• Simply writing, "R/O polymyositis" or "weakness", or worse, "muscle weakness" (we would not be concerned about weakness of character here, so using the term muscle weakness in this context seems oddly redundant) does not provide the pathologist with any useful clinical information and is a disservice to the patient. (medscape.com)
  • Centronuclear myopathy (CNM) is a heterogeneous group of muscle disorders primarily characterized by muscle weakness and variable degrees of respiratory dysfunction caused by mutations in MTM1, DNM2, RYR1, TTN and BIN1. (nih.gov)
  • Symptoms of respiratory weakness were reported by 15/47 (32%) patients. (nih.gov)
  • Congenital myasthenic syndrome is a group of conditions characterized by muscle weakness (myasthenia) that worsens with physical exertion. (medlineplus.gov)
  • The muscle weakness typically begins in early childhood but can also appear in adolescence or adulthood. (medlineplus.gov)
  • Due to muscle weakness, affected infants may have feeding difficulties. (medlineplus.gov)
  • muscle weakness, and delayed development of motor skills. (medlineplus.gov)
  • XLMTM is a severe, inherited myopathy that causes severe skeletal muscle weakness, respiratory insufficiency and death in children. (mcw.edu)
  • In addition, defective MuSK function causes muscle weakness in patients as seen in disorders such as Myasthenia gravis and congenital myasthenic sydromes. (meduniwien.ac.at)
  • Patients with chronic respiratory diseases (CRDs) have a disorder in muscle structure and function, but their function increases with physical progress and decreases the risk of general, and muscular weakness are more likely to develop sarcopenia. (intechopen.com)
  • Patients older than 6 months present with motor delays and/or slowly progressive muscle weakness. (medscape.com)
  • Late-onset GSD II is characterized by proximal muscle weakness and respiratory compromise. (medscape.com)
  • Adults with late-onset GSD II typically present with proximal muscle weakness between the second and sixth decades of life. (medscape.com)
  • Glycogen storage in skeletal muscle leads to hypotonia and weakness. (medscape.com)
  • Patients with adult-onset glycogen-storage disease type II typically present with proximal muscle weakness between the second and sixth decades of life. (medscape.com)
  • Three days later, the patient presented with bilateral facial weakness and proximal muscle strength worsened. (bvsalud.org)
  • Aims To assess mitochondrial biogenesis, MRC assembly and MRC function in R6/2 and human skeletal muscle. (bmj.com)
  • The purpose of this study was to examine the effects of respiratory alkalosis on human skeletal muscle metabolism at rest and during submaximal exercise. (mcmaster.ca)
  • Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle. (uoguelph.ca)
  • Sex-Differences in Mitochondrial Respiratory Function in Human Skeletal Muscle. (uoguelph.ca)
  • We are comprised of biomedical scientists with integrated interests in skeletal muscle, ageing, development, exercise, pain, rehabilitation and the physiology and medicine of aerospace environments. (kcl.ac.uk)
  • Aiming to improve clinical care through a better understanding of respiratory physiology in health. (kcl.ac.uk)
  • As a highly competitive athlete I have always been interested in understanding skeletal muscle physiology. (uoguelph.ca)
  • However, when I was introduced to the research process and a larger understanding of skeletal muscle physiology during my masters training at the University of Waterloo, I immediately found a career I was interested in pursing. (uoguelph.ca)
  • My interest in understanding how muscle utilizes substrates (carbohydrates and fats) during exercise was further strengthened during my PhD at the University of Guelph, as I became aware of the ability to apply general physiology to the study of various diseases. (uoguelph.ca)
  • The anatomy and histology of the integument and skin structures, the cardiovascular, respiratory, immune, endocrine, urogenital and digestive systems all of which serves as basis for the physiology component of the module. (up.ac.za)
  • Skeletal muscle dysfunction in chronic obstructive pulmonary disease. (nih.gov)
  • Background: Passive training of specific locomotor muscle groups by means of neuromuscular electrical stimulation (NMES) might be better tolerated than whole body exercise in patients with severe chronic obstructive pulmonary disease (COPD). (bmj.com)
