Skin autoimmune panniculitis lupus erythematosus. Medical search. Frequent questions

Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. (wikipedia.org)
The current version includes several subsets of cutaneous lupus erythematosus (CLE): acute (ACLE) (bullous SLE, toxic epidermal necrolysis), subacute (SCLE), chronic cutaneous lupus (CCLE) PIK3R1 (discoid lupus, lupus panniculitis, lupus erythematosus tumidus, and lupus chilblain), presence of oral or nasal ulcers, and noncicatricial alopecia [3]. (oscars2019info.com)
Cutaneous lupus erythematosus (CLE) is an interferon (IFN)-driven autoimmune disease that may be limited to the skin or can be associated with systemic lupus erythematosus (SLE). (frontiersin.org)
Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune skin disease that can occur isolated to the skin or with additional systemic manifestation in several organs [systemic lupus erythematosus (SLE)] ( 1 ). (frontiersin.org)
Cutaneous lupus erythematosus (CLE) can be divided into 3 main subtypes: acute, subacute, and chronic, all of which demonstrate photosensitivity. (medscape.com)
Acute cutaneous lupus erythematosus (ACLE) most commonly presents as symmetric erythema overlying the malar cheeks and nasal bridge with sparing of the nasolabial folds (butterfly rash). (medscape.com)
Subacute cutaneous lupus erythematosus (SCLE) characteristically presents as annular or psoriasiform plaques in a photodistribution. (medscape.com)
Chronic cutaneous lupus erythematosus (CCLE) can be further divided into 3 main types: discoid lupus erythematosus (DLE), tumid lupus, and lupus panniculitis. (medscape.com)
In a 2009 study from Olmstead County, Minnesota, Durosaro et al demonstrated that the incidence of cutaneous lupus erythematosus (CLE) is comparable to that of SLE. (medscape.com)
Relative to SLE, epidemiologic studies on chronic cutaneous lupus erythematosus (CCLE) are rare and limited to populations without racial diversity. (cdc.gov)
Cutaneous lupus erythematosus (CLE) comprises multiple dermatological disorders, which may be skin-limited or found in association with underlying systemic lupus erythematosus (SLE). (cdc.gov)

Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. (merckmanuals.com)
CONCLUSION: The presence of ghost adipocytes is a rather unique histopathological feature consistent with pancreatic panniculitis and should be considered in combination with the overall clinical picture to determine the underlying etiology. (bvsalud.org)
The present study aimed to report all the cases of children admitted to our tertiary pediatric hospital with the diagnosis of EN to evaluate the epidemiology, clinical manifestations, etiology, treatment, and the course of this disease in the pediatric age. (bvsalud.org)
The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)
Therefore, most current textbooks present a classification based on location (for example, conditions of the mucous membrane), morphology (chronic blistering conditions), etiology (skin conditions resulting from physical factors), and so on. (blaauwberg.net)
However, the exact etiology of discoid lupus erythematosus (DLE) is not well understood. (medscape.com)

CLE can be classified based on clinical and histopathologic findings: typical morphological subsets are acute cutaneous (ACLE), subacute cutaneous (SCLE), intermittent cutaneous [ICLE, also termed lupus erythematosus tumidus (LET)], and chronic cutaneous (CCLE) lupus erythematosus ( 2 , 3 ). (frontiersin.org)
CCLE can be further subdivided into chronic discoid lupus erythematosus (CDLE), lupus erythematosus profundus (LEP) and chilblain lupus erythematosus (ChLE), of which CDLE represents the most frequent CCLE subtype ( 4 ). (frontiersin.org)
CCLE: Epidermal atrophy, hyperkeratosis (primarily follicular), vacuolar degeneration of basal keratinocytes, thickened basement membrane zone (PAS stain), edema, dense lymphocytic perivascular and periadnexal infiltrate at all levels, and, including subcutaneous fat in lupus profundus. (cyberderm.net)
Age-standardized incidence rates stratified by sex and race were calculated for discoid lupus erythematosus (DLE) in particular and for CCLE in general. (cdc.gov)
CCLE comprises discoid lupus erythematosus (DLE), lupus erythematosus profundus (LEP), lupus erythematous tumidus (LET) and chilblain lupus erythematosus (CHLE). (cdc.gov)

