• Medical applications of anticancer and antimalarial drugs often suffer from low aqueous solubility, high systemic toxicity, and metabolic instability. (rsc.org)
  • The clinical application of gambogic acid, a natural component with promising antitumor activity, is limited due to its extremely poor aqueous solubility, short half-life in blood, and severe systemic toxicity. (dovepress.com)
  • However, conventional chemotherapy suffers lack of aqueous solubility, lack of selectivity and multidrug resistance. (ualberta.ca)
  • Hydrophobic nature of chemotherapeutics leads to poor aqueous solubility and low bioavailability which can be overcome by nanocrystals, albumin based nanoparticles, liposomal formulation, polymeric micelles, cyclodextrin and chitosan based nanoparticles. (ualberta.ca)
  • This review focuses the role of nanotherapeutics to overcome lack of selectivity, multidrug resistance and lack of aqueous solubility of conventional cancer chemotherapy. (ualberta.ca)
  • This chemical shows low aqueous solubility and dissolution rate and this has become the main concern in the industry that require dissolution of this chemical. (azpdf.org)
  • How to improve the solubility, bio-availability and therapeutic performance of pharmaceutical ingredients has become the top concern for the majority of drug developers," said the Marketing Manager of CD Formulation. (selfgrowth.com)
  • This research describe an approach to improve the solubility of benzoic acid by using co-solvent. (azpdf.org)
  • Surface Active Agent - Surfactants, for instance, polyethylene glycol glycerol can be used to prepare lipid-based formulations that significantly improve solubility and thus oral bioavailability through various self-emulsifying systems. (selfgrowth.com)
  • As a reliable partner in the drug formulation field, we are fully devoted to solving problems concerning solubility, bioavailability, and drug absorption. (selfgrowth.com)
  • 5 - 10 Unfortunately, gambogic acid has poor solubility (less than 0.5 μg/mL), a short half-life (less than 1 hour in dogs and less than 20 minutes in rats), and low bioavailability, which limits its application. (dovepress.com)
  • The virtual 2020 Global Drug Bioavailability Enhancement Summit this past December showcased novel technologies and platforms aimed at addressing bioavailability and solubility challenges. (drug-dev.com)
  • The driver for novel strategies to resolve solubility issues, with a target of improving bioavailability, often stems from a requirement to get more information about the key relationships using less API, in a reduced time frame," says Andrew Parker, PhD, Director Open Innovation, Small Molecules, Oral and Speciality Drug Delivery, Catalent. (drug-dev.com)
  • This annual Drug Development & Delivery report introduces readers to some novel approaches to improving bioavailability and solubility that have one commonality: they treat each molecule as unique. (drug-dev.com)
  • Where drug solubility is inade-quate to generate the necessary driv-ing force for drug release, it creates a typical 'no release, no bioavailability' situation, explains Dr. Lai. (drug-dev.com)
  • A second approach to overcome solubility/bioavailability is to enhance solubility by adapting solid dispersion/solid solution technology to the Diffucap concept. (drug-dev.com)
  • Adare also announced the launch of a small non-GMP laboratory for the exploration of various technologies that may be suitable for solubility/ bioavailability enhancement. (drug-dev.com)
  • Researchers at UCLA have successfully manipulated nanomaterials to create a new drug-delivery system that promises to solve the challenge of the poor water solubility of today's most promising anticancer drugs and thereby increase their effectiveness. (news-medical.net)
  • The poor solubility of anticancer drugs is one of the major problems in cancer therapy because the drugs require the addition of solvents in order to be easily absorbed into cancer cells. (spiritindia.com)
  • Since many effective anticancer agents have poor water solubility, the development of novel delivery systems for these molecules without the use of organic solvents has received significant attention. (spiritindia.com)
  • The observed solubilities plotted against ionic strength of the solution are similar for strong electrolytes. (cdc.gov)
  • The sulfate solubility in synthetic brines (principally nacl) confirms the ionic strength-sulfate solubility relationships. (cdc.gov)
  • and ( 3) gases that have a low water solubility and are lipid soluble such that they are primarily absorbed in the pulmonary region and likely to act systemically. (cdc.gov)
  • To meet that goal, an approach was taken that would provide for an integrated understanding of system and data needs using information generally available for all gases such as water solubility. (cdc.gov)
  • A categorization scheme of gases was developed and em- bedded in a framework for choosing model structure as well as different default DAFs based on the fundamental knowledge that absorption rate was determined by water solubility and reactivity, with reactivity defined as the propensity to dissociate, oxidize, or metabolize. (cdc.gov)
  • ECS member Jiaxing Huang used freshman-level chemistry to solve the solubility mystery of graphene oxide films. (electrochem.org)
  • I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