  • 1 Traditionally, exercise intolerance has been ascribed to respiratory mechanical and/or pulmonary gas exchange disturbances and their perceptual consequences which are manifest mainly as breathlessness (dyspnoea), especially on exertion. (bmj.com)
  • A retrospective study was made in Riyadh, Saudi Arabia, on the impact of pulmonary rehabilitation on respiratory parameters and health care utilization in a group of outpatients with chronic lung diseases other than chronic obstructive pulmonary disease. (who.int)
  • Idea: Development of a Sarcopenia Center to diagnose and treat skeletal muscle loss due to chronic obstructive pulmonary disease. (clevelandclinic.org)
  • 2009) Effects of obstructive pulmonary disease and heart failure on skeletal muscle. (utah.edu)
  • He is a core investigator with the UCSF Respiratory Epidemiology Group and served as Chair of the International Society of Heart and Lung Transplantation Pulmonary Council Quality of Life Workforce from 2012-2021. (ucsf.edu)
  • His research interests include disease management for patients with chronic obstructive pulmonary disease (COPD) and other chronic lung diseases, with particular expertise in exercise performance, physical training, rehabilitation, nutrition and skeletal muscle dysfunction in COPD. (lboro.ac.uk)
  • Knee extensor strength and endurance, whole body exercise capacity, and health related quality of life (Chronic Respiratory Disease Questionnaire, CRDQ) were assessed. (bmj.com)
  • Noncommunicable diseases include a number of highly prevalent diseases, such as cardiovascular diseases, chronic respiratory diseases, cancer, diabetes, neuropsychiatric disorders and arthritis [ 2 ]. (ersjournals.com)
  • Diabetic patients with and without chronic lung disease are at increased risk of respiratory infection. (ersjournals.com)
  • Regular physical activity helps to maintain a healthy body and reduces the risk of noncommunicable diseases (NCDs) such as cardiovascular diseases, cancers, chronic respiratory diseases and diabetes. (who.int)
  • We randomly selected patients (N = 38) with mean age of 72 ± 1.0 years old men and women elderly with chronic respiratory diseases such as asthma, COPD, bronchiectasis and obesity with dyspnea score ≥ 2 in MRC index. (intechopen.com)
  • Comparing femur bone and rectus femoris muscle parameters as indicators for diagnosis of sarcopenia in chronic respiratory patients, we observed that in rectus femoris muscle, ultrasound is the most effective foot muscle detector. (intechopen.com)
  • It is increasingly appreciated that physical activity and rehabilitation play crucial roles in the management of chronic respiratory diseases. (lboro.ac.uk)
  • The remainder of this article addresses the key clinical characteristics and pathologic findings on muscle biopsy of selected examples of disorders from 4 different categories of muscle disease: immune-mediated (inflammatory) myopathies, muscular dystrophies, metabolic myopathies, and congenital myopathies. (medscape.com)
  • Noncommunicable diseases, including cardiovascular, metabolic and respiratory diseases, among others, are the major medical challenge of the 21st century. (ersjournals.com)
  • In this State of the Art review we present the basic concepts of systems biology, use some examples to illustrate the potential of network medicine to address complex medical problems, and review some recent publications that show how a systems-based research strategy can contribute to improve our understanding of multimorbidity and age-related respiratory diseases. (ersjournals.com)
  • Respiratory dysfunction was defined as an FVC below 70% of predicted and/or a daytime pCO2 higher than 6 kPa. (nih.gov)
  • Thirty-three individuals (54%) with different genotypes except autosomal dominant (AD)-BIN1-related CNM showed respiratory dysfunction. (nih.gov)
  • Second, dysfunction and necrosis of the diaphragm owing to concurrent skeletal muscle involvement (that is, myositis and rhabdomyolysis) can lead to respiratory failure, even when myocardial inflammation and function seem to have stabilized 3 . (nature.com)
  • Muscle biopsies were taken at rest and after 1 and 15 min of exercise. (mcmaster.ca)
  • These effects were not seen after 15 min of exercise, with no further differences in muscle metabolism between conditions. (mcmaster.ca)
  • The results from the present study suggest that respiratory alkalosis may play an important role in lactate accumulation during the transition from rest to exercise in acute hypoxic conditions, but that other factors mediate lactate accumulation during steady‐state exercise. (mcmaster.ca)
