Single magnetic resonance spectroscopy. Medical search. Frequent questions

My group exploits the complementary nature and distance dependence of nuclear magnetic resonance (NMR) and single molecule fluorescence, in particular single molecule Förster Resonance Energy Transfer (FRET), to study the conformational landscape and dynamics of IDPs at molecular resolution. (fu-berlin.de)
In this work conventional pulse NMR was used to study the chemical shift of nuclear polarized 129Xe on different preparations of the (111)-surface of an iridium single crystal. (uni-marburg.de)
Nuclear magnetic resonance spectroscopy (NMR) is one of the most successful physical methods. (uni-marburg.de)
Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. (cdc.gov)
Nuclear magnetic resonance spectroscopy enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity, and structures for 12 of the 13 serogroups (all but serogroup D) from N. meningitidis capsular polysaccharides have been reported ( 6 - 15 ). (cdc.gov)
The modification of surface passivation is evidenced by both Fourier transform infrared spectroscopy and nuclear magnetic resonance measurements. (fzu.cz)
This limitation makes SPM fall short compared with noninvasive spectroscopic methods such as optical spectroscopy, neutron scattering and nuclear magnetic resonance. (nature.com)
Isolated 1 was characterized by several forms of spectroscopy including nuclear magnetic resonance, electronic absorption, and mass spectrometry. (ku.edu)
In particular, the spectroscopic tools within the Nijmegen Centre for Advanced Spectroscopy will be in the focus of this lecture series, including a variety of laser spectroscopic methods, Nuclear Magnetic Resonance, Spectroscopy in High Magnetic Fields, Nano/Single Molecule Spectroscopy combined with scanning probe microscopy methods. (ru.nl)
Chemical characterization by nuclear magnetic resonance spectroscopy indicated that the free amino acid L-tryptophan was the natural sperm attractant in H. rufescens . (biologists.com)
4. Z. Luz and B.L. Silver, The acid catalyzed exchange of phosphorus bonded hydrogen in aqueous solutions of dialkyl phosphonates studied by nuclear magnetic resonances. (weizmann.ac.il)
7. M. Sheinblatt and Z. Luz, Hydrogen exchange in benzylmercaptan studied by nuclear magnetic resonance. (weizmann.ac.il)
9. Z. Luz and S. Meiboom, Nuclear magnetic resonance study of the protolysis of trimethylammonium ion in aqueous solution-order of the reaction with respect to water. (weizmann.ac.il)
11. Z. Luz and S. Meiboom, Nuclear magnetic resonance study of the solvation of Co++ in methanol-water mixtures. (weizmann.ac.il)
14. Z. Luz, Nuclear magnetic resonance and optical spectroscopy of [Co(MeOH)5Cl]+ in methanol and the kinetics of methanol exchange of the solvation shell. (weizmann.ac.il)
15. Z. Luz, Nuclear magnetic resonance study of cobalt-chlorine complexes in methanol. (weizmann.ac.il)
19. I. Pecht and Z. Luz, Oxygen exchange between periodate and water studied by 17O nuclear magnetic resonance. (weizmann.ac.il)
21. Z. Luz and G. Yagil, Water 17O nuclear magnetic resonance shift in aqueous solutions of 1:1 electrolyte. (weizmann.ac.il)
22. Z. Luz and B.L. Silver, The acid catalyzed oxygen exchange of acetyl-acetone in dioxane-water solution measured by oxygen-17 nuclear magnetic resonance. (weizmann.ac.il)
23. B.L. Silver, Z. Luz, S. Peller and J. Reuben, Intramolecular hydrogen bonding in the hydrogen anions of some carboxylic acids in water-methanol mixtures, Evidence from nuclear magnetic resonance. (weizmann.ac.il)
24. Z. Luz and I. Pecht, Oxygen-17 nuclear magnetic resonance and oxygen exchange in aqueous solutions of telluric acid. (weizmann.ac.il)
28. Z. Luz, B.L. Silver and D. Fiat, O-17 nuclear magnetic resonance of manganese (III) tris(acetyacetonate). (weizmann.ac.il)
29. P. Greenzaid, Z. Luz and D. Samuel, A nuclear magnetic resonance study of the reversible hydration of aliphatic aldehydes and ketones. (weizmann.ac.il)
Designs of CW and pulse Electron Nuclear Double Resonance (ENDOR) spectrometers, which are very important techniques for studying precisely hyperfine interactions and local environment of paramagnetic ions in carbon-based materials are included. (benthamscience.com)
Next, Kurt Wüthrich - recipient of the 2002 Nobel Prize in Chemistry for the development of nuclear magnetic resonance (NMR) spectroscopy - made a brief statement about imaging macromolecules in solution, which are under the regime of Brownian motion. (lindau-nobel.org)
An experimentally determined model of the single finger is proposed that is consistent with circular dichroism, one- and two-dimensional nuclear magnetic resonance, and visual spectroscopy of the single-finger peptide reconstituted in the presence of zinc. (embl.de)
Nuclear magnetic resonance spectroscopy is a key technology for determining the structures of molecules and visualising the anatomy of living tissue. (edu.au)
Nuclear magnetic spectroscopy i.e. (chemistrywithwiley.com)
NMR spectroscopy provides information about desired molecules and the environment based on the interactions of nuclear magnetic moments with electromagnetic radiation. (chemistrywithwiley.com)
METHODS: In this single center study conducted from October 2018-2019, lipid constituents from lipoprotein subclasses were quantified by targeted nuclear magnetic resonance spectroscopy. (cdc.gov)
The Emerging Field of Medicines Authentication by Nuclear Quadrupole Resonance Spectroscopy (Counterfeit Medicines Volume II: Detection, Identification and Analysis, ILM Publications, 2013). (lu.se)