ACLE and SCLE occur with disseminated maculopapular to gyrated skin lesions, predominantly in sun-exposed skin. (frontiersin.org)
Most of the skin findings of DLE and SCLE can be found in SLE. (cyberderm.net)

Erythema nodosum is a condition that forms painful lesions of bluish-red nodules which can resemble bruising on the skin in the shin area. (news-medical.net)
Lesions of pustules form in the folds of the patient's skin and rupture. (news-medical.net)
Skin lesions include malar butterfly erythema (flat or raised) that generally spares the nasolabial folds. (merckmanuals.com)
The lesions can then develop severe scarring, and the centre areas may appear lighter in color with a rim darker than the normal skin. (wikipedia.org)
Patients with systemic lupus erythematous develop discoid lupus lesions with some frequency. (wikipedia.org)
Discoid lupus erythematosus (DLE) skin lesions first present as dull or purplish red, disc-shaped flat or raised and firm areas of skin. (wikipedia.org)
On darker skin, the lesions often lose skin pigmentation in the center and develop increased, dark skin pigmentation around the rim. (wikipedia.org)
On lighter skin, the lesions often develop a gray color or have very little color change. (wikipedia.org)
The skin lesions are most often in sun-exposed areas localized above the neck, with favored sites being the scalp, bridge of the nose, upper cheeks, lower lip, and ear and hands 24% of patients also have lesions in the mouth (most often the palate), nose, eye, or vulva, which are all mucosal parts of the body. (wikipedia.org)
The lesions often lose skin pigment and become white with areas of increased skin pigment, with or without areas of redness, and have a sunken appearance. (wikipedia.org)
In addition to their skin lesions, they may also have swelling and redness around their eyes, as well as blepharitis. (wikipedia.org)
Darker-skinned patients are often left with severe scarring and skin color changes even after the lesions get better. (wikipedia.org)
Sun exposure triggers lesions in people with discoid lupus erythematous (DLE). (wikipedia.org)
Most experts consider DLE an autoimmune disease since pathologists see antibodies when they biopsy the lesions and look at the tissue under the microscope. (wikipedia.org)
However, scientists do not understand the connection between these antibodies and the lesions seen in discoid lupus. (wikipedia.org)
ABSTRACT: A 42-year-old woman with history of rheumatoid arthritis and erythema nodosum from 8 years ago, who was treated with CellCept and prednisolone, was admitted to the rheumatology service due to skin lesions in the upper and lower extremities. (bvsalud.org)
CLE occurs in several morphologic subtypes ranging from isolated, disc-shaped plaques to disseminated skin lesions. (frontiersin.org)
The typical histopathologic pattern of skin lesions is named interface dermatitis and characterized by a lymphocytic infiltrate and necroptotic keratinocytes at the dermo-epidermal junction. (frontiersin.org)
Lupus erythematosus (LE) skin lesions typically feature a histopathologic pattern termed interface dermatitis, defined by the presence of necroptotic keratinocytes and an epitheliotropic cytotoxic lymphocytic infiltrate at the dermo-epidermal junction ( 7 , 8 ). (frontiersin.org)
Polyclonal B-cell activation with autoantibody formation: direct pathogenic antibodies (autoimmune haemolytic anaemia), circulating immune complexes (vasculitis, nephritis), antibody-mediated cytotoxicity (skin lesions). (cyberderm.net)
In discoid lupus erythematosus persistent several mm to cm sharply bordered, sometimes confluent, and painful lesions with triad of erythema, follicular keratotic plugs, and atrophy (each of which can dominate clinical picture). (cyberderm.net)
Electrodesiccation: A procedure that uses an electrical current to remove specific skin lesions. (dralpana.com)

