Skeletal muscle glucose homeostasis blood glucose postprandial period. Medical search. Frequent questions

In individuals with normal carbohydrate metabolism, insulin levels rise concordantly to drive glucose into the body's tissues and maintain blood glucose levels in the normal range. (wikipedia.org)
Accumulated evidence from genetic animal models suggests that the brain, particularly the hypothalamus, has a key role in the homeostatic regulation of energy and glucose metabolism. (nature.com)
The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. (nature.com)
Here we comprehensively review the above topics, discussing the main findings related to the role of the brain in the homeostatic regulation of energy and glucose metabolism. (nature.com)
However, larger, adequately powered, randomized, placebo-controlled, double-blind trials examining multiple measures of carbohydrate and lipid metabolism and insulin homeostasis are needed. (lww.com)
A deeper understanding of the effects of these medications on glucose metabolism and their underlying mechanisms of action is crucial for the treatment of diabetic patients with sleep disorders. (vdocuments.mx)
In this review we focus on the bene ﬁ cial impact of sleep on glucose metabolism and suggest a possible strategy for therapeutic intervention against sleep-related metabolic disorders. (vdocuments.mx)
However, it is important to note that some studies have indicated that REM sleep plays an important role in glucose metabolism. (vdocuments.mx)
Acute statin withdrawal does not interfere with the improvements of a session of exercise in postprandial metabolism. (medscape.com)
Whole blood-based transcriptional risk score for nonobese type 2 diabetes predicts dynamic changes in glucose metabolism. (medscape.com)
Answered Jan 30, 2019 Author has 300 answers and 174.4k answer views Growth hormone (GH) counteracts, in general, the effects of insulin on glucose and lipid metabolism but shares protein anabolic properties with insulin. (diabetestalk.net)
Growth hormone (GH) counteracts, in general, the effects of insulin on glucose and lipid metabolism but shares protein anabolic properties with insulin. (diabetestalk.net)
Effects of Growth Hormone on Glucose Metabolism Mller N. Jrgensen J.O.L. Abildgrd N. rskov L. Schmitz O. Christiansen J.S. I have read the Karger Terms and Conditions and agree. (diabetestalk.net)
During surgery, amino acids administration would maintain the body homeostasis, and counteract the disadvantageous fasting metabolism. (scirp.org)
Adipose tissue plays a crucial role in the regulation of energy homeostasis, insulin sensitivity, and lipid/carbohydrate metabolism. (diabetesjournals.org)
In addition to the positive associations of IL-6 and leptin with insulin resistance and secretion, NGF was higher in the GDM patients and strongly linked to glucose metabolism, insulin resistance and pancreatic β cell function in Chinese pregnant women in the second trimester. (biomedcentral.com)
Janowska J, Chudek J, Olszanecka-Glinianowicz M, Semik-Grabarczyk E, Zahorska-Markiewicz B. Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women. (medsci.org)
We have studied the relationship between clinical and biochemical parameters and C-peptide and anti-inflammatory IL-10, as well as selected markers of inflammation and endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in obese women with various degree of glucose metabolism disturbance. (medsci.org)
Obese patients were spited in subgroups based on the degree of glucose metabolism disorder. (medsci.org)
Sedentary behaviors reduce lipoprotein lipase activity, muscle glucose, protein transporter activities, impair lipid metabolism, and diminish carbohydrate metabolism. (researchgate.net)
This type of diabetes is associated with older age, obesity, family history of diabetes, history of gestational diabetes, impaired glucose metabolism, physical inactivity, and race/ethnicity. (gotomydoctor.com)

Skeletal muscle mass was estimated by bioelectrical impedance analysis and was presented as a skeletal muscle mass index (SMI), a body weight-adjusted appendicular skeletal muscle mass value. (biomedcentral.com)
however, most previous reports used a cross-sectional study design that revealed an association between decreased appendicular skeletal muscle mass (ASM) and increased age [ 1 3 4 5 ], with few reported longitudinal studies [ 2 6 ]. (e-dmj.org)

Sarcopenia describes the loss of skeletal muscle mass, strength, and physical performance. (sharecare.com)
As individuals age, reduced levels of physical activity and sarcopenia (loss of skeletal muscle mass and strength) are associated with physical frailty and disability. (e-enm.org)
Recently, several studies have suggested that the loss of skeletal muscle mass may contribute to metabolic disease. (e-enm.org)

