• Thus, the two substrates of this enzyme are NADPH and NAD + , whereas its two products are NADP + and NADH . (wikipedia.org)
  • The four substrates of this enzyme are (+)-abscisate, NADPH, H + , and O 2 , whereas its three products are 8'-hydroxy-abscisate, NADP + , and H 2 O. (alchetron.com)
  • At the highest OTR condition, a decrease in the NADPH/NADP + ratio of threefold was observed, probably as a response to the high respiration rate induced by the respiratory protection of the nitrogenase under diazotrophic conditions, correlating with a high expression of the uncoupled respiratory chain genes ( ndhII and cydA ) and induction of the expression of the genes encoding the nitrogenase complex ( nifH ). (biomedcentral.com)
  • FMN reductase (NADPH) (EC 1.5.1.38, FRP, flavin reductase P, SsuE) is an enzyme with systematic name FMNH2:NADP+ oxidoreductase. (wikipedia.org)
  • It follows that aerobic organisms have equipped themselves with specific H 2 O 2 dismutases and H 2 O 2 reductases, of which catalase and the alkyl hydroperoxide reductase (AhpR) are the best-studied prokaryotic members. (biomedcentral.com)
  • Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
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  • This enzyme catalyses the following chemical reaction: FMNH2 + NADP+ ⇌ {\displaystyle \rightleftharpoons } FMN + NADPH + H+ The enzymes from bioluminescent bacteria contain FMN. (wikipedia.org)
  • These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. (cancerindex.org)
  • In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. (lookformedical.com)
  • Together with this unique character of NADPH oxidation, phylogenetic analysis of NDH-2 from various organisms suggests that NDH-2 of C. glutamicum is more closely related to yeast or fungal enzymes than to other prokaryotic enzymes. (rhea-db.org)
  • This enzyme belongs to the family of oxidoreductases , specifically those acting on NADH or NADPH with NAD+ or NADP+ as acceptor. (wikipedia.org)
  • The systematic name of this enzyme class is NADPH:NAD+ oxidoreductase ( Re / Si -specific). (wikipedia.org)
  • This enzyme belongs to the family of oxidoreductases, to be specific those acting on paired donors, with O 2 as oxidant and incorporation or reduction of oxygen. (alchetron.com)
  • The systematic name of this enzyme class is abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating) . (alchetron.com)
  • This enzyme had an ability to catalyze electron transfer from NADH and NADPH to oxygen as well as various artificial quinone analogs at neutral and acidic pHs respectively. (rhea-db.org)
  • The reduction of native quinone of C. glutamicum, menaquinone-2, with this enzyme was observed only with NADH, whereas electron transfer to oxygen was observed more intensively with NADPH. (rhea-db.org)
  • The enzyme has a preference for NADPH as the reductant, with NADH being a poor substitute [2]. (enzyme-database.org)
  • Its ability to catalyze electron transfer from donors (NADH, NADPH) to acceptors (oxygen, ferricyanide, cytochrome c, gCYTB5-III) were studied in spectrophotometric rate assays. (trentu.ca)
  • Alcohol dehydrogenase (ADH) contributes significantly to NADH-dependent C-nitroso reduction by cytosol relative to NAD(P)H: quinone oxidoreductase (NQOR). (lsu.edu)
  • The objective of the current studies was to examine the role of caspase 3 (CPP32) and NAD(P)H:quinone oxidoreductase (NQO1) in the signaling of genistein-and β-lapachone (bLap)-induced apoptosis in human prostate carcinoma cells PC3. (biomedcentral.com)
  • NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) is a widely-distributed FAD-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes, at rates that are comparable with NADH or NADPH. (dundee.ac.uk)
  • Electron transfer ability from NADH to menaquinone and from NADPH to oxygen of type II NADH dehydrogenase of Corynebacterium glutamicum. (rhea-db.org)
  • NADPH is the preferred electron donor, while cytochromes are the preferred electron acceptors. (trentu.ca)
  • Structural modeling of complexes with the flavin, coenzyme, and substrate suggested specific residues contributing to the NbaA catalytic activity, assuming a ping-pong reaction mechanism. (canada.ca)
  • The coenzyme is therefore found in two forms in cells: NAD + is an oxidizing agent - it accepts electrons from other molecules and becomes reduced , this reaction forms NADH, which can then be used as a reducing agent to donate electrons. (wikidoc.org)
  • This means the coenzyme can continuously cycle between the NAD + and NADH forms without being consumed. (wikidoc.org)
  • Oxidoreductases Acting on CH-CH Group Donors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
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  • Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. (systemsbiology.net)
