• Thus, we investigated the effects of Pu-erh tea extract (PTE) on ovariectomy-induced osteoporosis in rats and on osteoclastogenesis in vitro. (researchgate.net)
  • Conclusion: PTE can ameliorate ovariectomy-induced osteoporosis in rats and suppress osteoclastogenesis in vitro. (researchgate.net)
  • Estrogen plays a role in maintaining body weight, since ovariectomy in rats, resulting in hypoestrogenemia, also results in significant weight gain. (medicaljournal-ias.org)
  • Ovariectomy significantly increased body weights of the rats on the normal rat chow diet and the three vitamin E supplemented diets. (medicaljournal-ias.org)
  • Aim: To evaluate the influence of ovariectomy combined with lack of masticatory force in the evolution of periodontal disease induced in rats. (bvsalud.org)
  • Methods: Forty rats were bilaterally ovariectomized and 40 were submitted to sham ovariectomy. (bvsalud.org)
  • Olive oil effectively mitigated ovariectomy-induced osteoporosis in rats, and is a promising candidate for the treatment of postmenopausal osteoporosis. (biomedcentral.com)
  • Under such background, we have supplemented Ovariectomized (OVX) - rats with olive oil four weeks before ovariectomy with an aim to evaluate the efficacy of olive oil supplementation starting before menopause. (biomedcentral.com)
  • EXPERIMENTAL APPROACH: Six months after ovariectomy, rats were randomly allocated to different groups and treated, daily, with genistein aglycone (1 and 10mg/kg s.c.), raloxifene hydrochloride (0.05 and 0.5mg/kg s.c.) or 17-α-ethinyloestradiol (0.003 and 0.03mg/kg s.c.) for 12 weeks. (unime.it)
  • All the treatments significantly restored this depressed molecular profile revealed in OVX rats. (unime.it)
  • Genistein aglycone, 1mg/kg , also significantly increased the thickness of collagen and breaking strength of skin in the OVX rats. (unime.it)
  • CONCLUSIONS AND IMPLICATIONS: Relatively long-term, systemic treatment with genistein aglycone shows comparable efficacy to oestrogen in reversing some molecular, histological and functional changes of the skin associated with ovariectomy in aged rats. (unime.it)
  • In this study, we evaluated the effects of ovariectomy, an animal model of hormonal depletion on some biochemical and behavioral parameters in female adult rats. (ufrgs.br)
  • Initially, we investigated the effect of ovariectomy on some parameters of energy metabolism (Na+,K+-ATPase, pyruvate kinase and respiratory chain enzymes) in striatum of female adult rats. (ufrgs.br)
  • We also tested the effect of ovariectomy on the creatine kinase activity in cytosolic and mitochondrial fractions prepared from hippocampus of female rats. (ufrgs.br)
  • Our results showed that ovariectomy significantly increased the activity of cytosolic creatine kinase, but did not alter the activity of creatine kinase in the mitochondrial fraction of hippocampus of female adult rats. (ufrgs.br)
  • Finally, we investigated the effect of ovariectomy on anxiety-like behavior in female adult rats. (ufrgs.br)
  • We investigated the effect of ovariectomy (OVX) and hormonal treatment for 10 weeks by estradiol and progesterone on muscarinic M 4 receptor subtype in different brain areas of female rats. (uaeu.ac.ae)
  • Ovariectomy significantly decreased the exploratory activity of the rats compared to the sham group. (uaeu.ac.ae)
  • Female rats with intact ovaries and ovariectomized (OVX) females treated with 17β-estradiol, progesterone, or placebo were subjected to transient, unilateral middle cerebral artery occlusion followed by reperfusion (I/R). The maximum contractile response, measured my wire myography, in response to the endothelin B receptor agonist sarafotoxin 6c was increased in female arteries after I/R, but the maximum response was significantly lower in arteries from OVX females. (lu.se)
  • AIM Ovariectomy of female rats induces significant bone-loss by depriving endogenous estrogen production. (dtu.dk)
  • CTX decreased significantly compared to vehicle treatment over the five week treatment period in the S-M treated but not in the S-G treated rats. (dtu.dk)
  • OVX-induced increased serum ALP, calcium, and phosphorous levels were significantly attenuated in Asthiposhak-treated rats. (ijpsr.com)
  • 2) The W/ D value and lung coefficient of rats in LPS-low group, LPS-mid group and LPS-high group increased significantly, and acute pulmonary edema appeared. (alljournal.ac.cn)
  • Prevent the body from rejecting transplanted significantly increase this background with this observation, the removal of endogenous estrogens following ovariectomy increases mortality associated with LPS challenge in rats, and this effect was reverted by estrogens treatment. (thetravelcenter.com)
  • Ovariectomy in adult mice did not increase severity, but paradoxically estrogen supplementation after ovariectomy did increase CNV severity. (duke.edu)
  • Ovariectomy up-regulated M 4 receptors in the dentate gyrus, CA1, CA3, frontal cortex and hypothalamus whereas the estrogen treatment restored M 4 binding to that of the sham group. (uaeu.ac.ae)