It is done without exposing subjects to ionizing radiation like it is done in positron emission tomography (PET) or single-photon emission computed tomography (SPECT) studies. (wikipedia.org)
Existing technology, such as Positron Emission Tomography (PET), Magnetic Resonance Spectroscopy (MRS), and Single-photon emission computed tomography (SPECT), are currently optimal only for a limited range of molecules. (nih.gov)
Although medulloblastoma has a highly characteristic appearance on computed tomography (CT) scanning, magnetic resonance imaging (MRI) is the preferred tool. (medscape.com)

Planar microresonators are fabricated in the NIST Nanofab, tested in our laboratory, and incorporated into a commercial 9 GHz or NIST-built 34 GHz electron paramagnetic resonance (EPR) spectrometer for measurements of thin films and other volume-limited samples. (nist.gov)
for example, inductive-detection electron paramagnetic resonance (EPR) spectroscopy currently requires sample volumes on the order of tens of microliters. (nist.gov)
X-band electron paramagnetic resonance spectroscopy confirms the paramagnetic nature of 2, and reveals a narrow signal at g = 2.006, consistent with the majority of the unpaired electron density being localized on the 4,4´-NO2bpy ligand. (ku.edu)
Building on the findings from Chapter 1, cyclic voltammograms collected with complex 3, bearing the 4-nitro-2,2´-bipyridyl ligand, reveal slow chloride ligand loss upon one-electron reduction, implicating significant stabilization of the singly-reduced form by the single electron-withdrawing nitro group. (ku.edu)
In particular, ultrafast XFEL spectroscopy is used to evaluate the methionine-S-Fe bond in cytochrome c, and its entatic control by the protein in determining function (electron transfer vs. apoptosis). (stanford.edu)
25. B.L. Silver, Z. Luz and C. Eden, Electron spin resonance of parabenzo-semiquininone-17O. (weizmann.ac.il)
The advantages of using multifrequency Electron Paramagnetic Resonance (EPR) in studying carbon-based materials are discussed. (benthamscience.com)
Hyperfine spectroscopies, ESEEM, ENDOR and HYSCORE, determined the electron hyperfine couplings of unpaired electrons with magnetic nuclei, thus allowing the evaluation of the extent of the π-system and the presence of different types of nuclei. (benthamscience.com)
For example, the complementary approaches of single-particle cryo-electron microscopy (cryo-EM) and X-ray crystallography increases the range of possibilities. (lindau-nobel.org)

Software package with sequences and protocols for single voxel proton spectroscopy. (siemens-healthineers.com)
Single-voxel proton Magnetic Resonance Spectroscopy STEAM sequence can be used to investigate, non invasively, a wide range of brain diseases. (lacittadina.org)
In vivo single-voxel proton MRS provides a sensible and non-invasive characterization of canine brain lesions. (lacittadina.org)

Fisher information in Time-Domain Spectroscopy (arXiv, 2023) [ pdf ]. (lu.se)

In fMRS, depending on the focus of the study, either single-voxel or multi-voxel spectroscopic technique can be used. (wikipedia.org)
To obtain structural information, we synthesized single and double zinc finger peptides from the yeast transcription activator ADR1, and assessed the metal-binding and DNA-binding properties of these peptides, as well as the solution structure of the metal-stabilized domains, with the use of a variety of spectroscopic techniques. (embl.de)

