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beta-Crystallin A Chaingamma-CrystallinsCrystallinsLens, Crystallinebeta-Crystallin B Chainbeta-Crystallinsalpha-Crystallinsalpha-Crystallin A ChainCataractalpha-Crystallin B ChainMolecular Sequence DataAmino Acid Sequencedelta-CrystallinsLens Nucleus, CrystallineOctopodiformesBase SequenceElectrophoresis, Gel, Two-DimensionalCattleInterleukin-1betaProto-Oncogene Proteins c-mafSequence Homology, Amino AcidElectrophoresis, Polyacrylamide GelEye ProteinsChromatography, GelSolubilityAgingSequence Alignmentbeta 2-MicroglobulinMolecular ChaperonesCloning, MolecularProtein DenaturationDeaminationCircular DichroismArgininosuccinate LyaseRNA, MessengerRecombinant ProteinsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationScattering, RadiationModels, Molecular

ProteinsLensGreekAlphaMammalianVertebrateStructuralHomologousAcidicPeptideProteinSequenceHighMajorClassesMouse

Proteins4

• The domains share high similarity with other crystallin proteins. (wikipedia.org)
• Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. (lookformedical.com)
• The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits. (lookformedical.com)
• Structural analysis of the rate-limiting transition states in the folding of Im7 and Im9: similarities and differences in the folding of homologous proteins. (shengsci.com)

Lens2

• A subclass of crystallins that found in the lens (LENS, CRYSTALLINE) of VERTEBRATES. (lookformedical.com)
• A class of crystallins that provides refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. (lookformedical.com)

Greek1

• Gamma-crystallins are similar in structure to BETA-CRYSTALLINS in that they both form into a Greek key-like structure. (lookformedical.com)

Alpha4

• [5] [6] The propeptide region has an open-sandwich antiparallel-alpha/antiparallel-beta fold, with two alpha-helices and four beta-strands with a (beta/alpha/beta)x2 topology. (wikipedia.org)
• Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses. (lookformedical.com)
• One of the subunits of alpha-crystallins. (lookformedical.com)
• The transcription of the beta-globin genes in mouse erythroleukemia cells has been examined by hybridizing labeled RNA obtained from isolated nuclei after chain elongation in the presence of [alpha-32P]UTP. (shengsci.com)

Mammalian3

• 1. Sequence characterization of gamma-crystallins from lip shark (Chiloscyllium colax): existence of two cDNAs encoding gamma-crystallins of mammalian and teleostean classes. (nih.gov)
• 8. Characterization of gamma-crystallins from eye lenses of shark: closer structural similarity to mammalian than other piscine gamma-crystallins? (nih.gov)
• Previous attempts to crystallize mammalian γS-crystallin were unsuccessful. (nih.gov)

Vertebrate3

• 10. Sequence analysis of frog alpha-crystallin cDNA and its deduced primary structure: comparison of alpha A subunit chains among different vertebrate species. (nih.gov)
• 16. The protein sequence homology of gamma-crystallins among major vertebrate classes and their DNA sequence homology to heat-shock protein genes. (nih.gov)
• Crystallins are the dominant structural components of the vertebrate eye lens. (nih.gov)

Structural1

• 3. Characterization of gamma-crystallin from a catfish: structural characterization of one major isoform with high methionine by cDNA sequencing. (nih.gov)

Homologous1

• Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. (nih.gov)

Acidic2

• 13. Sequence analysis of four acidic beta-crystallin subunits of amphibian lenses: phylogenetic comparison between beta- and gamma-crystallins. (nih.gov)
• Alpha and beta families are further divided into acidic and basic groups. (nih.gov)

Peptide1

• Multiple binding sites overlap with those of the protective mini αA-crystallin chaperone MAC peptide. (bvsalud.org)

Protein1

• The top two drugs, closantel (C), an antihelminthic drug, and gambogic acid (G), a xanthonoid, attenuated thermal-induced protein unfolding and aggregation as shown by turbidimetry fluorescence spectroscopy dynamic light scattering and electron microscopy of human or mouse recombinant crystallins. (bvsalud.org)

Sequence5

• 6. Characterization of gamma-crystallins from a hybrid teleostean fish: multiplicity of isoforms as revealed by cDNA sequence analysis. (nih.gov)
• 9. Sequence analysis of one major basic beta-crystallin (beta Bp) of amphibian lenses: evolutionary comparison and phylogenetic relatedness between beta- and gamma-crystallins. (nih.gov)
• 12. Sequence analysis of frog rho-crystallin by cDNA cloning and sequencing: a member of the aldo-keto reductase family. (nih.gov)
• 15. Octopus S-crystallins with endogenous glutathione S-transferase (GST) activity: sequence comparison and evolutionary relationships with authentic GST enzymes. (nih.gov)
• 19. Facile cloning and sequence analysis of goose delta-crystallin gene based on polymerase chain reaction. (nih.gov)

High1

• 17. Carp gamma-crystallins with high methionine content: cloning and sequencing of the complementary DNA. (nih.gov)

Major1

• 18. The amino-terminal sequences of four major carp gamma-crystallin polypeptides and their homology with frog and calf gamma-crystallins. (nih.gov)

Classes1

• Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. (nih.gov)

Mouse1

• Induced transcription of the mouse beta-globin transcription unit in erythroleukemia cells. (shengsci.com)