The brain integrates metabolic signals from peripheral tissues such as the liver, pancreas, adipose tissue, gut and muscle. (nature.com)
Glycogen is most abundant in the liver and muscle. (medscape.com)
In the liver, glycogen is a storage form of glucose. (medscape.com)
In the early stages of fasting, the liver provides a steady source of glucose from glycogen breakdown (or glycogenolysis). (medscape.com)
With prolonged fasting, glucose is generated in the liver from noncarbohydrate precursors through gluconeogenesis. (medscape.com)
Insulin rapidly increases the expression of Per2 in insulin-sensitive tissues like the liver, muscle, or adipose tissue, but not the lung or brain [ 17 ] . (encyclopedia.pub)
Furthermore, skeletal muscle is considered to be an endocrine organ because it releases myokines that mediate crosstalk between muscle, adipose tissue, the liver, brain, and other organs in autocrine and paracrine fashions [ 13 ]. (biomedcentral.com)
Glycogen synthetase catalyzes the rate-limiting reaction for glycogen synthesis in the liver by transferring glucose units from uridine 5'-diphosphate (UDP)-glucose to a glycogen primer. (medscape.com)
Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver, adipose tissue, pancreas, bone, and the cardiovascular system. (e-enm.org)
Therefore, herein, we focus on the relationships between skeletal muscle mass and metabolic diseases, including metabolic syndrome and non-alcoholic fatty liver disease. (e-enm.org)
As a fuel source, carbohydrates replenish glycogen stores in the muscle and liver. (chevaun.com)

Uncoupling protein 1 (UCP1), which is predominantly expressed in the brown adipose tissue, also plays an important role in energy homeostasis [ 7 ]. (hindawi.com)

Gestational diabetes mellitus (GDM) is the most common complication during pregnancy and is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. (e-dmj.org)

Waning levels of the hormone estrogen can impair your body's ability to use starches and blood glucose (sugar) effectively. (sharecare.com)
One of these strategies involves following the Meal Sequence Pyramid Per Satiety Response, which has been shown to improve insulin sensitivity and the body's response to glucose. (sharecare.com)
Eating at this time can spike your blood sugar before bedtime and increase the likelihood it'll remain high while you sleep and your body's resting. (sharecare.com)
The primary role of insulin is to manage circulating concentrations of nutrients (principally glucose, amino acids, and fatty acids, the body's three main fuels), keeping them within an optimal range, and coordinating the shift between metabolic fuels that is required when a person consumes more of one or the other. (blogspot.com)
Type I diabetes, that is called insulin-dependent diabetes mellitus (IDDM) or juvenile-onset diabetes develops when the body's immune system destroys pancreatic β-cells, the only cells in the body that produce the hormone insulin that regulates blood glucose. (gotomydoctor.com)
The goal is to match the body's need for glucose depending on activity or activity level overall. (chevaun.com)

If hyperinsulinaemia is not supported by an exogenous amino acid supply, plasma as well as muscle free amino acid concentrations fall because of reduced splanchnic release. (bmj.com)
2 On the other hand, if amino acid concentrations are maintained at normal or higher concentrations, net protein deposition in muscle will occur because of stimulation of synthesis and possibly because of a simultaneous decrease in breakdown. (bmj.com)
As a consequence, these cells have high concentrations of intracellular glucose during hyperglycaemia. (madridge.org)
They also maintain blood glucose concentrations as fuel for the body, but also for the brain. (chevaun.com)

Since GH secretion is inhibited in the fed state these actions are mainly important in the postprandial or fasting state. (diabetestalk.net)
Which of the following acts as a rate-limiting step that controls glucose-regulated insulin secretion? (primrosekitten.org)

95% CI, 0.77 to 0.98 in obese) after adjusting for other strong risk factors (e.g., baseline glycosylated hemoglobin and homeostasis model assessment of insulin resistance). (e-dmj.org)

In these patients increased endogenous glucose production, decreased muscle glucose uptake and rising blood glucose levels are observed. (diabetestalk.net)

Feeding characteristically results in postprandial hyperglycemia and glucosuria, in addition to increased blood lactate levels, because glycogen synthesis is limited, and excess glucose is preferentially converted to lactate by means of the glycolytic pathway. (medscape.com)
Which is NOT a response to an abnormally high concentration of blood glucose (hyperglycemia)? (primrosekitten.org)
80% V̇ o 2max ) causes a seven- to eightfold increase in glucose production ( R a ) and a fourfold increase in glucose uptake ( R d ), resulting in hyperglycemia, whereas moderate exercise (ME) causes both to double. (diabetesjournals.org)

