Small molecule drugs drug therapy combination. Medical search. Frequent questions

Trametinib and cobimetinib are oral small-molecule inhibitors of MEK1 and MEK2, signaling molecules downstream of BRAF in the MAP kinase pathway. (medscape.com)
Bortezomib is the first drug approved in the group of anticancer agents known as proteasome inhibitors. (medscape.com)
Grembecka's research team is also testing their menin inhibitors together with drugs that specifically target other molecular defects in aggressive leukemias. (cancer.org)
14. New developments in the treatment of metastatic melanoma: immune checkpoint inhibitors and targeted therapies. (nih.gov)
We screened a library of bioactive small molecules for activators and inhibitors of innate immune signaling through IRF3 and NFkB pathways with the goals of advancing pathway understanding and discovering probes for immunology research. (harvard.edu)
Background Radiation therapy (RT) has the potential to enhance the efficacy of immunotherapy, such as checkpoint inhibitors, which has dramatically altered the landscape of treatments for many cancers, but not yet for pancreatic ductal adenocarcinoma (PDAC). (bmj.com)
Conclusion Our RT model allows examining the immune-modulatory effects of RT alone and in combination with immune-checkpoint inhibitors in the pancreas/local microenvironment. (bmj.com)
Among all targeted therapies, small molecule inhibitors have gained considerable momentum in the market owing to their small size, high penetrability and targetability towards the cancer cells. (medgadget.com)
To further enhance their efficacy in the management of cancer, these drugs are mainly used in combination with BRAF inhibitors. (medgadget.com)
Several studies are on-going which are evaluating the role of these drugs in combination with other cancer targeting regimes including immunotherapy, EFGR inhibitors, chemotherapy, and other tyrosine kinase inhibitors. (medgadget.com)
The zebrafish model presented here is simpler and more convenient than traditional methods of screening for NHEJ inhibitors and can be utilized in large-scale drug screens for NHEJ inhibitors and for the development of novel anticancer drugs. (dovepress.com)
The UCSF Center for Discovery and Innovation in Parasitic Diseases ( www.cdipd.org ) has identified commercial anti-hypercholesterolemia statin drugs - inhibitors of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) - as potent schistosomicidal compounds. (ucsf.edu)
Specific drug classes studied include HIV reverse transcriptase inhibitors, protease inhibitors, entry inhibitors (selective CCR5 and CXCR4 antagonists), and integrase inhibitors. (hopkinsmedicine.org)
Therefore, myeloid therapies have gained significant attention as a potential adjunct to currently used therapies, such as immune checkpoint inhibitors, dendritic cell vaccines, oncolytic viruses, and chemoradiation to enhance therapeutic response. (rootsanalysis.com)

The ADDP will continue to support mid- and late-stage preclinical development for small molecules and biologics. (nih.gov)
The same principles apply to the patenting of biological drugs (biologics). (penningtonslaw.com)
Biologics include large peptides and recombinant proteins such as insulin and growth hormone, monoclonal antibodies, recombinant DNA, antibody-drug conjugates, fusion proteins and synthetic vaccines. (penningtonslaw.com)
Given the often significantly greater expense involved in the development of biologics (compared to small molecule drugs), and originator companies' need to recoup that cost, it is unsurprising that secondary patents often play a key role in the lifecycles of biologics. (penningtonslaw.com)
It is now common medical practice to use biologics in combination therapy, usually with a small molecule drug. (penningtonslaw.com)
Although biologics may only be prescribed when conventional disease-modifying antirheumatic drugs (DMARDs) have not worked, they are often administered in combination with MTX. (penningtonslaw.com)
SciLucent has extensive experience in efficiently devising and executing integrated nonclinical development strategies for drugs, biologics, devices, and combination products for multiple therapeutic indications and routes of administration. (scilucent.com)
The "Myeloid Cells Targeting Therapeutics Market by Type of Molecule (Small Molecule and Biologics), Therapeutic Area (Oncological Disorders and Rare Disorders), Route of Administration (Intravenous and Oral) and Geography (North America, Europe and Asia Pacific), 2021-2035" report offers an extensive study on the current market landscape, offering an informed opinion on the likely evolution of the myeloid cells targeting therapeutics market. (rootsanalysis.com)

Strategies for targeted drug delivery utilizing small molecule conjugates or nanocarriers. (mdpi.com)
And antibody-drug conjugates (ADCs) are a premier example of this personalized approach to cancer treatment. (medium.com)

Various newly developed peptide-based drugs are expected to be a promising new class of antitumor therapeutics. (adcreviews.com)
This includes immune-based and host-targeted forms, with emphasis on broad-spectrum therapeutics and those targeting pathogens for which no standard clinical treatment exists or for which drug resistance poses a significant public health concern. (nih.gov)
Therapeutics of interest include small molecules, biopharmaceuticals, nucleic acids, or peptides to be used as monotherapy or in combination, or as adjunctive therapy, with other drugs. (nih.gov)
Recent advances in cancer therapeutics clearly demonstrate the need for innovative multiplex therapies that attack the tumor on multiple fronts. (genengnews.com)
Altogether, our findings establish that OVs can serve as replicating vehicles for amiRNA therapeutics with the potential for combination with small molecule and immune checkpoint inhibitor therapy. (genengnews.com)
We believe these observations are transformative for the fields of oncolytic viruses, miRNA therapeutics and exosome-based therapies. (genengnews.com)
It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. (researchandmarkets.com)
The industry has been working to address this issue by using more tightly targeted therapeutics or combination approaches that allow for lower (and less toxic) doses, but The Scripps Research Institute is looking back to the start, to the very origin of such drugs. (drugdiscoverynews.com)