Paller and Mancini - Hurwitz Clinical Pediatric Dermatology, 6th Edition, comprehensively covers the full range of skin disorders in children, offering authoritative, practical guidance on diagnosis and treatment in a single volume. (medicscenter.com)
This award-winning, evidence-based text has been fully revised and updated, and is an essential resource for anyone who sees children with skin disorders. (medicscenter.com)
Discusses new tests for subclassifying disease, such as the myositis-specific antibodies of juvenile dermatomyositis, genotyping, and immunophenotypes of inflammatory skin disorders. (medicscenter.com)
Our center is recognized for excellence in the diagnosis and management of a variety of inflammatory and autoimmune disorders that affect the joints, muscles, skin, blood vessels, brain, and other vital organs. (clevelandclinic.org)
Rheumatic and autoimmune diseases are disorders which can affect any part of the body including the joints, muscles, connective tissues, and soft tissues around the joints and bones. (clevelandclinic.org)
There are many possible causes including :* Post-injection * Trauma* Local impairment of blood supply (ischaemia)* Immune disorders* Bacterial or fungal infections - may be secondary invaders* Idiopathic - sterile panniculitis What Breeds does it commonly affect? (famousskincarefordogs.com)
SLE has a variety of signs of most often cases are presented because of lameness or skin disorders. (famousskincarefordogs.com)
Medical care must include assessment for and treatment of other confounding or concurrent autoimmune disorders. (medscape.com)
Wierzbicka et al reported good airway patency for more than 24 months in eight of 12 patients with relapsing polychondritis or other autoimmune disorders treated with this approach. (medscape.com)
Dermatologist: A medical doctor specializing in skin, hair, and nail disorders. (dralpana.com)
characterized by skin disorders, blood vessels, and various internal organs. (epainassist.com)

Dermatomyositis: An inflammatory disease marked by muscle weakness and a distinctive skin rash. (dralpana.com)
Persons with dermatomyositis often present with skin disease as one of the initial manifestations, and it may be the sole manifestation at onset in perhaps as many as 40% of individuals with this condition. (medscape.com)

However, B cells are increasingly considered to have additional functions, supported by studies finding them to occur in highest numbers in chronic discoid lupus erythematosus (CDLE), a subtype in which autoantibodies are often absent. (frontiersin.org)

However, patients who present initially with discoid lupus infrequently develop systemic lupus. (wikipedia.org)
Discoid lupus can be divided into localized, generalized, and childhood discoid lupus. (wikipedia.org)
When discoid lupus is on the scalp, it starts as a red flat or raised area of skin that then loses hair and develops extensive scarring. (wikipedia.org)
When discoid lupus is on the lip, it often has a grey or red colour with a thickened top layer of skin (known as hyperkeratosis), areas where the top layer has worn away (known as erosion), and a surrounding rim of redness. (wikipedia.org)
When a patient initially presents with discoid lupus, the doctor should ensure that the patient does not have systemic lupus erythematosus. (wikipedia.org)
If the patients do indeed have discoid lupus, the doctor may see tiny spines of keratin that look like carpet tacks and are called langue au chat. (wikipedia.org)
Discoid lupus erythematosus on the face. (medscape.com)
Chronic scarred lesion of discoid lupus erythematosus. (medscape.com)
Discoid lupus erythematosus (DLE) is responsible for 50-85% of cases of CLE and occurs 2-3 times more frequently in women than in men. (medscape.com)
Although the prognosis of patients with discoid lupus erythematosus (DLE) is favorable regarding mortality, morbidity can be considerable. (medscape.com)

Nephrology: nephritis, nephritic proteinuria associated with systemic autoimmune disease. (clevelandclinic.org)

Treatment of refractory hypocomplementaemic urticarial vasculitis syndrome progressing to systemic lupus erythematosus with belimumab. (uk-erlangen.de)

Erythema induratum, also known as nodular vasculitis or Bazin disease, is categorized as a tuberculid skin eruption, which is a group of skin conditions associated with an underlying or silent focus of tuberculosis (TB). (medscape.com)
Although erythema induratum and nodular vasculitis were once considered to be the same disease, nodular vasculitis is now considered a multifactorial syndrome of lobular panniculitis in which tuberculosis may or may not be one of a multitude of etiologic components. (medscape.com)
Patients with erythema induratum have a positive tuberculin skin test result and a marked increase in their peripheral T-lymphocyte response to the purified protein derivative (PPD) of tuberculin, which can cause a delayed-type hypersensitivity reaction. (medscape.com)
In a retrospective study of 65 patients with histologically diagnosed erythema induratum in Spain between 1976 and 1994, 89% had a positive tuberculin skin test. (medscape.com)
Skin involvement also was observed during the observation: 4(8%) of them developed erythema similar "butterfly" rash, livedo reticularis and photosensitivity with high titer of circulating immune complexes, ANA and anti-dsDNA antibodies like systemic lupus erythematosus, 1 patient had hemorrhagic rash on legs with developing of hemorrhagic vasculitis. (biomedcentral.com)
Erythema nodosum (EN), although relatively uncommon in the pediatric population, is the most frequent type of panniculitis in children. (bvsalud.org)
Erythema: Redness of the skin. (dralpana.com)