  • [2] Such reactions (summarized in formula below) involve the removal of two hydrogen atoms from the reactant (R), in the form of a hydride ion , and a proton (H + ). The proton is released into solution, while the reductant RH 2 is oxidized and NAD + reduced to NADH by transfer of the hydride. (wikidoc.org)
  • Purification conferred 6-fold higher specific activity of NADH:ubiquinone-1 oxidoreductase with a 3.5-fold higher recovery than that previously reported (K. Matsushita et al. (rhea-db.org)
  • However, it is well known that the NADPH is consumed during PHB biosynthesis and the alginate biosynthesis produces NADH in this bacterium. (biomedcentral.com)
  • This study provides evidence that C. glutamicum NDH-2 is a source of the reactive oxygen species, superoxide and hydrogen peroxide, concomitant with NADH and NADPH oxidation, but especially with NADPH oxidation. (rhea-db.org)
  • These findings suggest that NQO1 may exercise a selective "gatekeeping" role in regulating the proteasomal degradation of specific proteins, thereby broadening the cytoprotective role of NQO1 far beyond its highly effective antioxidant functions. (dundee.ac.uk)
  • An oxidoreductase involved in pyrimidine base degradation. (bvsalud.org)
  • The engineered strain converts glucose to ethanol via acetate and acetaldehyde, catalyzed by the host-encoded aldehyde ferredoxin oxidoreductase AOR and heterologously expressed AdhA, in an energy-conserving, redox-balanced pathway. (brenda-enzymes.info)
  • The midpoint potential of the NAD + /NADH redox pair is −0.32 volts , which makes NADH a strong reducing agent. (wikidoc.org)
  • Cell-specific transcriptional control of mitochondrial metabolism by TIF1? (harvard.edu)
  • Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi" (PDF). (wikipedia.org)
  • Interaction with C4 dicarboxylic acids and identification of a novel L -aspartate: fumarate oxidoreductase activity. (enzyme-database.org)
  • In vitro kinetic assays on crude hktE - pgdx - H. influenzae Rd extracts revealed the presence of NAD(P)H:peroxide oxidoreductase activity, which, however, appears to be physiologically insignificant because of its low affinity for H 2 O 2 ( K m = 1.1 mM). (biomedcentral.com)
  • NADPH-dependent pNSP reduction by liver cytosol of ADH+ animals is mostly dicumarol-sensitive which implicates NQOR as the major NADPH-dependent activity. (lsu.edu)
  • The specific activity of class IV sigma ADH was estimated at about 1632 nmol/min/mg. (lsu.edu)
  • 1. Fischer, D., Ebenau-Jehle, C. and Grisebach, H. Phytoalexin synthesis in soybean: purification and characterization of NADPH:2'-hydroxydaidzein oxidoreductase from elicitor-challenged soybean cell cultures. (qmul.ac.uk)
  • The oxygen incorporated need not be derived from O 2 with NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor. (alchetron.com)
  • LSADH catalyzed the enantioselective reduction of some ketones with high enantiomeric excesses: phenyl trifluoromethyl ketone to (S)-1-phenyltrifluoroethanol (>99% e.e.), acetophenone to (R)-1-phenylethanol (99% e.e.), and 2-heptanone to (R)-2-heptanol (>99% e.e.) in the presence of 2-propanol without an additional NADH regeneration system. (brenda-enzymes.info)
  • An oxidoreductase that catalyzes the conversion of 3-oxo-delta4 steroids into their corresponding 5alpha form. (jefferson.edu)
  • structurally, it belongs to the homodimeric NADH:flavin mononucleotide (FMN) oxidoreductase-like fold family. (canada.ca)
  • [ 15 ] demonstrated a specific role of the endothelial cell BH4 deficiency and eNOS uncoupling in the development of angiotensin II-induced vascular disease. (medscape.com)
  • The initial two steps leading to the sequential formation of 2-hydroxy/aminobenzoate and 3-HAA are catalyzed by a NADPH-dependent 2-NBA nitroreductase (NbaA) and 2-hydroxylaminobenzoate mutase (NbaB), respectively. (canada.ca)
  • These studies showed that changes in the ratio of NADH/NAD + determined the metabolic products. (biomedcentral.com)
  • Type II NADH dehydrogenase of Corynebacterium glutamicum (NDH-2) was purified from an ndh overexpressing strain. (rhea-db.org)
  • To our knowledge, there have been no studies about the relationship between NADH and NADPH levels and the metabolic behavior of A. vinelandii . (biomedcentral.com)
  • Mutational analysis supports the roles of Asn40, Asp76, and Glu113, which are predicted to form the binding site for a divalent metal ion implicated in FMN binding, and a role in NADPH binding for the 10-residue insertion in the �5-{alpha}2 loop. (canada.ca)
  • NADH also absorbs at higher wavelengths, with a second peak in UV absorption at 339 nm with an extinction coefficient of 6,220 M -1 cm -1 . (wikidoc.org)