The first-in-human Phase I/II AUGMENT 101 study, led by Ghayas Issa, M.D. , evaluated the safety and anti-tumor activity of SNDX-5613 - an oral small-molecule inhibitor of the menin-MLL interaction - for children and adults with advanced MLLr and NPM1m acute myeloid or lymphoid leukemias. (eurekalert.org)

We demonstrate that this inhibition is mediated by the small molecule binding to AMA1 and blocking the formation of AMA1-RON complex. (nih.gov)
In this study, we investigated the antitumor efficacy of the combination therapies with radiation and PD-1 blockade or IDO1 inhibition or both. (bmj.com)
Virus-directed targeting of ARID1A coupled with small-molecule inhibition of the methyltransferase EZH2 leads to the synthetic lethal killing of both infected and uninfected tumor cells. (genengnews.com)

Their research, published November 24 in the journal Nature Nanotechnology , found that the therapy shrunk tumors in mice with colon and pancreatic cancer. (scienceboard.net)
[10] AXL has been implicated as a cancer driver and correlated with poor survival in numerous aggressive tumors including triple-negative breast cancer (TNBC), acute myeloid leukemia (AML), non-small-cell lung cancer (NSCLC), pancreatic cancer and ovarian cancer, among others. (wikipedia.org)
Their new study (" Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy "), published in Nature Communications, " demonstrates that this approach can shrink tumors and significantly prolong survival in several cancer models in mice. (genengnews.com)
From hijacking the vascular system to feed tumors and camouflaging itself from immune checkpoints, to evolving to develop resistance to previously effective drugs, cancer has dozens of ways to evade treatment. (drugdiscoverynews.com)
Pairing drugs with antibodies to better direct them to tumors is a familiar concept, as seen by the rapid growth of the antibody-drug conjugate market. (drugdiscoverynews.com)
Such a combination therapy to treat testicular tumors may be much better tolerated. (bionity.com)
In addition, Kura is conducting a Phase 1/2 trial (KURRENT) of tipifarnib in combination with the PI3Kα inhibitor alpelisib to address larger genetic subsets of HNSCC patients, including those who whose tumors are dependent on HRAS and/or PI3Kα pathways. (biospace.com)
As of September 11, 2023, the data cutoff, 44 patients with NRAS mutant melanoma and BRAF-altered solid tumors were enrolled across 6 exarafenib plus binimetinib combination dose cohorts, including 24 patients who continue on therapy. (krqe.com)

[ 40 , 41 ] Despite high initial response rates, one-half of patients with previously untreated stage IV or unresectable stage III melanoma receiving BRAF-targeted monotherapy relapse within about 6 months because of the development of drug resistance. (medscape.com)
Although MEK-inhibitor monotherapy has limited utility for treating advanced metastatic melanoma, phase III trials have demonstrated that combination therapy with a BRAF/MEK inhibitor has better efficacy than BRAF-inhibitor monotherapy for previously untreated unresectable or metastatic disease. (medscape.com)
These studies have established dabrafenib/trametinib combination regimens as FDA-approved options for the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations. (medscape.com)
As is the case with dabrafenib/trametinib, vemurafenib/cobimetinib combination regimens are approved to treat patients who have unresectable or metastatic melanoma with BRAF V600E or V600K mutations. (medscape.com)
The US Food and Drug Administration (FDA) approved the combination of encorafenib ( Braftovi , Array BioPharma) and binimetinib ( Mektovi , Array BioPharma) today for patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-approved test. (medscape.com)
The PFS and OS advantages seen to date with the combination compared with monotherapy are "unprecedented" in the field of targeted therapy for melanoma, said Jeffrey Weber, MD, PhD, from the Perlmutter Cancer Center at the NYU Langone Medical Center, New York City, in a Medscape commentary earlier this month. (medscape.com)
Cite this: FDA Approves New Targeted Combo Therapy for Melanoma - Medscape - Jun 27, 2018. (medscape.com)
1. Advances in targeted therapy for unresectable melanoma: new drugs and combinations. (nih.gov)
2. Targeting drivers of melanoma with synthetic small molecules and phytochemicals. (nih.gov)
4. Current and future roles of targeted therapy and immunotherapy in advanced melanoma. (nih.gov)
6. New drug targets in metastatic melanoma. (nih.gov)
10. Recent advances in melanoma systemic therapy. (nih.gov)
19. Current systemic therapies for melanoma. (nih.gov)
20. Emerging targeted therapies for melanoma. (nih.gov)
Currently, the market is mainly dominated by Mekinist which is mainly due to its widespread use in the management of multiple cancers including melanoma, thyroid and non-small cell lung cancer. (medgadget.com)
Whole genome sequencing of tumours revealed mutations which are targetable by existing drugs used to treat lung cancer and melanoma. (sciencedaily.com)
The EGFR mutation identified is targeted by an existing EGFR inhibitor drug called afatinib, used to treat lung cancer, whereas drugs designed to treat melanoma skin cancer target BRAF. (sciencedaily.com)
Dose exploration for the combination of exarafenib and binimetinib is currently underway in the KN-8701 clinical trial, with a primary focus on NRAS mutant melanoma. (krqe.com)
NRAS alterations are detected in approximately 20-25% of melanoma patients, and as of today, there are no approved targeted therapies available for this subgroup, highlighting a significant unmet medical need. (krqe.com)