There are several diseases that affect the gastrointestinal region that, in turn, also affect the appearance and natural function of the skin. (news-medical.net)
Edition after edition, it reflects the latest insights into skin diseases and skin biology--and their practical relevance to general internal medicine--while covering the scientific foundations of the specialty. (edu.au)
This classic yet cutting-edge text is supported by the expert insights of more than 500 internationally respected contributors, and it covers everything dermatologists need to know about skin, dermatologic signs of underlying disease, and the management of all skin diseases, including acne, skin cancer, and psoriasis. (edu.au)
Skin Diseases. (edu.au)
The aim of this study is to determine systemic uncommon non-classical manifestations of FMF and reveal the possible association with autoimmune diseases. (biomedcentral.com)
FMF may have systemic manifestations of autoimmune diseases. (biomedcentral.com)
Features new content outline boxes for faster navigation, hundreds more clinical images, and authors' tips for the diagnosis and treatment of pediatric skin diseases. (medicscenter.com)
The Center for Pediatric Rheumatology provides comprehensive diagnosis, treatment, and follow-up care for children and adolescents who are living with juvenile arthritis and a wide range of autoimmune and rheumatologic diseases. (clevelandclinic.org)
While only a small number of skin diseases account for most visits to the physician, thousands of skin conditions have been described. (blaauwberg.net)
Treatment of calcinosis - Treatment of calcinosis cutis associated with autoimmune connective tissue diseases involves careful consideration of the need for treatment and the selection of an appropriate treatment regimen. (medilib.ir)
Effects of casirivimab/imdevimab on systemic and mucosal immunity against SARS-CoV-2 in B-cell depleted patients with autoimmune rheumatic diseases refractory to vaccination. (uk-erlangen.de)
NOBLES JP, DE GENNES C, BOUSQUET O. Skin diseases related to hepatitis B vaccine. (revahb.fr)
The diagnosis can be difficult, particularly in the early stages, because many of the symptoms are very common and require differentiation with other diseases, especially connective tissue, such as systemic lupus erythematosus. (epainassist.com)
Diseases of the skin with a genetic component, usually the result of various inborn errors of metabolism. (bvsalud.org)

Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)
Raynaud's Syndrome begins before one year after skin involvement, pulmonary fibrosis is early, there is kidney disease characterized by the so-called scleroderma renal crisis, which is associated with high blood pressure: Between 20 and 30% of patients with this type of Scleroderma have anti-Scl 70 antibodies (Antitopoisomerase I). It is vitally important to monitor the lung, kidney, and heart for their progressive evolution to insufficiencies or severe conditions. (epainassist.com)

Lupus erythematosus is a polygenic autoimmune disease linked to various HLA subtypes, immune signaling, and environmental factors, which ultimately leads to autoantibody production and T-cell dysfunction. (medscape.com)

Inflammatory bowel disease (IBD) is one particular ailment that can negatively affect skin health. (news-medical.net)
This skin condition presents as tender, reddish-purple inflammatory nodules on the face, neck, and arms. (news-medical.net)
Chronic inflammatory autoimmune disease with marked immunogenetic component which involves the skin and/or other organs. (cyberderm.net)
Acne: A common inflammatory skin condition resulting in pustules and cysts, predominantly on the face, back, and chest. (dralpana.com)
type 1 autoimmune pancreatitis , interstitial nephritis , Riedel's thyroiditis , Mikulicz's disease , Küttner's tumor , inflammatory pseudotumors (in various sites of the body), mediastinal fibrosis and some cases of retroperitoneal fibrosis . (mdwiki.org)

According to the Lupus Foundation of America , emotional stress can trigger lupus flares. (healthline.com)
The Lupus Foundation of America recommends scheduling breaks, such as 20 minutes during the workday or one full day on the weekend. (healthline.com)
Pamphlets from the Lupus Foundation of America, Inc. concerning skin disease and photosensitivity are useful adjuncts to verbally delivered information. (medscape.com)

