Spastic symptoms paraparesis. Medical search. Frequent questions

Tropical spastic paraparesis (TSP), is a medical condition that causes weakness, muscle spasms, and sensory disturbance by human T-lymphotropic virus resulting in paraparesis, weakness of the legs. (wikipedia.org)
Some of the signs of Tropical spastic paraparesis are: Leg instability Urinary dysfunction. (wikipedia.org)
In Tropical spastic paraparesis, HTLV-1 shows elevated cellular acquired immune response as well as high production of proinflammatory cytokines. (wikipedia.org)
Among the methods of diagnosing tropical spastic paraparesis are MRI (magnetic resonance imaging) and lumbar puncture (which may show lymphocytosis). (wikipedia.org)
A synthetic derivative, 17-alpha-ethinyltestosterone, can be used to treat Tropical spastic paraparesis, improvement in motor and bladder function was reported but not sustainable. (wikipedia.org)
Mogamulizumab, an anti-CCR4 IgG1 monoclonal antibody, is also being researched as a possible treatment for Tropical spastic paraparesis. (wikipedia.org)
The prognosis for Tropical spastic paraparesis indicates some improvement in a percentage of cases due to immunosuppressive treatment. (wikipedia.org)
For several decades, the term tropical spastic paraparesis was used to describe a chronic and progressive clinical syndrome that affected adults living in equatorial areas of the world. (wikipedia.org)
medical citation needed] Tropical myeloneuropathies are classified as two separate syndromes: tropical ataxic neuropathy (TAN) and tropical spastic paraparesis (TSP). (wikipedia.org)
They are placed together because they are found in tropical countries, although tropical spastic paraparesis has occurred in temperate countries (e.g. (wikipedia.org)
HTLV-1-associated myelopathy/tropical spastic paraparesis is a slowly progressive disorder of the spinal cord caused by the human T-lymphotropic virus 1 (HTLV-1). (msdmanuals.com)
HTLV-1-associated myelopathy/tropical spastic paraparesis is more common among women because HTLV-1 infection is more common among women. (msdmanuals.com)
In people with HTLV-1-associated myelopathy/tropical spastic paraparesis, the muscles in both legs gradually become weak. (msdmanuals.com)
Early Juvenile Human T-cell Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Study of 25 Patients. (bvsalud.org)
Human T-cell lymphotropic virus type-1 ( HTLV-1 ) may cause severe diseases such as HTLV-1-associated myelopathy / tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). (bvsalud.org)
In order to better understand and manage HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a rare virus-induced neurodegenerative disease, we have established a registration system known as HAM-net to gather data from patients all over Japan. (biomedcentral.com)
Introduction: tropical Spastic Paraparesis or HTLV-associated Myelopathy (HAM/TSP) is a chronic infectious and inflammatory disease that can interfere with various aspects of individuals life and, thereby alter their Quality of Life (QoL). (bvsalud.org)
HTLV-1 associated inflammatory myopathies (HAIM) present similarities with idiopathic inflammatory myopathies (IIM) and with tropical spastic paraparesis or HTLV-1 associated myelopathy (TSP/HAM). (symptoma.com)
The prevalence rates of the other less common neurological disorders were 62 for hemiparesis (15 of which were for cerebrovascular accidents), 20 for cerebral palsy, 16 for optic atrophy, 12 for perceptive deafness, 10 for tropical spastic paraparesis, 7 for Parkinson's disease and 5 for motor neuron disease, ataxia and chorea/athetosis. (nih.gov)

