• symptoms
  • Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness during treatment with simvastatin or similar medications, especially if these symptoms are accompanied by fever or dark colored urine. (drugs.com)
  • significantly
  • Combining these medications may significantly increase the blood levels of simvastatin. (drugs.com)
  • Grapefruit juice can significantly increase the blood levels of simvastatin. (drugs.com)
  • We observed that simvastatin stimulation of rat BMSCs resulted in significantly increased expression of endothelial-specific genes and proteins, including von Willebrand factor (vWF), CD31, vascular endothelial-cadherin (VE-cadherin), vascular endothelial growth factor receptor-2 (VEGFR2, Flk-1), and VEGF receptor 1 (VEGFR-1, Flt-1). (mendeley.com)
  • Simvastatin also significantly increased capillary tubelike formation of the BMSCs. (mendeley.com)
  • risk
  • The primary uses of simvastatin are to treat dyslipidemia and to prevent atherosclerosis-related complications such as stroke and heart attacks in those who are at high risk. (wikipedia.org)
  • In people with both high cholesterol levels and heart disease, simvastatin has been effective in reducing the risk of heart attack and deter the need for bypass surgery and angioplasty. (fsu.edu)
  • The molecules we are measuring are thought to be important in the development of Alzheimer's disease (AD), and we are testing whether simvastatin can change proteins to a level that is associated with a reduced risk for AD. (bioportfolio.com)
  • years
  • after a few months I have found the culprit: it was simvastatin (called "Lipex" in New Zealand), which my GP had prescribed me 2 years beforehand to control my cholesterol level. (medhelp.org)
  • effect
  • Overall, there is insufficient evidence to conclude that simvastatin has an effect in delaying the onset and progression of AMD. (wikipedia.org)
  • Simvastatin: No tumorigenic effect was seen in a 72-week carcinogenicity study using mice at the low dose levels. (wikipedia.org)
  • Therefore, we examined the effect of simvastatin on BMSC differentiation into endothelial cells and the underlying mechanisms involved in this process. (mendeley.com)
  • Data
  • These data suggest that simvastatin induces rat BMSCs differentiation into endothelial cells via a Notch signaling pathway. (mendeley.com)
  • evidence
  • Simvastatin: While animal studies failed to reveal evidence of teratogenicity, animal studies with other HMG-CoA reductase inhibitors revealed an increase in the incidence of skeletal malformations. (drugs.com)