The aim of this study was to investigate, and compare with pravastatin and simvastatin, the tissue-specific distribution of rosuvastatin. (aspetjournals.org)
Bolus intravenous doses (5 mg/kg) of radiolabeled rosuvastatin, pravastatin, and simvastatin were administered to rats, and initial uptake clearance (CL uptake ) in various tissues was calculated. (aspetjournals.org)
0.001) larger than that of pravastatin (0.703 ml/min/g tissue), and rosuvastatin was taken up by the hepatic cells more selectively and efficiently than pravastatin. (aspetjournals.org)
However, adrenal CL uptake of simvastatin (1.55 ml/min/g tissue) was larger than hepatic CL uptake , and simvastatin was distributed to other tissues more easily than rosuvastatin. (aspetjournals.org)
After administration of rosuvastatin and pravastatin, silver grains were distributed selectively in the intracellular space of the liver, but more rosuvastatin (3.3 ± 1.0 × 10 5 particles/mm 2 ) than pravastatin (2.0 ± 0.3 × 10 5 particles/mm 2 ) tended to distribute to the liver. (aspetjournals.org)
The results of this study indicated that rosuvastatin was taken up by hepatic cells more selectively and more efficiently than pravastatin and simvastatin. (aspetjournals.org)
14 C]Rosuvastatin (1.15 MBq/mg), [ 14 C]pravastatin (1.17 MBq/mg), and [ 14 C]simvastatin (1.85 MBq/mg) were synthesized at Shionogi and Co., Ltd. (Osaka, Japan). (aspetjournals.org)
14 C]Rosuvastatin and [ 14 C]pravastatin were dissolved in physiological saline. (aspetjournals.org)
Using the search terms atorvastatin, simvastatin,pravastatin, rosuvastatin, fluvastatin, lovastatin, prospective trial, and randomized trial, the MEDLINE/EMBASE and the Cochrane Collaboration databases were reviewed for prospective randomized primary and secondary prevention trials of statin monotherapy. (unboundmedicine.com)
Other variants of the drug include fluvastatin (Lescol), pravastatin (Lipostat), rosuvastatin (Crestor) and simvastatin (Zocor). (express.co.uk)
atorvastatin) even though both of simvastatin and pravastatin could activate mevalonate pathways, suggesting the statin-mediated antiproliferative effects depended on non-mevalonate pathway. (nih.gov)
Like other members of its class (the "statins"), simvastatin lowers total serum cholesterol and particularly low density lipoprotein (LDL) cholesterol concentrations, thereby reducing the risk of atherosclerosis and its complications - myocardial infarction and stroke. (nih.gov)
Pravastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). (safemedication.com)
John Albers and colleagues compared the effects of two commercially used statins, simvastatin and pravastatin, on two different types of brain cells, neurons and astrocytes (support cells that help repair damage). (sciencedaily.com)
Statin3
Describe the relevance of the finding that simvastatin, but not pravastatin, seems to interfere with sleep quality and increase patient-reported sleep problems to clinicians in the care of their patients receiving statin therapy. (medscape.org)
Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)
Combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. (wikipedia.org)
Zocor1
Simvastatin is available generic forms and under the commercial name of Zocor in tablets of 5, 10, 20, 40 and 80 mg. the recommended dose is 5 to 80 mg daily based upon tolerability and lipid levels. (nih.gov)
Ezetimibe1
Simvastatin is also available as a fixed combination with ezetimibe under the brand name Vytorin. (nih.gov)
Hepatic3
Simvastatin (sim" va stat' in) is an orally available inhibitor of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the major rate-limiting enzyme in cholesterol synthesis. (nih.gov)
Coadministration with these agents may cause increases in simvastatin levels and potentiate its hepatic or muscle toxicity. (nih.gov)
Myopathy1
Simvastatin and Pravastatin: Concomitant use results in increased concentrations and increased risk of simvastatin or pravastatin-related myopathy. (globenewswire.com)
Cyclosporine1
Use of simvastatin is contraindicated in medications that are strong inhibitors of cytochrome P450 activity (such as cyclosporine, ketoconazole, diltiazem, ciprofloxacin or amiodarone), and dose adjustments are appropriate for its use with other agents that inhibit CYP 3A4. (nih.gov)
Doses1
ALT elevations are clearly more frequent in patients taking higher doses of simvastatin (40 and 80 mg daily). (nih.gov)
Medicines1
The class is on the World Health Organization's List of Essential Medicines with simvastatin being the listed medicine. (wikipedia.org)
Lipoprotein1
Pravastatin is also used to reduce the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. (safemedication.com)
Liver5
Simvastatin was less liver-specific (it also distributed to the spleen and adrenal). (aspetjournals.org)
Rare cases of acute liver failure and death have been attributed to simvastatin. (nih.gov)
But in view of the wide use of simvastatin, clinically apparent liver injury is exceeding rare and is estimated to occur in 1 per 100,000 patient years of exposure. (nih.gov)
Simvastatin is metabolized to some extent in the liver (via CYP 3A4) and is excreted in bile. (nih.gov)
Risk3
