• Resistant WTC-LI cases had significantly higher soluble vascular cell adhesion molecule and lower myeloperoxidase, with RRs of 2.24 and 2.89, respectively (AUC 0.830). (cdc.gov)
  • In a subgroup of participants serum samples were taken at recruitment and at 20 and 30 weeks' gestation and later analyzed for soluble fms-like tyrosine kinase-1, soluble endoglin, endothelin-1, placental growth factor, and soluble vascular cell adhesion molecule 1. (nih.gov)
  • OBJECTIVE: This study aimed to determine whether simultaneous decreases in the serum levels of cell adhesion molecules (intracellular cell adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin) and. (koreamed.org)
  • Soluble vascular cell adhesion molecule-1, a protein related to the endothelium and a marker of atherosclerosis, was also decreased after the meal containing the plant-based fat. (tissuerecovery.com)
  • Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. (jci.org)
  • Vascular cell adhesion molecule-1 (VCAM-1), an inducible cell-cell recognition protein on the endothelial cell surface (EC), has been associated with early stages of atherosclerosis. (jci.org)
  • Additionally, increased levels of soluble vascular cell adhesion molecules were detected in these patients, suggesting endothelial cell activation. (elsevierpure.com)
  • There was a significant correlation between blood lead levels and vascular cell adhesion molecule-1 (VCAM-1). (bibliomed.org)
  • Serum levels of interleukin (IL) 1b, IL-6 and soluble vascular cell adhesion molecule-1 (sVCAM-1) were determined by ELISA. (ox.ac.uk)
  • Soluble cell adhesion molecules (sCAMs) are a class of cell adhesion molecule (CAMs - cell surface binding proteins) that may represent important biomarkers for inflammatory processes involving activation or damage to cells such as platelets and the endothelium. (wikipedia.org)
  • ABSTRACT This study assessed changes in serum levels of cytokines IFN and IL-10 (biomarkers of in ammatory changes) and soluble biomarkers sICAM-1 and sE-selectin (biomarkers of endothe- lial dysfunction) in diabetic patients with and without nephropathy. (who.int)
  • Soluble VCAM-1 antigen was elevated in human diabetic plasma. (jci.org)
  • The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and yet the affinity of CD4 for its ligand, peptide-major histocompatibility class II (pMHC II) on antigen-presenting cells, is so weak that it was previously unquantifiable. (lu.se)
  • Antigen binds to IgE that is bound to tissue mast cells and blood basophils, triggering release of preformed mediators (eg, histamine, proteases, chemotactic factors) and synthesis of other mediators (eg, prostaglandins, leukotrienes, platelet-activating factor, cytokines). (msdmanuals.com)
  • sICAM, soluble intracellular adhesion molecule. (cdc.gov)
  • They include soluble isoforms of the cell adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). (wikipedia.org)
  • IL-10 (biomarqueurs de modi cations de l'état in ammatoire) et de biomarqueurs solubles sICAM-1 et sE-sélectine (biomarqueurs du dysfonctionnement endothélial) chez des patients diabétiques atteints et non atteints de néphropathie. (who.int)
  • The main finding in this article has to do with a protein called sICAM-1 (soluble cell adhesion molecule). (cannonpointe.com)
  • Receptor-specific adhesion and clinical disease in Plasmodium falciparum. (kemri-wellcome.org)
  • In view of the accelerated vascular disease observed in patients with diabetes, and the enhanced expression of VCAM-1 in diabetic rabbits, we examined whether irreversible advanced glycation endproducts (AGEs), could mediate VCAM-1 expression by interacting with their endothelial cell receptor (receptor for AGE, RAGE). (jci.org)
  • The inhibitory effect of anti-RAGE IgG, a truncated form of the receptor (soluble RAGE) or N-acetylcysteine on VCAM-1 expression indicated that AGE-RAGE-induced oxidant stress was central to VCAM-1 induction. (jci.org)
  • Beyond chemokines our approach is broadly applicable to alternative systems of chemo- and haptotaxis such as cells migrating along gradients of adhesion receptor ligands vs. any soluble cue. (nature.com)
  • Once in the lymph node, the cells experience a second chemokine, (C-C motif) ligand19 (CCL19), which interacts with the same receptor (C-C chemokine receptor 7, CCR7) but interacts only weakly with sugars. (nature.com)
  • Calculations indicated, however, that CD4/pMHC II binding would increase rates of T-cell receptor (TCR) complex phosphorylation by threefold via the recruitment of Lck, with only a small, 2-20% increase in the effective affinity of the TCR for pMHC II. (lu.se)
  • Many studies have postulated that increased production of cell adhesion molecules (CAMs) on the vascular endothelium (blood vessel lining) plays a role in the development of arterial plaque, with the suggestion from both in vitro and in vivo studies that the CAM production is increased by dyslipidemia (abnormal lipid levels in the blood). (wikipedia.org)