Whether or not you have lupus, your body may experience symptoms when you are under stress. (healthline.com)
The study found that exposure to trauma, even if there were no symptoms of PTSD, was strongly associated with lupus. (healthline.com)
Those with many PTSD symptoms were also at greater risk for lupus. (healthline.com)

The autoimmune disease lupus erythematosus, which can attack various cells, organs, and tissues in the body, can also lead to koilonychia. (news-medical.net)
Panniculitis is an aggravation of the fatty layer underneath the skin which occurs due to Crohn's disease (inflammation of the digestive system) or ulcerative colitis (inflammation of the colon and rectum). (news-medical.net)
This skin symptom can be the result of ulcerative colitis or Crohn's disease. (news-medical.net)
Rheumatoid Arthritis (RA) Rheumatoid arthritis is a chronic systemic autoimmune disease that primarily involves the joints. (merckmanuals.com)
A lupus flare is a period of time when disease activity gets worse. (healthline.com)
INTRODUCTION: Pancreatic panniculitis is a rare skin manifestation of pancreatic disease. (bvsalud.org)
Pancreatic panniculitis can be a primary presenting feature and possible complication of pancreatic disease. (bvsalud.org)
The etiologic diagnosis of EN was made in 38 children (55.9%): 29 (42.6%) had infection-related EN (in particular EBV and ß-hemolytic streptococcus), 6 (8.8%) had Crohn's disease, 1 celiac disease, 1 Sjogren syndrome, and 1 Hodgkin lymphoma. (bvsalud.org)
It is evident that skin involvement in SLE patients represents a hallmark of the Ivermectin disease for most patients and is also an opportunity to understand some aspects of its pathogenesis. (oscars2019info.com)
Autoimmune disease of the skin and multiple internal organs. (dermacompass.net)
Systemic lupus erythematosus commonly known as SLE is a rare autoimmune mediated disease which is seen in dogs. (famousskincarefordogs.com)
NSF is a fibrotic disease of the skin and internal organs that develops in patients with renal insufficiency after exposure to gadolinium-based contrast agents (GBCAs). (medscape.com)
SSc is a systemic connective tissue disease characterized by vasomotor instability, fibrosis, and immunologic disturbances, as well as by atrophy of the skin, subcutaneous tissue, muscles, and internal organs. (medscape.com)
Treatment principles - The treatment of dystrophic calcinosis cutis associated with autoimmune connective tissue disease is often difficult. (medilib.ir)
Is the underlying autoimmune connective tissue disease adequately treated? (medilib.ir)
Treatment of underlying disease - Suppression of activity of the associated autoimmune disease is suggested based upon the theory that autoimmune disease-related tissue injury contributes to risk for cutaneous calcification ( algorithm 1 ) [ 2 ]. (medilib.ir)
DLE may occur in the absence of systemic disease, or it may occur in association with systemic lupus erythematosus (SLE). (medscape.com)
Dermatosis: A general term for skin disease. (dralpana.com)
A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint. (xenbase.org)
Muscle disease may occur concurrently, may precede the skin disease, or may follow the skin disease by weeks to years. (medscape.com)

Scleroderma-like syndrome was developed in 1 patient with Raynaud's phenomenon and skin induration of wrists and face and pneumofibrosis. (biomedcentral.com)
Other non-specific skin changes: Raynaud's syndrome, diffuse alopecia, vascultis/vasculopathy, maculopapular and other exanthems. (cyberderm.net)
Raynaud's syndrome can occur many years before skin involvement. (epainassist.com)

Reddened (erythematous), firm, painful nodules in the skin. (famousskincarefordogs.com)

Common manifestations may include arthralgias and arthritis, Raynaud syndrome, malar and other rashes, pleuritis or pericarditis, renal or central nervous system involvement, and autoimmune cytopenias. (merckmanuals.com)
Skin Manifestations. (edu.au)
Germline HAVCR2 mutations are frequently detected in subcutaneous panniculitis-like T-cell lymphoma (SPTCL) patients with/without hemophagocytic lymphohistiocytosis (HLH) but factors associated with variable manifestations remain undetermined. (bvsalud.org)
Such importance is evidenced in the structure of the new SLICC (Systemic Lupus International Collaborating Clinics) criteria set for the classification of patients with SLE, Ivermectin which has expanded the catalog of skin manifestations as criteria to ease the classification of otherwise nonclassifiable SLE patients. (oscars2019info.com)

that is, nodular vasculitis is a form of lobular panniculitis associated with subcutaneous blood vessel vasculitis that leads to ischemic changes. (medscape.com)
Effective and safe treatment of anti-CD38 therapy in systemic lupus erythematosus-associated refractory cerebral vasculitis induces immune tolerance. (uk-erlangen.de)