This lowers the ratio of these branched-chain amino acids in the bloodstream relative to tryptophan (an aromatic amino acid), making tryptophan preferentially available to the large neutral amino acid transporter at the blood-brain barrier. (wikipedia.org)
It is now apparent that both increased insulin and increased availability of amino acids are important for maximizing muscle protein anabolism. (bmj.com)
5 However, consumption of both amino acids and CHO results in much greater effects on muscle protein anabolism, 6 suggesting an interactive effect between insulin, amino acid availability, and resistance exercise. (bmj.com)
Also, it is well established that the stimulatory effect of amino acids on muscle protein synthesis is greater after exercise than at rest. (bmj.com)
ERAS protocol recommends preoperative carbohydrate and early enteral nutrition, but does not include infusion of amino acids during the perioperative period. (scirp.org)

During periods of fasting, when little to no glucose is taken in enterally, glycogen releases glucose to be used by tissues that need them to function. (medscape.com)
Insulin is a key regulator of glucose uptake and utilization in insulin-responsive tissues. (encyclopedia.pub)

There is however evidence that GH acutely decreases glucose oxidation (secondary to an increase in lipid oxidation) and suppresses muscle uptake of glucose, suggesting that GH redistributes glucose fluxes into a non-oxidative pathway, which could be a build up of glycogen depots through gluconeogenesis. (diabetestalk.net)

Cortisol counteracts insulin and can lead to increased hepatic gluconeogenesis , reduced peripheral utilization of glucose, and increased insulin resistance. (wikipedia.org)
Because skeletal muscle is the major site of insulin-mediated glucose utilization (up to 80% in the postprandial state), losses in skeletal muscle mass may lead to metabolic impairments [ 12 ]. (biomedcentral.com)

Glucoregulation during low- and moderate-intensity exercise is primarily mediated by an increase in the portal venous glucagon-to-insulin ratio ( 1 ), which stimulates hepatic glucose output, maintaining euglycemia largely through a feedback mechanism ( 2 - 4 ) that matches the increment to the increased requirements. (diabetesjournals.org)
Insufficient hepatic O 2 in animal and human studies has been shown to elicit a hepatorenal reflex in response to increased hepatic adenosine, resulting in the stimulation of renal as well as muscle sympathetic nerve activity and activating the renin angiotensin system. (surgicalneurologyint.com)

Appropriate resistance exercise leads to significant skeletal muscle hypertrophy, which can occur through an increase in protein synthesis, a decrease in protein degradation, or both. (bmj.com)
Obviously, the hormonal milieu of the muscle also has a major impact on protein synthesis. (bmj.com)
ASP increases the efficiency of triacylglycerol synthesis in adipocytes leading to enhanced postprandial lipid clearance. (diabetesjournals.org)
Skeletal muscle mass is regulated by a balance between MPS [muscle protein synthesis] and MPB [muscle protein breakdown]. (losethempounds.com)
Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. (jci.org)
Glucose has been reported to increase the de novo synthesis of diacylglycerol (DAG) and translocate and activate protein kinase C (PKC) in rat adipocytes. (jci.org)
Insulin can increase muscle protein synthesis provided you take in a sufficient amount of protein [4] , which is the whole point of a protein supplement! (priceplow.com)

[2] This process is called gluconeogenesis, a metabolic pathway generating glucose from non-carbohydrate substrates. (chevaun.com)

Exercise has proved effective in attenuating the unfavourable response normally associated with postprandial hypertriglyceridemia (PHTG) and accompanying oxidative stress. (biomedcentral.com)
The ingestion of a high fat meal induces postprandial oxidative stress, inflammation and a rise in DNA damage that remains unaltered by one hour of preceding exercise. (biomedcentral.com)

ETHNOPHARMACOLOGICAL RELEVANCE: Myelosuppression, also known as bone marrow suppression (BMS), is a pathological phenomenon of the decrease in the production of blood cells and further lead to immune homeostasis disorder. (bvsalud.org)

Following food intake, increased blood glucose levels trigger pancreatic β-cells to secrete insulin. (encyclopedia.pub)

Which of the following GLUTs is an insulin-responsive glucose transporter? (primrosekitten.org)
Akt signaling prompts glucose transporter 4 (GLUT4) to translocate to the cell membrane where it initiates cellular glucose uptake. (encyclopedia.pub)
It is well known that aerobic exercise increases not only energy expenditure but also glucose uptake of the muscle cells by translocating the glucose-transporter from the cytoplasm to the cell surface, leading to lowering plasma glucose level and attenuating insulin resistance [ 2 ]. (hindawi.com)