[ 42-44 ] To bypass possible BRAF-inhibitor therapy resistance, other drugs have been developed to target the MAP kinase pathway in different ways. (medscape.com)
For patients receiving BRAF-inhibitor therapy, the panel recommends regular dermatologic evaluation with referral to a dermatologist to monitor for skin complications. (medscape.com)
Among recommended BRAF-targeted therapy options, the BRAF/MEK inhibitor combination is preferred over BRAF inhibitor monotherapy based on improved outcomes and similar risk of toxicity. (medscape.com)
In patients with documented BRAF V600 mutations, choosing between first-line checkpoint immunotherapy and BRAF-targeted therapy can be difficult given the lack of comparative phase III clinical trials. (medscape.com)
Encorafenib is a small-molecule BRAF inhibitor and binimetinib is a small-molecule MEK inhibitor. (medscape.com)
The combinational therapy helps to simultaneously inhibit the BRAF kinase as well as MEK1/MEK2 activity. (medgadget.com)
We found mutations affecting EGFR and BRAF, both of which are targets for existing drugs. (sciencedaily.com)

Plasmodium falciparum resistance to artemisinin derivatives, the first-line antimalarial drug, drives the search for new classes of chemotherapeutic agents. (nih.gov)
Application of small molecules in combination therapies to overcome drug resistance. (mdpi.com)
The rapid emergence and spread of anti-malarial drug resistance has been a major challenge in malaria control efforts. (wustl.edu)
Thus, understanding the complex mechanisms that underlie drug resistance is critical to prevent the further spread of resistance and to develop new drugs in order to diversify the tools available to treat microbial infections. (wustl.edu)
Fosmidomycin-resistant Plasmodium falciparum strains were generated in vitro in order to investigate possible mechanisms of resistance to this drug. (wustl.edu)
In recent years, AXL has emerged as a key facilitator of immune escape and drug-resistance by cancer cells, leading to aggressive and metastatic cancers. (wikipedia.org)
AXL has been shown to be a key driver of drug-resistance to targeted therapies, immuno therapies and chemotherapy in various animal models. (wikipedia.org)
Based on current knowledge of AXL's role in therapy resistance, future studies will help to determine whether AXL has a translational application as a biomarker for predicting therapeutic response to established drugs. (wikipedia.org)
Apart from concerns over possible drug resistance, PZQ has a number of failings. (ucsf.edu)
Two cancer drugs based on enediynes have been approved, but treatment resistance is a common problem for these compounds. (drugdiscoverynews.com)
Shen noted that this implies that microbes in the gut could then pass these proteins on to their human hosts, thereby conferring drug resistance. (drugdiscoverynews.com)
Future efforts to survey the human microbiome for resistance elements should be an important part of natural product-based drug discovery programs. (drugdiscoverynews.com)
Leukemias with MLLr occur in infants, children and adults, and are associated with resistance to standard therapies. (eurekalert.org)
And bispecific ADCs (BsADCs) could help address issues related to endocytosis, toxicity, and drug resistance of ADC drugs. (medium.com)

Small molecules as modulators of immune responses in cancer immunotherapy. (mdpi.com)
The treatment of cancer by controlling the function of immune cells is also a research hotspot of peptide drugs. (adcreviews.com)

Importantly, truly relevant disease model systems which mimic real time auditory/vestibular dysfunction needs to be developed and tested in therapeutic treatment environment, wherein lead molecules can be selected and appropriate safety and efficacy studies conducted. (nih.gov)
Thus, the development of additional therapeutic options is urgent, as is the establishment of combinatorial regimens to improve efficacy and reduce the potential for the emergence of drug-resistant variants. (nature.com)
This study focused on the antiviral mechanisms of action and in vivo efficacy of clofazimine, which is an FDA-approved molecule that was discovered as an anti-tuberculosis drug and was later used for the treatment of leprosy 16 . (nature.com)
In December 2019, Aurinia Pharmaceuticals announced positive efficacy and safety results from its pivotal AURORA Phase III trial of voclosporin, in combination with mycophenolate (MMF) and low-dose corticosteroids, for lupus nephritis treatment . (delveinsight.com)
The FOA encourages a broad array of preclinical activities including lead optimization, efficacy testing, safety evaluation, stability testing, manufacturing, scale-up, and investigational new drug-enabling activities to name a few. (nih.gov)
These findings raise the possibility that the human microbiota might impact the efficacy of enediyne-based drugs and should be taken into consideration when developing new chemotherapies," he added. (drugdiscoverynews.com)