The data generated by fMRS usually shows spectra of resonances, instead of a brain image, as with MRI. (wikipedia.org)
fMRS is based on the same principles as in vivo magnetic resonance spectroscopy (MRS). However, while conventional MRS records a single spectrum of metabolites from a region of interest, a key interest of fMRS is to detect multiple spectra and study metabolite concentration dynamics during brain function. (wikipedia.org)
In the literature 13C fMRS is commonly referred to as functional 13C MRS or just 13C MRS. Typically in MRS a single spectrum is acquired by averaging enough spectra over a long acquisition time. (wikipedia.org)
In addition, single-nanocrystal spectroscopy reveals the occurrence of a systematic fine structure in the emission single spectra, which is connected with an intrinsic property of small nanocrystals since a very similar structure has recently been observed in specially passivated semiconductor CdZnSe nanoparticles. (fzu.cz)
Analysis of EPR spectra, spin Hamiltonians, EPR lineshapes, evaluation of spin-Hamiltonian parameters, and simulation of single-crystal and powder spectra are also explained. (benthamscience.com)
The aim of this study was to investigate MRS spectra of canine single-lesion brain diseases of inflammatory, neoplastic or metabolic origin (hepatic encephalopathy). (lacittadina.org)
Spectra obtained by single-voxel MRS examination were divided for each category. (lacittadina.org)

Quantum sensors with nitrogen-vacancy (NV) diamonds have key potential in chemical analysis, NMR spectroscopy, and materials characterization. (researchandmarkets.com)

chemical compound: Proton magnetic resonance spectroscopy: …the protons in the compound tetramethylsilane, (CH3)4Si. (britannica.com)
3. B.L. Silver and Z. Luz, Rates and mechanisms of protolysis of trimethyl-phosphonium ion in aqueous solution studied by proton magnetic resonance. (weizmann.ac.il)
20. Z. Luz and R.G. Shulman, Proton magnetic resonance shifts in aqueous solutions of paramagnetic metal ions. (weizmann.ac.il)

Co-authors outside our institution contributed by applying single-nanocrystal spectroscopy and performing NMR, FTIR, STM and dynamic light-scattering measurements. (fzu.cz)
Numerous studies are under way to identify specific imaging markers for different types of dementia, including cerebral volumetric measurements, diffusion imaging, spectroscopy, very-high-field MRI scans of senile plaques, and PET scan markers of senile plaques. (medscape.com)

Functional magnetic resonance spectroscopy of the brain (fMRS) uses magnetic resonance imaging (MRI) to study brain metabolism during brain activation. (wikipedia.org)
Therefore, it is sometimes referred to as dynamic MRS, event-related MRS or time-resolved MRS. A novel variant of fMRS is functional diffusion-weighted spectroscopy (fDWS) which measures diffusion properties of brain metabolites upon brain activation. (wikipedia.org)
In single-voxel fMRS the selection of the volume of interest (VOI) is often done by running a functional magnetic resonance imaging (fMRI) study prior to fMRS to localize the brain region activated by the task. (wikipedia.org)
Magnetic resonance spectroscopies based on inductive detection are powerful and versatile techniques that can provide atomic-level structural and functional information about a wide range of samples under broadly variable conditions. (nist.gov)
Summary/conclusions Modalities of measuring physiological change after SRC were categorised into the following: functional MRI, diffusion tensor imaging, magnetic resonance spectroscopy, cerebral blood flow, electrophysiology, heart rate, exercise, fluid biomarkers and transcranial magnetic stimulation. (bmj.com)
There is accumulating research, however, that shows promise for the future clinical application of functional magnetic resonance imaging in sport concussion assessment and management. (bmj.com)
Herein we report on a pilot study involving twelve participants with ALS and nine age-matched healthy controls who underwent high-resolution resting state functional magnetic resonance imaging at an ultra-high field of 7 Tesla. (biorxiv.org)
A variety of imaging modalities, including structural and functional magnetic resonance imaging (MRI) and positron emission tomography (PET) studies of cerebral metabolism, have shown characteristic changes in the brain of patients with Alzheimer disease in prodromal and even presymptomatic states. (medscape.com)

Neutron Spin-Echo spectroscopy (NSE) on the other hand, offers the highest energy resolution in the field of neutron spectroscopy and allows the study of slow collective motions in proteins up to several hundred nanoseconds and in the nanometer length-scale. (lu.se)