A further longitudinal study is needed to elucidate the casual relationship between low muscle mass and metabolic syndrome incidence across the full age range of the population, beyond the sarcopenia context. (biomedcentral.com)

When post-exercise hyperinsulinaemia is supported by hyperaminoacidaemia induced by protein hydrolysate and leucine ingestion, net protein deposition in muscle should occur. (bmj.com)
This is in line with the recent data obtained by Borsheim et al , 4 who showed that protein balance over the muscle remains negative after resistance exercise when only carbohydrate (CHO) is ingested. (bmj.com)
In sharp contrast, amino acid ingestion alone significantly increases muscle protein anabolism after resistance exercise. (bmj.com)
Mouse monoclonal to NCOR1 water-soluble form of the prion protein (ws-PrP) in blood plasma and brain of Syrian hamster [3]. (tam-receptor.com)

Insulin stimulates the uptake of valine, leucine, and isoleucine into skeletal muscle, but not uptake of tryptophan. (wikipedia.org)

Highly coordinated interactions between the brain and peripheral metabolic organs are critical for the maintenance of energy and glucose homeostasis. (nature.com)
Integration of peripheral metabolic signals andthe central nervous system maintains energy homeostasis. (nature.com)
Further, the postprandial release of insulin resets peripheral clocks by regulating the expression of core circadian genes. (encyclopedia.pub)
Genomic DNA was extracted from peripheral blood cells using a GFX Genomic Blood DNA Purification Kit (GE Healthcare, UK). (hindawi.com)
Both the sympathetic and parasympathetic systems have central (inside the brain) and peripheral (outside the brain) components and together these two systems essentially control our heart rate, blood pressure, digestion, temperature regulation, sweating, urination, and sexual function. (philaholisticclinic.com)
Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy. (e-dmj.org)

Though the diagnostic criteria for MetS has been variably defined in the literature, most definitions now include the presence of at least three of the following: Abdominal obesity, insulin resistance, hypertension, elevated fasting plasma glucose, high serum triglycerides, and low high-density lipoprotein levels. (surgicalneurologyint.com)

Objective: To compare the acute and chronic effects of low-volume high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) on glycemic control, body composition and continuous glucose monitoring (CGM) in older women with type 2 diabetes (T2D). (mdpi.com)
OGTT metrics surpass continuous glucose monitoring data for T1D prediction in multiple-autoantibody-positive individuals. (medscape.com)

Skeletal muscle mass was negatively associated with metabolic syndrome prevalence in previous cross-sectional studies. (biomedcentral.com)
The aim of this study was to investigate the impact of baseline skeletal muscle mass and changes in skeletal muscle mass over time on the development of metabolic syndrome in a large population-based 7-year cohort study. (biomedcentral.com)
An increase in relative skeletal muscle mass over time has a potential preventive effect on developing metabolic syndrome, independently of baseline skeletal muscle mass and glycometabolic parameters. (biomedcentral.com)
Therefore, we investigated whether baseline skeletal muscle mass and its changes over time have independent associations with metabolic syndrome development in a large 7-year longitudinal study. (biomedcentral.com)

While there are numerous theories surrounding this behavior, such as decreased blood flow to the brain, neurohormonal modulation of sleep through digestive coupled signaling, or vagal stimulation, very few have been explicitly tested. (wikipedia.org)
citation needed] The flow of oxygen and blood to the brain is extremely tightly regulated by the circulatory system and does not drop after a meal. (wikipedia.org)
Substantial evidence indicates that the brain, particularly the hypothalamus, is primarily responsible for the regulation of energy homeostasis. (nature.com)
The present review will recapitulate the new mechanisms underlying the Heart-brain Axis (HBA) vulnerability during the perioperative period in healthy and morbidly obese patients. (benthamscience.com)

The PlanHab wash-out period corresponded to a profound life-style change (i.e., reintroduction of exercise) that resulted in stepwise amelioration of the negative physiological symptoms, indicating that exercise apparently prevented the crosstalk between the microbial physiology, mucin degradation and proinflammatory immune activities in the host. (frontiersin.org)

Which of the following glucose transporters is crucial for glucose uptake by skeletal muscle and fat? (primrosekitten.org)
[16] It does this by decreasing the translocation of glucose transporters (especially GLUT4 ) to the cell membrane. (wikipedia.org)
Glucose-induced activation of DAG/PKC signaling in microsomes was not associated with a change in the translocation of Glut-4 transporters from microsomes to the plasma membrane, a biological response that is known to be stimulated by agonists, e.g., phorbol esters, which increase DAG/PKC signaling in plasma membranes, as well as in microsomes. (jci.org)