  • Several host molecules have been implicated in mediating cerebral and non-cerebral cytoadherence of P. falciparum -infected RBCs to the host endothelium [ 1 ], a process that helps the parasite evade immune clearance in the spleen. (biomedcentral.com)
  • Endothelial cell-selective adhesion molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein that belongs to the JAM family of immunoglobulin superfamily molecules. (reliatech.de)
  • The aim of this study was to investigate the association of SNPs of three adhesion molecule genes, ICAM1 , PECAM1 and CD36 , with severity of falciparum malaria in a malaria-endemic and a non-endemic region of India. (biomedcentral.com)
  • The extracellular region contains one V type and one C2 type Ig domain and is involved in homophilic adhesion. (reliatech.de)
  • Cell migration is mainly governed by adhesion of cells to substrates (other cells or connective tissue) and by extracellular signalling molecules acting as motogenic stimuli or directional guidance cues 2 . (nature.com)
  • At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
  • These cytokines recruit eosinophils, CD4 + T cells, and macrophages, which are present in early morphea lesions and in eosinophilic fasciitis. (medscape.com)
  • There is increasing evidence from clinical and experimental studies for a causative role of chronic inflammation in initiation and progression of atherosclerosis [ 10 ], where the release of cytokines from platelets, immune, endothelial and smooth muscle cells play a key role [ 10 , 11 ]. (hindawi.com)
  • Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta. (ox.ac.uk)
  • The majority of data on chemokine gradient sensing is based on in vitro studies employing soluble gradients. (nature.com)
  • We tracked migration of dendritic cells towards immobilized gradients of the chemokine CCL21 and varying superimposed soluble gradients of CCL19. (nature.com)
  • While mesenchymal and epithelial cells are dominated by adhesive interactions the amoeboid crawling of leukocytes is largely controlled by guidance cues of the chemokine family 3 , 4 . (nature.com)
  • The prevailing paradigm of chemokine function is that spatial diffusion-based gradients of chemokines induce polarization and directed migration of the responding cells towards the chemokine source 5 . (nature.com)
  • The best understood example for the significance of immobilized vs. soluble chemokine gradients is the trafficking of dendritic cells (DCs). (nature.com)
  • The cellular expression of CAMs is difficult to assess clinically, but these soluble forms are present in the circulation and may serve as markers for CAMs. (wikipedia.org)
  • There was no correlation between high levels of soluble E-cadherin in sera and abnormal E-cadherin expression by the tumour (P = 0.077). (ox.ac.uk)
  • BACKGROUND: Endothelial adhesion molecule expression induced by pro-inflammatory cytokine plays an important role in vascular endothelial cell injury, leading to vascular disease. (koreamed.org)
  • Exposure of cultured human ECs to AGEs induced expression of VCAM-1, increased adhesivity of the monolayer for Molt-4 cells, and was associated with increased levels of VCAM-1 transcripts. (jci.org)
  • We studied the expression of this molecule on the leukocytes of patients with myelodysplastic syndromes (MDSs) in an effort to detect acquired deficiencies of this molecule. (elsevierpure.com)
  • We found decreased expression of CD43 on the neutrophils of these patients, and we correlated this finding with the activation status of these cells as it is denned by their phenotypes. (elsevierpure.com)
  • In conclusion, we believe that the decreased expression of CD43 on the neutrophils of MDS patients is associated with activation of these cells and is probably due to cleavage of the molecule from the cell surface and that the same mechanism is possibly responsible for the parallel down-reeulation of CD44 and CD53. (elsevierpure.com)
  • MIF was identified as a major regulator of atherogenesis by promoting the recruitment of mononuclear cells, activating inflammatory signaling pathways, and transdifferentiating macrophages into foam cells in the vessel wall as well as by enhancing collagenase expression and matrix degradation, the latter contributing to plaque destabilization [ 18 - 20 ]. (hindawi.com)
  • Molecules such as ICAM-1 and VCAM-1 are inducible (e.g. by TNF) and their expression levels are elevated during acute malaria infection [ 6 ]. (biomedcentral.com)
  • PURPOSE: To research the effects of iloprost (IL) and hyperbaric oxygen (HBO) combination treatment on lung injury and on tumor necrosis factor alpha (TNF-α), myeloperoxidase (MPO), malondialdehyde (MDA), and soluble. (koreamed.org)
  • The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. (embl.de)