NIA's large-scale target and biomarker discovery programs and translational centers have successfully expanded the drug discovery target landscape and created a need for next-generation brain imaging compounds as essential tools in this effort. (nih.gov)
University of Chicago researchers are using tiny molecules called advanced nanoparticles to deliver compounds that suppress tumor growth and metastasis. (scienceboard.net)
A team of researchers at SCTL, led by Dr. Ilyas Singeҫ, tested more than 15,000 U.S. Food and Drug Administration-approved drugs and compounds that led to identification of small-molecule cocktails that would protect iPSCs from cellular stress and improve cell survival. (nih.gov)
The small molecule compound fosmidomycin inhibits the MEP pathway enzyme deoxyxylulose 5-phosphate (DXR) and is in clinical trials for combination therapy with other anti-malarial compounds. (wustl.edu)
Whether a combination is considered obvious may also depend on the medical field in which the compounds are used. (penningtonslaw.com)
The question TSRI explored in recent work was the mechanism by which the compounds that are engineered into natural product-based drugs are kept safe from their own toxicity. (drugdiscoverynews.com)
Cell and gene therapies deliver immunomodulatory compounds following SCI . (mayo.edu)
Therapeutic compounds can be delivered to the spinal cord through gene therapy directly to produce the compounds needed or through implantation of genetically modified cells that secrete the compounds. (mayo.edu)
This allows for continuous drug delivery of compounds with short half-lives in areas that are not typically bioavailable. (mayo.edu)

Potential restoration of auditory/vestibular function by the delivery of a targeted gene, drug or other synthetic/biological compound presents a unique opportunity to combine both basic scientific research with the simultaneous development of a potential clinical therapeutic. (nih.gov)
At present, there has been no specific drug or other cellular therapeutic developed for the ear and thus large pharmaceutical companies remain uninterested. (nih.gov)
This creates an opportunity to develop new outreach programs to foster joint collaborative ventures between large and small biotechnology and pharmaceutical companies, and federal agencies to streamline and fastrack pharmaceutical therapeutic development for inner ear and vestibular disease. (nih.gov)
The collaboration will evaluate therapeutic approaches using SENS-401 in combination with cochlear implants, with preclinical studies initiating in 2018, and potential clinical trials to begin as soon as 2019. (cochlear.com)
The preclinical combination studies will evaluate SENS-401's therapeutic effect on hearing outcomes achieved with Cochlear's implantable devices. (cochlear.com)
The drug has the inherent advantage over legacy CNIs such as cyclosporine or tacrolimus due to its flat-dosing, thereby eliminating the need for therapeutic drug monitoring. (delveinsight.com)
Bioconjugates containing KLA polypeptides can be applied to the development of various anticancer therapeutic drugs. (adcreviews.com)
Over the past few decades, the therapeutic application of monoclonal antibodies (mAbs) has played a significant role in the shift towards tailoring therapies with the highest safety margin to specific patient subgroups. (medium.com)

This Special Issue aims to highlight the latest developments in small molecule-based approaches for targeted cancer therapy and diagnosis and addresses the associated challenges. (mdpi.com)
Combination regenerative and neuromodulatory approaches promote plasticity, regeneration and immunomodulation. (mayo.edu)

Cutaneous toxicities can require biopsies to confirm the diagnosis, especially in patients who are not responsive to topical or oral steroids, since the selection of biologic drugs depends on accurate diagnosis. (stanfordchildrens.org)
In 2017 the U.S. Food and Drug Administration (FDA) approved 40 new drugs and granted 48 noteworthy biologic licenses. (mhmedical.com)
One reason why patents for biologic and small molecule combinations may not always be robust is because the co-administration of two or more medicines to treat disease is often a routine medical practice. (penningtonslaw.com)

The lipid phosphatidylserine (PS), usually found inside the tumor cell membrane, migrates to the cell surface in response to chemotherapy drugs. (scienceboard.net)
The researchers found that treatment with chemotherapy drugs fluorouracil and oxoplatin (FuOXP) led to increased levels of Xkr8, a protein that controls PS distribution. (scienceboard.net)
Often, a combination of chemotherapy drugs are used together. (healthychildren.org)
This insidious cancer invasion also limits the effectiveness of chemotherapy drugs and radiation therapy. (news-medical.net)
For two decades, standard-of-care therapy for newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL) has been the combination of the antibody rituximab plus chemotherapy drugs cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). (eurekalert.org)

