• 1993). A partially testable predictive model of psychosocial factors in the etiology of cervical cancer. (scirp.org)
  • This study provided robust and confirmatory evidence of the important role of obesity and diastolic blood pressure as important risk factors of RCC and novel evidence of an important role of circulating insulin in the disease's etiology," said Spectrum Health urologist Richard Kahnoski, MD. "But further research is needed to fully understand these important relationships. (medicalxpress.com)
  • The study, The influence of obesity-related factors in the etiology of renal cell carcinoma -A mendelian randomization study, was published January 3, 2019 in PLOS Medicine . (medicalxpress.com)
  • Psychosocial Risk Factors of Cancer Diseases: How Specific Are They? (scirp.org)
  • Kreitler, S. , Kreitler, M. and Barak, F. (2013) Psychosocial Risk Factors of Cancer Diseases: How Specific Are They? (scirp.org)
  • There are a number of measures that quantify the public health burden due to specific risk factors for specific diseases. (nih.gov)
  • Obesity is a major risk factor for insulin resistance and type 2 diabetes as well as for cardiovascular diseases. (diabetesjournals.org)
  • The Role of Splicing Factor SF3B4 in Congenital Diseases and Tumors. (nih.gov)
  • Further studies are warranted to help identify host predisposing factors for urinary bacterial colonization in cats with these diseases. (avmi.net)
  • Diabetes, cardiovascular diseases, cancers and chronic respiratory diseases share common risk factors with oral diseases;3 some of these factors, like excessive intake of sugar and alcohol, use of tobacco and poor oral hygiene, can be avoided. (who.int)
  • It has well-known risk factors: poverty, malnutrition, infectious diseases such as measles, malaria and HIV/AIDS. (who.int)
  • State-Specific Prevalence Part. (cdc.gov)
  • This study examined the prevalence and risk factors of BV of 130 non-pregnant women attending a hospital of Kerman University of Medical Sciences. (who.int)
  • Fox, B. (1998) Psychosocial factors in cancer incidence and prognosis. (scirp.org)
  • Previous studies indicated a range of risk factors associated with these poor outcomes, including maternal psychosocial and economic wellbeing. (springer.com)
  • Our primary aim was therefore to explore ethno-specific risk factors for PTB and SGA, in particular in relation to psychosocial health, within an urban, multi-ethnic, socially disadvantaged cohort. (springer.com)
  • Other psychosocial risk factors also play a role. (visionsteen.com)
  • Note 1:** **Site-Specific Factors 3-6** are used to code the presence or absence of lymph node involvement in each of 7 different levels and other groups defined by TNM. (cancer.gov)
  • Moore KJ, Sussman DA, Koru-Sengul T. Age-Specific Risk Factors for Advanced Stage Colorectal Cancer, 1981-2013. (cdc.gov)
  • These findings confirm the hypothesis that the CO variables of colorectal cancer are disease specific and may be considered as psychological risk factors for colorectal cancer. (scirp.org)
  • MEF2A is a transcription factor in the Mef2 family. (wikipedia.org)
  • The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. (wikipedia.org)
  • However, a strong association between DNA methylation and age-dependent gene expression was found for various transcription factors (i.e. (ugent.be)
  • In conclusion, our results indicate that DNA methylation regulates neurodevelopmental gene expression dynamics through steering transcription factor activity, but does not explain sexually dimorphic gene expression patterns in zebra finch telencephalon. (ugent.be)
  • A network of super enhancer(SE) driven transcription factors(TFs) underlies lineage identity and their dysregulation leads to cancer. (nih.gov)
  • The primary measure of interest is the attributable fraction (AF), representing the fraction of cases or deaths from a specific disease that would not have occurred in the absence of exposure to a specific risk factor either in the exposed population or the population as a whole. (nih.gov)
  • AFs can be multiplied by the total number of cases of a given disease to obtain a "body count"--the absolute number of preventable cases due to a specific risk factor. (nih.gov)
  • A new study confirms the long-suspected role of obesity as a risk factor for developing renal cell carcinoma (RCC), a type of kidney cancer, and identifies several specific obesity-related factors. (medicalxpress.com)
  • Early-onset of frequent drinking is a significant risk factor for drinking problems and a long-term alcohol use disorder. (visionsteen.com)
  • To determine the proportion of adults who are participating in regular physical activity, regardless of the level of intensity, CDC analyzed data from the 1994 Behavioral Risk Factor Surveillance System (BRFSS). (cdc.gov)
  • Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. (wikipedia.org)
  • Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. (jci.org)
  • Here, we investigated whether in MS patients oral myelin treatment, containing both myelin basic protein (MBP) and proteolipid protein (PLP), induced antigen specific MBP or PLP reactive T cells that either secreted IL4, TGF-beta1, or alternatively did Th1 type sensitization occur as measured by IFN-gamma secretion. (jci.org)