  • The term pemphigus refers to a group of autoimmune blistering diseases of the skin and mucous membranes characterized histologically by intraepidermal blister and immunopathologically by the finding of in vivo bound and circulating immunoglobulin G (IgG) antibody directed against the cell surface of keratinocytes. (medscape.com)
  • Levels of soluble fms-like tyrosine kinase-1 and soluble endoglin increased among those who developed preeclampsia, but there was no difference in levels of these antiangiogenic factors (nor any of the other serum analytes measured) among those treated with enoxaparin compared to those receiving standard high-risk care only. (nih.gov)
  • Higher levels of neuron specific enolase (NSE) and lower levels of soluble neuron cell adhesion molecule (sNCAM) were associated with higher scores on the inattention, hyperactivity/impulsivity and executive functioning scales of the Conners-3, as well as working memory and initiate scales of the MI from the BRIEF. (biomedcentral.com)
  • We examined the blood levels of total serum IgE, white blood cell count/differential count (WBC/DC), eosinophil counts (EC), eosinophil cationic protein (ECP) and specific IgE.A total of 208 children with AD were enrolled in this study. (bvsalud.org)
  • CD43 (also known as leukosialin and sialophorin) is a surface sialoglycoprotein expressed at high levels on most leukocytes implicated in adhesion, antiadhesion, and activation/proliferation mechanisms. (elsevierpure.com)
  • Elevated levels of blood lead also show correlation with soluble CD40 ligand (sCD40L). (bibliomed.org)
  • Host adhesion molecules play a significant role in the pathogenesis of Plasmodium falciparum malaria and changes in their structure or levels in individuals can influence the outcome of infection. (biomedcentral.com)
  • Alterations in levels or structure of these molecules would thus affect an individual's response to P. falciparum infection and consequent disease manifestation. (biomedcentral.com)
  • It is governed by cell-extrinsic molecular factors, which can either emerge in the soluble phase or as immobilized, often adhesive ligands. (nature.com)
  • Here, we developed a microfluidic chamber that allows measurement of cell migration in combined response to surface immobilized and soluble molecular gradients. (nature.com)
  • Diabetic nephropathy (DN) is a leading selectin), and soluble thrombomodulin--are cause of chronic renal failure and is a grow- providing further evidence of the relation- ing concern given the increasing incidence ship between endothelial cell activation and of type 2 diabetes. (who.int)
  • Cell surface receptors containing an immunoglobin domain. (embl.de)
  • Killer cell inhibitory receptors. (embl.de)
  • A class of cellular membrane receptors that either have an intrinsic guanylate cyclase activity or are closely coupled to specific guanylate cyclases within the cell. (bvsalud.org)
  • We compared antibody responses to high-dose egg-based inactivated (HD-IIV3), recombinant (RIV4), and cell culture-based (ccIIV4) vs standard-dose egg-based inactivated influenza vaccine (SD-IIV4) among health care personnel (HCP) aged 18-65 years in 2 influenza seasons (2018-2019, 2019-2020). (cdc.gov)
  • Ubiquitin enzymes, ubiquitin and proteasome activity in blood mononuclear cells of MCI, Alzheimer and Parkinson patients. (uibk.ac.at)
  • 2022. Exposure to arsenic and level of Vitamin D influence the number of Th17 cells and production of IL-17A in human peripheral blood mononuclear cells in adults. (nih.gov)
  • Binding of Plasmodium falciparum-infected erythrocytes to soluble platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): frequent recognition by clinical isolates. (kemri-wellcome.org)
  • Immunofluorescence staining with a mixture of primary human dermal lymphatic endothelial cells (HDLEC) / normal human dermal fibroblasts (NHDF) with anti-human ESAM (green) [Cat# 102-42AG] and anti-human CD31 (red) [Cat# 101-M92]. (reliatech.de)
  • Immunofluorescence staining of CD31 (red) and ESAM (green) in a mixture of primary human dermal lymphatic endothelial cells (HDLEC) and the mouse myoblast cell line C2C12 with monoclonal mouse anti-human CD31 #WM-59 [Cat# 101-M92] and polyclonal rabbit anti-human ESAM [Cat# 102-PA42AG]. (reliatech.de)
  • Inflammation, cell adhesion molecules, and stroke: tools in pathophysiology and epidemiology? (wikipedia.org)
  • The salivary scavenger and agglutinin (SALSA), also known as gp340 and dmbt1, is an antimicrobial and inflammation-regulating molecule located at the mucosal surfaces. (researchgate.net)
  • Effective clearance of inflammatory cells is required for resolution of inflammation. (koreamed.org)
  • Identification of frequently recognized dimorphic T-cell epitopes in plasmodium falciparum merozoite surface protein-1 in West and East Africans: lack of correlation of immune recognition and allelic prevalence. (kemri-wellcome.org)
  • Cell adhesion molecules in bladder cancer: soluble serum E-cadherin correlates with predictors of recurrence. (ox.ac.uk)
