GLYCOPROTEINSProteinsMycobacterial glycolipidsAntigenGolgiBiosurfactantsMycobacteriumAccumulationPhospholipidsBuildupPhenolicMediateEukaryoticLigandsSynthesisMembraneAbundantAntibodiesTrisaccharideInteractionCarbohydratesTissuesCarbohydrateProteinBreakdownMonosaccharideCellCellsCERAMIDESVesicleSolubleStructuralFormFunctionalVirusesAnalyseFunctionSpecificAnalyticsPlease visitEntriesTypeDiseaseFormationVisitStudiesResponsibleWorkEvidence
GLYCOPROTEINS9
- Glycans are the vital components of glycoproteins, glycolipids, and proteoglycans. (transcriptionfactor.org)
- Glycoproteins are grouped by the type of carbohydrate and the amino acid linkage site. (transcriptionfactor.org)
- The Golgi apparatus is basically the site for the modification, completion, and exportation of secretory proteins and glycoproteins. (jotscroll.com)
- Which is the important site of formation of glycoproteins and glycolipids in eukaryotic cells? (jeeneetqna.in)
- The human genome contains at least 35 genes that encode Golgi sulfotransferases that function in the secretory pathway, where they are involved in decorating glycosaminoglycans, glycolipids, and glycoproteins with sulfate groups. (lu.se)
- This enzyme plays a role in the breakdown of complexes of sugar molecules (oligosaccharides) attached to certain proteins (glycoproteins) and fats (glycolipids). (medlineplus.gov)
- A lack of enzyme activity results in an incomplete breakdown of glycolipids and glycoproteins. (medlineplus.gov)
- Brain cells are particularly sensitive to the buildup of glycolipids and glycoproteins, which can result in cell death. (medlineplus.gov)
- Accumulation of glycolipids and glycoproteins also occurs in other organs such as the liver, spleen, skin, heart, pancreas, and kidneys, contributing to the additional symptoms of fucosidosis. (medlineplus.gov)
Proteins3
- Caveolae, plasmalemmal invaginations in which several other glycolipid-anchored proteins are concentrated, are not seen in neuroblastoma cells analyzed by thin-section or deep-etch electron microscopy. (rupress.org)
- These sphingolipid transfer proteins were initially identified as glycolipid transfer proteins (GLTPs) due to their specificity for transferring glycosphingolipids between membranes. (umn.edu)
- Membrane proteins can have a number of functions, such as transport proteins, enzymes (more on these shortly), receptor sites, cell adhesion, attachment to the cytoskeleton. (olemiss.edu)
Mycobacterial glycolipids1
- Although mycobacterial glycolipids are among the first-line molecules involved in host-pathogen interactions, their contribution in virulence remains incomplete. (biomedcentral.com)
Antigen4
- The four main human blood types (A, B, AB, O) are determined by the oligosaccharide attached to a specific glycolipid on the surface of red blood cells, which acts as an antigen. (wikipedia.org)
- A new histo-blood group system was discovered, based on the identification of Forssman glycolipid antigen on human red blood cells. (ashpublications.org)
- In this research, RBCs of blood groupâ O were converted to blood groupâ A through two approaches: by chemical ligation of the cells' glycocalyx with synthetic blood groupâ A tetrasaccharide, and by insertion of synthetic glycolipid carrying the same Aâ antigen into the cells' membranes. (bvsalud.org)
- VC 2006 Wiley-Liss, Inc. a glycolipid antigen with globo-series carbohydrate core structures (Kannagi et al. (lu.se)
Golgi1
- The glycolipid is assembled in the Golgi apparatus and embedded in the surface of a vesicle which is then transported to the cell membrane. (wikipedia.org)
Biosurfactants1
- For more information about glycolipid biosurfactants, please visit Evonik's Biosurfactants website . (industryintel.com)
Mycobacterium3
- In addition, Geerdink's thesis describes the synthesis of a putative sex pheromone of a parasitic wasp ( Trichogramma turkestanic ) and our efforts towards the synthesis of another glycolipid from Mycobacterium tuberculosis (DAT2) and a sulfo-glycopeptidolipid from Mycobacterium avium (S-GPL). (rug.nl)
- Here, we provide evidence for the involvement of the specific trisaccharide unit of the phenolic glycolipid-1 (PGL-1) of Mycobacterium leprae in determining the bacterial predilection to the peripheral nerve. (ed.ac.uk)
- Sulfolipid-1 (SL-1) is an abundant sulfated glycolipid and potential virulence factor found in Mycobacterium tuberculosis. (rcsb.org)
Accumulation2
- In the case of G M2 gangliosidosis, an activator protein is deficient, which leads to the accumulation of ganglioside G M2 and related glycolipids in neuronal cells. (medscape.com)
