• endothelial
  • Xu J, Liu X, Chen J, Zacharek A, Cui X, Savant-Bhonsale S, Liu Z, Chopp M. Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway. (mendeley.com)
  • Therefore, we examined the effect of simvastatin on BMSC differentiation into endothelial cells and the underlying mechanisms involved in this process. (mendeley.com)
  • We observed that simvastatin stimulation of rat BMSCs resulted in significantly increased expression of endothelial-specific genes and proteins, including von Willebrand factor (vWF), CD31, vascular endothelial-cadherin (VE-cadherin), vascular endothelial growth factor receptor-2 (VEGFR2, Flk-1), and VEGF receptor 1 (VEGFR-1, Flt-1). (mendeley.com)
  • These data suggest that simvastatin induces rat BMSCs differentiation into endothelial cells via a Notch signaling pathway. (mendeley.com)
  • liver
  • Simvastatin is contraindicated with pregnancy, breastfeeding, and liver disease. (wikipedia.org)
  • He or she may want to conduct basic liver function labs taken to make sure that you are not having any damage to your liver from the simvastatin. (zocdoc.com)
  • participants
  • Results from one trial showed participants assigned to simvastatin had lower odds (0.51 OR) of having AMD progression at three years compared to those assigned to placebo, though the results were not significant. (wikipedia.org)
  • Participants will be randomly assigned to Placebo or Simvastatin. (bioportfolio.com)
  • risk
  • The primary uses of simvastatin are to treat dyslipidemia and to prevent atherosclerosis-related complications such as stroke and heart attacks in those who are at high risk. (wikipedia.org)
  • The Heart Protection Study evaluated the effects of simvastatin in people with risk factors including existing cardiovascular disease, diabetes, or stroke but having relatively low LDL cholesterol. (wikipedia.org)
  • In people with both high cholesterol levels and heart disease, simvastatin has been effective in reducing the risk of heart attack and deter the need for bypass surgery and angioplasty. (fsu.edu)
  • The molecules we are measuring are thought to be important in the development of Alzheimer's disease (AD), and we are testing whether simvastatin can change proteins to a level that is associated with a reduced risk for AD. (bioportfolio.com)
  • levels
  • Simvastatin: No tumorigenic effect was seen in a 72-week carcinogenicity study using mice at the low dose levels. (wikipedia.org)
  • I have thought perhaps that simvastatin has affected my hormone levels but can't find anything conclusive on the internet. (zocdoc.com)
  • years
  • after a few months I have found the culprit: it was simvastatin (called "Lipex" in New Zealand), which my GP had prescribed me 2 years beforehand to control my cholesterol level. (medhelp.org)
  • effect
  • Overall, there is insufficient evidence to conclude that simvastatin has an effect in delaying the onset and progression of AMD. (wikipedia.org)