Ecto-5'-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5'-monophosphate (AMP) to adenosine in nociceptive circuits. (biomedcentral.com)
Ecto-5'-nucleotidase (NT5E) is a glycosyl phosphatidylinositol (GPI)-anchored membrane protein that catalyzes the hydrolysis of extracellular AMP to adenosine [ 1 ]. (biomedcentral.com)
Thus, deficiencies in adenosine production or A 1 R signaling cause similar behavioral phenotypes. (biomedcentral.com)
Holmes AP, Nunes AR, Cann MJ, Kumar P. Ecto-5'-Nucleotidase, Adenosine and Transmembrane Adenylyl Cyclase Signalling Regulate Basal Carotid Body Chemoafferent Outflow and Establish the Sensitivity to Hypercapnia. (medscape.com)
Wolff G, Truse R, Decking U. Extracellular Adenosine Formation by Ecto-5'-Nucleotidase (CD73) Is No Essential Trigger for Early Phase Ischemic Preconditioning. (medscape.com)
ATP, released by cells, is rapidly metabolized by extracellular nucleotidases to adenosine, a potent signaling molecule that can activate several cell surface receptors to produce myriad effects on both parenchymal and immune cells throughout the body (Figure 1 ). (jci.org)
We found (i) a larger activity-dependent release of ATP and adenosine during the period of synaptogenesis in the hippocampus, (ii) a peak of expression of the ecto-5'-nucleotidase, the ratelimiting enzyme for the formation of adenosine from extracellular ATP in synapses during this critical period, and (iii) a peak of peri/post-synaptic expression of A2AR concomitant with the period of synaptogenesis. (sorbonne-universite.fr)
Since GABA exerts a similar function during development and GABA and adenosine are co-released at some synapses, I further investigated the interplay between these two pathways. (sorbonne-universite.fr)
CD73, also designated ecto-5′-nucleotidase (NT5E), is one kind of ecto-nucleotidase that plays a critical role in the catabolism of extracellular ATP to adenosine and the maintenance of immune homeostasis [ 1 , 2 ]. (biomedcentral.com)
Cytosolic2
Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (nih.gov)
The two cytosolic forms of the enzyme have similar characteristics, but can be differentiated on the basis of their preferential affinities for nucleotide substrates. (wikipedia.org)
NT5E2
Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5'-nucleotidase (CD73). (medscape.com)
Ecto-5' -Nucleotidase CD73 (NT5E), vitamin D receptor and FGF23 gene polymorphisms may play a role in the development of calcific uremic arteriolopathy in dialysis patients - Data from the German Calciphylaxis Registry. (cdc.gov)
Pyrimidine6
The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. (nih.gov)
A) in NT5C3A associated with hereditary pyrimidine 5'-nucleotidase deficiency: two cases report and literature review]. (nih.gov)
A New Homozygous Mutation (c.393-394del TA/c.393-394del TA) in the NT5C3 Gene Associated With Pyrimidine-5'-Nucleotidase Deficiency: A Case Report. (nih.gov)
The intracellular pyrimidine 5'-nucleotidase NT5C3A is a negative epigenetic factor in interferon and cytokine signaling. (nih.gov)
Numerous studies have shown that erythrocyte pyrimidine 5′-nucleotidase activity is significantly lowered in patients with lead poisoning, and that pyrimidine 5′-nucleotidase activity can be used as an index of lead poisoning. (wikipedia.org)
This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. (nih.gov)
In addition to AST and ALT, alkaline phosphatase , 5' nucleotidase, and gamma-glutamyl transpeptidase (GGT) are a few of the other enzymes located in the liver. (medicinenet.com)
Given the widespread occurrence of NADases and their prominent role in microbial infection mechanisms we wondered whether pathogenic fungi may also produce similar enzymes. (nature.com)
However, if the above scenario for the evolutionary replacement of RNA enzymes by protein enzymes is correct, why did a similar replacement not occur with cosubstrates? (heresy.is)
Extracellular1
One of the soluble forms appears to be derived from the GPI-anchored ex-5'-nucleotidase and has an extracellular location. (wikipedia.org)
Protein1
SVEVs isolated from lyophilized venoms collected from four different species of snakes ( Agkistrodon contortrix contortrix , Crotalus atrox , Crotalus viridis and Crotalus cerberus oreganus ) were analyzed by mass spectrometry-based proteomic, which allowed the identification of proteins belonging to eight main functional protein classes such as SVMPs, serine proteinases, PLA 2 , LAAO, 5′nucleotidase, C-type lectin, CRISP and Disintegrin. (nature.com)
Deficiency7
To diagnose 5-nucleotidase deficiency syndrome, doctors may perform blood and urine tests to measure the levels of purines and their byproducts. (mellaly.com)
There is no cure for 5-nucleotidase deficiency syndrome, but there are treatments that can help manage symptoms and prevent complications. (mellaly.com)
Scientists have tested gene therapy in animal models of 5-nucleotidase deficiency syndrome and are now exploring the safety and efficacy of the technique in clinical trials. (mellaly.com)
Precision medicine, which uses genetic and molecular data to personalize healthcare, may also play a role in the future treatment of 5-nucleotidase deficiency syndrome. (mellaly.com)
Living with 5-nucleotidase deficiency syndrome can be challenging, especially for those with severe symptoms. (mellaly.com)
