Significantly simvastatin. Medical search. Frequent questions

Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)
Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. (wikipedia.org)
Describe the relevance of the finding that simvastatin, but not pravastatin, seems to interfere with sleep quality and increase patient-reported sleep problems to clinicians in the care of their patients receiving statin therapy. (medscape.org)
Fifty-six patients (aged 44-80 years) with stable COPD (a mean forced expiratory volume in 1 second [FEV1] 55%), were randomly assigned (1:1) to receive simvastatin 40 mg/day or to receive no statin treatment. (nih.gov)
Statin treatment significantly increased 2-h glucose (2hPG) at follow-up, with a nominally significant increase in fasting glucose (FPG). (medicalxpress.com)
Ezetimibe and simvastatin tablets further enhance Teva's statin portfolio. (tevapharm.com)
Lung cancer incidences rates in statin users were found to be significantly reduced (55% risk reduction) in the Veterans Affairs (VA) Health Care System case control study [ 5 ]. (biomedcentral.com)
Simvastatin is a statin with pleiotropic effects that can also act as an anti-oxidant agent, and these pharmacologic properties may contribute to its potential anti-cancer activity. (biomedcentral.com)
Healthcare providers recommend that patients on statin therapy, including simvastatin, atorvastatin (Lipitor) and lovastatin, avoid taking any grapefruit product, such as grapefruit, grapefruit juice and grapefruit supplement. (drugsdb.com)
This medication has a major role in LDL-lowering when a statin alone is not sufficient and can be administered as a single tablet when combined with simvastatin (Vytorin). (medscape.com)

Like other members of its class (the "statins"), simvastatin lowers total serum cholesterol and particularly low density lipoprotein (LDL) cholesterol concentrations, thereby reducing the risk of atherosclerosis and its complications - myocardial infarction and stroke. (nih.gov)
Statins have been associated with a significantly lower risk of breast (8), colorectal (9), and lymph cancers (10-12) in several observational studies (10,13). (cdc.gov)
Comparable to statins': Soya milk could help significantly lower cholesterol. (express.co.uk)
Reductions in LDL cholesterol levels with combination therapy (32 to 48 percent) were significantly superior to colesevelam or statins alone (7 to 16 percent and 22 to 34 percent, respectively). (aafp.org)
Diabetes did not significantly alter the BRB, but both statins decreased the volume of distribution of 70- and 40-kDa dextrans in the retina. (diabetesjournals.org)
Conclusion: The ability of individual statins to lower serum cholesterol concentration varied, with atorvastatin and simvastatin being the most effective. (ox.ac.uk)
Simvastatin, and other cholesterol-lowering statins, are metabolized in the body through an enzyme system called cytochrome P450 system. (drugsdb.com)
Pretreatment with statins (pravastatin or simvastatin) significantly inhibited the clustering. (kalenbiomed.com)

The aim of this study was to investigate, and compare with pravastatin and simvastatin, the tissue-specific distribution of rosuvastatin. (aspetjournals.org)
Bolus intravenous doses (5 mg/kg) of radiolabeled rosuvastatin, pravastatin, and simvastatin were administered to rats, and initial uptake clearance (CL uptake ) in various tissues was calculated. (aspetjournals.org)
The results of this study indicated that rosuvastatin was taken up by hepatic cells more selectively and more efficiently than pravastatin and simvastatin. (aspetjournals.org)
Atorvastatin, pravastatin and simvastatin inhibited CYP3A4 activities with IC 50 values of 48.0, 14.1 and 3.10 µmol/l, respectively. (karger.com)
Lipostat, Pravastatin and Simvastatin are just a few of the medications that are available at euroClinix to treat high cholesterol. (euroclinix.net)
Its absolutely critical, Dr. A compared rosuvastatin against atorvastatin, pravastatin, and simvastatin and eating no more than 100 calories of added sugar all others, and lowered triglycerides significantly more than simvastatin and two percent getting the placebo. (ripyard.com)

ALT elevations are clearly more frequent in patients taking higher doses of simvastatin (40 and 80 mg daily). (nih.gov)
High doses of simvastatin are also contraindicated with the widely used antihypertensive amlodipine. (wikipedia.org)
There is evidence to suggest that rare side effects such as joint pain, memory loss, and muscle cramps are more likely to occur in patients who take higher doses of simvastatin. (wikipedia.org)
High doses of orally administered simvastatin has previously been shown to improve fracture healing in a mouse femur fracture model. (biomedcentral.com)
In this study, simvastatin was administered either subcutaneously or directly to the fracture area, with the goal of stimulating fracture repair at acceptable doses. (biomedcentral.com)
We therefore conducted a number of experiments on fracture repair in which we administered the simvastatin as one daily subcutaneous injection in doses ranging from 1 to 100 mg/kg body weight. (biomedcentral.com)
My husband, at age 68, backed into the garage be treated with atorvastatin and simvastatin at doses typically. (ripyard.com)