  • I use a variety of techniques to examine mitochondrial function (isolated mitochondria, permeabilized fibres, whole muscle incubations), use molecular biological approaches to up-and down-regulate mitochondrial proteins, as well exercise, altered nutrition and aerobic training to study novel regulation in mitochondrial bioenergetics. (uoguelph.ca)
  • Controlling CPT-I M-CoA Sensitivity in Skeletal Muscle: The Importance of AMPK-Independent Regulation of Intermediate Filaments During Exercise. (uoguelph.ca)
  • Conclusions: For severely disabled COPD patients with incapacitating dyspnoea, short term electrical stimulation of selected lower limb muscles involved in ambulation can improve muscle strength and endurance, whole body exercise tolerance, and breathlessness during activities of daily living. (bmj.com)
  • 3 Evidence has accumulated to suggest that, as part of this vicious cycle, deconditioning of skeletal muscle occurs which contributes significantly to exercise intolerance in this patient population. (bmj.com)
  • 5 Boutellier U, Buchel R, Kundert A, Spengler C. The respiratory system as an exercise limiting factor in normal trained subjects. (thieme-connect.de)
  • Harber MP, Konopka AR, Douglass MD, Minchev K, Kaminsky LA, Trappe TA, Trappe S (2009) Aerobic exercise training improves whole muscle and single myofiber size and function in older women. (springer.com)
  • Harber MP, Konopka AR, Undem MK, Hinkley JM, Minchev K, Kaminsky LA, Trappe TA, Trappe S (2012) Aerobic exercise training induces skeletal muscle hypertrophy and age-dependent adaptations in myofiber function in young and older men. (springer.com)
  • The respiratory system is a limiting factor of exercise capacity in adults. (wku.edu)
  • 2009) Exercise limitation in COPD: The role of skeletal muscle. (utah.edu)
  • 2009) Richardson, R.S. (2009) Exercise limitation in COPD: The role of skeletal muscle. (utah.edu)
  • 2008) Richardson, R.S. (2008) Skeletal muscle in COPD and CHF as targets for exercise training Exercise in Medicine, NTNU, Trondheim, Norwary. (utah.edu)
  • To determine whether differences exist in exercise performance, muscle function, and muscle mitochondrial oxidative capacity and content between symptomatic and asymptomatic statin users, and control subjects. (medscape.com)
  • Statin use attenuated substrate use during maximal exercise performance, induced muscle fatigue during repeated muscle contractions, and decreased muscle mitochondrial oxidative capacity. (medscape.com)
  • [ 2 ] However, 7% to 29% of patients are reported to develop muscle complaints while receiving statin treatment, [ 3 ] and these complaints may be exacerbated by exercise. (medscape.com)
  • [ 4-6 ] Although the mechanisms are poorly understood, statins have been shown to reduce muscle mitochondrial oxidative capacity and content in humans [ 7-10 ] and impair exercise-mediated mitochondrial adaptations in skeletal muscle. (medscape.com)
  • Few studies have examined the effects of statins on muscle contractile function and exercise performance, and even fewer studies have examined this in statin users with muscle complaints. (medscape.com)
  • For example, the Effect of Statins on Skeletal Muscle Function and Performance (STOMP) trial is, to our knowledge, the only randomized, double-blind clinical trial that has examined aerobic exercise performance and muscle strength before and after treatmentwith placebo or high-dose atorvastatin. (medscape.com)
  • Also, muscle biopsy specimens were not obtained in the STOMP trial to investigate whether changes in mitochondrial content and/or function occur during statin treatment andwhether they relate to muscle complaints and exercise performance. (medscape.com)
  • The aim of the current study was to examine whether differences exist in aerobic exercise performance, muscle contractile function, and muscle mitochondrial oxidative capacity and content between long-term symptomatic and asymptomatic statin users, and control subjects who did not use a statin drug. (medscape.com)
  • Functional sympatholysis has been identified as an underappreciated cause of poor contracting muscle perfusion (53) and may result in functional changes in exercise capacity (12). (researchgate.net)
  • Herein, we tested the hypothesis that a single high-fat Western meal would impair the ability of contracting skeletal muscle to offset vascular responsiveness to sympathetic activation during exercise, termed functional sympatholysis. (researchgate.net)