Strümpell first described hereditary forms of spastic paraplegia (see the image below) in 1883, with Lorrain later providing more extensive detail. (medscape.com)
Photograph of a 16-year-old girl with complicated hereditary spastic paraplegia. (medscape.com)
Hereditary spastic paraplegia (HSP) is characterized by weakness and spasticity of the lower extremities. (scielo.br)
Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous group of diseases involving weakness and spasticity of the lower extremities combined with additional neurological or non-neurological manifestations ( 1 1 Finsterer J, Loscher W, Quasthoff S, Wanschitz J, Auer-Grumbach M, Stevanin G. Hereditary spastic paraplegias with autosomal dominant, recessive, X-linked, or maternal trait of inheritance. (scielo.br)
The inheritance of Kjellin's syndrome is autosomal recessive, and the syndrome is characterized by spastic paraplegia, mental retardation, amyotrophy, thin corpus callosum, and macular dystrophy ( 2 2 Webb S, Patterson V, Hutchinson M. Two families with autosomal recessive spastic paraplegia, pigmented maculopathy, and dementia. (scielo.br)
Multiple sclerosis, B12 deficiency, human T-cell lymphotrophic virus-1 infection, structural inflammatory lesions of the spinal cord, motor neuron disease, and hereditary spastic paraplegia have been excluded. (cdc.gov)
SENDA is a recently established subtype of neurode-generation with brain iron accumulation 14 that begins with early-onset spastic paraplegia and mental retardation, which remain static until adulthood. (nature.com)
Troyer syndrome is a complex hereditary spastic paraplegia. (medlineplus.gov)
Burgunder JM, Hunziker W. Hereditary spastic paraplegia: clues from a rare disorder for a common problem? (medlineplus.gov)
SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia. (medlineplus.gov)
A clinical and radiological study of a complicated hereditary spastic paraplegia. (medlineplus.gov)
Hereditary spastic paraplegia type 4 (SPG4) in Russian patients. (hspersunite.org.au)
BACKGROUND: Mutations in the SPAST gene are the most frequent cause of hereditary spastic paraplegia (HSP). (hspersunite.org.au)
We aim to extend the mutation spectrum of spastic paraplegia 4 (SPG4) and carried out experiment in vitro to explore the influence of the SPAST gene mutation on the function of corresponding protein. (hspersunite.org.au)
moreover, no genetic linkage between spinal disc herniation and spastic paraplegia has ever been described. (bmj.com)
A family with consanguineous parents and four of eight sibs affected by multiple disc herniations and spastic paraplegia was clinically and genetically analysed. (bmj.com)
On the whole, a susceptibility locus for disc herniation and autosomal recessive spastic paraplegia was found on chromosome 6q23.3-q24.1. (bmj.com)
As far as upper spinal disc herniations and related paraplegia are concerned, similar genetic studies have not yet been reported, in spite of considerable information collected about hereditary spastic paraplegia (HSP). (bmj.com)
Hereditary spastic paraplegia (HSP) a degenerative genetic disorder with stiffness and weakness of leg and hip muscles gait difficulties and issues with walking. (disabled-world.com)
Hereditary spastic paraplegia (HSP) is a group of degenerative genetic disorders involving the spinal cord which are characterized by stiffness and progressive weakness of the affected person's legs. (disabled-world.com)
There is a rare form of infantile-onset ascending hereditary spastic paralysis (IAHSP) that is considered by some in the field of medical research to be a rare type of hereditary spastic paraplegia. (disabled-world.com)
I was recently told by the neurologist that he thinks I have hereditary spastic paraplegia, I was wondering if anyone could tell me if this comes in flare ups/exacerbations. (alsforums.com)
I have a UMN diagnosis of hereditary spastic paraplegia that. (alsforums.com)
As many of you know, I was originally diagnosed with the upper motor neuron disorder, hereditary spastic paraplegia, but a change in symptoms, no family history, and ambiguous. (alsforums.com)
I was diagnosed with hereditary spastic paraplegia at Houston Methodist, but I don't have a family history or clear genetic evidence. (alsforums.com)
My current diagnosis is hereditary spastic paraplegia, but I have no family history of it and my symptoms don't really. (alsforums.com)
The disorder I've been diagnosed with, hereditary spastic paraplegia, typically affects mostly the legs and generally does not cause atrophy, a lower. (alsforums.com)
Hi all, As many of you know, I was diagnosed with Hereditary Spastic Paraplegia last summer. (alsforums.com)
I copied this from a post in another group PLS study, at Mass General in Boston, Dr. Paganoni recently received the Virginia Sweeney Fellowship to study PLS from the Spastic Paraplegia Foundation. (alsforums.com)
They will develop slight or incomplete hind end paralysis (paraparesis), which will progress to total rear end paralysis (paraplegia), accompanied by varying degrees of urinary and/or fecal incontinence. (rehabvet.com)

