• SENDA is a recently established subtype of neurode-generation with brain iron accumulation 14 that begins with early-onset spastic paraplegia and mental retardation, which remain static until adulthood. (nature.com)
  • I was recently told by the neurologist that he thinks I have hereditary spastic paraplegia, I was wondering if anyone could tell me if this comes in flare ups/exacerbations. (alsforums.com)
  • I have a UMN diagnosis of hereditary spastic paraplegia that. (alsforums.com)
  • As many of you know, I was originally diagnosed with the upper motor neuron disorder, hereditary spastic paraplegia, but a change in symptoms, no family history, and ambiguous. (alsforums.com)
  • I was diagnosed with hereditary spastic paraplegia at Houston Methodist, but I don't have a family history or clear genetic evidence. (alsforums.com)
  • My current diagnosis is hereditary spastic paraplegia, but I have no family history of it and my symptoms don't really. (alsforums.com)
  • The disorder I've been diagnosed with, hereditary spastic paraplegia, typically affects mostly the legs and generally does not cause atrophy, a lower. (alsforums.com)
  • Hi all, As many of you know, I was diagnosed with Hereditary Spastic Paraplegia last summer. (alsforums.com)
  • I copied this from a post in another group PLS study, at Mass General in Boston, Dr. Paganoni recently received the Virginia Sweeney Fellowship to study PLS from the Spastic Paraplegia Foundation. (alsforums.com)
  • Hereditary spastic paraplegia (HSP) a degenerative genetic disorder with stiffness and weakness of leg and hip muscles gait difficulties and issues with walking. (disabled-world.com)
  • Hereditary spastic paraplegia (HSP) is a group of degenerative genetic disorders involving the spinal cord which are characterized by stiffness and progressive weakness of the affected person's legs. (disabled-world.com)
  • There is a rare form of infantile-onset ascending hereditary spastic paralysis (IAHSP) that is considered by some in the field of medical research to be a rare type of hereditary spastic paraplegia. (disabled-world.com)
  • Spastic paraplegia 11 (SPG11) should be suspected in individuals with the following clinical and imaging findings. (nih.gov)
  • Kjellin syndrome is characterized by retinal degeneration, autosomal recessive hereditary spastic paraplegia, and thin corpus callosum initially associated with spastic paraplegia 15 (SPG15) but more often occurring in individuals with SPG11. (nih.gov)
  • See Spastic Paraplegia 15 . (nih.gov)
  • this can be easily misdiagnosed as hereditary spastic paraplegia. (dovepress.com)
  • The objective of this study was to investigate the frequency of late-onset leukodystrophies in patients with spastic paraplegia. (dovepress.com)
  • We performed genetic analysis using a custom-designed gene panel for leukodystrophies in 112 hereditary spastic paraplegia-like patients. (dovepress.com)
  • In terms of clinical manifestations, in addition to spastic paraplegia, three adrenomyeloneuropathy probands also had adrenocortical insufficiency, two Alexander disease probands developed urinary retention, one CTX proband developed cataracts and chronic diarrhea and the other presented with chronic diarrhea and mild tendon xanthomatosis. (dovepress.com)
  • Patients with late-onset spastic paraplegia should be screened for underlying leukodystrophies, irrespective of the presence of additional complicating symptoms and neuroimaging abnormalities. (dovepress.com)
  • Several reports have shown that various late-onset leukodystrophies, such as X-linked adrenoleukodystrophy (ALD) and Krabbe disease (KD), may present as spastic paraplegia (SP) without leukodystrophy on neuroimaging and be easily misdiagnosed as hereditary spastic paraplegia (HSP) on clinical grounds. (dovepress.com)
  • Strümpell first described hereditary forms of spastic paraplegia (see the image below) in 1883, with Lorrain later providing more extensive detail. (medscape.com)
  • Photograph of a 16-year-old girl with complicated hereditary spastic paraplegia. (medscape.com)
  • The clinico-radiologic definition of SSD includes segmental agenesis or dysgenesis of the spine, segmental abnormality of the underlying spinal cord and nerve roots, congenital paraplegia or paraparesis and congenital lower limb deformities. (bioline.org.br)
  • Hereditary spastic paraparesis (HPS) linked to mutations in the spastin gene (SPG4) is considered to be a pure form of spastic hereditary paraparesis. (bmj.com)
  • HSP, also known as familial spastic paraplegias or Strumpell-Lorrain disease, comprises a clinically and genetically heterogeneous group of hereditary disorders characterized by slowly progressive spastic paraparesis. (medscape.com)
  • I have a form of Muscular Dystrophy called Hereditary Spastic Paraparesis. (wafb.com)
  • This pedigree was also affected by familial spastic paraparesis, a rare neurodegenerative disorder of the central motor system characterized by progressive spasticity of the lower limbs. (alzforum.org)
  • Mr Shahrul, 23, was diagnosed with lower limbs spastic paraparesis when he was 16, and found drive through a new sport - wheelchair racing. (straitstimes.com)
