• prion
  • There are numerous types of prion diseases in humans, and CJD is the most common. (case.edu)
  • In the study, the researchers collected skin samples from 38 patients with assistance from the National Prion Disease Pathology Surveillance Center at Case Western Reserve School of Medicine and measured their prion levels. (case.edu)
  • Using a highly sensitive in vitro assay developed and conducted by Byron Caughey's group at the NIH, they detected prion protein aggregates in the skin samples from all of CJD patients. (case.edu)
  • Prion levels were 1,000-100,000 times lower in the skin than in the brain, and only detectable by this extremely sensitive assay. (case.edu)
  • The level of prion infectivity detected in CJD skin was surprisingly significant, but still much lower than that in CJD brains," cautioned Qingzhong Kong, associate professor of pathology and neurology at Case Western Reserve School of Medicine. (case.edu)
  • Prion transmission risk from surgical instruments contaminated by skin prions should be much lower than that of instruments contaminated by brain tissue. (case.edu)
  • Case Western Reserve School of Medicine researchers plan to further evaluate the potential risk of skin prion transmission through non-neurosurgeries, primarily using mouse models. (case.edu)
  • treatment
  • Before applying treatment to the surface of the skin: wash the affected areas with soap and water and remove the crusts, allowing the skin to dry in the air. (netdoctor.co.uk)
  • Skin disorders of dogs vary from acute, self-limiting problems to chronic or long-lasting problems requiring life-time treatment. (wikipedia.org)
  • In addition, there now was a focus on small molecules modulating the function of human polymerase alpha which at a time modulates proliferation of keratinocytes and various viruses including human papilloma viruses (HPV), which is most relevant in the context of non-melanoma skin cancer treatment. (wikipedia.org)
  • superficial
  • Play media Abscesses may occur in any kind of solid tissue but most frequently on skin surface (where they may be superficial pustules (boils) or deep skin abscesses), in the lungs, brain, teeth, kidneys, and tonsils. (wikipedia.org)
  • arthritis
  • The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is one of the institutes and centers that make up the National Institutes of Health, an agency of the United States Department of Health and Human Services (HHS). (wikipedia.org)
  • August 1950-An arthritis program was established within the National Institute of Arthritis and Metabolic Diseases under Public Law 81-692. (wikipedia.org)
  • May 1972-P.L. 92-305 renamed the Institute the National Institute of Arthritis, Metabolism, and Digestive Diseases. (wikipedia.org)
  • January 1975-The National Arthritis Act (P.L. 93-640) established the National Commission on Arthritis and Related Musculoskeletal Diseases to study the problem of arthritis and to develop an arthritis plan. (wikipedia.org)
  • April 1976-After a year of study and public hearings, the commission issued a comprehensivtre plan aimed at diminishing the physical, economic and psychosocial effects of arthritis and musculoskeletal diseases. (wikipedia.org)
  • 1982-HHS conferred bureau status on the Institute, resulting in creation of the Division of Arthritis, Musculoskeletal and Skin Diseases and the appointment of a Division Director. (wikipedia.org)
  • November 1985-The Health Research Extension Act of 1985, P.L. 99-158, established the National Institute of Arthritis and Musculoskeletal and Skin Diseases to increase research emphasis. (wikipedia.org)
  • The legislation provided for the development of a plan for a national arthritis and musculoskeletal diseases program and established two interagency coordinating committees, one on arthritis and musculoskeletal diseases and one on skin diseases. (wikipedia.org)
  • It also expanded the activities of the National Arthritis Advisory Board to include these diseases. (wikipedia.org)
  • October 2000-The Children's Health Act of 2000 (P.L. 106-310) directed NIAMS to expand and intensify research programs on juvenile arthritis and related conditions, in coordination with other NIH Institutes and the Arthritis and Musculoskeletal Diseases Interagency Coordinating Committee. (wikipedia.org)
  • childhood
  • Skin warts are most common in childhood and typically appear and regress spontaneously over the course of weeks to months. (wikipedia.org)