Symptoms are mild and may include spastic paraparesis of the lower limbs, ataxia, hypertonia (excessive muscle tone), mild peripheral neuropathy, and urinary problems. (en-academic.com)
Symptoms may include leg stiffness, progressive spastic paraparesis (stiffness, weakness and/or paralysis) of the lower extremities, and ataxia. (en-academic.com)
The epilepsy, parkinsonism, progressive ataxia, spastic paraparesis, and demyelinating polyneuropathy occur in the clinical picture of a neurological nature. (amedi.sk)
Bulbar signs, ataxia, palatal myoclonus, spastic paraparesis with hyperreflexia, and autonomic dysfunction are the most observed clinical manifestations. (biomedcentral.com)
A disorder where degeneration of certain parts of the brain and spinal cord results in symptoms such as blindness, tremor, speech problems and ataxia. (checkorphan.org)
Clinically, X-ALD can present a wide spectrum of phenotypes, being the most frequent Adrenomyeloneuropathy, with ataxia, spastic paraparesis, sexual and sphincter dysfunction. (endocrine-abstracts.org)

Approximately 15% of patients follow a primary progressive or progressive relapsing course from disease onset, usually characterized by symptoms of progressive myelopathy (gait instability, spasticity, bladder symptoms) and cognitive impairment. (medscape.com)
Symptoms typically consist of a progressive myelopathy associated with increasing degrees of paralysis (e.g., quadriparesis/plegia, paraparesis/plegia). (surgicalneurologyint.com)
In ADVANCE, leriglitazone reduced the progression of cerebral lesions and incidence of cALD, as well as the progression of myelopathy symptoms, such as balance deterioration. (minoryx.com)

however, only the 2 subtypes involving mutations of SPG11 and SPG15 are associated with Kjellin's syndrome ( 1 1 Finsterer J, Loscher W, Quasthoff S, Wanschitz J, Auer-Grumbach M, Stevanin G. Hereditary spastic paraplegias with autosomal dominant, recessive, X-linked, or maternal trait of inheritance. (scielo.br)
Troyer syndrome is part of a group of genetic disorders known as hereditary spastic paraplegias. (medlineplus.gov)
Hereditary spastic paraplegias are divided into two types: pure and complex. (medlineplus.gov)
AIM: To investigate molecular, clinical and genealogical characteristics of SPG4 in a first representative Russian group, to estimate SPG4 proportion among all DNA-diagnosed spastic paraplegias. (hspersunite.org.au)
MATERIAL AND METHODS: Fifty unrelated Russian families with SPG4 detected in the course of clinical and molecular studies of spastic paraplegias were studied. (hspersunite.org.au)
9 On clinical grounds, spastic paraplegias are characterised by spasticity, hyperreflexia, and progressive lower limb paresis. (bmj.com)
Hereditary spastic paraplegias (HSPs) are characterised by lower limb spasticity due to degeneration of the corticospinal tract. (biomedcentral.com)
Hereditary spastic paraplegias (HSPs) encompass a group of neurodegenerative disorders with lower limb spasticity due to degeneration of the corticospinal tract as most prominent sign. (biomedcentral.com)

She has a spastic gait disturbance, mental retardation, and extrapyramidal symptoms. (medscape.com)

Spastic paraparesis is stiffness, or spasticity, in the muscles of both the arms and legs (spastic quadriparesis) or in the muscles of both legs (spastic paraparesis). (childneurologyfoundation.org)
In the past, HSP was also classified as type I or type II, based on the patient's age at the onset of symptoms and on the amount of spasticity versus weakness. (medscape.com)