  • Consultant Respiratory Physician Professor Michael Steiner, and sports and exercise consultant Dr Patrick Wheeler from the University Hospitals of Leicester NHS Trust are the first clinicians to take up University positions that will see them work with Loughborough academics under the 'exercise is medicine' agenda. (lboro.ac.uk)
  • Professor Steiner is a leading member of the Centre for Exercise and Rehabilitation Science and the Leicester Respiratory Biomedical Research Unit at Glenfield Hospital. (lboro.ac.uk)
  • Acute rhabdomyolysis with hyperkalemia followed by ventricular dysrhythmias, cardiac arrest, and death has occurred after use in apparently healthy pediatric patients who were subsequently found to have undiagnosed skeletal muscle myopathy. (nih.gov)
  • Knowledge of the fundamentals of muscle biopsy pathology is useful to promote understanding of the pathogenesis of many types of neuromuscular disorders and assists the non-pathologist clinician to understand reports that he or she receives for the muscle biopsies from his or her patients. (medscape.com)
  • The article Skeletal Muscle - Structure and Histology provides a review of normal skeletal muscle histology and ultrastructure, including the histologic appearance of normal muscle with some of the various stains that are used for the processing of muscle biopsies. (medscape.com)
  • Most muscle biopsies exhibit a constellation of pathologic findings that must be synthesized to arrive at a diagnosis. (medscape.com)
  • Early nonclinical translational studies and the pathological evaluation of muscle biopsies from ASPIRO have been performed in the laboratory of Michael W. Lawlor, MD, PhD, associate professor of pathology and associate director of the Medical College of Wisconsin Neuroscience Research Center. (mcw.edu)
  • the involvement of the peripheral nervous system (PNS) in COVID-19 is rare and, to date, morphological aspects from muscle and nerve biopsies have not been reported. (bvsalud.org)
  • Here, we describe a case of Guillain-Barré Syndrome (GBS) related to COVID-19 and demonstrate findings from peripheral nerve and skeletal muscle biopsies. (bvsalud.org)
  • Farinatti PT, Monteiro WD (2010) Walk-run transition in young and older adults: with special reference to the cardio-respiratory responses. (springer.com)
  • Feeding with amino acids can stimulate protein synthesis in all tissues, especially in skeletal muscle as reviewed by Davis et al. (nature.com)
  • In neonates, this area is a dense neural sheet, but, in children and adults, the respiratory and olfactory tissues interdigitate. (medscape.com)
  • In April 2023, Professor Katsuhiko Funai at University of Utah published a study in Life Metabolism entitled 'Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice'(DOI: 10.1093/lifemeta/load014). (news-medical.net)
  • Altogether, the evidence suggests that weight loss leads to an increase in skeletal muscle mitochondrial energy production efficiency, thereby reducing energy expenditure throughout the body. (news-medical.net)
  • 2023). Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice. (news-medical.net)
  • My research is primarily focused on understanding the regulation of mitochondrial bioenergetics, with a particular interest in studying fatty acid oxidation (breakdown of fat yielding energy) in skeletal and cardiac muscle. (uoguelph.ca)
  • In the classic infantile form of Pompe disease, clinically significant glycogen storage occurs in cardiac muscle. (medscape.com)
  • It is a bronchial smooth muscle relaxant, a CNS stimulant, a cardiac muscle stimulant, and a diuretic. (drugs.com)
  • At rest, no effects on muscle metabolism were observed in response to R‐Alk. (mcmaster.ca)
  • In skeletal muscle, like brain a post-mitotic tissue, multiple mitochondrial DNA deletions as well as variable deficits in complex I of the mitochondrial respiratory chain (MRC), abnormal calcium handling, and reduced expression of PGC-1α have been described. (bmj.com)
  • Methods/techniques We used quadriceps muscle tissue from 12-week old R6/2 HD transgenic mice, and near to motor onset pre-manifest HD (n = 20), early onset HD patients (n = 20) and sex and age matched healthy controls (n = 20), as part of the Multi-Tissue Molecular signatures in HD project (MTM-HD). (bmj.com)
  • A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]. (virtualflybrain.org)
