• Chou, HC & Chen, CM 2020, ' Cathelicidin attenuates hyperoxia-induced intestinal injury through inhibition of NF-κB activity in newborn rats ', Experimental and Molecular Pathology , vol. 113, 104269. (tmu.edu.tw)
  • In rings of bovine bronchi (3rd-5th order, 3-5mm internal diameter), isometric contractions were significantly potentiated when the oxygen tension in the Krebs- Henseleit solution was lowered from 524mm Hg (hyperoxia) to either 147 mm Hg (normoxia) or 26mm Hg (hypoxia). (gla.ac.uk)
  • The ability of the dilator agents salbutamol, atrial natriuretic peptide (ANP), sodium nitroprusside (SNP) and isosorbide dinitrate (ISDN) to reverse methacholine-induced tone was also altered by changing the oxygen tension, although the pattern of response differed between the various agents: The ability of salbutamol to reverse the induced tone was attenuated in hypoxia, whereas ANP was more effective in hypoxia than either hyperoxia or normoxia. (gla.ac.uk)
  • ISDN and SNP were similar in that they were both more effective in either hypoxia or normoxia than in hyperoxia. (gla.ac.uk)
  • In hyperoxia, ANP protected against methacholine challenge, but in hypoxia, ANP actually potentiated the methacholine-induced contractions. (gla.ac.uk)
  • The ability of both SNP and ISDN to protect against methacholine challenge was enhanced when the oxygen tension was reduced from hyperoxia to either normoxia or hypoxia. (gla.ac.uk)
  • Tracheal rings (internal diameter ~2mm) isolated from rats exposed to 14 days of chronic hypobaric hypoxia (500-550mBar) produced contractions to methacholine, endothelin-1 (ET-1) and potassium chloride which were significantly less than responses in control rats. (gla.ac.uk)
  • The role of hypoxia and hyperoxia in the development and progression of IPF has not been explored. (biomedcentral.com)
  • VEGF-A receptors and co-receptors were differentially expressed by hypoxia and hyperoxia. (biomedcentral.com)
  • Our data supports a potential role for hypoxia, hyperoxia and VEGF-A xxx a isoforms as drivers of fibrogenesis. (biomedcentral.com)
  • Dense areas of lung fibrosis have been shown to be hypoxic [ 7 ] and high flow oxygen is used therapeutically in these conditions but the role of hypoxia and hyperoxia in the development and progression of IPF is unknown. (biomedcentral.com)
  • We investigated the effect of hypoxia and hyperoxia on VEGF receptor, co-receptor and VEGF-A isoform expression in fibroblasts explanted from histologically normal lung (normal fibroblasts, NF) compared to those from IPF tissue (fibrotic fibroblasts, FF). (biomedcentral.com)
  • We examined the effect of hypoxia and hyperoxia on fibroblast synthetic function. (biomedcentral.com)
  • Hypoxia stimulated NF and FF fibronectin mRNA to the same extent, whilst hyperoxia significantly up-regulated fibronectin mRNA in FF only. (biomedcentral.com)
  • We then explored the effect of hypoxia and hyperoxia on VEGF-A isoform expression. (biomedcentral.com)
  • PanVEGF-A and VEGF-A xxx a mRNA levels were significantly up-regulated in response to hypoxia in NF and FF, although the FF response to hypoxia was significantly less than NF (Fig. 1a ). (biomedcentral.com)
  • Similarly, NF and FF VEGF-A xxx b mRNA (data not shown) and VEGF-A 165 b protein (Fig. 1b ) were not significantly altered in response to hypoxia or hyperoxia. (biomedcentral.com)
  • a Vascular endothelial growth factor-A (VEGF-A) mRNA levels in Normal (NF) and Fibrotic (FF) fibroblast total RNA lysates in response to 24 h exposure to hypoxia and hyperoxia. (biomedcentral.com)
  • In contrast, the expression levels of 95 genes were significantly altered in the hypoxic P12.5 retinas, which contained several known hypoxia- regulated genes including Vegfa and Hif1a. (elsevierpure.com)
  • The phenomenon is known in medicine as the hypoxia - hyperoxia paradox. (lentifurdo.hu)
  • Improved epidermis tone, fewer wrinkles, a lot more energy, better concentration, elevated sleep and, in these types of worrying coronavirus times, a stronger disease fighting capability, are just a few of the benefits offered by spotty hypoxia-hyperoxia therapy. (wiwoch.com)
  • That oxygen machine chugs apart, sounding not dissimilar into a generator, and we as well as low oxygen (hypoxia) pertaining to five minutes, followed by means of three minutes of higher oxygen (hyperoxia). (wiwoch.com)
  • Preclinical studies have demonstrated that neonatal hyperoxia injures the distal small intestine and activates nuclear factor-κB (NF-κB). (tmu.edu.tw)