  • This equilibrium can be expressed in the form of an equilibrium constant known as the solubility product, 𝐾 s p . (nagwa.com)
  • The presence of strongly fluoride-binding ions, such as Al 3+ , and Ca 2+ may reduce the absorption of fluoride, possibly by decreasing the solubility. (europa.eu)
  • However, the ability to crystallize or solve an NMR structure of your protein once fragments are bound to it makes it far easier to understand how those molecules bind to a target of interest and to begin to develop those fragments into larger molecules. (the-scientist.com)
  • Join us in solving global challenges Get in touch 'Future Protein NL' aims to inspire and inform you about what is going on the Netherlands in the field of alternative proteins. (issuu.com)
  • It also is an invitation to get in touch with us and join us in solving the global protein challenge together. (issuu.com)
  • Knowledge of the solubilities of baso4 and srso4 in solutions containing nacl, cacl2, mgcl2, and nahco3 is needed to solve geologic and petroleum production problems. (cdc.gov)
  • Since pathogenecity of uric acid in the organism is manifested by precipitation of NaHU following its saturation in the tissue fluid, we consider that the solubility of NaHU in the tissue fluid is an indispensable factor in determining the normal range of the serum uric acid level. (go.jp)
  • Solubility of oxygen in equilibration with air in fresh water and seawater (salt water) - pressures ranging 1 - 4 bar abs . (engineeringtoolbox.com)
  • The sugar substitute saccharin 1C7H5NO3S2, for example, is a very weak acid having Ka = 2.1 * 10-12 and a solubility in water of 348 mg/100 mL. (pearson.com)
  • Hint: Equilibrium equations for the dissociation of saccharin and water must be solved simultaneously. (pearson.com)
  • Conjugation of hydrophilic polymers with small molecule drugs to produce polymer-drug conjugate systems has been demonstrated to be a viable formulation strategy for utilizing hydrophobic drugs in a water-soluble manner, which may offer advantages over the corresponding parent drugs, including fewer side effects, improved solubility, passive tumor targeting, an improved pharmacokinetic profile, and lower plasma concentrations. (dovepress.com)
  • Vat dyes are designed to solve this concern with molecules that can be made water-soluble, but only during the dyeing or vatting process. (wikisummaries.org)
  • Aluminium potassium fluoride is a salt with a water solubility of circa 5 g/L. Once solved, the salt is hydrolysed to its ions F-, Al3+ and K+. (europa.eu)
  • However, despite the high solubility of calcium carbonate minerals in water, less than half of the carbon in the crust is returned to the atmosphere this way. (ntu.edu.sg)
  • Solubility is the ability of a substance to dissolve in water. (rappellingequipment.com)
  • Black tourmaline will not dissolve in water because it has a low solubility. (rappellingequipment.com)
  • Although studies have demonstrated their effectiveness against carcinomas of the stomach, colon, neck and bladder, as well as against breast cancer, small-cell lung cancer and leukemia in vitro, clinical application of CPT in humans has only been carried out with CPT derivatives that have improved water solubility. (spiritindia.com)
  • Adare leveraged its solvent-han-dling capability, which is a natural ex-tension of Adare's Microcap ® technology, using cyclohexane to overcome the solubility challenge through the well-established solid dis-persion/solid solution approach," says Dr. Lai. (drug-dev.com)
  • For hydrophobic sorbents (and analytes), use a sample diluent with as little organic solvent as possible to ensure sample solubility. (chromatographyonline.com)
  • In other words, solubility is the maximum amount of solute that dissolves in a solvent to form an equilibrium. (toppr.com)
  • As we heat a solution can increase or decrease solubility, increasing pressure of the solution can increase or decrease solubility, if the solute is non-polar and the solvent is polar it does not dissolve so for making as a solution both solute and solvent should be of same nature. (toppr.com)
  • Measuring solubility of crystal in various solvent is a key factor in compound characterizing during the whole discovery and development process where it allows engineers to design and optimize crystallization process. (azpdf.org)
  • During his work, he has developed the basic principles and outlined ways to solve many problems of internal dosimetry. (wikipedia.org)
  • Smart nanocarrier-based drug delivery systems provide means of solving these problems at once. (rsc.org)
  • To solve these problems, an amphiphilic polymer-drug conjugate was prepared by attachment of low molecular weight (ie, 2 kDa) methoxy poly(ethylene glycol) methyl ether (mPEG) to gambogic acid (GA-mPEG 2000 ) through an ester linkage and characterized by 1H nuclear magnetic resonance. (dovepress.com)
  • 11 , 12 Solubilizers such as Cremophor ® EL (polyethoxylated castor oil, Sigma-Aldrich, St Louis, MO, USA) and L-arginine have been introduced to solve these problems. (dovepress.com)
  • I won't try to rigorously define the boundaries for classification, but the kinds of technologies I'm writing about are associated with important new capabilities or clear turning points in how civilization solves problems. (lesswrong.com)
