Currently, the development of antiviral agents targeting host proteins to combat viral infection has received great attention. (bvsalud.org)
Nucleotide1
MxA transcripts with distinct first exons and modulation of gene expression levels by single-nucleotide polymorphisms in human bronchial epithelial cells. (edu.au)
Interferon12
Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR. (ox.ac.uk)
Interferon stimulates the expression of a number of genes encoding enzymes with antiviral activities, including myxovirus resistance-1 (MxA), 2-5-oligoadenylate synthetase 1 (OAS-1) and double-stranded RNA-dependent protein kinase (PKR). (ox.ac.uk)
Polymorphisms in the interferon-induced genes, MxA, OAS-1 and PKR appear thus associated with HCV outcome. (ox.ac.uk)
Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene. (wikipedia.org)
In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. (wikipedia.org)
Genes related to T cell activation, cytotoxic cell-mediated (or type 1) immunity, B cell growth and differentiation, pathogen recognition, myeloid cell function, type I interferon pathway activation, and leukocyte recruitment were found expressed at different levels in most or all MS brain immune infiltrates. (biomedcentral.com)
Comparison of data obtained in meningeal and white matter infiltrates revealed higher expression of genes related to interferonγ production, B cell differentiation, cell proliferation, lipid antigen presentation, and T cell and myeloid cell recruitment, as well as more widespread EBV infection in the meningeal samples. (biomedcentral.com)
Multivariate analysis grouped genes expressed in meningeal and white matter immune infiltrates into artificial factors that were characterized primarily by genes involved in type 1 immunity effector mechanisms and type I interferon pathway activation. (biomedcentral.com)
An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA . (lookformedical.com)
It functions as a transcriptional activator for the INTERFERON TYPE I genes. (lookformedical.com)
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression . (lookformedical.com)
IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence. (lookformedical.com)
Influenza1
Explanation: Influenza is not an autoimmune disorder as it is caused by a virus, Myxovirus Influenzae . (sanfoundry.com)
Differentiation-associated1
Analysis of anti-melanoma differentiation-associated gene 5 antibody in Hong Kong Chinese patients with idiopathic inflammatory myopathies: diagnostic utility and clinical correlations. (cdc.gov)
Polymorphisms1
We examined whether polymorphisms in these genes influenced the outcome of hepatitis C virus (HCV) infection. (ox.ac.uk)
Inhibit1
They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. (lookformedical.com)
Recombinant3
In this work, we applied the recombinant cytolethal distending toxin (CDT) holotoxin and cdt-deficient mutants to assess whether CDT interacted with TJ proteins of airway tract cells. (bvsalud.org)
Description: Epigen Recombinant Human produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 72 amino acids and having a molecular mass of 7.9 kDa. (tuberculosisdrugresearch.org)
Regulation1
In addition, the erythrocytes generated an antiviral immune gene activation after PRV infection, with significant up-regulation of IFN-α, RIG-I, Mx and PKR transcripts. (biomedcentral.com)
Binds1
PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA , and activates transcription. (lookformedical.com)
Lytic2
Enhanced PCR-based methods were used to investigate expression of 75 immune-related genes and 6 EBV genes associated with latent and lytic infection. (biomedcentral.com)
EBV genes were detected in brain samples from 9 of 11 MS patients with expression patterns suggestive of in situ activation of latent infection and, less frequently, entry into the lytic cycle. (biomedcentral.com)
CRISPR2
Overexpression of OCLN in target cells made them more susceptible to G. parasuis adhesion, whereas ablation of OCLN expression by CRISPR/Cas 9 gene editing technology in target cells decreased their susceptibility to bacterial adhesion. (bvsalud.org)
Abstract Background and Aim: We previously developed the gene-editing by electroporation (EP) of Cas9 protein method, in which the CRISPR/Cas9 system was introduced into porcine in vitro fertilized (IVF) zygotes through EP to disrupt a target gene. (edu.vn)
Cellular1
To test this hypothesis, we analyzed expression of viral and cellular genes in brain-infiltrating immune cells. (biomedcentral.com)
Inflammatory2
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. (lookformedical.com)
Theoretically, the possibilities include (1) a primary T-cell mediated autoimmune response causing muscle damage, (2) a primary degenerative process involving abnormal protein processing leading to a secondary inflammatory response, and (3) separate and independent immune and degenerative processes caused by an external trigger. (medscape.com)
INTERFERONS1
Introduction Myxovirus resistance protein 1 (Mx1) is a type I/III interferons-induced protein conferring the hosts an antiviral property against several viruses. (edu.vn)
Genetic1
Currently, CPV-2 is classified into CPV-2a, CPV-2b and CPV-2c based on genetic variation in the VP2 gene. (edu.vn)
Kinase1
In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)
Activation1
Simultaneous Inhibition of ALK2 and ALK3 Down-Regulates the BMP Pathway and Sets off the Activation of Genes Feature for Articular Cartilage in Adult Individual MSCs. (bakingandbakingscience.com)
Amino1
The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. (wikipedia.org)
Antibody1
The plant-orange matter is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. (worldcarecouncil.org)
Epithelial cells1
Our results indicated that CDT induced the TJ occludin (OCLN) expression in newborn pig tracheal epithelial cells within the first 3 hours of bacterial infection, followed by a significant decrease. (bvsalud.org)
Viruses1
The heat shock protein 90 (HSP90) is a critical host factor and has important regulatory effects on the infection of various viruses. (bvsalud.org)
Infection1
The results showed that the knockdown of HSP90AB1 and HSP90 inhibitor VER-82576 treatment resulted in a reduction in TGEV M gene mRNA levels, the N protein level, and virus titers in a dose-dependent manner, while the knockdown of HSP90AA1 and KW-2478 treatment had no significant effect on TGEV infection. (bvsalud.org)
Activity1
Here, Biobran's anti-SARS-CoV-2 activity was assessed using MTT and plaque reduction assays, RT-PCR, ELISA techniques, and measurements of SARS-CoV-2-related gene expression and protein levels. (biobran.org)
Clinical1
These two important mechanisms of approaching cancer, principally through the clinical application of the P53 tumor suppressor gene and other apoptotic players that for the past 15 years have been included in my cancer strategy as a diagnostic, prognosis, and follow up treatment. (biobran.org)
Cell1
In the last years higher attention focused on the role of immunoregulation both in the insulin production by β-cell of Langerhans-islets and in the insulin sensitivity (resistance) of insulin receptors. (biobran.org)
Type2
Abstract Canine parvovirus type 2 (CPV-2) is a small, single-stranded DNA virus causing fatal haemorrhagic enteritis in dogs. (edu.vn)
To characterize the type from the hMSC-derived cartilaginous tissue attained by GNAS treatment with the various compounds, gene-expression adjustments of the -panel of transient or articular cartilage personal genes were assessed by quantitative RT-PCR. (bakingandbakingscience.com)
Higher1
In summary, highly virulent G. parasuis strain SC1401 stimulated the tight junction expression, resulting in higher bacterial adhesion to respiratory tract cells, and this process is closely related to CDT. (bvsalud.org)
Control2
Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS . (lookformedical.com)
binding to ALK1 being a mechanism involved with this model (Fig. S1and and and and 0.05) in expression weighed against the control. (bakingandbakingscience.com)
Wide1
Proteins secreted by vertebrate cells in response to a wide variety of inducers. (lookformedical.com)
Treatment1
Expression of s-IBM is variable, but all cases eventually evolve into a syndrome of diffuse, progressive, asymmetric, proximal, and distal weakness that is generally refractory to immunosuppressive treatment. (medscape.com)