  • Although the use of exogenous surfactant and protective ventilation strategies has improved survival, the long-term pulmonary consequences of neonatal hyperoxia are unknown. (johnshopkins.edu)
  • Here, we investigate whether neonatal hyperoxia alters pulmonary function in aging mice. (johnshopkins.edu)
  • In contrast, hyperoxia up-regulated panVEGF-A and VEGF-A xxx a mRNA levels in FF but had no significant effect on NF or FF VEGF-A protein expression. (biomedcentral.com)
  • The lowered MLIs and cytokines and the increased VEGF expression and vascular density indicated that the surfactant and surfactant + hUC-MSCs (3 × 10 4 cells) treatment attenuated hyperoxia-induced lung injury. (biomedcentral.com)
  • The surfactant + hUC-MSCs (3 × 10 5 cells) group exhibited a significantly lower MLI and significantly higher VEGF expression and vascular density than the surfactant + hUC-MSCs (3 × 10 4 cells) group did. (biomedcentral.com)
  • Exposure of newborn premature infants to hyperoxia downregulates retinal VEGF. (medscape.com)
  • The Hyperoxia trial, on the other hand, randomly assigned study participants to either a fraction of inspired oxygen (F io 2 ) of 100% ( i.e., the hyperoxia arm) or F io 2 of at least 35% (the normoxia arm). (anesthesiaexperts.com)
  • Our previous study found that mesenchymal stem cells (MSCs) attenuated hyperoxia-induced lung injury and the combination therapy of surfactant and human umbilical cord-derived MSCs (hUC-MSCs) did not have additive effects on hyperoxia-induced lung injury in neonatal rats. (biomedcentral.com)
  • Mean baseline movement in fetuses found as neonates to have intrauterine growth retardation (N = 18) was significantly lower than that of normal fetuses (N = 34). (elsevierpure.com)
  • Consecutive daily administration of intratracheal surfactant and hUC-MSCs can be an effective regimen for treating hyperoxia-induced lung injury in neonates. (biomedcentral.com)
  • By 67 weeks of age, mice exposed to 100% oxygen between postnatal days 1 to 4 showed significantly a shortened life span (56.6% survival, n= 53) compared to siblings exposed to room air as neonates (100% survival, n = 47). (johnshopkins.edu)
  • People exposed to hyperoxia as neonates may be at increased risk for pulmonary hypertension. (johnshopkins.edu)
  • The rats reared in hyperoxia and treated with NS yielded significantly higher mean linear intercepts (MLIs) and interleukin (IL)-1β and IL-6 levels and significantly lower vascular endothelial growth factors (VEGFs), platelet-derived growth factor protein expression, and vascular density than did those reared in RA and treated with NS or surfactant. (biomedcentral.com)
  • This study investigated long-term outcomes of hyperoxia on retinal morphology and function using a mouse model of oxygen-induced ischemic retinopathy (OIR). (molvis.org)
  • Neonatal Sprague Dawley rats were reared in either room air (RA) or hyperoxia (85% O 2 ) from postnatal days 1 to 14. (biomedcentral.com)
  • Sprague-Dawley rat pups were reared in either room air (RA) or hyperoxia (85% O 2 ) and were randomly treated with low-dose cathelicidin (4 mg/kg, LDC) and high-dose cathelicidin (HDC, 8 mg/kg) in 0.05 mL of normal saline (NS) administered intraperitoneally on postnatal days 1-6. (tmu.edu.tw)
  • The prolonged exposure of neonatal rats to hyperoxia results in a decrease in alveolarization and vascularization similar to human bronchopulmonary dysplasia (BPD) [ 2 , 3 ]. (biomedcentral.com)
  • Gene microarrays containing more than 47,000 transcripts were used to study the changes in gene expression in retinas isolated immediately (P12) and at 12 hours (P12.5) after exposure to hyperoxia. (elsevierpure.com)
  • As oxygen administration continues, the volume of inspired nitrogen (and its level within distal alveoli) diminishes significantly. (capnoacademy.com)
  • 0.01) compared to room air-exposed animals, and the maximal values of contractile responses were 1.8 ± 0.17 g in hyperoxia group and 1.13 ± 0.15 g, respectively. (unizg.hr)
  • Term-born rat models are appropriate for studying the effects of hyperoxia on preterm infants with respiratory distress because rats are born at the saccular stage, which is approximately equivalent to a human gestational age of 30 weeks [ 1 ]. (biomedcentral.com)
  • Both term and preterm hAECs expressed VEGFA, PDGFB, ANGPT1, and FOXC1, which significantly increased after TNFa and IFN? (monash.edu)
  • Recently, it has been shown that echocardiographic right ventricular performance markers significantly worsen already on the 7th day of life (DOL) in very preterm infants who will later be diagnosed with BPD [ 15 ]. (biomedcentral.com)