  • Provide counseling and classes to encourage questions and to help solve problems, such as possible ways to avoid transmission of HIV to an uninfected spouse and to children. (medscape.com)
  • Studying how carbon is recycled in the deep Earth, researchers from NTU and the University of Cambridge aim to develop better ways to help solve the carbon dioxide crisis. (ntu.edu.sg)
  • These results will also help us develop better ways to lock carbon into the solid Earth and out of the atmosphere, potentially providing a route to help solve the climate crisis. (ntu.edu.sg)
  • Guided by the EU principles of innovative doctoral training, the ESRs will be educated in the context of a close interaction between academia, research institutes, commercial enterprises and unique large-scale research infrastructures to be able to tackle the interdisciplinary approaches needed to bring nanotechnology to the market place and to educate the workforce that will help solve the European Societal Challenges and the UN Sustainable Development Goals. (lu.se)
  • The amylose content was reduced after acid hydrolysis, reducing the peak viscosity (2599-1049 cP), while the solubility was significantly increased. (bvsalud.org)
  • The solubility product  𝐾  s p of a compound is the product of the concentrations of the ions in a saturated solution raised to the power of their respective stoichiometric coefficients. (nagwa.com)
  • The solubility was measured in various concentrations of the major solutes by use of liquid scintillation technique to detect the so4 in solution. (cdc.gov)
  • Leckband but monodisperse and tetrameric at high salt concentrations and Israelachvili, 2001), has not proven to be a fruitful (near the BPTI solubility limit). (lu.se)
  • Solubility is the ability of one substance to dissolve with another substance. (toppr.com)
  • One ap-proach to overcome such a pH-dependent solubility issue in the case of an alkaline drug is to use an organic acid as the drug core or an acid layer prior to using it as the substrate for the drug layer, which is then followed by a rate-controlling membrane. (drug-dev.com)
  • In contrast, the short-chain content of the deamylose-acid hydrolysis samples was reduced considerably, exacerbating the trend towards reduced starch orderliness and increased solubility. (bvsalud.org)
  • In this explainer, we will learn how to explain and calculate the solubility product. (nagwa.com)
  • I don't see how to solve the problem at all, without information about what the product solubilities are. (physicsforums.com)
  • The Bechtel Sulfur Adsorbent Technology (BSAT) solves the root cause of this problem. (bechtel.com)
  • To solve this problem, we "borrowed" an approach from metallurgy. (tugraz.at)
  • In an attempt to solve this problem, we prepared an experimental solution consisting of composition similar to the tissue fluid and determined the solubility of NaHU in the solution to obtain an approximate value of the solubility of NaHU in the authentic tissue fluid. (go.jp)
  • Particular emphasis is placed on the scientific basis of how we should understand the causes of the lack of oxygen in the bottom of the Baltic Sea and how we can best tackle this big problem and solve it as quickly as possible. (lu.se)
  • These procedures currently free products from HIV and HCV (lipid-enveloped viruses) but do not solve the problem of transmission of non-lipid-enveloped viruses such as HAV, parvovirus B19, and TTV. (medscape.com)
  • will increase the solubility of the gas in the polymer. (scirp.org)
  • When enhanced solubility is neces-sary, the binder polymer is strategically selected based on its ability to form a solid dispersion/solid solution with the drug, usually through a sol-vent system. (drug-dev.com)
  • Monodisperse and activated PEGs, or Chetosensar™ technology may solve solubility challenges during drug discovery and development. (sigmaaldrich.com)
  • Such dramatic change in solubility poses great challenges in the design of an extended-release dosage form using Adare's Diffucap ® -coated pellet technology. (drug-dev.com)
  • We are solving global challenges together. (issuu.com)
  • To explain this discrepancy, researchers from NTU and the University of Cambridge subjected carbonate minerals to the high pressures and temperatures commonly experienced at subduction zones and determined the solubility of the minerals under these conditions. (ntu.edu.sg)
  • That is what ECS member Jiaxing Huang - along with a team of Northwestern University researchers - has done in order to solve the mystery that surrounds the solubility of graphene oxide films. (electrochem.org)
  • He has developed a computational model based on an original system for estimating the solubility of aerosols of transuranic nuclides. (wikipedia.org)
  • We selected the piezoceramic system (Ba,Ca)TiO3, which exhibits a curved line of solid solubility in its phase diagram. (tugraz.at)
  • Solubility data plays an important role in the industry. (azpdf.org)
  • Additionally, the synergistic modification improved native starch's lower solubility and enhanced the resistant starch content. (bvsalud.org)
  • In the case of solubility products, the reactants in this heterogeneous equilibrium are the insoluble solid, and the amount that changes between the initial start of the dissolution and the equilibrium is so small that it can be considered constant and is therefore incorporated into 𝐾 s p . (nagwa.com)