Lonza, Switzerland, which already had supplied an early intermediate, methyl acetoacetate, during drug development, soon became the main supplier of more and more advanced precursors. (wikipedia.org)
We have spearheaded the development of an advanced small molecule library containing high-value small molecule tools, chemical biology probes, and approved and candidate drugs for screening in matrix format. (nih.gov)
Participation in these groups provides patients with early access to the latest anticancer drug development clinical research studies, some of them pioneered at Cincinnati Children's. (cincinnatichildrens.org)
In 2006, NIA launched the Alzheimer's Drug Development Program (ADDP) as a major funding vehicle to support the most challenging and costly steps of preclinical drug development and seamlessly connect promising drug targets to first-in-human testing. (nih.gov)
and enable a precision medicine approach to drug development by delivering INDs for PET ligands that can be developed into companion diagnostics. (nih.gov)
The NIDCD held a workshop to discuss the current and future state of molecular therapy development in auditory and vestibular disease. (nih.gov)
Optimistically, now is the time to streamline federal oversight hurdles to therapy development and to make targeted therapy development more attractive. (nih.gov)
Key areas of interest include development of clinically relevant models that can be used for lead molecule selection and safety studies for specific clinical applications. (nih.gov)
In efforts to accelerate the development of therapies for COVID-19, a library of known drugs that encompassed approximately 12,000 clinical-stage or FDA-approved small molecules was previously profiled 15 . (nature.com)
Grembecka's lab focuses on the discovery and development of small molecules for targeted therapies in cancer. (cancer.org)
The nerve cells developed through this process have cellular features similar to nerve cells found in the human body and displayed biomarkers that are useful for drug development. (nih.gov)
However, the development of iPSC-based therapy can be difficult, partly due to cell-culture induced stress that affects the quality of cells. (nih.gov)
The lack of high quality iPSCs can limit production of the large amounts of cells needed for disease research, tissue engineering, drug development and regenerative medicine. (nih.gov)
among the targets of the screen are several molecules that may merit further development as anti-inflammatory drugs. (harvard.edu)
Dysregulation and overactivation of MAPK pathway occurs in almost one-third of malignancies, thus making it potential target for the drug development process. (medgadget.com)
Zebrafish is an ideal model for drug screening due to the specificity of its early embryonic development and similarity of tumor cell generation. (dovepress.com)
The industry partner can be a large or small, domestic or foreign, pharmaceutical, biotechnology, bioengineering, or chemical company, or a related non-profit entity with an established track record in product development. (nih.gov)
The World Health Organization encourages the discovery and development of new drug candidates. (ucsf.edu)
First, in partnership with an industry leader in statin drug development (Merck Sharp & Dohme Corp. ("Merck")), we will employ quantitative and 'targeted' phenotypic screening of privileged statin libraries to obtain a preliminary understanding of the structural determinants of statin analogs that kill the parasite in vitro, including those that improve killing activity over commercial statins already tested. (ucsf.edu)
In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Usher Syndrome collaborations, licensing, mergers and acquisition, funding, designations and other product related details. (researchandmarkets.com)
This segment of the Usher Syndrome report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. (researchandmarkets.com)
The development of treatments to promote some level of recovery must involve the right combination of neuroprotection, neuroregeneration and neuroplasticity. (mayo.edu)
This has shifted oncology drug development towards tissue-agnostic, biomarker-driven treatments that target specific molecular alterations. (medium.com)
As of last year, there are 14 ADC drugs available worldwide, with many more in preclinical and clinical development. (medium.com)
Currently, there are BsADCs approved by the Federal Drug Administration (FDA) and the European Medicines Agency (EMA), with over 200 in preclinical development and clinical trials. (medium.com)
The review encompassed various factors, including the Company's cash runway, near-term pipeline value creation prospects, the evolving regulatory landscape for targeted therapies, commercial potential, development strategy, and other relevant considerations. (krqe.com)
ical pharmacology of antiviral drugs, drug interactions, and oral, topical and injectable HIV microbicide development. (hopkinsmedicine.org)

ADCs, considered the ' homing missiles ' of cancer therapy, represent the optimal combination of mAbs and small molecule drugs to create a single, highly specific, and cytotoxic moiety. (medium.com)

We found that this molecule, which has been approved by the US Food and Drug Administration, inhibits cell fusion mediated by the viral spike glycoprotein, as well as activity of the viral helicase. (nature.com)
Their new drug (MI-3454) inhibits the ability of a critical protein called menin to interact with these fusion proteins, and their results have proven fruitful in mice with MLL leukemia, according to a recently published study in The Journal of Clinical Investigation. (cancer.org)

Our prior studies demonstrated that PD ligand-1 and indoleamine 2,3-dioxygenase 1 (IDO1) were induced on tumor epithelia of PDACs following neoadjuvant therapy including RT, suggesting RT may prime PDAC for PD-1 blockade antibody (αPD-1) or IDO1 inhibitor (IDO1i) treatments. (bmj.com)
The dual combination of RT/IDO1i and triple combination of RT/αPD-1/IDO1i did not improve survival compared with RT/αPD-1, although all of these combinations offer similar local tumor control. (bmj.com)
Albumin is an interesting target for tumor targeting and chemotherapeutic drug delivery. (adcreviews.com)
Discovery of rapid and high-throughput techniques to screen for an effective NHEJ inhibitor drug is imperative for the suppression of NHEJ during tumor treatment. (dovepress.com)
An advantage of small-molecule PPF -- which has been previously used in clinical trials in an attempt to treat Alzheimer's disease and dementia -- is that it can penetrate the blood-brain barrier and reach the tumor. (news-medical.net)
Our data suggests that PPF, working in combination with TMZ and radiation, could limit glioblastoma invasion and improve the clinical outcome for brain tumor patients,' said Dr. Tran, the study's senior author. (news-medical.net)