  • A negative correlation between high levels of IL-6-specific c-aAb and plasma levels of C-reactive protein was observed, indicating cytokine-neutralizing levels of c-aAb in healthy blood donors. (ku.dk)
  • In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. (nih.gov)
  • Factor V (Coagulation Factor Five) is a 330kDa protein of the coagulation system encoded by the F5 gene. (rndsystems.com)
  • Justia Criminal Law California Criminal Jury Instructions (CALCRIM) (2023) Enhancements and Sentencing Factors CALCRIM No. 3250. (justia.com)
  • In order to develop appropriate targeted preventative strategies to improve perinatal outcome in disadvantaged groups, a greater understanding of ethno-specific risk factors is required. (springer.com)
  • 1) Background: The aim of our study was to identify specific risk factors for fatal outcome in critically ill COVID-19 patients. (uni-koeln.de)
  • OBJECTIVES: The purpose of this study was to assess the clinicopathologic risk factors for positive urine culture outcome in cats with chronic kidney disease (CKD), diabetes mellitus (DM), uncontrolled hyperthyroidism (HT), or lower urinary tract disease (LUTD). (avmi.net)
  • Decreasing urine specific gravity was not associated with positive urine culture when controlled for disease but pyuria, bacteriuria, and hematuria were all associated with positive urine culture outcome. (avmi.net)
  • Many factors have been investigated as potential predictors of clinical outcome in BCa. (biomedcentral.com)
  • This research should focus on developing more accurate and reliable methods for quantifying company-specific risks and exploring the impact of emerging trends, such as technological advancements and regulatory changes, on the CSRP. (financestrategists.com)
  • Specific risk factors and their odds ratios were derived. (uni-koeln.de)
  • The nomogram graphically displays the importance of these 14 factors for mortality. (uni-koeln.de)
  • However, no systematic review has summarised the relations of combined lifestyle factors with cancer morbidity and mortality. (nature.com)
  • Cohort studies investigating the association of combined lifestyle factors with risks of incident cancer and cancer mortality were selected. (nature.com)
  • Fresh whole blood has long been thought of as the criterion standard for transfusion, but the advent of whole blood fractionation techniques subsequent to World War II provided a means of more efficient use of the various components (i.e., packed red blood cells [PRBCs], fresh frozen plasma [FFP], individual factor concentrates, platelet concentrates, cryoprecipitate). (medscape.com)
  • Injections of treatment products, called clotting factor concentrates (or factor), into a vein - a process known as infusion - can help manage and treat bleeding disorders . (cdc.gov)
  • This study investigated the association between ten clinicopathological characteristics and cancer-specific survival (CSS) in patients with bladder cancer. (biomedcentral.com)
  • Opinions are embraced and defended, but transfusion of red blood cells has not reliably demonstrated increased survival, other than in 2 specific populations, as follows: (1) those with active hemorrhage, and (2) those with active cardiac ischemia. (medscape.com)
  • The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. (wikipedia.org)
  • Pitx2a and Pitx2c are endogenously expressed in C3H10T1/ 2 cells, and these cells express factors that differentially regulate PITX2 isoform activities. (lu.se)
  • A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. (wikipedia.org)
  • These data suggest that autoimmunity against endogenous cytokines is a relatively common phenomenon in healthy individuals, and that predictive factors for high, potentially neutralizing c-aAb levels vary depending on the cytokine in question, and may differ from predictors of general c-aAb presence. (ku.dk)
  • The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are 1 class of identified factors. (wikipedia.org)
  • Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. (wikipedia.org)
  • Bleeding disorders, such as hemophilia and von Willebrand disease (VWD) , are conditions in which the blood does not clot properly due to a lack of specific clotting factor proteins in the blood. (cdc.gov)
  • Factor Va is the activated form of factor V and the cofactor of Xa. (sigmaaldrich.com)
  • Unlike most other coagulation factors, Factor V is not enzymatically active but functions as a cofactor. (rndsystems.com)
  • It serves as a critical cofactor for the pro-thrombinase activity of factor Xa that results in the activation of pro-thrombin to thrombin. (rndsystems.com)
  • Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. (sigmaaldrich.com)
  • Arizona Department of Transportation's (ADOT's) approach to selecting the location and type of safety projects in its strategic traffic safety plan relies, in part, on crash modification factors (CMFs), which are multiplicative factors used to predict how safety countermeasures will affect crash frequency and severity at a given site or group of sites based on their past performance. (trb.org)
  • However, other important risk factors can predict and contribute to teen alcoholism. (visionsteen.com)