  • Soluble cell adhesion molecules in monocytes of Alzheimer´s disease and mild cognitive impairment. (uibk.ac.at)
  • Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
  • Pemphigus vulgaris is an autoimmune, intraepithelial, blistering disease affecting the skin and mucous membranes and is mediated by circulating autoantibodies directed against keratinocyte cell surfaces. (medscape.com)
  • Monocytes deliver bioactive nerve growth factor through a brain capillary endothelial cell-monolayer in vitro and counteract degeneration of cholinergic neurons. (uibk.ac.at)
  • Although it is conceivable that cells can equally respond to gradients of soluble and/or immobilized chemokines, almost all cell biological information available about-gradient sensing is based on in vitro studies employing soluble gradients. (nature.com)
  • It has been shown in vitro that the directionality of DCs migrating on homogenously immobilized CCL21 can be biased by gradients of soluble CCL19 10 . (nature.com)
  • Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
  • ESAM is expressed on endothelial cells, activated platelets and megakaryocytes, and can be found associated with cellto cell junctions. (reliatech.de)
  • Polymorphisms in host adhesion molecules have been correlated with the outcome of P. falciparum infection in studies from Africa and south-east Asia. (biomedcentral.com)
  • found evidence and they did not require insulin therapy of endothelial cell injury in renal failure for glucose control. (who.int)
  • The affinity of CD4/pMHC II therefore seems to be set at a value that increases T-cell sensitivity by enhancing phosphorylation, without compromising ligand discrimination. (lu.se)
  • The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)
  • Such information is mediated immunity, secreting the cytokine crucial to determine the optimal approach interferon-gamma (IFN) that inhibits Th2 to improve the immune response of DN cell differentiation. (who.int)
  • Frequencies of peripheral blood myeloid cells in healthy Kenyan children with alpha+ thalassemia and the sickle cell trait. (kemri-wellcome.org)
  • Homocysteine enhances transmigration of rat monocytes through a brain capillary endothelial cell monolayer via ICAM-1. (uibk.ac.at)
  • Connective-tissue growth factor is a soluble mediator that enhances and perpetuates the profibrotic effects of TGF-beta. (medscape.com)
  • Here, we report that a soluble form of CD4 failed to bind detectably to pMHC II in surface plasmon resonance-based assays, establishing a new upper limit for the solution affinity at 2.5 mM. (lu.se)
  • Dans une cohorte de 43 patients atteints de lupus érythémateux disséminé (19 présentant un lupus érythémateux disséminé stable et 24 un lupus érythémateux disséminé évolutif) et un groupe témoin comprenant 20 sujets sains, la présence répétée de molécules d'adhésion des cellules vasculaires sous forme soluble (sVCAM-1) était associée de manière significative à l'activité du lupus érythémateux disséminé. (who.int)
  • Les IFN et les IL-10 étaient signi cativement élevés chez ceux qui présentaient une néphropathie diabétique (ND) et une maladie rénale en phase terminale (MRPT) par rapport aux témoins et aux patients diabétiques sans ND. (who.int)
  • T-cells have 2 subsets of betic patients with and without nephropathy. (who.int)
  • Th2 cells produce cy- patients which might reduce the morbidity tokine interleukins IL-4 and IL-10, which and mortality due to infection. (who.int)
  • These mediators cause vasodilation, increased capillary permeability, mucus hypersecretion, smooth muscle spasm, and tissue infiltration with eosinophils, type 2 helper T (TH2) cells, and other inflammatory cells. (msdmanuals.com)
  • Proposed factors involved in the pathogenesis of morphea include endothelial cell injury, immunologic (eg, T lymphocyte) and inflammatory activation, and dysregulation of collagen production. (medscape.com)
  • Endothelial cell injury is currently thought to be the inciting event in the pathogenesis of morphea. (medscape.com)
  • PURPOSE: This study aimed to investigate the effect of adipose-derived stem cell (ADSC) transplantation on atherosclerosis (AS) and its underlying mechanisms. (koreamed.org)
  • Despite evidence suggesting that in vivo chemokines are often immobilized to sugar residues, limited information is available how cells respond to immobilized chemokines. (nature.com)
  • A previous blueberry trial bolsters this finding and goes on to document immune enhancing activity as well - an increase in natural kill cells. (healthyfellow.com)
  • As important components of the host immune system host cell adhesion molecules may also play a role in parasite-induced immune regulation. (biomedcentral.com)
  • However, when presented multivalently on magnetic beads, soluble CD4 bound pMHC II-expressing B cells, confirming that it is active and allowing mapping of the native coreceptor binding site on pMHC II. (lu.se)
  • Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)