In addition to the studies below, forthcoming press releases will feature groundbreaking clinical studies on chimeric antigen receptor (CAR) T cell therapies for patients with lymphoma (Abstracts 2 , 93 , 739 ) and targeted therapies for patients with acute myeloid leukemia (Abstracts 371 , 691 , 794 ). (eurekalert.org)

Cancer cells are constantly evolving new ways to evade our therapies, so we designed this therapy to target cancer on multiple fronts at the same time," said senior author Carolina Ilkow, PhD, assistant professor in the faculty of medicine and senior scientist at The Ottawa Hospital. (genengnews.com)

ADCs, one of the fastest growing drug classes in oncology, address the limitations of chemotherapy, or monoclonal antibody therapy, by providing a means of targeting the vulnerability of cancer cells. (medium.com)

Developers may be able to extend patent protection by patenting other technological advances related to the drug such as new formulations, dosage forms or regimens, and new combinations with other pharmaceuticals. (penningtonslaw.com)
This includes regimens using biologicals such as obinutuzumab (Gazyvaro®) which is only licensed in the UK for combination chemotherapy, although it may be given on its own for subsequent maintenance therapy. (penningtonslaw.com)

This program offers researchers access to a screening methodology capable of identifying new drug-drug combinations for deciphering overlapping pathways in systems biology and potential clinical examinations. (nih.gov)
The Company's pipeline consists of small molecule drug candidates that target cancer signaling pathways. (biospace.com)
Additional objectives are characterization of pathways of drug metabolism, and identification of clinically significant harmful and beneficial drug interactions mediated by hepatic and intestinal cytochrome P450 isoforms. (hopkinsmedicine.org)

Researchers have identified uric acid as a potential therapy to enhance recovery from acute ischemic stroke using a new method for conducting preclinical animal research. (nih.gov)
In a small study, researchers used a device that stimulates the spinal cord to restore arm and hand mobility in two stroke patients, allowing them to perform daily life activities, such as using a fork to eat a meal. (nih.gov)
Using an experimental drug, researchers were able to suppress a mutated amyotrophic lateral sclerosis (ALS) gene. (nih.gov)
In a small study, researchers funded by the National Institutes of Health captured more than 1,000 hours of brain recordings from patients with OCD in the clinic and at home. (nih.gov)
Researchers discover a small molecular inhibitor with big potential for children with mixed lineage leukemia (MLL). (cancer.org)
To facilitate the discovery of drugs that will be effective in humans, researchers supported by the Common Fund's Regenerative Medicine Program made use of human pluripotent stem cells (hPSCs), which are cells that can become almost any type of human cell. (nih.gov)
The researchers note that while many groups are investigating therapies based on RNA and extracellular vesicles, these therapies are much more difficult to manufacture and store than viral therapies. (genengnews.com)
TGen researchers have linked TROY to the cellular mechanisms that enable glioblastomas to invade normal brain cells, and resist anti-cancer drugs. (news-medical.net)

Postdoctoral Fellowship - Neuroprotective and regenerative therapies for spinal cord injury. (mayo.edu)

Here we show that clofazimine-an anti-leprosy drug with a favourable safety profile 3 -possesses inhibitory activity against several coronaviruses, and can antagonize the replication of SARS-CoV-2 and MERS-CoV in a range of in vitro systems. (nature.com)
Remdesivir has been shown to exhibit pan-coronavirus inhibitory potential 10 , and has been granted approval by the US Food and Drug Administration (FDA) for the treatment of COVID-19 on the basis of the reduced time taken to recover following treatment with this drug 11 . (nature.com)
Recovery following injury is limited, and regeneration often fails due to a hostile microenvironment created by secondary injury events, such as cell death, demyelination, inhibitory molecules and inflammation. (mayo.edu)

If we also look at the metastatic treatment market as a whole, pioneers such as OnsoSec may pave the road for the success other therapies that are more complex. (thecancerconsortium.org)
IMMU stock is up 4% YTD, mainly due to the patent filing in May of its antibody-based metastatic therapy. (thecancerconsortium.org)

Combinations of clofazimine and remdesivir exhibited antiviral synergy in vitro and in vivo, and restricted viral shedding from the upper respiratory tract. (nature.com)