  • On examination, spastic rigidity of the lower limbs and bilateral talipes equinovarus deformity were present in both. (bioline.org.br)
  • [ 4 ] HSP is also called familial spastic paraparesis and Strümpell-Lorrain syndrome. (medscape.com)
  • Genetic disorder resulting in familial branchial myoclonus, spastic paraparesis, and cerebellar ataxia. (mhmedical.com)
  • Detailed history and examination are necessary to determine the progression of neurologic impairment (bulbar palsy, degree of spastic paraparesis and cerebellar ataxia). (mhmedical.com)
  • Most of them showed an ataxic-spastic picture, two a "pure" cerebellar phenotype, and one a "pure" spastic presentation. (unicatt.it)
  • Neurological involvement included parkinsonism, cerebellar ataxia and spastic paraparesis. (bmj.com)
  • For several decades, the term tropical spastic paraparesis was used to describe a chronic and progressive clinical syndrome that affected adults living in equatorial areas of the world. (wikipedia.org)
  • Clinical, genetical and neuroradiological investigations were carried out in a large family with autosomal dominant spastic paraparesis and in a sporadic case with spastic paraparesis. (bmj.com)
  • [ 7 ] This condition is clinically classified as taking either a pure (uncomplicated) form or a complicated form, depending on whether the paraparesis exists in isolation or in conjunction with other major clinical features. (medscape.com)
  • Background Clear therapeutic suggestions for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing because of the insufficient randomized double-blind controlled clinical studies. (ampkpathway.com)
  • Objectives: To determine the prevalence of falls in human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients and possible factors associated to their occurrence. (fiocruz.br)
  • HTLV-1-associated myelopathy/tropical spastic paraparesis is a slowly progressive disorder of the spinal cord caused by the human T-lymphotropic virus 1 (HTLV-1). (msdmanuals.com)
  • HTLV-1-associated myelopathy/tropical spastic paraparesis is more common among women because HTLV-1 infection is more common among women. (msdmanuals.com)
  • In people with HTLV-1-associated myelopathy/tropical spastic paraparesis, the muscles in both legs gradually become weak. (msdmanuals.com)
  • Early Juvenile Human T-cell Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Study of 25 Patients. (bvsalud.org)
  • Human T-cell lymphotropic virus type-1 ( HTLV-1 ) may cause severe diseases such as HTLV-1-associated myelopathy / tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). (bvsalud.org)
  • In order to better understand and manage HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a rare virus-induced neurodegenerative disease, we have established a registration system known as HAM-net to gather data from patients all over Japan. (biomedcentral.com)
  • Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. (fiocruz.br)
  • It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (kegg.jp)
  • She has a spastic gait disturbance, mental retardation, and extrapyramidal symptoms. (medscape.com)
  • Clinically, X-ALD can present a wide spectrum of phenotypes, being the most frequent Adrenomyeloneuropathy, with ataxia, spastic paraparesis, sexual and sphincter dysfunction. (endocrine-abstracts.org)
  • This present study aimed at reflecting on the body changes suffered by Paraparesis Tropical Spastic (HAM/ TSP) carriers, as well as to raise some subjective transformations as the disease progresses. (bvsalud.org)
  • Secondary cases occurred among genetically related and through migration of affected persons from villages along unrelated persons in a setting of prolonged intrahousehold the Viliui River in Eastern Siberia, where VE has been en- contact with a patient manifesting the disease. (cdc.gov)
  • Some of the signs of Tropical spastic paraparesis are: Leg instability Urinary dysfunction. (wikipedia.org)
  • Spastic paraparesis is stiffness, or spasticity, in the muscles of both the arms and legs (spastic quadriparesis) or in the muscles of both legs (spastic paraparesis). (childneurologyfoundation.org)
  • Tropical spastic paraparesis (TSP), is a medical condition that causes weakness, muscle spasms, and sensory disturbance by human T-lymphotropic virus resulting in paraparesis, weakness of the legs. (wikipedia.org)
  • A 2-year-old male child and a 3-year-old female child presented with spastic paraparesis and dribbling incontinence of urine since birth. (bioline.org.br)
  • Case Description -A 3-year-old French Bulldog was evaluated because of acute signs of back pain and spastic paraparesis. (avma.org)
  • medical citation needed] Tropical myeloneuropathies are classified as two separate syndromes: tropical ataxic neuropathy (TAN) and tropical spastic paraparesis (TSP). (wikipedia.org)
  • Less severe versions may cause progressive stiffening in the legs, also known as spastic paraparesis. (childneurologyfoundation.org)
  • Three patients (males, black, ages 37, 40 and 57) attended a university clinic with a progressive paraparesis of obscure origin. (scielo.br)