FDG uptake in the panniculitis lesion is rarely reported in the literature. (bvsalud.org)

Within each given group, the incidence is higher among darker skin individuals, suggesting that the degree of pigmentation rather than race/ethnicity per se may be more contributory to PIH development. (barefacedtruth.com)

Some drugs (eg, hydralazine , procainamide , isoniazid , anti-tumor necrosis factor [TNF] drugs) cause a reversible lupus-like syndrome. (merckmanuals.com)
Also panniculitis (1 patient), aphthae (2 patients), angiorethinopathy(2 patients), mononeyropathy and polyneyropathy ( 2 patients respectively), pneumonitis (4 patients), xerophthalmia (1 patient) like Sjogren's syndrome were observed. (biomedcentral.com)
Hematology: autoimmune cytopenia, autoimmune lymphoproliferative syndrome (ALPS). (clevelandclinic.org)

We identified 98 candidate genes containing rare variation that in aggregate show association with SLE many of which have recognized immunological function, but also function and expression related to relevant tissues such as the joints, skin, blood or central nervous system. (frontiersin.org)

Distinct papules and subcutaneous nodules may be present in patients with NSF, and the skin may develop a woody texture. (medscape.com)
Tumid lupus typically presents with juicy papules and plaques that heal without scarring, whereas lupus panniculitis involves the subcutaneous tissue, leading to painful subcutaneous nodules that heal with depression and atrophy. (medscape.com)

The specificity of autoimmune injury to cartilaginous tissues has led investigators to test the hypothesis that a cartilage-specific autoantibody is central to the pathogenesis of relapsing polychondritis. (medscape.com)

It results in small inflamed nodules appearing on the surface of the skin. (famousskincarefordogs.com)

Postinflammatory hyperpigmentation ("PIH") is an acquired condition in which excessive melanin deposition occurs at sites of skin inflammation or injury. (barefacedtruth.com)

however, the pathogenesis is autoimmune. (medscape.com)

Skin involvement is important in the detection of SLE patients. (oscars2019info.com)
Depends on systemic involvement (CNS lupus, lupus nephritis). (cyberderm.net)
The skin involvement is limited to the distal part of the limbs (up to the elbows and/or knees) and to the face. (epainassist.com)
It also includes Systemic Scleroderma without skin involvement, the so-called Sine Scleroderma. (epainassist.com)

Panniculitis is inflammation of fat under the skin. (famousskincarefordogs.com)
Atopic Dermatitis: A chronic skin disorder causing dry, itchy inflammation, often associated with allergies. (dralpana.com)
Dermatitis: Inflammation of the skin. (dralpana.com)

A rheumatoid arthritis that involves an autoimmune. (xenbase.org)

Generations of clinicians, skin biologists, residents, and educators have acclaimed Fitzpatrick's as the most authoritative and complete guide to dermatologic basic sciences, histopathology, diagnosis, and treatment. (edu.au)
This observational study retrospectively considered all children evaluated to the emergency room (ER) of Meyer Children's University Hospital, Florence, Italy, discharged with a diagnosis of EN over a 12-year period (from January 2009 to December 2021). (bvsalud.org)
In 30 patients (45%), no definitive diagnosis was reached, and they were defined as having idiopathic EN. (bvsalud.org)
Formal diagnosis of NSF is usually made with a deep skin biopsy, which may show thickened collagen bundles with surrounding clefts, mucin deposition, and proliferation of fibroblasts and elastic fibers. (medscape.com)
The diagnosis of a many conditions often also requires a skin biopsy which yields histologic information that can be correlated with the clinical presentation and any laboratory data. (blaauwberg.net)

Basal Cell Carcinoma: The most common form of skin cancer, typically caused by sun exposure. (dralpana.com)
This is particularly true for those with higher Fitzpatrick skin types who may not typically normally wear sunscreen or realize the darkening effects UV irradiation has on hyperpigmentation. (barefacedtruth.com)