- The accumulation of glycolipid causes noncancerous (benign) skin growths (angiokeratomas) to form on the lower part of the trunk. (msdmanuals.com)
Phospholipids2
- Glycolipids are phospholipids with the sugar chains added. (olemiss.edu)
- Hence, in low-moisture conditions, glycolipids may persist while phospholipids are preferentially hydrolyzed. (mcmaster.ca)
Buildup1
- It is caused by a buildup of glycolipid in tissues. (msdmanuals.com)
Phenolic1
- An unusual phenolic alcohol is found as a component of glycolipids in Mycobacteria . (gerli.com)
Mediate1
- Blood types are an example of how glycolipids on cell membranes mediate cell interactions with the surrounding environment. (wikipedia.org)
Eukaryotic1
- Glycolipids are found on the surface of all eukaryotic cell membranes, where they extend from the phospholipid bilayer into the extracellular environment. (wikipedia.org)
Ligands2
- This approach could help cell biologists in site-specific and cell-friendly modification of glycocalyx by other ligands. (bvsalud.org)
- To illustrate the potential of such a biophysical approach, I will, in my presentation, first focus on the interaction between norovirus and glycolipid-containing membranes and investigate the role of ligands mobility and ligand clustering in modulating the affinity of the virus particle to the membrane. (lu.se)
Synthesis1
- This thesis presents a short protecting group free route to trehalose amide glycolipids, thus allowing for the synthesis of the straight chain glycolipid amides 1a-e in four steps and in excellent (53-61%) overall yields (Figure 1). (vuw.ac.nz)
Membrane1
- The vesicle merges with the cell membrane so that the glycolipid can be presented on the cell's outside surface. (wikipedia.org)
Abundant1
- The cell wall of pathogenic mycobacteria is abundant with complex glycolipids whose roles in disease pathogenesis are mostly unknown. (ed.ac.uk)
Antibodies4
- Antigens which are not present in an individual's blood will cause antibodies to be produced, which will bind to the foreign glycolipids. (wikipedia.org)
- Ac2SGL, one of the glycolipids in the cell enveloppe of M. tuberculosis , stimulates the production of antibodies and is considered as a candidate for a tuberculosis vaccine. (rug.nl)
- We also examined sera for anti-glycolipid antibodies, a biomarker of GBS, and C jejeunispecific antibodies, a biomarker of C jejeuni exposure. (cdc.gov)
- Anti-glycolipid IgG antibodies were more common among male poultry workers as compared to male referents (p = 0.07). (cdc.gov)
Trisaccharide1
- Restoration of fucosylation by insertion of synthetic glycolipids in the form of H (type 2) trisaccharide Fucα1-2Galß1-4GlcNAc restored adhesion. (bvsalud.org)
Interaction1
- An example of how glycolipids function within the body is the interaction between leukocytes and endothelial cells during inflammation. (wikipedia.org)
Carbohydrates1
- Selectins, a class of lectins found on the surface of leukocytes and endothelial cells bind to the carbohydrates attached to glycolipids to initiate the immune response. (wikipedia.org)
Tissues1
- In Fabry disease, a glycolipid, which is a product of fat metabolism, accumulates in tissues. (msdmanuals.com)
Carbohydrate2
- Glycolipids are lipids with a carbohydrate attached by a glycosidic (covalent) bond. (wikipedia.org)
- The saccharide of the glycolipid will bind to a specific complementary carbohydrate or to a lectin (carbohydrate-binding protein), of a neighboring cell. (wikipedia.org)
Protein3
- Amide glycolipids 1a-e were demonstrated to be Mincle agonists with comparable activity to their ester counterparts, as determined using a green fluorescent protein (GFP) reporter cell line assay. (vuw.ac.nz)
- A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits. (rupress.org)
- The cellular prion protein (PrPc) is a glycolipid-anchored, cell surface protein of unknown function, a posttranslationally modified isoform of which PrPSc is involved in the pathogenesis of Creutzfeldt-Jakob disease, scrapie, and other spongiform encephalopathies. (rupress.org)
Breakdown1
- The enzyme needed to breakdown the glycolipid, called alpha-galactosidase A, does not work correctly. (msdmanuals.com)
Monosaccharide1
- The essential feature of a glycolipid is the presence of a monosaccharide or oligosaccharide bound to a lipid moiety. (wikipedia.org)
Cell4