  • A major problem for urologists is identifying prognostic factors that can predict cancer progression. (biomedcentral.com)
  • As a result, it is crucial for the agency to employ a robust CMF estimation method that can cope with the issues of traffic exposure, stochastic fluctuations of traffic crashes, and other sources of bias when evaluating the effectiveness of a specific treatment or a proposed design element. (trb.org)
  • In a cohort of elite young volleyball players, male sex, volume of training, and match exposure were all noted to be risk factors. (medscape.com)
  • Multivariable logistic regression models adjusted for sociodemographic and clinical characteristics were fitted to identify risk factors for advanced stage CRC presentation. (cdc.gov)
  • Younger age, taller body stature, higher body weight, and sport-specific loading characteristics of the knee extensor apparatus were all risk factors for developing jumper's knee. (medscape.com)
  • Using a validated bead-based multiplex assay we assessed plasma levels of IL-1α, IL-6, IL-10, IFNα and GM-CSF-specific c-aAb in 8,972 healthy blood donors. (ku.dk)
  • Brain-derived neurotrophic factor measurements in mouse serum and plasma using a sensitive and specific enzyme-linked immunosorbent assay. (bvsalud.org)
  • Development of a fungus-specific PCR assay for detecting low-level fungi in an indoor environment. (cdc.gov)
  • A fungus-specific PCR assay using only one primer set has been developed for detecting indoor fungi. (cdc.gov)
  • It is unclear, however, whether these associations are specific to the particular populations studied, or if they are generalizable to other population groups. (springer.com)
  • Factor V, a glycoprotein is usually seen in the alpha granules of platelets and in plasma. (sigmaaldrich.com)
  • As mouse platelets do not contain BDNF , this confounding factor is absent in the mouse . (bvsalud.org)
  • Psychological factors form a part of the background factors. (scirp.org)
  • In most cases, a complex interaction between biological, psychological and social factors contributes to the emergence of mental health and neurological problems. (who.int)
  • Developing a broad array of Arizona-specific CMFs could help ADOT evaluate the safety benefits and costs of proposed and implemented projects more accurately. (trb.org)
  • This study's purpose is to evaluate murine osteoblast proliferation in the presence of various exogenous soluble growth factors as measured by fluorescence units. (allenpress.com)
  • Assessing the prognostic significance of specific clinicopathological features plays an important role in surgical management after radical cystectomy. (biomedcentral.com)
  • Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic potential in type 2 diabetes. (cam.ac.uk)
  • These results show that the biological roles of SOCS-3 and PTP-1B do not fully overlap and that targeting both factors might improve therapeutic effects of their inhibition in obesity and type 2 diabetes. (diabetesjournals.org)
  • Brain-specific inactivation of these genes individually in the mouse partially protects against diet-induced obesity (DIO) and insulin resistance. (diabetesjournals.org)
  • These results suggest that the oral administration of antigens generates antigen specific TGF-beta1 secreting Th3 cells of presumed mucosal origin that represent a distinct lineage of T cells. (jci.org)
  • Estimating specific variance for items in factor analysis - how to achieve the theoretical maximum? (stackexchange.com)
  • This study used an alternative methodology commonly referred to as mendelian randomization, which allows researchers to test for a causal effect from observational data in the presence of confounding factors. (medicalxpress.com)
  • The relative importance of subjective and structural factors for individual adaptation to climate change by forest owners in Sweden. (nature.com)
  • A company-specific risk premium (CSRP) is an additional rate of return that investors expect to earn for bearing the unique, non-systematic risks associated with a particular company. (financestrategists.com)
  • By accounting for the unique risks associated with a specific company, investors can better estimate the value of the company's shares and make more informed decisions about their investments. (financestrategists.com)
  • Company-specific risk premium is distinct from other risk premiums, such as the market risk premium, which represents the additional return investors expect to earn for bearing the systematic risks associated with the overall market. (financestrategists.com)
  • Accurately estimating the CSRP allows investors to better understand the unique risks associated with a specific company and make more informed decisions about their investments . (financestrategists.com)
  • Conclusions This study confirms known risk factors for PTB and SGA, along with a new variable of interest, financial strain. (springer.com)
  • 4) Conclusions: There are risk factors that are specific to the subpopulation of critically ill COVID-19 patients. (uni-koeln.de)
  • Even when environmental factors are accounted for (i.e., growing up in another home), genetics still played a role in predisposition. (visionsteen.com)