  • Spastic paraparesis may lead to fixed limb deformities with difficulty in positioning and venous access. (mhmedical.com)
  • A synthetic derivative, 17-alpha-ethinyltestosterone, can be used to treat Tropical spastic paraparesis, improvement in motor and bladder function was reported but not sustainable. (wikipedia.org)
  • Spastic paraparesis can also include difficulties with walking or with bowel or bladder control. (childneurologyfoundation.org)
  • HSMN with spastic paraparesis, or HSMN with optic atrophy) and/or patterns of inheritance (i.e. (neuroophthalmology.ca)
  • In Tropical spastic paraparesis, HTLV-1 shows elevated cellular acquired immune response as well as high production of proinflammatory cytokines. (wikipedia.org)
  • Among the methods of diagnosing tropical spastic paraparesis are MRI (magnetic resonance imaging) and lumbar puncture (which may show lymphocytosis). (wikipedia.org)
  • Mogamulizumab, an anti-CCR4 IgG1 monoclonal antibody, is also being researched as a possible treatment for Tropical spastic paraparesis. (wikipedia.org)
  • The prognosis for Tropical spastic paraparesis indicates some improvement in a percentage of cases due to immunosuppressive treatment. (wikipedia.org)
  • They are placed together because they are found in tropical countries, although tropical spastic paraparesis has occurred in temperate countries (e.g. (wikipedia.org)
  • Progression can include spastic paraparesis, ataxia, and generalized limb anesthesia. (cap.org)
  • Examples of neurogenetic conditions include Huntington's disease, myotonic dystrophy, hereditary spastic paraparesis, and ataxia among others. (albertahealthservices.ca)
  • How can I or my loved one help improve care for people with HTLV-1-associated myelopathy/tropical spastic paraparesis? (nih.gov)
  • Where can I find more information about HTLV-1-associated myelopathy/tropical spastic paraparesis? (nih.gov)
  • HTLV-1-associated myelopathy/tropical spastic paraparesis is a slowly progressive disorder of the spinal cord caused by the human T-lymphotropic virus 1 (HTLV-1). (msdmanuals.com)
  • HTLV-1-associated myelopathy/tropical spastic paraparesis is more common among women because HTLV-1 infection is more common among women. (msdmanuals.com)
  • In people with HTLV-1-associated myelopathy/tropical spastic paraparesis, the muscles in both legs gradually become weak. (msdmanuals.com)
  • Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (unl.pt)
  • HTLV-1 also causes a neurologic disease called tropical spastic paraparesis/HTLV-1 associated myelopathy. (nih.gov)
  • Human T-cell leukemia virus type 1 (HTLV-1) is associated with a variety of clinical manifestations, including tropical spastic paraparesis or HTLV-1-associated myelopathy (TSP/HAM). (pasteur.fr)
  • and spastic paraplegia. (ed.ac.uk)
  • People with FA2H gene mutations and some of the movement problems seen in FAHN were once classified as having a separate disorder called spastic paraplegia 35. (medlineplus.gov)
  • Autosomal recessive spastic paraplegia type 15 is a complex form of hereditary spastic paraplegia characterized by a childhood to adulthood onset of slowly progressive lower limb spasticity (resulting in gait disturbance, extensor plantar responses and decreased vibration sense) associated with mild intellectual disability, mild cerebellar ataxia, peripheral neuropathy (with distal upper limb amyotrophy) and retinal degeneration. (nih.gov)
  • When Do Symptoms of Autosomal recessive spastic paraplegia type 15 Begin? (nih.gov)
  • Troyer syndrome is a complex hereditary spastic paraplegia. (nih.gov)
  • Burgunder JM, Hunziker W. Hereditary spastic paraplegia: clues from a rare disorder for a common problem? (nih.gov)
  • SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia. (nih.gov)
  • A clinical and radiological study of a complicated hereditary spastic paraplegia. (nih.gov)
  • Silver syndrome is a rare variant of autosomal dominant complicated hereditary spastic paraparesis (HSP), in which spasticity of the lower limbs is accompanied by amyotrophy of the hands and occasionally also the lower limbs. (nih.gov)
  • CMT5 refers to patients with autosomal dominant spastic paraparesis (partial loss of movement in the lower limbs) with sensory neuropathy. (mda.org)
  • Troyer syndrome is part of a group of genetic disorders known as hereditary spastic paraplegias. (nih.gov)
  • Hereditary spastic paraplegias are divided into two types: pure and complex. (nih.gov)
  • Common diagnoses seen in the clinic include cerebral palsy, stroke, acquired or traumatic brain injury, spinal cord injury, multiple sclerosis, hereditary spastic paraparesis and ALS. (vch.ca)
  • Newly diagnosed with Spastic paraparesis-cataracts-speech delay syndrome? (globalgenes.org)
  • Secondary cases occurred among genetically related and through migration of affected persons from villages along unrelated persons in a setting of prolonged intrahousehold the Viliui River in Eastern Siberia, where VE has been en- contact with a patient manifesting the disease. (cdc.gov)
  • A spastic gait and difficulty walking is noted in early childhood and most individuals never walk unassisted. (arizona.edu)