• cells
  • In constant 100 μ m lidocaine, current-clamped Purkinje cells continued to fire spontaneously. (jneurosci.org)
  • The activation of protein kinase C completely suppresses the opening BK channels in intact rat anterior pituitary cells in physiological saline. (epfl.ch)
  • Adrenal glucocorticoids Adrenal glucocorticoids regulate adaptation mechanisms to environmental challenges ( ) and can modify the electrical excitability of BK channels in human embryonic kidney cells. (epfl.ch)
  • proteins
  • There is evidence of changes in BK channel activity by phosphorylation and/or interaction by G proteins, by mechanical stretch, and by various endothelium-derived vasoactive substances . (epfl.ch)
  • human
  • This finding indicated that channel dysfunction could lead to human disorders in which pain is a prominent symptom. (jci.org)
  • control
  • The voltage and metal sensors all control the opening of the same ionic pore in response to various physiological signals . (epfl.ch)
  • type
  • Moreover, each type of neuronal BK channels are differentially sensitive to PKA-dependent phosphorylation. (epfl.ch)