Lastly, Hartmut Michel summarized the three most impactful methods in the field - X-ray crystallography, NMR spectroscopy, and cryo-EM - and their integral role in the development of new drugs. (lindau-nobel.org)

Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps . (cdc.gov)
As single-active site catalysts, homogeneous catalysts have the advantage of being well defined on a molecular level and readily soluble in the reaction medium. (nature.com)
We have employed a multidimensional approach involving electronic absorption, S and Cu K-edge XAS, EPR, and resonance Raman spectroscopies together with QM/MM computational analysis to examine the relationships between structure and molecular mechanism in this reaction. (stanford.edu)
Second-tier imaging with molecular methods, preferably with fluorodeoxyglucose positron emission tomography (FDG-PET) (or single-photon emission CT [SPECT] if PET is unavailable), can provide greater diagnostic specificity. (medscape.com)
We cannot admit students with a predominantly biological or biochemical educational background, unless this is supplemented with several university-level courses in mathematics (analysis, linear algebra) and physical chemistry (thermodynamics, statistical mechanics, molecular spectroscopy). (lu.se)
Advanced (4th year) courses are offered in biophysical chemistry and molecular spectroscopy (including quantum mechanics). (lu.se)

In adults, noninvasive chemical shift encoded Cartesian magnetic resonance imaging (MRI) and single-voxel magnetic resonance (MR) spectroscopy (SVS) accurately quantify hepatic steatosis but require breath-holding. (springer.com)
For the metabolic group all the patients affected from hepatic encephalopathy diagnosed by clinical examination, blood cell count, biochemical panel, AmmoniaCheck (Menarini) determination and optional hystopatology of the liver and, finally, a large group of patients who had normal spectroscopy. (lacittadina.org)
CPS I is the most plentiful single protein in hepatic mitochondria, accounting for about 20% of the matrix protein. (medscape.com)

Axial, T2-weighted magnetic resonance imaging (MRI) scan reveals atrophic changes within bilateral temporal lobes with prominence of the sylvian fissures. (medscape.com)

NMR targets magnetic nuclei by aligning them with an applied constant magnetic field and perturbing this alignment using an alternating magnetic field. (edu.au)

Recently, 1 H-magnetic resonance spectroscopy chemical shift imaging (CSI) using choline/creatine (Cho/Cr) or choline/N-acetylaspartate (Cho/NAA) ratios has emerged as a new non-invasive, widely available alternative. (bmj.com)
Magnetic resonance imaging revealed extradural spinal cord compression at the ventral right aspect of the intervertebral disk space L3-4. (avma.org)
Marcel's main focus lies on the integration of microfluidic lab-on-a-chip technology with NMR spectroscopy and imaging. (southampton.ac.uk)
Coronal, T1-weighted magnetic resonance imaging (MRI) scan in a patient with moderate Alzheimer disease. (medscape.com)

An Overview of NQR Signal Detection Algorithms , Magnetic Resonance Detection of Explosives and Illicit Materials (NATO Science for Peace and Security Series B: Physics and Biophysics), 2014. (lu.se)

Marcel Utz is Professor of Magnetic Resonance, Microfluidics, and Complex Materials within Chemistry at the University of Southampton. (southampton.ac.uk)
He currently heads the section of Magnetic Resonance within the School of Chemistry. (southampton.ac.uk)
NMR Spectroscopy is one of the most important and powerful techniques used in organic chemistry for structural elucidation of Organic (and inorganic) compounds and biomacromolecules. (chemistrywithwiley.com)

Researchers have used the nitrogen-vacancy (NV) center inside a single nanodiamond for quantum sensing to overcome the problem of random particle rotation. (phys.org)
A proton is charged particle and it spins due to which a magnetic field is produced giving rise to a magnetic movement 'μ' the direction of μ will be along the axis of spin, depending on whether the spin is clockwise or anticlockwise (the spin quantum number is + ½ or - ½ respectively). (chemistrywithwiley.com)

A New Strategy for the Preparation of Peptide-Targeted Radiopharmaceuticals Based on an Fmoc-Lysine-Derived Single Amino Acid Chelate (SAAC). (syr.edu)
Dive into the research topics of 'A New Strategy for the Preparation of Peptide-Targeted Radiopharmaceuticals Based on an Fmoc-Lysine-Derived Single Amino Acid Chelate (SAAC). (syr.edu)

