramuscularly. (nature.com)
The immense diversity of the T-cell receptor (TCR) enables specific antigen recognition ( 3 , 4 ). (frontiersin.org)
They are less effective than T-cell-mediated cytotoxic mechanisms. (msdmanuals.com)

Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children. (ox.ac.uk)

The therapeutic candidate comprises of Epstein-Barr virus-specific cytotoxic T lymphocytes (EBV-CTL). (pharmaceutical-technology.com)

check also tag CHILD or specific HN - 2008 FX - Adolescent Nutrition FX - Infant Nutrition DH - Maternal Nutrition DI - 052505 MN - SP6.021.072 MS - Nutrition of a mother which affects the health of the INFANT as well as herself. (bvsalud.org)

These substance-specific estimates, which are intended to serve as screening levels, are used by ATSDR health assessors to identify contaminants and potential health effects that may be of concern at hazardous waste sites. (cdc.gov)

Cytotoxic T lymphocytes (CTL) play a central role in successful control of HIV. (ox.ac.uk)
Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. (pharmaceutical-technology.com)

In the present experiments we tried to determine whether dengue virus-specific CD4+ CD8- CTL3 are present in short-term bulk cultures. (umassmed.edu)

High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo. (ox.ac.uk)

Anatomy38

Organisms14

Diseases13

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Health Care2

CTLs19

0201-restricted cytotoxic1

Peptides4

Expressing viral2

Epitopes6

Cells19

Clones5

Proteins1

Recognize2

Receptors1

Responses8

Inhibit1

Antibodies2

Humans1

Antigen-specific1

Infections1

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Atypical1

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IgG11

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Peptide1

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Infected adults1

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Skin1