- The saccharides that are attached to the polar head groups on the outside of the cell are the ligand components of glycolipids, and are likewise polar, allowing them to be soluble in the aqueous environment surrounding the cell. (wikipedia.org)
- Enzymes called glycosyltransferases link the saccharide to the lipid molecule, and also play a role in assembling the correct oligosaccharide so that the right receptor can be activated on the cell which responds to the presence of the glycolipid on the surface of the cell. (wikipedia.org)
- The main function of glycolipids in the body is to serve as recognition sites for cell-cell interactions. (wikipedia.org)
- Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation. (southernbiotech.com)
Cells4
- Glycolipids are also responsible for other responses, notably the recognition of host cells by viruses. (wikipedia.org)
- All splenic and peritoneal IgM + cells of both B-1 and B-2 lineages are CD19 + , with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. (southernbiotech.com)
- The degree of lymphocyte adhesion to native and the "H-restored" (glycolipid-loaded) EA.hy 926 cells was comparable. (bvsalud.org)
- We stably engineered O-glycan sulfation capacities in HEK293 cells by site-directed knockin of sulfotransferase genes in combination with knockout of genes to eliminate endogenous O-glycan branching (core2 synthase gene GCNT1) and/or sialylation capacities in order to provide simplified substrates (core1 Galβ1-3GalNAcα1-O-Ser/Thr) for the introduced sulfotransferases. (lu.se)
CERAMIDES1
- In patients, inability to degrade sulfated glycolipids, especially the galactosyl-3-sulfate ceramides, characterizes metachromatic leukodystrophy (MLD). (medscape.com)
Vesicle1
- here, discrete export signals on the cargo are recognized and captured by specific receptors that are concentrated at sites of vesicle budding. (biologists.com)
Soluble2
- Soluble cargo can be recruited to ER exit sites by signal-mediated processes (cargo capture) or by bulk flow. (biologists.com)
- A site on the alpha subunit acts against negatively charged sulfated substrates, while a site on the beta subunit acts against neutral water-soluble substrates. (medscape.com)
Structural1
- iii) the structural basis for the more focused glycolipid selectivity of a fungal GLTP ortholog as well as the GLTPH domain of human FAPP2. (umn.edu)
Form1
- This is the initial binding mechanism, which is followed by the expression of integrins which form stronger bonds and allow leukocytes to migrate toward the site of inflammation. (wikipedia.org)
Functional1
- The UG website uses functional and anonymous analytics cookies. (rug.nl)
Viruses1
- Rafts appear to function as organizing regions for signaling kinases as well as target sites for certain viruses and bacteria. (umn.edu)
Analyse2
Function2
Specific1
- The hglK gene is required for localization of heterocyst-specific glycolipids in the cyanobacterium Anabaena sp. (uchicago.edu)
Analytics1
- AT Internet's audience measurement tool Analytics is deployed on this site in order to obtain information on visitors' navigation and to improve its use. (inrae.fr)
Please visit1
- To see the latest features, please visit our beta site . (glycosmos.org)
Entries1
- Glycolipid entries from the LIPID MAPS Structure Database (LMSD) . (glycosmos.org)
Type2
- Trehalose glycolipids, consisting of α,α'-trehalose esterified at the 6- and 6'- positions with lipids, exhibit adjuvant activity by binding and activating Macrophage inducible C-type lectin (Mincle). (vuw.ac.nz)
- Evonik received the award for RHEANCE® One, a special type of glycolipid biosurfactant derived from renewable raw materials. (industryintel.com)
Disease2
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- Fabry disease occurs when the body lacks enzymes needed to break down a glycolipid. (msdmanuals.com)
Formation1
- it is characterized by a defect in formation and stabilization of the alpha subunit active site. (medscape.com)
Visit1
- In addition to the optimal functioning of the website, we work together with third parties to offer you personalized content based on your visit. (rug.nl)
Studies1
- This report is the first example of trehalose amide glycolipids acting as Mincle agonists, and further studies into the potential of the amides as vaccine adjuvants will be undertaken in due course. (vuw.ac.nz)
Responsible1
- CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. (cdc.gov)
Work2
Evidence1
- At the driest site (Yungay), based on the relative abundance and (14)C content of GLFA and PLFA, there was evidence of possible preservation. (mcmaster.ca)