Due to differences in modalities, time course, study design and outcomes, it is not possible to define a single 'physiological time window' for SRC recovery. (bmj.com)

Random motion is averaged out in single-molecule approaches like cryo-EM and causes unwanted artifacts. (lindau-nobel.org)
However, he mentioned that new single-molecule techniques are being created that eliminate such artifacts. (lindau-nobel.org)
The intramolecular magnetic field around an atom in a molecule changes the resonance frequency, thus giving access to details of the electronic structure of the molecule and its individual functioning groups. (edu.au)

Methods Thirty-two patients with DIG were examined with single-slice CSI on a 3 T MRI and MET-PET. (bmj.com)
The images produced by spectroscopy have also proved useful in the planning of radiotherapy treatment plans for brain and of course for the assessment of the potential damage caused by radiation therapy in the follow-up of patients who underwent a brain radiosurgery. (lacittadina.org)
Several single gene disorders share clinical and radiologic characteristics with multiple sclerosis and have the potential to be overlooked in the differential diagnostic evaluation of both adult and paediatric patients with multiple sclerosis. (medscape.com)

Moreover, single crystals suitable for X-ray diffraction analysis were grown, and the structure of 1 solved with the help of Dr. Victor W. Day. (ku.edu)

In recent years, the prerequisites were established for conventional pulse NMR on single crystals under UHV conditions to be carried out successfully along with the use of highly polarized xenon. (uni-marburg.de)

Multi-voxel spectroscopy usually is performed when the specific volume of interest is not known or it is important to study metabolite dynamics in a larger brain region. (wikipedia.org)
Xe-129 NMR Study on Xenon Monolayers and Thin Films Adsorbed on Single Crystal Metals and Carbonaceous Ad-Layers by: Kraft, Lars P. (uni-marburg.de)

transcranial magnetic stimulation (TMS), technique based on electromagnetic induction that is used to stimulate neurons in the brain cortex (the outer layer of brain tissue, or gray matter). (britannica.com)

In this work, a new divergent synthetic route was developed, in which known synthetic steps were strategically assembled to provide straightforward access to a small family of [Cp*Rh] complexes bearing a single substituent at the 4-position of the bpy ligand. (ku.edu)

My work aims to develop a highly sensitive magnetic spectroscopy device used to interrogate metabolism in single cells. (sloankettering.edu)

To balance the need for temporal resolution and sufficient SNR, fMRS requires a high magnetic field strength (1.5 T and above). (wikipedia.org)
Multi-voxel spectroscopy provides information about group of voxels and data can be presented in 2D or 3D images, but it requires longer acquisition times and therefore temporal resolution is decreased. (wikipedia.org)

2) If the spin is such that the magnetic field, produced by the proton is in the opposite direction as the external magnetic field (opposing orientation) then the energy of the system is increased and the system is unstable [E = + μH), '+ ve sign' indicates higher energy system. (chemistrywithwiley.com)
When a spinning proton is placed in an external magnetic field then the axis of spin inscribes a circular path about the axis of the external magnetic field and such a motion is called Larmor'sprecessional motion . (chemistrywithwiley.com)

It boasts a magnetic field in excess of 600,000 times that of the Earth's magnetic field. (edu.au)
1) If the spin is such that the magnetic field (aligned orientation) then the energy of the system is lowered and the system is stable. (chemistrywithwiley.com)
g' factor is essentially a measure of the ratio between frequency and magnetic field. (chemistrywithwiley.com)
If the magnetic field is applied along the z-direction, the g-value is designated as g11. (chemistrywithwiley.com)

These results might promote the development of heterogeneous catalysts with molecularly defined single active sites exhibiting a comparable activity to homogeneous catalysts. (nature.com)

Bioassay-guided fractionation was employed to isolate the chemoattractant, yielding a single pure, fully active compound after reversed-phase and size-exclusion high-performance liquid chromatography. (biologists.com)

Different corticosteroid regimens (single-day high dose pulse vs multiple lower doses) may contribute to the discrepant results of prior studies. (cdc.gov)

An analysis that might take days on a smaller NMR takes just a single day, speeding up the rate of discovery. (edu.au)

They contain a short beta hairpin and an alpha helix (beta/beta/alpha structure), where a single zinc atom is held in place by Cys(2)His(2) (C2H2) residues in a tetrahedral array. (embl.de)

Anatomy18

Organisms5

Diseases21

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment66

Psychiatry and Psychology7

Phenomena and Processes46

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20231

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