  • According to this cognitive-motivational approach the major factors responsible for disease are a pathogene, background factors and a physiological program implementing the disease processes. (scirp.org)
  • They consist of specific cognitive contents forming a motivational disposition, representing four types of beliefs referring to specific contents. (scirp.org)
  • Here, we conduct a series of meta-analyses using data from 106 studies (90 papers) conducted in 23 different countries to examine how 13 motivational factors relate to various adaptation behaviours. (nature.com)
  • Research has disproportionally focused on studying experience and risk perception, flooding and hurricanes, and preparedness behaviours, while other motivational factors, hazards and adaptive behaviours have been understudied. (nature.com)
  • Mendelian randomization allows us to circumvent many of the limitations of traditional observational study by use of genetic proxies of suspected risk factors . (medicalxpress.com)
  • Identify the risk factors for opioid overdose. (cdc.gov)
  • Dr. Brian Lane provided investigative and methodological input into a new study that identifies specific obesity-related risk factors for kidney cancer. (medicalxpress.com)
  • These factors include multiple measures of obesity, diastolic blood pressure and fasting insulin. (medicalxpress.com)
  • These obesity-related factors are inherently interrelated, and traditional observational studies have not been able to determine which individual factors directly influence RCC risk and which are merely correlated with the underlying causal factor," said Brian Lane, MD, Ph.D., a board-certified urologist and Betz Family Endowed Chair for Cancer Research at Spectrum Health. (medicalxpress.com)
  • Component of splicing factor SF3b plays a key role in translational control of polyribosomes on the endoplasmic reticulum. (nih.gov)
  • In spite of widespread use, data supporting specific practice paradigms for whole blood and component therapy transfusion are lacking, the notable exception being in the primary treatment of hemorrhagic shock. (medscape.com)
  • The objectives are to: (1) Work with ADOT to compile a prioritized list of six to eight implemented safety projects for which new, Arizona-specific CMFs are desired. (trb.org)
  • Zhang, M. , Zhong, C. and Yu, F. (2017), "The role of context-specific factors in IFDI's influence on OFDI of developing country: Evidence from China", Journal of Chinese Economic and Foreign Trade Studies , Vol. 10 No. 2, pp. 172-187. (emerald.com)
  • The company-specific risk premium is a critical factor in estimating the cost of equity capital and plays a vital role in various financial valuations and models. (financestrategists.com)
  • One unit is equivalent to the Factor V activity in 1.0 mL of normal human plasma at pH 7.4 at 37 °C. (sigmaaldrich.com)
  • Osteoblast proliferation rates indicate that the in vitro supplementation of 2% residual calcium-DFDBA with the combination of IGF and TGF-β, IGF and PDGF, and PDGF and TGF-β significantly ( P ≤ .05) enhance murine osteoblast activity and proliferation at 7 days compared with the control containing no exogenous growth factors. (allenpress.com)
  • Q: is there a specific method, which allows to extract the maximally possible sum of individual variances of a covariance matrix, and if there is a special method, how is it defined? (stackexchange.com)
  • So, before starting your cost calculator you must consider the relevant features, choice of a specific operating system, time allocation, individual functionalities, etc. (aalpha.net)
  • The risk factors for teen alcoholism and early teen alcohol use vary, but parental and peer influences are the most powerful. (visionsteen.com)
  • By using a statewide population-based cancer registry, this study examines sociodemographic and clinical disparities in CRC and characterizes advanced stage CRC risk factors with specific attention to age-specific risk factors. (cdc.gov)
  • Recognition and Specificity Factors in Plant Disease. (gc.ca)
  • Furthermore, we show that a Taylor contracting model with firm-specific capital and sticky wage and with a relatively short price contract length of four quarters is able to outperform, in terms of empirical fit, the standard Calvo model with homogeneous production factors and high nominal price stickiness. (repec.org)
  • We assume that the agents' reward functions and the system dynamics are described in terms of factored rules. (aaai.org)
  • I think the main thing we're trying to get at is you can't really isolate any 'if X then use Y' elements - everything is kinda related, and it can have cross-'factor' effects, but it doesn't have to, and all of this can change by the minute, intent, query, location, website, etc. (seroundtable.com)
  • John added, "and it can have cross-"factor" effects" where sometimes doing well with one factor will drive success in another factor. (seroundtable.com)
  • On the basis of a literature review, this paper constructed an empirical model to further study the moderating effects of context-specific factors on the influence of inbound foreign direct investment (IFDI) on outbound foreign direct investment (OFDI). (emerald.com)
  • Corrosion resistance is the ability of a material to withstand the effects of a specific environment. (proplate.com)