Provides a careful balance of narrative text, useful tables, and 1,300 high-quality clinical photographs, helping you recognize virtually any skin condition you're likely to see. (medicscenter.com)
Clinical Images: Tissue remodeling in autoimmune statin-induced necrotizing autoimmune myopathy. (uk-erlangen.de)

This is a skin condition which most commonly affects males. (news-medical.net)

In addition, these patients have an increased, though still small, risk for aggressive skin squamous cell carcinoma. (wikipedia.org)
Rarely squamous cell carcinoma (lupus carcinoma) develops in old DLE scars. (cyberderm.net)
The epidermis is the most superficial layer of skin, a squamous epithelium with several strata: the stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale. (blaauwberg.net)

This condition can often trigger a range of skin conditions for certain patients. (news-medical.net)
Systemic lupus erythematosus (SLE) is more common and severe among Black and Asian patients than among White patients. (merckmanuals.com)
Sixty-eight patients with EN were included. (bvsalud.org)
its direct and initial effects are detectable in the skin of SLE patients. (oscars2019info.com)
In some patients, the skin may resemble the texture of an orange (ie, peau d'orange), as seen in this abdominal image. (medscape.com)
Aside from photoprotections (always the first line of defense), there are a variety of medications and procedures that can safely and effectively treat PIH in darker skinned patients. (barefacedtruth.com)

Contact Dermatitis: A skin rash caused by contact with a certain substance. (dralpana.com)

The dermis contains two vascular networks that run parallel to the skin surface-one superficial and one deep plexus-which are connected by vertical communicating vessels. (blaauwberg.net)

It presents with red, painful, inflamed and coin-shaped patches of skin with a scaly and crusty appearance, most often on the scalp, cheeks, and ears. (wikipedia.org)

Six cases with HAVCR2Y82C mutation manifested with HLH without panniculitis. (bvsalud.org)
Recently, we have implemented and successfully applied a method based on genotype imputation of rare variation, on a set of genes detected by exome sequencing as possible candidates for association to systemic lupus erythematosus (SLE) by mutation in members of Icelandic SLE-multicase families ( 15 ). (frontiersin.org)
An epidermolysis bullosa that is characterized by recurrent blistering located in the lamina lucida of the basement membrane secondary to minor trauma, which can cause limited wounds, dehydration, electrolyte abnormalities, severe infection, among other issues, and has_material_basis_in mutation in genes related to laminin 332, which strengthens the skin. (xenbase.org)

Pyoderma gangrenosum can be diagnosed with a skin biopsy. (news-medical.net)
Skin excisional biopsy was performed, and the results suggested panniculitis. (bvsalud.org)

Two main types of Scleroderma are known: Morphea (with patches of bulging skin and increased or decreased pigmentation) and Linear Scleroderma (band or line of bulging skin that appears on legs and arms, and can also affect the subcutaneous tissue and the muscle below). (epainassist.com)

The dermis is the layer of skin between the epidermis and subcutaneous tissue, and comprises two sections, the papillary and reticular dermis. (blaauwberg.net)

The above image shows the classic presentation of systemic sclerosis (SSc), also known as systemic scleroderma: thickened skin, a pinched nose, taut skin, and numerous telangiectasias. (medscape.com)

Anatomy10

Organisms4

Diseases57

Chemicals and Drugs67

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes20

Information Science1

Named Groups3

Health Care11

Cutaneous lupus11

Etiology6

CCLE5

SCLE2

Lesions22

Disorders11

Dermatomyositis2

Chronic discoid1

Discoid lupus10

Associated with systemic1

Urticarial vasculitis1

Erythema7

Diseases14

Antibodies2

Subtypes1

Inflammatory5

Foundation of America3

Symptoms3

Disease20

Raynaud's3

Erythematous1

Manifestations4

Vasculitis2

Lesion1

Incidence1

Syndrome3

Joints1

Subcutaneous nodules2

Tissues1

Nodules1

Occurs1

Pathogenesis1

Involvement4

Inflammation3

Involves1

Diagnosis5

Typically2

Clinical2

Commonly1

Squamous3

Patients6

Rash1

Vascular1

Scalp1

Mutation3

Biopsy2

Linear scleroderma1

Comprises1

Systemic sclerosis1