To exclude secondary forms of spastic paraparesis standard diagnostic procedures covered MRI of head and spine, vitamin B12 and folic acid levels, very long chain fatty acids (VLCFA), neurometabolic screening (Krabbe disease, metachromatic leukodystrophy, GM1-gangliosidosis, GM2-gangliosidoses Tay Sachs and Sandhoff, Gaucher disease) and cerebrospinal fluid analysis. (biomedcentral.com)

It is characterized by progressive spastic paralysis of the legs and sensory loss, associated with adrenal gland insufficiency and small gonads. (en-academic.com)

The patient complained for the first time of symptoms of stiffness and weakness of legs. (openventio.org)

It manifests as a slowly progressive, painless spastic paraperesis with sensory loss, imbalance, and sphincter dysfunction. (medscape.com)
AMN is characterized by progressive spastic paraparesis, sensory dysfunction, and incontinence. (globalgenes.org)
Infected patients may also have symptoms of autonomic dysfunction leading to constipation and, in some cases, sexual dysfunction. (medscape.com)

We report the genetic detection of B. valaisiana in the CSF of a 61-year-old man with a history of spastic paraparesis, which is strong clinical evidence of advanced neuroborreliosis. (cdc.gov)
Herein the author presented one additional case of HM with typical symptoms and undertook a retrospective survey in a manner of comprehensive review in order to determine the clinical and pathophysiological features and treatment of HM. (openventio.org)
Whereas all patients showed clinical signs of spastic paraparesis, MEPs were normal in 27% of patients and revealed a broad spectrum with axonal or demyelinating features in the others. (biomedcentral.com)
Electrophysiological abnormalities correlated with the severity of clinical symptoms. (biomedcentral.com)
Here, we report clinical improvement of an AxD type II patient who presented area posterma-like symptoms. (biomedcentral.com)

[ 4 ] HSP is also called familial spastic paraparesis and Strümpell-Lorrain syndrome. (medscape.com)

The onset of symptoms ranged from 43 years to the early 60s (mean: 49 years). (alzforum.org)
This form progresses chronically with onset of symptoms typically in adulthood and poor prognosis. (globalgenes.org)
Fifty-four of the patients were deemed "rapid progressors," defined as a patient who progressed from the onset of motor symptoms to at least OMDS 5 within two years, and 15 of those were "very rapid progressors," defined as those who reached at least OMDS 6. (biomedcentral.com)
Both rapid progressors and very rapid progressors exhibited several statistically significant traits compared to the other patients: older when motor symptoms first manifested, older when first diagnosed, higher OMDS, higher HAQ-DI score, shorter gap between disease onset and diagnosis, and shorter disease duration from onset to present day. (biomedcentral.com)
Death usually occurs within 1 to 10 years after the onset of symptoms. (en-academic.com)

A 39-year-old male, without a history of spinal dysraphism, presented with a progressive spastic quadriparesis. (surgicalneurologyint.com)

People with Troyer syndrome can experience a variety of signs and symptoms. (medlineplus.gov)
The symptoms are nonspecific and overlap with fibromyalgia and chronic fatigue syndrome. (arkansasbluecross.com)
The area postrema syndrome consists of uncontrollable vomiting, brain stem lesions, and weight loss symptoms and has been reported in association with inherited white matter disorders such as AxD [ 4 ]. (biomedcentral.com)

More than one in 10 people successfully treated with antibiotics for Lyme disease go on to develop chronic, sometimes debilitating and poorly understood symptoms of fatigue and brain fog that may last for years after their initial infection has cleared up. (lymetalk.net)
Diagnostic criteria for HSP included (i) spastic paraparesis or spastic tetraparesis with legs earlier and more severely affected than arms or (ii) spastic paraparesis as early and prominent sign of a neurodegenerative multisystem disease after exclusion of other causes. (biomedcentral.com)
Any one of these three signs and symptoms should suggest Ménière's disease or other labyrinthine disease as well as eighth nerve pathology. (checkorphan.org)