In this way, 10 mice received an approximate local dose of simvastatin of 0.1 mg per kg per day for the duration of the experiment and 10 mice received the vehicle compound. (biomedcentral.com)
Secondly, subcutaneously implanted osmotic mini-pumps were used to deliver a continuous systemic dose of simvastatin. (biomedcentral.com)

Atorvastatin and simvastatin were the most effective drugs in achieving the target. (ox.ac.uk)
Atorvastatin and simvastatin achieved the greatest percentage reduction in serum cholesterol concentrations (30.1%, 95% confidence interval 28.8% to 31.4% and 28.0%, 26.7% to 29.3%, respectively). (ox.ac.uk)

Simvastatin occasionally causes myopathy manifested as muscle pain, tenderness or weakness with creatine kinase above ten times the upper limit of normal (ULN). (tevapharm.com)
When letermovir is coadministered with cyclosporine, use of either pitavastatin is contraindicated due to significantly increased pitavastatin concentrations and risk of myopathy or rhabdomyolysis. (medscape.com)

Simvastatin (sim" va stat' in) is an orally available inhibitor of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the major rate-limiting enzyme in cholesterol synthesis. (nih.gov)
In heart protection studies, simvastatin showed the ability to lower LDL cholesterol by about 1·5 mmol/L, which resulted in substantial reductions in mortality rates. (wikipedia.org)
The Heart Protection Study evaluated the effects of simvastatin in people with risk factors including existing cardiovascular disease, diabetes, or stroke, but having relatively low LDL cholesterol. (wikipedia.org)
The aim of the present work was to shed light on the role played by the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and memory consolidation in rodents through the inhibition of the key and rate-limiting enzyme 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) both in vivo and in vitro with simvastatin. (nature.com)
Ezetimibe and simvastatin tablets are indicated for the reduction of elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG), and non-high-density lipoprotein cholesterol (non-HDL-C), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary (heterozygous familial and non-familial) hyperlipidemia or mixed hyperlipidemia. (tevapharm.com)
The researchers noted that the properties of this soy flour were even more potent than simvastatin - a popular drug used to treat high levels of "bad" cholesterol and fat levels in the blood. (express.co.uk)
Lipid lowering drugs differed significantly for pretreatment serum cholesterol concentration, most recent cholesterol concentration, and the associated percentage reduction. (ox.ac.uk)
However, it is difficult to predict the increase in the cholesterol-reducing effect of simvastatin because of the many variables that can potentially interact with the drug metabolism and mechanism of action. (drugsdb.com)

However, adrenal CL uptake of simvastatin (1.55 ml/min/g tissue) was larger than hepatic CL uptake , and simvastatin was distributed to other tissues more easily than rosuvastatin. (aspetjournals.org)
14 C]Rosuvastatin (1.15 MBq/mg), [ 14 C]pravastatin (1.17 MBq/mg), and [ 14 C]simvastatin (1.85 MBq/mg) were synthesized at Shionogi and Co., Ltd. (Osaka, Japan). (aspetjournals.org)
The effect of rosuvastatin and simvastatin therapy (10 mg/kg) for 5 weeks on blood-brain barrier (BBB), blood-retinal barrier (BRB), and cardiac muscle permeability of streptozotocin-induced diabetic rats was studied. (diabetesjournals.org)

Patients in the simvastatin group took simvastatin 20 mg orally daily during two perioperative periods: from the 7th to the 5th preoperative day and from the 2nd day after decannulation until the 7th postoperative day. (hindawi.com)

The cause of hepatic injury from simvastatin is unknown. (nih.gov)
Coadministration with these agents may cause increases in simvastatin levels and potentiate its hepatic or muscle toxicity. (nih.gov)