Current indications for simvastatin are hypercholesterolemia and reduction in risk for death from coronary, cerebrovascular and peripheral artery disease in patients with these diseases. (nih.gov)
Det europeiske legemiddelkontorets komité for legemiddelovervåking - PRAC (Pharmacovigilance Risk Assessment Committe), utarbeider en rekke anbefalinger til oppdatering av produktinformasjon og regulatoriske tiltak som følge av signalutredning. (legemiddelverket.no)
Pravastatin is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. (safemedication.com)
Therapy2
Up to 5% of patients taking simvastatin chronically may experience minor elevations in serum ALT levels during therapy, but confirmed elevations to above three times the upper limit of normal (ULN) occur in only 1% to 2% of patients. (nih.gov)
Isolated cases of an autoimmune hepatitis-like syndrome associated with simvastatin therapy have been reported, some of which did not reverse completely with discontinuation, resulting in a chronic hepatitis requiring long term immunosuppressive therapy. (nih.gov)
Effects2
Additionally, the use of simvastatin plus classII histone deacetylase (HDAC) inhibitor (MC1568) induced further overexpression of p27(KIP1) by inhibiting HDAC5 induction originated from downregulated EZH2 in CRC cells and synergistically led to considerable antiproliferative effects. (nih.gov)
Our results show that HMGR inhibition by simvastatin induces anxiogenic-like effects in the social interaction but not in the elevated plus-maze test, and improves memory consolidation in the inhibitory avoidance task. (nature.com)
Patients1
In several studies, ALT elevations were no more frequent in patients taking 10 and 20 mg of simvastatin daily than in placebo recipients. (nih.gov)
BLOOD1
Lowering your blood level of cholesterol and fats with pravastatin has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks. (safemedication.com)
Expression1
pravastatin also increased the expression of another Alzheimer's hallmark, amyloid precursor protein (APP). (sciencedaily.com)
Atorvastatin7
Studies compared the multiple-dose pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with 4 inhibitors of cytochrome P450-3A4 isoenzymes in healthy subjects. (nih.gov)
0.001) increased the AUC (and C(max)) of all 3 statins, most markedly simvastatin ( approximately 10-fold increase in AUC) and simvastatin acid (12-fold), followed by atorvastatin (greater than fourfold) and then pravastatin (almost twofold). (nih.gov)
Pravastatin has a neutral drug interaction profile relative to cytochrome P450-3A4 inhibitors, but these substrates markedly increase systemic exposure to simvastatin and atorvastatin. (nih.gov)
Finland's national health database allowed detailed analysis so that decreased risk of death could be calculated by the type of statin taken: including simvastatin (HR, 0.47), atorvastatin (HR, 0.27), fluvastatin (HR, 0.35), and pravastatin (HR, 0.50). (naturalmedicinejournal.com)
While this has been shown to hold true for simvastatin (FloLipid, Zocor), lovastatin (Altoprev), and atorvastatin (Lipitor), grapefruit juice is not associated with higher blood concentrations of pravastatin (Pravachol), which is why it's sometimes viewed as the safest statin (Fukazawa, 2004). (ro.co)
Certain lipid-lowering drugs, such as the 'statins' - lovastatin, simvastatin, pravastatin - and gemfibrozil as well as oral agents which lower blood sugar, such as tolazamide and glyburide, cause a decrease in serum levels of coenzyme Q10 and reduce the effects of coenzyme Q10 supplementation (7,8). (wanderings.net)
Rosuvastatin and pravastatin3
After administration of rosuvastatin and pravastatin, silver grains were distributed selectively in the intracellular space of the liver, but more rosuvastatin (3.3 ± 1.0 × 10 5 particles/mm 2 ) than pravastatin (2.0 ± 0.3 × 10 5 particles/mm 2 ) tended to distribute to the liver. (aspetjournals.org)
Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta. (bvsalud.org)
We performed functional experiments using primary human umbilical vein endothelial cells , trophoblast cells and preterm preeclamptic placental explants to assess the affect of simvastatin , rosuvastatin and pravastatin on sFlt-1 and sENG secretion and compared the relative potency of each statin at reducing these factors ( Inhibitory Concentration 50 ). (bvsalud.org)
A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents. (cdc.gov)
Decreases1
Pravastatin decreases placental secretion of sFlt-1 in vitro and is currently being examined in clinical trials as a potential treatment for preeclampsia . (bvsalud.org)
Dose1
2011, the US Food and Drug Administration (FDA) issued a drug safety communication on the 80-mg dose of simvastatin because of an increased risk for muscle toxicity. (saratoga.com)
The class is on the World Health Organization's List of Essential Medicines with simvastatin being the listed medicine. (wikipedia.org)
Cells2
Simvastatin was the most potent inhibitor of sFlt-1 secretion from endothelial cells (IC 50 3.2 µM), trophoblast cells (IC 50 61.4 µM) and placental explants. (bvsalud.org)
Simvastatin may be a more potent inhibitor of sFlt-1 secretion from endothelial cells , trophoblast cells and placenta from women with preterm preeclampsia than either pravastatin or rosuvastatin . (bvsalud.org)