In patients with renal failure or highly aggressive disease, therapy with vincristine, Adriamycin (doxorubicin), and dexamethasone (VAD) may be preferred. (medscape.com)
In elderly patients or patients in whom autologous transplantation is not possible in the future, melphalan and prednisone (MP) therapy is preferred because of its ease of administration and low toxicity. (medscape.com)
It is indicated as monotherapy, in combination with dexamethasone, or in combination with lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma in patients who have received at least 1 prior line of therapy. (medscape.com)
Clofazimine, which is orally bioavailable and comparatively cheap to manufacture, is an attractive clinical candidate for the treatment of outpatients and-when combined with remdesivir-in therapy for hospitalized patients with COVID-19, particularly in contexts in which costs are an important factor or specialized medical facilities are limited. (nature.com)
Most cancer patients in the United States receive some form of radiation therapy during the course of their disease, and its effects have been studied for more than a century. (nih.gov)
During that time, there has been tremendous progress in radiation therapy and advances in the treatment of patients. (nih.gov)
Their introduction into the market has shown high adoption rates by patients owing to their high specificity, targetability, and ability to overcome the limitations of conventional cancer therapies. (medgadget.com)
In a significant breakthrough, the Translational Genomics Research Institute (TGen) has identified a drug, propentofylline or PPF, that could help treat patients with deadly brain cancer. (news-medical.net)
PPF could be easily translated to the clinic as an adjuvant therapy in combination with standard of care treatment for GBM patients. (news-medical.net)
Tagraxofusp-erzs, an anti-CD123 targeted therapy, is the first and only approved targeted therapy for treatment of patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare, but highly aggressive hematologic malignancy. (eurekalert.org)
A new subgroup analysis reports results from the original clinical trial (across 4 stages) stratified by age and baseline disease involvement (skin only, systemic only, skin and systemic) in the 65 patients who received tagraxofusp as the first line of therapy for BPDCN. (eurekalert.org)
no patients discontinued therapy because of treatment-related side effects. (eurekalert.org)
SAN DIEGO, Jan. 20, 2022 (GLOBE NEWSWIRE) -- Kura Oncology , Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, today announced that the U.S. Food and Drug Administration (FDA) has lifted the partial clinical hold on the KOMET-001 Phase 1b study of KO-539 in patients with relapsed or refractory acute myeloid leukemia (AML). (biospace.com)
Tipifarnib, a potent, selective and orally bioavailable farnesyl transferase inhibitor, has received Breakthrough Therapy Designation for the treatment of patients with HRAS mutant HNSCC and is currently in a registration-directed trial (AIM-HN) in patients with this devastating disease. (biospace.com)
In August, the FDA granted Orphan Drug Designation to Faron Pharmaceuticals' bexmarilimab used for the treatment of patients suffering from acute myeloid leukemia. (rootsanalysis.com)

Scientists often rely on animal models to research pain treatments, but use of these models is not optimal because physiological differences between humans and animals can lead to drug candidates that do not work well or are toxic in humans. (nih.gov)
The companies which have their Usher Syndrome drug candidates in the most advanced stage, i.e. (researchandmarkets.com)

The hereditary material DNA is similar to an extremely long strip of Morse code, on which the assembly instructions for the cellular molecules are found. (bionity.com)

With the rapid growth of bioinformatics knowledge related to peptides and proteins, peptide-based drug design strategies have become increasingly active recently. (adcreviews.com)
In the past, peptide-based drugs have not been widely used due to serious problems such as low selectivity and rapid degradation of peptides in biological systems. (adcreviews.com)

As such, drug combinations which include at least one routinely used drug (often a small-molecule compound) are likely to be considered obvious from a patentability perspective, particularly where that drug is used in other combinations. (penningtonslaw.com)

The goal of the Regenerative Medicine Program was to produce resources to accelerate stem cell-based therapies. (nih.gov)
Ahad M. Siddiqui, Ph.D., conducts research into regenerative neuroimmunology, where combinatorial therapies that promote regeneration through modulation of the inflammatory response are used to improve functional recovery. (mayo.edu)

SENS-401 has demonstrated in preclinical models (noise and drug induced hearing loss) the capacity to enhance survival and preserve functional integrity of hair cells in the inner ear. (cochlear.com)

But adding a PD-1 inhibitor drug to "release" the brakes resulted in significantly improved survival in mice. (scienceboard.net)

Part 1 looked back at first-in-class and "me-too" small molecule drug approvals, breakthrough therapies, and new companion diagnostic tests for therapies targeting cancer. (mhmedical.com)

In the double-blind, Phase III POLARIX study, R-CHOP was compared with pola-R-CHP, a combination of polatuzumab vedotin - a CD79b-targeting antibody-drug conjugate - and rituximab plus cyclophosphamide, doxorubicin and prednisone (R-CHP). (eurekalert.org)

Basic biological research must continue in identifying genes and signaling cascades important to the scientific information base, but must be broadened to integrate issues of inner ear and vestibular pathology, homeostasis, delivery, and immunology specific to a targeted therapy scenario. (nih.gov)

Off-target effects are a stumbling block for any kind of drug, but for cancer, where drugs must be strong enough to kill off resilient cells that are designed to survive and spread, unintended toxicity is a particular issue. (drugdiscoverynews.com)
Scientific objectives of clinical studies include characterization of early drug activity, toxicity, and pharmacokinetics. (hopkinsmedicine.org)

The drug had obtained fast track designation from the FDA in March 2016 and in June 2021, Aurinia Pharmaceuticals announced that the Company's licensing partner, Otsuka Pharmaceutical Europe, filed an initial Marketing Authorization Application for voclosporin for the lupus nephritis treatment to the EMA. (delveinsight.com)

Rational design and synthesis of small molecules targeting specific oncogenic targets, such as kinases, receptors, and transcription factors. (mdpi.com)

These results indicate which existing drugs could be used to help children overcome these tumours in infancy. (sciencedaily.com)

[ 5 ] Clinical trials are under way to address questions regarding the optimal sequencing and/or combination of these agents. (medscape.com)
The next stage will be the support for critical phase I clinical trials to test safety of new therapies. (nih.gov)
iPSCs-based therapy is already being tested in clinical trials to treat retinal degeneration, heart failure, and neurological diseases [1] and have the potential to treat chronic wounds [2]. (nih.gov)
This research used a Maraba virus that has been tested in human clinical trials as a cancer therapy, but the strategy could be applied to other viruses as well. (genengnews.com)