Simvastatin is also available as a fixed combination with ezetimibe under the brand name Vytorin. (nih.gov)
Teva Pharmaceutical Industries Ltd., (NYSE and TASE:TEVA) today announced the launch of generic Vytorin ®1 (ezetimibe and simvastatin) tablets in the U.S. (tevapharm.com)
Ezetimibe and simvastatin tablets are indicated for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g. (tevapharm.com)
Limitations of Use: No incremental benefit of ezetimibe and simvastatin tablets on cardiovascular morbidity and mortality over and above that demonstrated for simvastatin has been established. (tevapharm.com)
Ezetimibe and simvastatin tablets have not been studied in Fredrickson type I, III, IV, and V dyslipidemias. (tevapharm.com)
Ezetimibe and simvastatin should be administered to women of childbearing age only when such patients are highly unlikely to conceive. (tevapharm.com)
The monthly cost of ezetimibe is $78, atorvastatin 20 mg is $108, lovastatin 20 mg is $37-71, and ezetimibe 10 mg/simvastatin 20 mg (Vytorin) is $86. (aafp.org)

The ability of lovastatin, mevastatin and simvastatin to inhibit the melanoma cell proliferation was examined using cytotoxicity and apoptosis assays. (biomedcentral.com)
Lovastatin, mevastatin and simvastatin inhibited the growth, cell migration and invasion of HT144, M14 and SK-MEL-28 melanoma cells. (biomedcentral.com)
The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) trial to evaluate the efficacy of lovastatin for preventing coronary events, found a significantly decreased incidence of new melanomas in the lovastatin arm compared with the placebo arm. (biomedcentral.com)

Use of simvastatin is contraindicated in medications that are strong inhibitors of cytochrome P450 activity (such as cyclosporine, ketoconazole, diltiazem, ciprofloxacin or amiodarone), and dose adjustments are appropriate for its use with other agents that inhibit CYP 3A4. (nih.gov)
The present study was designed to investigate the effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (atorvastatin, pravastatin, simvastatin) on the pharmacokinetics of losartan and its active metabolite EXP-3174 in rats. (karger.com)

Simvastatin is a hypolipemic drug with proven efficacy in the prevention of cardiovascular diseases. (nih.gov)
Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (druglib.com)

Simvastatin is available generic forms and under the commercial name of Zocor in tablets of 5, 10, 20, 40 and 80 mg. the recommended dose is 5 to 80 mg daily based upon tolerability and lipid levels. (nih.gov)
ZOCOR (simvastatin) is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus . (druglib.com)

In the chemotaxis migration assay, pretreatment with fluvastatin and simvastatin inhibited the migration of human CD4+ T cells towards CCL20. (nih.gov)

Simvastatin 10mg, 20mg, and 40 mg contain red and yellow ferric oxide. (hipaaspace.com)

Up to 5% of patients taking simvastatin chronically may experience minor elevations in serum ALT levels during therapy, but confirmed elevations to above three times the upper limit of normal (ULN) occur in only 1% to 2% of patients. (nih.gov)
Isolated cases of an autoimmune hepatitis-like syndrome associated with simvastatin therapy have been reported, some of which did not reverse completely with discontinuation, resulting in a chronic hepatitis requiring long term immunosuppressive therapy. (nih.gov)
Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. (tevapharm.com)
Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: A double-blind placebo-controlled trial. (druglib.com)
We aimed to investigate the antidepressant effects of simvastatin as an adjuvant therapy in patients with moderate to severe depression. (druglib.com)
Healthcare providers caution patient on simvastatin therapy against taking grapefruit products. (drugsdb.com)

Clinically apparent liver injury due to simvastatin is rare. (nih.gov)
But in view of the wide use of simvastatin, clinically apparent liver injury is exceeding rare and is estimated to occur in 1 per 100,000 patient years of exposure. (nih.gov)
In one clinically study, a 12-fold increase has been noted when simvastatin was taken together with a large amount of grapefruit juice. (drugsdb.com)

However, these increments were markedly inhibited by fluvastatin and simvastatin, but not by pravastatin. (nih.gov)

Simvastatin (1-10 µmol/l) enhanced the cellular uptake of rhodamine-123 in a concentration-dependent manner. (karger.com)
With one daily injection, the concentration of simvastatin would reach a peak relatively quickly, and then leave the organism. (biomedcentral.com)
conversely, most in vivo studies favored polylactide-co-glycolide and a 2 mg simvastatin concentration. (bvsalud.org)