  • The aim is to evaluate the effects of 2 consecutive days of intratracheal administration of surfactant and hUC-MSCs on hyperoxia-induced lung injury. (biomedcentral.com)
  • In vivo assessment of angiogenesis using vWF immunostaining revealed that hAEC treatment decreased angiogenesis in a bleomycin model of lung fibrosis but increased angiogenesis in a neonatal model of hyperoxia-induced lung injury. (monash.edu)
  • Maintaining normocapnia during hyperoxic treatment resulted in significantly higher DO 2 compared with standard O 2 treatment. (thornhillmedical.ca)
  • BUSINESS WIRE) -- Masimo (NASDAQ: MASI) announced today that in a study recently published in the Journal of Clinical Monitoring and Computing, researchers investigated the ability of Masimo ORi™ (Oxygen Reserve Index) to serve as a noninvasive indicator of the arterial partial pressure of oxygen (PaO2) during general anesthesia, to help avoid hyperoxia.1 ORi is an index of oxygenation in the moderate hyperoxic region (PaO2 range of 100 to 200 mmHg). (blogspot.com)
  • The expression of 83 gene transcripts was significantly altered in the hyperoxic P12 retinas. (elsevierpure.com)
  • Arterial oxygen saturation was similar in normothermic control and endotoxic mice breathing 15% O 2 (endotoxic mice at 37°C = 56.1% ± 6.8, controls at 37°C = 58.1% ± 3.4), but was non-significantly higher in hypothermic endotoxic mice (69.2% ± 12.5). (springeropen.com)
  • Although the mortality rate has greatly diminished with the use of surfactants, the proportion of surviving infants with severe sequelae, such as chronic lung disease, cognitive delays, cerebral palsy, and neurosensory deficits (ie, deafness and blindness), has not improved as significantly. (medscape.com)
  • After hyperoxia, HO-1(CM) -/- hearts showed suppression of the Pgc-1α/nuclear respiratory factor-1 (NRF-1) axis, swelling, low electron density mitochondria by electron microscopy (EM), increased cell death, and extensive collagen deposition. (jci.org)
  • In chronically hypoxic rats, however, the airway smooth muscle appears to be more sensitive to nitric oxide than control rats, which may explain why contractile responses are significantly smaller in the chronically hypoxic rats. (gla.ac.uk)
  • In previous study, we demonstrated that the addition of surfactant reduced the in vitro viability of human umbilical cord-derived MSCs (hUC-MSCs) through mitochondrial dysfunction and that a combination therapy of surfactant and hUC-MSCs had no additive effects on lung development in neonatal rats exposed to hyperoxia [ 14 ]. (biomedcentral.com)
  • The hyperoxia-reared rats exhibited significantly lower body weights, higher intestinal injury scores, lower occludin and ZO-1 expression, higher intestinal permeability and inducible IκB kinase inhibitor (IKKi) and NF-κB expression than the RA-reared rats. (tmu.edu.tw)
  • To test this possibility, 90% hyperoxia (90% O 2 , 0% CO 2 ) was given to bleo treated rats to inhibit the chemoreflex. (unmc.edu)
  • In this pooled-analyses study, we combined data from three published clinical trials (the DEXACET, Hyperoxia, and MINDDS ) across two institutions, each involving patients who underwent nonemergent cardiac surgeries. (anesthesiaexperts.com)
  • Lung volume decreases in the upright position due to cranial displacement of the abdomen due to hydrostatic pressure, and resistance to air flow in the airways increases significantly because of the decrease in lung volume. (wikipedia.org)
  • Treatment with Rho-kinase inhibitors either in vitro or in vivo reversed this effect of hyperoxia and normalized responses to control level. (unizg.hr)
  • Cellular and intracellular hyperoxia is imposed on isolated cells and isolated mitochondria at air-level oxygen pressures which are higher compared to cellular and intracellular oxygen pressures under tissue conditions in vivo. (bioblast.at)
  • Significantly reduces acute hypertension in vivo. (sheffield.ac.uk)
  • Our results demonstrated that MgSO 4 significantly attenuated the LPS-induced ALI, oxidative stress (decreased MDA levels), and lung inflammatory response. (cjphysiology.org)
  • This hyperoxia-vasocessation results in avascular peripheral retina, and it is seen clinically as stage 0 or stage 1 of retinopathy of prematurity. (medscape.com)
  • The "Guidelines for Prehospital Management of Severe Traumatic Brain Injury" from the Brain Trauma Foundation highlight the importance of the care provided immediately after the primary head injury, emphasizing it can significantly improve or worsen a secondary brain injury. (ems1.com)