  • Condition
  • Impetigo can affect healthy skin (primary) and also broken skin, which has been caused by another condition, eg eczema (secondary). (netdoctor.co.uk)
  • Disease-like psoriatic toenails, significant toenail abnormalities/dystrophies, toenail injuries or any other condition in the toenail which could interfere with study evaluations (e.g., prevent obtaining normal appearing nail, after clearing of onychomycosis, due to chemical damage, genetic or pigmentary disorders, etc. (clinicaltrials.gov)
  • The condition of a dog's skin and coat are also an important indicator of its general health. (wikipedia.org)
  • If a cat has a protein deficiency the cat will lose weight, then show poor coat condition such as scaly skin, dull, thinning, weak, and patchy hair. (wikipedia.org)
  • hypersensitivity
  • This report describes the frequency and characteristics of serious or life-threatening hypersensitivity reactions to the tuberculin skin test over an 11-year period through November 2000. (oup.com)
  • This category also includes hypersensitivity disorders and eosinophilic skin diseases such as atopic dermatitis, miliary dermatitis and feline eosinophilic granuloma and skin diseases caused by autoimmunity, such as pemphigus and discoid lupus. (wikipedia.org)
  • scabs
  • It's important that the school fully understands the nature of impetigo and that the presence of scabs does not necessarily mean that person remains infectious. (netdoctor.co.uk)
  • acute
  • A hot spot, or acute moist dermatitis, is an acutely inflamed and infected area of skin irritation created and made worse by a dog licking and biting at itself. (wikipedia.org)
  • treatments
  • Today, despite remarkable advances in medical research and treatments, infectious diseases remain a very serious threat, causing about one in four deaths worldwide, including approximately two-thirds of all deaths among children younger than age five. (clinipace.com)
  • lymph nodes
  • Lyme disease, or borreliosis, is caused by Borrelia burgdorferi and spread by Ixodes pacificus on the West coast of the United States and by I. scapularis (deer tick) in the rest of the U.S. Signs and symptoms include fever, joint swelling and pain, lameness, and swelling of the lymph nodes. (wikipedia.org)
  • Lymphadenopathy or adenopathy is disease of the lymph nodes, in which they are abnormal in size, number, or consistency. (wikipedia.org)
  • Infectious lymphadenitides affecting lymph nodes in the neck are often called scrofula. (wikipedia.org)
  • The most distinctive sign of bubonic plague is extreme swelling of one or more lymph nodes that bulge out of the skin as "buboes. (wikipedia.org)
  • hereditary
  • These include skin fragility syndrome (Ehlers-Danlos), hereditary hypotrichosis and congenital or hereditary alopecia. (wikipedia.org)
  • Signs
  • Signs include hair loss and scaling of the skin. (wikipedia.org)
  • Thick-skinned Bos indicus breeds including the Afrikaner and Afrikaner cross-breeds show less severe signs of the disease. (wikipedia.org)
  • Signs of hypervitaminosis A are overly sensitive skin, and neck pain causing the cat to be unwilling to groom its self, resulting in a poor coat. (wikipedia.org)
  • severe
  • Medications applied to the skin such as capsaicin or topical anesthetics (e.g., lidocaine) are used for mild pain and can be used in combination with oral medications for moderate to severe pain. (wikipedia.org)
  • sexually
  • All people testing positive for gonorrhea should be tested for other sexually transmitted diseases such as chlamydia, syphilis, and human immunodeficiency virus. (wikipedia.org)
  • It is a sexually transmitted disease, but can also be spread through contact with aborted fetuses. (wikipedia.org)
  • important
  • The virus has important economic implications since affected animals tend to have permanent damage to their skin, lowering the commercial value of their hide. (wikipedia.org)
  • Zinc is important for the skins function as it is involved in DNA and RNA, and therefore important for cells that divide rapidly. (wikipedia.org)
  • vector
  • Most of these diseases are spread directly from dog to dog, while others require a vector such as a tick or mosquito. (wikipedia.org)
  • pain
  • Sharp needles like pain on skin. (ourhealth.com)
  • Typically, the nerve pain (neuralgia) is confined to an area of skin innervated by a single sensory nerve, which is known as a dermatome. (wikipedia.org)