Patients provided written informed consent and were randomly divided into 2 groups (65 in the simvastatin group and 65 in the control group) by assigning random numbers from a random number table. (hindawi.com)
Current indications for simvastatin are hypercholesterolemia and reduction in risk for death from coronary, cerebrovascular and peripheral artery disease in patients with these diseases. (nih.gov)
In several studies, ALT elevations were no more frequent in patients taking 10 and 20 mg of simvastatin daily than in placebo recipients. (nih.gov)
Patients cannot breastfeed while on simvastatin due to potentially disrupting the infant's lipid metabolism. (wikipedia.org)
The aim of this study was to evaluate the influence of simvastatin on inflammatory markers in patients with COPD. (nih.gov)
In COPD patients, a 3-month treatment with simvastatin does not reduce circulating inflammatory markers. (nih.gov)
Conventional risk factors were significantly higher in patients with DN and they received more CVD-preventive treatment. (ku.dk)
All patients receiving simvastatin or calcium-channel blockers had higher numbers of EPC compared to patients not treated with these drugs. (ku.dk)

To investigate the effect and mechanism of simvastatin on myocardial injury in cardiac valve surgery with CPB. (hindawi.com)

An extended follow-up of the Heart Protection Study examined the long-term efficacy and safety of LDLc-lowering with simvastatin treatment. (medscape.com)

Seven RCTs assessed pain outcomes, simvastatin did not significantly affect pain in six studies. (bvsalud.org)

After 2 weeks as well as 3 months of simvastatin treatment, no significant reduction of any measured inflammatory markers was observed. (nih.gov)
In conclusion, the enhanced bioavailability of losartan might be mainly due to inhibition of P-gp in the small intestine and CYP3A subfamily-mediated metabolism of losartan in the small intestine and/or liver and to reduction of the CL/F of losartan by simvastatin. (karger.com)

Therefore, the aim of this study was to evaluate, in the human lung adenocarcinoma cell line GLC-82, the effects of a 24-hour treatment with simvastatin on hydrogen peroxide (H 2 O 2 )-induced changes in cell viability, ERK phosphorylation, matrix metalloproteinase (MMP) expression, innate immunity signaling, NF-κB activation and IL-8 secretion. (biomedcentral.com)

The present clinical randomized controlled trial explored the protective effect of perioperative simvastatin on cardiac muscle after CPB and the relationship of such effects to cardiomyocyte autophagy. (hindawi.com)
In 2012, the Clinical Pharmacogenetics Implementation Consortium has released guidelines regarding the use of rs4149056 genotype in guiding dosing of simvastatin and updated the guideline in 2014. (wikipedia.org)
The groups did not differ significantly in terms of demographic data, clinical symptoms, pharmacological treatment, spirometry, and lipid profile at baseline. (nih.gov)
High-dose simvastatin for aneurysmal subarachnoid hemorrhage: multicenter randomized controlled double-blinded clinical trial. (druglib.com)
Conducting a scoping review (SR) to assess scientific evidence for topical simvastatin 's impact on alveolar bone regeneration and determine its level of support for clinical applications. (bvsalud.org)
CLINICAL RELEVANCE This review provides critical insights into the effects of simvastatin on alveolar bone regeneration , informing potential benefits and possible challenges associated with its post-extraction application. (bvsalud.org)
Clinical studies indicate that grapefruit juice can significantly increase simvastatin levels in the blood. (drugsdb.com)
Since clinical studies show that even a glass of grapefruit juice, taken each day, can considerably increase simvastatin levels in the blood, it is best to avoid grapefruit products throughout the treatment. (drugsdb.com)

Given the current available information, simvastatin should not be recommended solely for the treatment of AMD. (wikipedia.org)
50% during simvastatin treatment. (nih.gov)
This study found a dramatic positive effect on biomechanical parameters of fracture healing by simvastatin treatment directly applied to the fracture area. (biomedcentral.com)
In conclusion, these findings suggest that simvastatin could play a role in prevention and treatment of lung cancer via modulation of important proinflammatory and tumorigenic events promoted by oxidative stress. (biomedcentral.com)

Continuous local delivery of simvastatin resulted in a 170% larger force at failure as well as a twofold larger energy uptake. (biomedcentral.com)

Our results show that HMGR inhibition by simvastatin induces anxiogenic-like effects in the social interaction but not in the elevated plus-maze test, and improves memory consolidation in the inhibitory avoidance task. (nature.com)

We also found that simvastatin, an inhibitor of the mevalonate pathway, induced GBM stem cells death. (tmc.edu)

Simvastatin is available as a generic medication, and is on the World Health Organization's List of Essential Medicines. (wikipedia.org)

Simvastatin is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. (hipaaspace.com)

Simvastatin is made from the fungus Aspergillus terreus. (wikipedia.org)

Oxidant-induced phenotypic changes may thus significantly contribute to the key pathogenic role played by bronchial epithelial cells in inflammatory airway disorders such as asthma and COPD. (biomedcentral.com)