However, the tryptophan content of turkey is comparable to chicken, beef, and other meats, and does not result in higher blood tryptophan levels than other common foods. (wikipedia.org)
Glycogen-storage disease type 0 (GSD-0), or glycogen synthetase deficiency, commonly appears in infancy and early childhood with fasting hypoglycemia accompanied by ketosis and low normal reference range blood levels of lactate and alanine. (medscape.com)
One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)
Human investigations suggest that fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. (lww.com)
Sleep disturbances have been implicated in the dysregulation of blood glucose levels and reported to increase the risk of type 2 diabetes (T2D) and diabetic complications. (vdocuments.mx)
Answered Jan 28, 2019 Author has 926 answers and 38.3k answer views Growth hormone is diabetogenic because it is an insulin antagonist, thereby preventing the action of insulin to bring down high blood sugar levels & promote the passage of sugar from the blood into the cells. (diabetestalk.net)
Which of the following statements is TRUE regarding the regulation of blood glucose levels? (primrosekitten.org)
In states of insulin resistance, the same amount of insulin does not have the same effect on glucose transport and blood sugar levels. (wikipedia.org)
There are multiple ways to measure insulin resistance such as fasting insulin levels or glucose tolerance tests, but these are not often used in clinical practice. (wikipedia.org)
Significant relationships were found between levels of glucose and sICAM-1and also E-selectin and HOMA-IR. (medsci.org)
RESULTS: None of LAB, losartan, and amlodipine exhibited effects on blood glucose levels. (e-dmj.org)
Lactic acidosis is characterized by elevated blood lactate levels, acidemia, electrolyte disturbances, an increased anion gap, and an increased lactate/pyruvate ratio. (pdr.net)

Venous blood samples were collected at baseline, immediately post-exercise or rest, as well as at 2, 4 and 6 h post-meal. (biomedcentral.com)
A total of 14,830 and 11,639 individuals who underwent health examinations at the Health Promotion Center at Samsung Medical Center, Seoul, Korea were included in the analyses of baseline skeletal muscle mass and those changes from baseline over 1 year, respectively. (biomedcentral.com)

Insulin signaling is preserved in skeletal muscle during early diabetic ketoacidosis. (medscape.com)
Hyperglycaemia has an important role in the pathogenesis of long-term complications and diabetic patients with poor blood glucose control are particularly at risk. (madridge.org)
Low blood sugar may occasionally be seen in a diabetic on anti-diabetic medicines due to fall in blood sugar. (diabetestalk.net)

The autonomic nervous system regulates the internal organs of the body, such as heart rate, blood pressure, digestion, and body temperature. (philaholisticclinic.com)

Glucose rapidly increased DAG content and PKC enzyme activity in microsomes, but not in plasma membranes or other membranes, during a 30-min treatment of rat adipocytes. (jci.org)

3] A different gene (GYS1, 138570) encodes muscle glycogen synthetase, which has normal activity in patients with glycogen-storage disease type 0. (medscape.com)

Presently, we examined the major subcellular site of PKC translocation/activation in response to glucose-induced DAG. (jci.org)

The primary outcomes of this study were changes in blood pressure and weight, and the secondary outcomes were changes in body composition, glycosylated hemoglobin A1c (HbA1c), and blood lipids. (researchgate.net)

The exact cause of postprandial somnolence is unknown but there are some scientific hypotheses: Increases in glucose concentration excite and induce vasodilation in ventrolateral preoptic nucleus neurons of the hypothalamus via astrocytic release of adenosine that is blocked by A2A receptor antagonists like caffeine. (wikipedia.org)
Evidence also suggests that the small rise in blood glucose that occurs after a meal is sensed by glucose-inhibited neurons in the lateral hypothalamus. (wikipedia.org)

Conventional medicine has type 2 diabetes pegged as a problem rooted in 'dysregulation of blood sugar control,' which is typically explained as 'an inability of your body to produce enough insulin. (detailshere.com)

As noted by Egan, enforced bedrest, such as acute hospitalization, can have a dramatic impact on your muscle mass. (losethempounds.com)
In children, this event may occur during acute GI illness or periods of poor enteral intake. (medscape.com)
We sought to examine the effects of acute hypoxia on central executive (selective attention and response inhibition) and non-executive (memory) performance and the extent to which impairments are potentially related to reductions in regional cerebral blood flow and oxygen delivery. (waseda.jp)