  • More proliferation was observed in muscle tissue of LBW-GLN than LBW-ALA piglets at 5 dpn, but there was no clear effect of supplementation on related gene expression. (nature.com)
  • Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
  • Glutamine is regarded as the most abundant amino acid in the body, is mainly synthesized in skeletal muscle 10 , and muscle tissue is the most important site for Gln storage 11 . (nature.com)
  • Large populations of lymphocytes, macrophages, and neutrophils are present in DMD muscle tissue [ 10 ]. (hindawi.com)
  • Subcutaneous (SAT) and intermuscular (IMAT) adipose tissue and muscle cross-sectional area (CSA) were measured at the mid-thigh using computed tomography. (springer.com)
  • Anatomy of the musculo-skeletal system integrated, the histology of connective tissue and muscles. (up.ac.za)
  • We discuss implications of our model approach for enhancing muscle models in general, as well as a few aspects regarding the significance of phosphate kinetics as one contributor to muscle fatigue. (frontiersin.org)
  • One of the first books addressing (muscle as well as whole body) fatigue was published at the beginning of the 20th century ( Mosso, 1904 ) and a multitude of research has followed since, see Gandevia (2001) for a thorough review. (frontiersin.org)
  • Commonly, muscle fatigue, i.e., the decline of the generable force level over time, is differentiated between central fatigue , i.e., the inability of the neural network to provide sufficient stimulation, and peripheral fatigue , i.e., the inability of the muscle cells to provide energy through metabolic activities (cf. (frontiersin.org)
  • Primary endpoints were inspiratory muscle strength and fatigue resistance index (FRI) 2 weeks following enrolment. (bmj.com)
  • These include: (1) stimulation of the respiratory center, (2) increased minute ventilation, (3) decreased threshold to hypercapnia, (4) increased response to hypercapnia, (5) increased skeletal muscle tone, (6) decreased diaphragmatic fatigue, (7) increased metabolic rate, and (8) increased oxygen consumption. (drugs.com)
  • Coggan AR, Spina RJ, King DS, Rogers MA, Brown M, Nemeth PM, Holloszy JO (1992) Skeletal muscle adaptations to endurance training in 60- to 70-year-old men and women. (springer.com)
  • Therefore, training with an appropriate physiological load should lead to adaptations of these muscles. (wku.edu)
  • Furfuryl-alcohol mainly affects the central nervous system, causing death by respiratory depression. (cdc.gov)
  • Muscles performing mechanical work become exhausted, that is, they fail to maintain high force levels for a longer time period. (frontiersin.org)
  • In dystrophin-deficient skeletal muscle, for example, mechanical injury and proteolysis may be important factors but do not fully explain DMD pathogenesis. (hindawi.com)
  • to provide skeletal muscle relaxation during surgery or mechanical ventilation. (nih.gov)
  • Without dystrophin, muscles are susceptible to mechanical injury and undergo repeated cycles of necrosis and regeneration. (medscape.com)
  • Decennial booster vaccination with adult tetanus toxoid and reduced diphtheria toxoid (Td) vaccine has been largely responsible for reducing the average annual number of tetanus and respiratory diphtheria cases reported during 2000--2006 to 31 and less than one, respectively. (cdc.gov)
  • Goodpaster BH, Kelley DE, Thaete FL, He J, Ross R (2000) Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. (springer.com)
  • 2008) Human muscle blood flow and metabolic assessment applied to aging. (utah.edu)
  • Contracting skeletal muscle can overcome sympathetic vasoconstrictor activity (functional sympatholysis), which allows for a blood supply that matches the metabolic demand. (researchgate.net)
  • We therefore propose that passive stimulation of locomotor muscle groups by neuromuscular electrical stimulation (NMES) may provide an alternative approach for improving physical capacity in severely compromised patients with COPD who present with incapacitating dyspnoea. (bmj.com)
  • The accessory inspiratory muscles and diaphragm are functionally and structurally skeletal muscles. (wku.edu)
  • Finally, by analyzing the lipidome of skeletal muscle in weight-loss mice, the authors found that weight loss accelerated the remodeling of mitochondrial cardiolipin (CL) acyl-chains to increase tetralinoleoyl CL (TLCL) content, a species of lipids thought to be functionally critical for the respiratory enzymes. (news-medical.net)
