• hepatic
  • It is hypothesized that silymarin will not lead to clearance of HCV infections but can prevent progression of liver disease in participants with chronic HCV hepatitis and, in some cases, reverse hepatic lesions that are already present, as well as improving the quality of life in individuals who use this dietary supplement. (clinicaltrials.gov)
  • doses
  • The new study was designed to measure the potential benefit of increasing doses of silymarin in patients with chronic HCV. (news-medical.net)
  • These data show that even higher-than-normal doses of silymarin don't significantly reduce ALT levels for patients with HCV,' said Reddy, noting that the doses used in the trial were three and five times higher than the customary dose. (news-medical.net)
  • clinical
  • Therefore, the objective of this review is to assess the clinical efficacy and safety of silymarin by application of systematic approach. (springer.com)
  • Silymarin has metabolic and cell-regulating effects at concentrations found in clinical conditions, namely carrier-mediated regulation of cell membrane permeability, inhibition of the 5-lipoxygenase pathway, scavenging of reactive oxygen species (ROS) of the R-OH type and action on DNA-expression, for example, via suppression of nuclear factor (NF)-κB. (springer.com)
  • Although there were no clinical end-points in the four trials considered in patients with alcoholic liver disease, histological findings were reported as improved in two out of two trials, improvement of prothrombin time was significant (two trials pooled) and liver transaminase levels were consistently lower in the silymarin-treated groups. (springer.com)
  • Reviews of the literature covering clinical studies of silymarin vary in their conclusions. (wikipedia.org)
  • treatment
  • In spite of some positive results in patients with acute viral hepatitis, no formally valid conclusion can be drawn regarding the value of silymarin in the treatment of these infections. (springer.com)
  • safety
  • Silymarin is has a good safety record and only rare case reports of gastrointestinal disturbances and allergic skin rashes have been published. (springer.com)