Symptoms can vary depending on the severity of the disorder. (childneurologyfoundation.org)
The mode of inheritance cannot be used to predict the severity of the disorder, however, because symptoms can vary greatly within each type. (medscape.com)
Due to this, some people who inherit a gene mutation for HSP might even be unaware of any symptoms that are associated with the disorder. (disabled-world.com)
People with this disorder may experience additional symptoms, particularly as the condition worsens. (sperogenix.com)

Most rare diseases are genetic, and are present throughout a person's entire life, even if symptoms do not immediately appear. (sperogenix.com)

MRI may be performed on the brain and spinal cord to check for abnormalities such as spinal cord degeneration and other potential causes of symptoms. (wikipedia.org)
Typical symptoms of relapses may be referable to demyelinating pathology involving the optic nerves (e.g. optic neuritis), brainstem (e.g. internuclear ophthalmoplegia) or spinal cord (e.g. partial myelitis), although non-specific symptoms referable to the cerebral hemispheres or other brain regions can also occur (Katz Sand and Lublin, 2013). (medscape.com)
We also have leaflets on asymptomatic ALD (for males with the gene who do not yet have symptoms), and adrenomyeloneuropathy (AMN) , a condition that affects nerves in the spinal cord and body. (alextlc.org)

In general, HRQoL is worse in patients with CD than in healthy individuals, particularly in the presence of cardiovascular and/or gastrointestinal symptoms. (scielo.br)
ABSTRACT Symptoms in post-COVID-19 patients who require hospitalization can persist for months, significantly affecting their health-related quality of life (HRQoL). (scielo.br)
Although many patients present with erythema migrans, others first present with extracutaneous symptoms. (medscape.com)
On average, these patients were 63.2 years old, had experienced their first symptoms at age 44.2, and were diagnosed at age 51.3. (biomedcentral.com)
Some patients suffer from severe tetra- or paraparesis. (lymetalk.net)
Patients with CaPa usually present severe hypercalcemia with abrupt bone and renal diseases, neurologic manifestations and gastrointestinal symptoms. (endocrine-abstracts.org)

Signs and Symptoms: When this muscle is tight the horse shows discomfort, pulling the head to that side, resisting sideways motion to the opposite side and continuously stretching the neck and head. (integralbiosciences.com)

HSMN with spastic paraparesis, or HSMN with optic atrophy) and/or patterns of inheritance (i.e. (neuroophthalmology.ca)

The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. (medlineplus.gov)

The symptoms and severity vary among affected individuals, sometimes even among members of the same family. (nih.gov)

Learn about the symptoms and signs of neurological problems, how get effective treatment, and ultimately how to recover from neurological for the short and long-term. (psychguides.com)

Often, the diagnosis process is based on symptoms and one's risk of exposure to the virus. (wikipedia.org)

Although their initial symptoms were various, they both showed spastic paraparesis and sensory disturbance below the thoracic level. (elsevierpure.com)

In the group IDH/HAM/TSP, the neurological symptoms always begun during the period of activity of IDH. (bvsalud.org)
In addition to a wide range of neurological symptoms, signs of damage of other organ systems can be observed, some of them in childhood. (amedi.sk)

Less severe versions may cause progressive stiffening in the legs, also known as spastic paraparesis. (childneurologyfoundation.org)
Other symptoms include dizziness, swelling (edema) of the ankles or legs, chest pain, and a rapid heart rate. (sperogenix.com)

Spastic paraparesis can also include difficulties with walking or with bowel or bladder control. (childneurologyfoundation.org)
symptoms include AV heart block, tachyarrhythmias, and myopericarditis. (arkansasbluecross.com)

Among the group of disorders, mutations of a number of genes seem to cause the symptoms and findings that people experience. (disabled-world.com)

If the gene is discovered early, before symptoms appear, there is a chance of preventing symptomatic cerebral ALD from developing. (alextlc.org)

Symptoms, mainly difficulty in walking, began approximately 10 years earlier, with a slow progressive course of neuroborreliosis. (cdc.gov)

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Organisms4

Diseases46

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology3

Phenomena and Processes11

Information Science3

Health Care11

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Tropical spastic par19

Paraplegia30

Ataxia6

Myelopathy3

Paraplegias8

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Spasticity2

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