  • Although this phenomenon has long been identified and has been suggested that weight loss may alter skeletal muscle mitochondrial respiration, the mechanisms are not fully understood and direct evidence is lacking. (news-medical.net)
  • Theoretically, increasing respiratory resistance will create an overload on respiratory muscle which, in turn strengthens the diaphragm and accessory inspiratory muscles. (wku.edu)
  • Background In patients who have been mechanically ventilated, inspiratory muscles remain weak and fatigable following ventilatory weaning, which may contribute to dyspnoea and limited functional recovery. (bmj.com)
  • Understanding the mechanisms regulating cardiac & skeletal muscle mass, function & repair. (kcl.ac.uk)
  • Mechanisms such as the immune/inflammatory response to injury appear to contribute substantially to muscle pathophysiology. (hindawi.com)
  • Immune/inflammatory-mediated mechanisms, which result in muscle cell death and/or mechanisms leading to fibrosis, may be important initiators of lesions in dystrophin-deficient muscle. (hindawi.com)
  • The article Muscle Biopsy and Clinical and Laboratory Features of Neuromuscular Disease provides information about the procedure of muscle biopsy and background about the general features of the clinical presentations of neuromuscular disorders. (medscape.com)
  • Une étude rétrospective a été menée à Riyad (Arabie saoudite) pour connaître l'impact de la rééducation pulmonaire d'une part sur les paramètres respiratoires d'un groupe de patients en consultation externe pour des affections pulmonaires chroniques autres que la bronchopneumopathie chronique obstructive (BPCO) et d'autre part sur leur utilisation des soins de santé. (who.int)
  • In this paper we constructed a simple mathematical model to investigate the role of the immune response in muscle degeneration and subsequent regeneration in the mdx mouse model of Duchenne muscular dystrophy. (hindawi.com)
  • Duchenne muscular dystrophy (DMD) is a lethal, X-chromosome muscle wasting disease affecting approximately one in 3,500 boys [ 1 , 2 ]. (hindawi.com)
  • The X chromosome-linked mutation resulted in mice ( mdx mice) with high serum levels of muscle enzymes and with histological lesions comparable to those seen in human muscular dystrophy. (hindawi.com)
  • Herein, we discuss a recent report of a series of patients who were managed using a novel approach that involved personalized abatacept dosing, ruxolitinib and close respiratory monitoring, which was associated with low mortality. (nature.com)
  • Conclusions Inspiratory muscle training following successful weaning increases inspiratory muscle strength and quality of life, but we cannot confidently rule out an associated increased risk of in-hospital mortality. (bmj.com)
  • Muscle biopsy often contributes significantly to the evaluation of patients with neuromuscular disease. (medscape.com)
  • Goodpaster BH, Carlson CL, Visser M, Kelley DE, Scherzinger A, Harris TB, Stamm E, Newman AB (2001) Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study. (springer.com)
  • Unintended administration of succinylcholine chloride injection may result in paralysis, respiratory arrest and death. (nih.gov)
  • An ascending paralysis develops, and death can occur within 6-24 hours, secondary to respiratory muscle paralysis. (cdc.gov)
  • It displays antispasmodic effects on smooth muscles while causing paralysis of sensory nerves and, in rabbits, paralysis of skeletal muscles. (cdc.gov)
  • The muscle pathologist must analyze and interpret the histopathologic features within the individual clinical context to arrive at a diagnostic formulation that makes sense for a given patient. (medscape.com)
  • Here is an example to illustrate the lack of specificity of histopathologic findings and the importance of clinical information for interpretation of a muscle biopsy: A biopsy might exhibit myofibers that contain clear vacuoles on hematoxylin and eosin (H&E) sections. (medscape.com)
  • Data on respiratory function for other genotypes is limited. (nih.gov)
  • Respiratory function. (nih.gov)
  • Gene mutations lead to changes in proteins that play a role in the function of the neuromuscular junction and disrupt signaling between the ends of nerve cells and muscle cells. (medlineplus.gov)
  • The 12-week SJ program was easily performed by older adults with low skeletal muscle mass, improved aerobic capacity, muscle function, and muscle composition in older adults. (springer.com)