  • Macitentan treatment significantly increased pulmonary vessel count (p = 0.004) and decreased right to left ventricular wall diameter ratios (p = 0.002). (biomedcentral.com)
  • Hyperbaric O2 significantly increased CBF andCMRO2 for 6 hours (p ≤ 0.01). (ihmera.com)
  • In this study the authors directly compare hyperbaric oxygen (HBO2) and normobaric hyperoxia (NBH)treatment effects.Methods. (ihmera.com)
  • Dr. Keisuke Yoshida and colleagues at the Fukushima Medical University School of Medicine in Japan sought to evaluate whether ORi could provide continuous, noninvasive insight into avoiding excessive hyperoxia by comparing the relationship between PaO2 and ORi during various oxygen administration conditions. (blogspot.com)
  • Although this strategy is consistently endorsed by guidelines for the management of critically ill patients, explicit target values for PaO2 or arterial oxyhemoglobin saturations (SaO2) are not provided.1-3 A lack of attentive oxygen management may expose patients unnecessarily to hyperoxia, leading to potential iatrogenic harm. (pdfkul.com)
  • In cohort 2, the cord blood Angptl7 levels were significantly lower in infants who later developed BPD. (spandidos-publications.com)
  • In addition, high temperatures led to significantly lower internal PO2s. (pacific.edu)
  • Furthermore, cells from the BPD model express significantly lower levels of Lgr5, a marker of a new lung mesenchymal cell population we recently defined that can support alveolar differentiation. (charleshoodfoundation.org)
  • We identified that CPEB2 promoted PDGFRα mRNA translation in MYF progenitors and this positive regulation could be disrupted by H 2 O 2 , a hyperoxia-mimetic treatment. (biomedcentral.com)
  • Overall, the proportion of subjects in each treatment arm was not significantly different between the sexes for any of the included studies. (anesthesiaexperts.com)
  • Dr Ursula, whose patients fly set for treatment from as significantly afield as Dubai, Paris and america, explains the science lurking behind the treatment. (wiwoch.com)
  • Compared with in the control group, Angptl7 levels were significantly higher in the ACBMNCs infusion group in cohort 1. (spandidos-publications.com)
  • Increased oxygen levels stimulate capillary remodelling, regeneration of damaged tissues and organs, help prevent and fight infections, reduce inflammation and significantly speed up the healing process. (lentifurdo.hu)
  • Patients were screened for postoperative delirium using the Confusion Assessment Method (for MINDDS ) or a combination of Confusion Assessment Method and its intensive care unit (ICU) equivalent (Confusion Assessment Method-ICU, for the DEXACET and Hyperoxia trials). (anesthesiaexperts.com)
  • 5 per brass razoo (equivalent to climbing SOME, 900 metres) before turning to hyperoxia at 34 percent. (wiwoch.com)
  • Biophysical data examined included percentage of time spent in breathing, mean breath rate, and percentage of time spent in body movement during a 90-minute observation: 30-minute baseline, 15-minute hyperoxia, and 45-minute posthyperoxia. (elsevierpure.com)
  • The other 10 patients showed a change in Pa CO 2 of − 1.3 ± 2.2 mm Hg breathing oxygen and were classified as nonretainers (NR). Ventilation fell significantly from 9.0 ± 1.5 to 7.2 ± 1.2 L/min in the R group breathing oxygen (p = 0.007), whereas there was no change in ventilation in the NR group (9.8 ± 1.8 to 9.9 ± 1.8 L/min). (atsjournals.org)
  • Our study has two major limitations: (1) differences in the frequency of assessment of delirium between the trials, and (2) differences in the predefined diagnostic criteria for delirium, i.e. , within the first three postoperative days (for the MINDDS trial), or until patients were discharged (for the DEXACET and Hyperoxia trials). (anesthesiaexperts.com)
  • Fetal body movements and breathing movements increased significantly after hyperoxia in the intrauterine growth retardation group but not in the normal group. (elsevierpure.com)
  • Ruedrich, DA, Devoe, LD & Searle, N 1989, ' Effects of maternal hyperoxia on the biophysical assessment of fetuses with suspected intrauterine growth retardation ', American journal of obstetrics and gynecology , vol. 161, no. 1, pp. 188-192. (elsevierpure.com)
  • In preliminary studies, we found that lung stem cells have decreased ability to differentiate into alveolar organoids when co cultured with mesenchymal cells from the murine hyperoxia model of BPD. (charleshoodfoundation.org)
  • Dhaliwal et al found that ROP occurred with significantly greater frequency and severity in small-for-GA (SGA) infants compared with appropriate-for-GA (AGA) infants. (medscape.com)