In general, positive bone formation and the absence of adverse effects directly linked to topical simvastatin were observed across the study models. (bvsalud.org)
Intra-alveolar simvastatin post- tooth extraction has been to be shown to be effective and safe for preserving alveolar bone , with varied concentrations and carriers, with no significant adverse effects . (bvsalud.org)

Effect of simvastatin topical use on alveolar bone after tooth extraction: a scoping review. (bvsalud.org)

Rare cases of acute liver failure and death have been attributed to simvastatin. (nih.gov)
Simvastatin is metabolized to some extent in the liver (via CYP 3A4) and is excreted in bile. (nih.gov)
Simvastatin is contraindicated with pregnancy, breastfeeding, and liver disease. (wikipedia.org)
Simvastatin was less liver-specific (it also distributed to the spleen and adrenal). (aspetjournals.org)

The metabolite-parent AUC ratio was significantly decreased by 25.7%, suggesting that metabolism of losartan was inhibited by simvastatin. (karger.com)
This enzyme system is chiefly responsible for the first-pass metabolism of simvastatin which transforms it into more usable chemicals in the body. (drugsdb.com)
When grapefruit is taken together with simvastatin, its compounds interfere with the enzyme system resulting in altered drug metabolism and eventually accumulation of the drug in the body. (drugsdb.com)

This medication may interact with other medications or supplements, sometimes significantly. (groupeproxim.ca)
Grapefruit products are known to interact with several medications, and one of which is simvastatin. (drugsdb.com)

Simvastatin in the acute respiratory distress syndrome. (druglib.com)

0.05) increased by 59.6 and 45.8%, respectively, by simvastatin compared to those of control. (karger.com)

Drospirenone and estetrol also produced significantly lower increases in sex hormone-binding globulin compared with two other contraceptives containing ethinyl-estradiol. (uspharmacist.com)

Food does not significantly alter plasma concentrations. (uspharmacist.com)

However, few studies have revealed the effects of perioperative oral simvastatin on post-CPB changes in cardiac muscle autophagy or the influence of the degree of autophagy on postoperative cardiac function and prognosis [ 8 , 9 ]. (hindawi.com)
With daily simvastatin injections, no effects could be demonstrated for any of the parameters examined. (biomedcentral.com)

Simvastatin was approved for use in the United States in 1991 and is still widely used with more than 40 million prescriptions being filled yearly. (nih.gov)

If so, subcutaneous injections would not work, whereas a continuous subcutaneous release of simvastatin would yield positive results similar to the ones achieved when mixing it in the feed. (biomedcentral.com)

Pregnancy must be avoided while on simvastatin due to potentially severe birth defects. (wikipedia.org)
The drug should be discontinued if blood pressure rises significantly or is persistent, or if severe migraines occur. (uspharmacist.com)

Accordingly, the expression levels of PDGF (3-folds), Rac1 (1.6-folds), NF-κB (7-folds) and AngII (12-folds) significantly increased in the TAC group compared to the SHAM group, and these levels were also reduced by 25% to 64% with following drug intervention. (medsci.org)
Catalase and superoxide dismutase activity were reduced in the HFDF animals, whose levels were increased statistically significantly by extract of P farcta leaves. (uwi.edu)
The study further suggests that taking one glass of grapefruit juice everyday can significantly increase the simvastatin levels in the blood by about four-fold. (drugsdb.com)

After oral ingestion, simvastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. (druglib.com)

The empirical formula of simvastatin is C25H38O5 and its molecular weight is 418.57. (hipaaspace.com)

Diseases2

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Health Care1

Statin10

Statins8

Pravastatin and simvastatin6

Doses7

Dose of simvastatin2

Atorvastatin and simvastatin2

Myopathy2

Cholesterol8

Rosuvastatin3

Orally1

Hepatic2

Ezetimibe7

Lovastatin3

Inhibitors2

Cardiovascular2

Zocor2

Pretreatment1

20MG1

Therapy6

Clinically3

Fluvastatin1

Concentration3

Patients8

Myocardial1

Efficacy1

Outcomes1

Reduction2

Phosphorylation1

Clinical8

Treatment4

Uptake1

Improves1

Inhibitor1

Generic medication1

Lipid1

Aspergillus1

Inflammatory1

Adverse effects2

Bone1

Liver4

Metabolism3

Medications2

Acute1

0.051

Increases1

Concentrations1

Effects2

Million prescriptions1

Results1

Severe2

Levels3

Inactive1

Molecular1