  • Only statin-naive individualswere studied in STOMP, however, so the absence of deleterious changes in muscle function and performance may not apply to symptomatic statin users. (medscape.com)
  • On admission, his was afebrile, and without respiratory distress. (bvsalud.org)
  • Knowledge of the basic foundation of muscle biopsy also helps the clinician to understand in what situations a muscle biopsy would be expected to be helpful in assessment of the patient with neuromuscular disease and to be familiar with the types of information that it can provide. (medscape.com)
  • this will not present instruction on the subtleties of advanced muscle biopsy diagnosis. (medscape.com)
  • This article first presents and contrasts neurogenic and general myopathic features on muscle biopsy. (medscape.com)
  • Interpretation of a muscle biopsy can be a challenging task. (medscape.com)
  • Dr. Lawlor provided an in-depth presentation of the muscle biopsy data in a talk entitled "The ASPIRO Study: Improvements in XLMTM Muscle Biology Pathology and Biomarkers" at the Audentes ASGCT 2019 Satellite Symposium on May 1. (mcw.edu)
  • Maximal incremental cycling tests, involuntary electrically stimulated isometric quadriceps-muscle contractions, and biopsy of vastus lateralis muscle. (medscape.com)
  • The muscle biopsy revealed moderate neuromyopathic findings with positive expression for MHC-class I, C5b9, CD8 and CD68. (bvsalud.org)
  • The respiratory problems in congenital myasthenic syndrome result from impaired movement of the muscles of the chest wall and the muscle that separates the abdomen from the chest cavity ( the diaphragm ). (medlineplus.gov)
  • They performed femur bone mineral density (FBMD) and ultrasound on the rectus femoris muscle mid-tight cross-sectional area (RFMTCSA) in the quadriceps muscle. (intechopen.com)
  • Nerve agents are readily absorbed from the respiratory tract. (cdc.gov)
  • 1 mM in nasal ASL [ 8 ] and mean± sd 0.4±0.2 mM in the lower respiratory tract, 12.5 times lower than plasma concentrations, which are normally maintained at ∼5 mM [ 9 ]. (ersjournals.com)
  • Typically by the age of 12, DMD patients require the use of a wheelchair due to the loss of lower limb muscle strength. (hindawi.com)
  • The results showed that there was no significant change in mitochondrial proteomes or respiratory chain supercomplex formation in skeletal muscle of weight-loss mice, but oxidative phosphorylation efficiency significantly increased. (news-medical.net)
  • Two weeks of daily supervised inspiratory muscle training significantly improves inspiratory muscle strength and health-related quality of life in patients recently weaned from invasive ventilation. (bmj.com)
  • 2010) Oxidative-nitrosative stress and its impact on vascular O2 transport to skeletal muslce, American College of Sports Medicine, Baltimore, MA. (utah.edu)
  • Application of NMES has been consistently associated with increased mass, strength, and endurance of both normally and abnormally innervated muscles in a range of pathological conditions. (bmj.com)
  • 2010) Skeletal Muscle Blood Flow Assessment: Arterial Spin Labeling as an approach. (utah.edu)
  • We aimed to examine the effects of an easily performed SJ program on skeletal muscle, fat infiltration, and fitness in older adults. (springer.com)
  • Inspiratory muscle training may improve inspiratory muscle strength and endurance following weaning, potentially improving dyspnoea and quality of life in this patient group. (bmj.com)
  • [ 12 ] STOMP researchers found that more patients in the atorvastatin group than in the placebo group developed muscle complaints, but there were no differences in muscle strength and endurance, aerobic performance, or physical activity levels after 6 months of treatment. (medscape.com)
  • ASL glucose concentrations are the net result of diffusion of glucose from blood and interstitial fluid across the respiratory epithelium into the ASL, and removal of glucose from ASL by epithelial glucose transport processes. (ersjournals.com)
  • not appear to cross into the interstitial space of the muscle (Mortensen et al. (researchgate.net)
  • Although skeletal and respiratory involvement is frequently present in the juvenile form, cardiac involvement varies. (medscape.com)
  • Furthermore, intensive monitoring of respiratory status was initiated for these 30 patients, with prompt elective ventilatory support provided for those with early signs of respiratory failure ( n = 8). (nature.com)