In contrast, at lower-intensity exercise, attenuation or prevention of the R a increment occurs with exogenous glucose infusion ( 2 - 4 , 11 , 12 ). (diabetesjournals.org)

In those prescribed metformin for glucose control, improved acanthosis nigricans has been demonstrated (Romo, 2008). (gov.gy)

In a first series of experiments rats were injected once daily for a period of 10 days with HCS (100 g), GH (10 or 100 g) or prolactin (10 or 100 g), each thyroxine (T4, 0.5 g), and then challenged in a glucose tolerance test with glucose plus 0.03 units protamine zinc insulin (PZI) following a 6-h fast. (diabetestalk.net)

In a second series rats were pre-treated for a period of 22 days, beginning 14 days after hypophysectomy, and then injected with doses of PZI (0.4 units 1.6 units/day) that induced convulsions in unprotected (saline and prolactin-treated) rats run concurrently. (diabetestalk.net)

Effects of bariatric surgery on blood and vascular large extracellular vesicles according to type 2 diabetes status. (medscape.com)
Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes. (medscape.com)
Do Diabetes Also Mean Low Blood Sugar Level? (diabetestalk.net)
Diabetes means a condition of high blood sugar. (diabetestalk.net)
In latent diabetes, a precursor to diabetes, blood sugar level may be normal. (diabetestalk.net)
With that view, it seems reasonable to conclude that in order to control diabetes, you need a prescription for insulin, or drugs that raise insulin to counteract the elevated blood sugar. (detailshere.com)
There have been several attempts to develop a unified set of diagnostic criteria, and in 2009 the International Diabetes Federation, the American Heart Association, and the National Heart, Lung and Blood Institute developed a list of criteria that is now broadly accepted. (surgicalneurologyint.com)
Skeletal muscle is the largest insulin-sensitive tissue in the body, and skeletal muscle insulin resistance is a well-established key process in the development of type 2 diabetes mellitus (T2DM) [ 7 ]. (e-dmj.org)
The word "diabetes" (a Greek word that means "to pass through") was first used by Aretaeous of Capadocia in the 2nd century AD to describe a condition that is characterized by excess of sugar in blood and urine, hunger and thirst (MacFrlance et al. (gotomydoctor.com)

However, in intense exercise (IE) 80% V̇ o 2max , an up to eightfold increase in glucose production ( R a ) and a rise in glycemia occur, but plasma insulin (immunoreactive insulin [IRI]) changes little and glucagon (immunoreactive glucagon [IRG]) increases less than twofold ( 5 ). (diabetesjournals.org)
This glucose-induced increase in microsomal DAG was attended by increases in immunoreactive PKC alpha, beta, and epsilon. (jci.org)

The reason insulin suppresses fat burning is because it's a signal of glucose abundance. (blogspot.com)

Such precursors include alanine (derived from the breakdown of proteins in skeletal muscle) and glycerol (derived from the breakdown of triacylglycerols in fat cells). (medscape.com)

Although the passage of food into the gastrointestinal tract results in increased blood flow to the stomach and intestines, this is achieved by diversion of blood primarily from skeletal muscle tissue and by increasing the volume of blood pumped forward by the heart each minute. (wikipedia.org)

Anatomy45

Organisms13

Diseases23

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology1

Phenomena and Processes60

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture3

Information Science3

Health Care4

Metabolism21

Appendicular skeletal muscle mass2

Loss of skeletal muscle mass3

Liver11

Adipose tissue1

Intolerance1

Body's6

Concentrations4

Secretion2

Model assessment of insulin resistance1

Rising blood glucose levels1

Hyperglycemia3

Amino acids5

Tissues2

Uptake of glucose1

Utilization2

Hepatic2

Synthesis7

Gluconeogenesis1

Oxidative2

Immune homeostasis1

Pancreatic1

Transporter3

Mass and metabolic1

Protein4

Stimulates1

Peripheral6

Plasma glucose1

Continuous glucose2

Metabolic4

Brain4

Crosstalk1

Transporters3

Levels12

Baseline2

Diabetic3

Organs1

Adipocytes1

Glycogen synthetase1

Translocation1

Body composition1

Hypothalamus2

Dysregulation1

Acute3

Exogenous1

Metformin1

Tolerance test1

Convulsions1

Diabetes9

Increases2

Suppresses1

Proteins1

Primarily1