Patient support groups and resources can also provide valuable information and emotional support for those affected by 5-nucleotidase deficiency syndrome. (mellaly.com)
Patients with 5-nucleotidase deficiency syndrome can benefit from healthy lifestyle habits and patient support groups to manage their symptoms and improve their overall well-being. (mellaly.com)
Endothelial2
On the one hand, similar to endothelial cells, parenchymal epithelia must guide leukocytes to traverse them in order to reach a localized inflammatory focus, for example, in the lung or intestinal mucosa. (hindawi.com)
The role of ecto-5'-nucleotidase in endothelial dysfunction and vascular pathologies. (medscape.com)
5′-Nucleotidase (EC 3.1.3.5) is an enzyme which catalyzes the phosphorylytic cleavage of 5′-nucleotides. (wikipedia.org)
The purine salvage enzyme inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase catalyzes degradation of IMP to inosine. (rhea-db.org)
Nucleoside1
Nucleotides 1" By Boris (PNG), SVG by Sjef - en:Image:Nucleotides.png (Public Domain) via Commons Wikimedia, Lakna, a graduate in Molecular Biology & Biochemistry, is a Molecular Biologist and has a broad and keen interest in the discovery of nature related things, Difference Between Nucleotide and Nucleoside, 3. (paragonlockandsafe.com)
Membrane2
Studies of mammalian 5′-nucleotidases have shown that there exist at least four different forms of the 5′-nucleotidase enzyme: one membrane-bound form and three soluble forms. (wikipedia.org)
5′-Nucleotidase (5NT) is an intrinsic membrane glycoprotein that is present as an enzyme in a wide variety of mammalian cells. (medscape.com)
Patients1
These groups can connect patients with others who share similar experiences and help them find the right healthcare providers and treatment options. (mellaly.com)
Tumor1
The tumor of case 2 predominantly showed the features of papillary ependymoma, and some tumor cells were swollen and contained similar eosinophilic granules. (dehydrogenase-signal.com)
Activity2
Coculture of human aortic ECs with human monocytes (2 x 10 5 monocytes per 2-cm 2 well) led to a decrease in EC angiotensin- converting enzyme (ACE) activity (64.5±3.5% of control) but not aminopeptidase N, aminopeptidase P, and 5'-nucleotidase activities. (elsevierpure.com)
Monocyte-mediated reduction in ACE activity did not require cell to cell contact, since exposure of ECs to conditioned medium from cocultures (CCCM) or from monocyte cultures (MCM) produced a decrease in ACE activity similar to that observed in EC-monocyte cocultures. (elsevierpure.com)
Human2
Studies of the soluble form of human ecto-5′-nucleotidase, without a GPI anchor, have shown that the C-terminal domain holds the substrate-binding pocket, and that the aromatic purine motif of the substrate is stacked between two phenylalanine residues. (wikipedia.org)
Similar results were obtained using human umbilical vein EC-human monocyte and porcine aortic EC-porcine monocyte cocultures. (elsevierpure.com)
Formation1
Nous avons mis en évidence (i) une sécrétion activité-dépendante accrue d'adénosine et d'ATP pendant la période de synaptogenèse, (ii) un pic d'expression de l'enzyme limitant la formation de l'adénosine à partir de l'ATP extracellulaire, l'ecto-5'-nucleotidase, aux synapses pendant cette période critique, et (iii) un pic d'expression péri/post- synaptique du A2AR concomitant de la période de synaptogenèse. (sorbonne-universite.fr)
Processes1
5-Nucleotidase Syndrome is a rare genetic disorder that affects the way our body processes and eliminates waste. (mellaly.com)
Bound1
When fluorochrome conjugated antibodies are bound to BD® CompBeads, they have spectral properties very similar to cells. (bdbiosciences.com)
Specific4
The mutation in the NT5C2 gene causes the loss of a specific enzyme called 5-nucleotidase. (mellaly.com)
GGT can be used in a similar manner, but, generally, GGT levels are elevated in any hepatocellular injury, while 5NT is more specific to situations resulting in obstructive or cholestatic liver disease. (medscape.com)
The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. (inchem.org)
Production1
These strains also have great potential for the production of other nucleosides and similar derived chemicals. (biomedcentral.com)
Cells2
Similar to αβ T cells, γδ T cells also develop in embryos, and their intra-thymic development shows strict regulation and flexible plasticity [ 2 ]. (explorationpub.com)
A viral etiology, such as measles, has been proposed because nuclear inclusions in diseased osteoclasts that are similar to those seen in paramyxovirus-infected cells have been seen on electron microscopy. (msdmanuals.com)
Rare2
5-Nucleotidase Syndrome is a rare genetic disorder that affects a small number of people worldwide. (mellaly.com)
Intracytoplasmic GSK2126458 eosinophilic granules occasionally occur in astrocytic and oligodendroglial neoplasms, but an appearance of similar granules is very rare in ependymoma. (dehydrogenase-signal.com)
Properties2
Although the properties of the enzyme are similar to those of the IMP/GMP 5'-nucleotidase identified in various animals [Itoh (1993) Comp. (rhea-db.org)
it's very challenging to produce motion from moving parts due to the properties of the fluid -- it's similar to humans trying to run through treacle. (50webs.com)