Jolanta Grembecka, PhD, and colleagues are developing new therapies for MLL leukemia, which is caused by a genetic defect involving MLL1 gene that fuses with other genes to result in hybrid proteins that fuel cancer growth. (cancer.org)
These treatments use drugs to block the growth and spread of cancer by interfering with proteins involved in the cancer's growth (cell division) and its spread. (cancer.org)
With financial support through a research grant from the American Cancer Society (ACS), Grembecka's team has been developing and testing drugs in mice that specifically target MLL1 fusion proteins in acute leukemias. (cancer.org)
These genes encode proteins that enable bacteria to resist a subset of enediynes known as tiancimycins, which are being explored as a base for new cancer drugs. (drugdiscoverynews.com)

By blocking calcineurin, a signaling protein involved in T cell activation, the small molecule oral drug is designed to inhibit IL-2 and tamps down inflammation in the kidney. (delveinsight.com)

However, the rapid advancement of technology has resulted in multiple knowledge gaps in understanding the biology of the effects of radiation therapy on normal and malignant tissue. (nih.gov)
Radiation therapy uses high energy X-rays (photons or protons) to kill cancer cells. (healthychildren.org)
Radiation therapy may be part of treatment for childhood cancers that develop in soft tissue (rhabdomyosarcoma and sarcoma), the bones (Ewing Sarcoma), eye (retinoblastoma), lymph nodes (Hodgkin lymphoma), and nervous system (neuroblastoma, ependymoma, pontine glioma and astrocytoma), among other types. (healthychildren.org)
In addition, TGen laboratory research also found that PPF increases the effectiveness of a standard-of-care chemotherapy drug called temozolomide (TMZ), and radiation, to treat glioblastoma. (news-medical.net)

The Company is also developing KO-2806, a next-generation farnesyl transferase inhibitor, which is intended to target innovative biology and larger oncology indications through rational combinations. (biospace.com)

Since past few years, there have been drastic changes in the paradigm of cancer treatment with the rapid approval of several targeted drugs. (medgadget.com)
Treatment and control of schistosomiasis relies on just one drug, praziquantel (PZQ). (ucsf.edu)
Secondly, we will optimize and standardize the recombinant expression of active Schistosoma mansoni HMGR, which will be central to deriving the kinetic and crystallographic data necessary to prosecute a subsequent lead optimization program to identify candidate molecules for treatment of schistosomiasis. (ucsf.edu)
Oncolytic or "cancer-killing" viruses (OVs) represent up-and-coming multi-mechanistic immunotherapeutic drugs for the treatment of cancer," write the investigators. (genengnews.com)
Currently, chemotherapy, using cytotoxic small molecules to kill cancer cells, is the predominant conventional cancer treatment. (medium.com)
In addition, myeloid cell targeting therapies are being investigated for their potential in the treatment of various inflammatory disorders. (rootsanalysis.com)

To aggressively move molecular based therapies to the marketplace, clear milestones should be established. (nih.gov)
Emphasis will be placed on their mechanisms of action, molecular interactions, and potential for targeted cancer therapy and diagnosis. (mdpi.com)
In contrast, "small molecule" drugs are usually chemically and thermally stable with low molecular weights. (penningtonslaw.com)

Another example of KLA-based therapy is penetratin (a cell-penetrating polypeptide)-KLA conjugate. (adcreviews.com)

The discovery of drug combinations, however, is often the result of clinical speculation or trial-by-error strategies that result in a preponderance of failures. (nih.gov)

As they predicted, this combination approach has led to more complete and long-lasting remission of leukemia in mice. (cancer.org)

If an applicant is able to provide data to the EPO which demonstrates that a combination of drugs is particularly efficacious, a patent is often granted. (penningtonslaw.com)

When discovered, however, the synergy of two targeted therapies can yield spectacular results. (nih.gov)

Anatomy3

Organisms1

Diseases1

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes18

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science4

Named Groups1

Health Care2

Inhibitors14

Biologics8

Conjugates2

Therapeutics8

Oral small-molecule1

Inhibition3

Tumors8

Melanoma19

BRAF7

Resistance14

Immune2

Efficacy6

Compounds9

Therapeutic8

Approaches2

Biologic3

Chemotherapy drugs5

Development27

MAbs1

Inhibits2

Tumor6

Cell therapies1

Ways to evade1

Monoclonal1

Regimens2

Pathways3

Researchers8

Neuroprotective1

Inhibitory3

Metastatic2

Antiviral1

Patients15

Candidates2

Cellular1

Peptides2

Compound1

Regenerative2

Preclinical1

Inhibitor drug1

Approvals1

Antibody-drug conjugate1

Immunology1

Toxicity2

Company's1

Synthesis1

Overcome1

Clinical Trials4

Proteins4

Inflammation1

Radiation4

Rational1

Treatment6

Molecular3

Conjugate1

Strategies1

Mice1

Demonstrates1

Synergy1