  • Interestingly, progesterone significantly reduced tau hyperphosphorylation when administered both alone and in combination with estrogen. (nih.gov)
  • Treatment of breast cancer has included efforts to decrease estrogen levels by ovariectomy premenopausally and by use of anti-estrogens and progestational agents both pre- and post-menopausally, and these interventions lead to decreased tumor mass or delayed progression of tumor growth in some women. (roidsseek.com)
  • Our result showed that aged female mice had significantly larger CNV than age-matched males. (duke.edu)
  • Finally, CNV severity was significantly more severe in iNOS -/- mice, compared to iNOS +/+ mice after laser treatment. (duke.edu)
  • Ovariectomy increased CNTF expression, as well as immobility time, which was significantly reduced in CNTF-/- mice, suggesting that CNTF mediates overiectomy-induced immobility time, possibly in the amygdala. (etsu.edu)
  • Trabecular bone volume (BV/TV) was significantly reduced in PAFR-WT mice, but not in PAFR-KO mice, by ovariectomy. (cancer-ecosystem.com)
  • The reduction in bone mass in PAFR-WT mice was associated with an increase in bone turnover because osteoid thickness (O.Th) and osteoclast surface Forskolin cell signaling per bone surface (Oc.S/BS) mice were increased significantly in ovariectomized PAFR-WT relative to sham-operated PAFR-WT mice. (cancer-ecosystem.com)
  • The ovariectomy-induced reductions in Tb and BV/TV.N were avoided in PAFR-KO mice. (cancer-ecosystem.com)
  • The ovariectomy-induced upsurge in Tb.Sp was avoided in PAFR-KO mice also. (cancer-ecosystem.com)
  • O.Oc and Th.S/BS in WT-OVX mice were significantly increased weighed against values observed in KO-OVX mice, recommending how the decrease in bone tissue mass in PAFR-WT mice was connected with a rise in bone tissue turnover. (cancer-ecosystem.com)
  • Ovariectomy-induced depletion of sex steroid hormones in adult female 3xTg-AD mice significantly increased Aβ accumulation and worsened memory performance. (nih.gov)
  • Tests on recaptured mice indicated that the average number of contacts made between both males and females by mice that received the treatment - sham and testosterone - increased significantly increased after treatment. (vetscite.org)
  • Researchers also found that all mice at the separate untreated sites made significantly less contacts with other mice during the same time that the testosterone treatment significantly increased contacts. (vetscite.org)
  • Progesterone treatment had no effect on the ovariectomy-induced up-regulation of M 4 receptors. (uaeu.ac.ae)
  • The treatment with aliskiren significantly increased bone volume (BV/TV) and connectivity density (Conn.D) of trabecular bone at LV-2 and LV-5 as well as dramatically enhanced BV/TV, Conn.D, bone mineral density (BMD/BV) and decreased bone surface (BS/BV) at the distal femoral end. (edu.hk)
  • High-dose PTE significantly ameliorated OVX-induced estradiol (E2) deficiency. (researchgate.net)
  • It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone. (roidsseek.com)
  • Results showed that ovariectomy increases the activity of the enzymes Na+,K+-ATPase, succinate dehydrogenase and complex II. (ufrgs.br)
  • PM crude extract (PME) significantly down-regulated the expression of RANKL mRNA with no change in the OPG stage whereas MR elevated the expression of OPG mRNA with lowering stage of RANKL mRNA, ensuing within the increased OPG/ RANKL ratio, and consequently lead to reducing development of osteoporosis at molecular level . (perfect-curve.com)
  • resorption was significantly suppressed by a PAF receptor antagonist treatment or genetic PAF receptor deficiency. (cancer-ecosystem.com)
  • In addition, the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in pre-menopausal women. (nature.com)
  • To study the functional roles of EL, we recently generated transgenic (Tg) rabbits and reported that increased hepatic expression of EL in male Tg rabbits significantly reduced diet-induced hypercholesterolemia compared with non-Tg controls. (biomedcentral.com)
  • Female Tg rabbits showed similar levels of total cholesterol and lesion size of atherosclerosis compared with non-Tg rabbits and ovariectomy did not affect diet-induced hypercholesterolemia or atherosclerosis. (biomedcentral.com)
  • Moreover, in the in vitro studies, osteoclast differentiation using the differentiation cell model was significantly inhibited by PTE without cytotoxic effects. (researchgate.net)
  • The in vitro basal and TRH-stimulated TSH release was not significantly affected by Pg treatment. (scielo.org)
  • Male rabbits were under orchiectomy whereas female rabbits were under ovariectomy. (biomedcentral.com)
  • On a chow diet, both male and female Tg rabbits showed lower plasma lipids than non-Tg counterparts and this lipid-lowering effect of EL was not affected by either orchiectomy in male or ovariectomy in female Tg rabbits. (biomedcentral.com)
  • Female former entiate between hysterectomies with and exposure may be increased during phases of workers at the Bunker Hill smelter in Idaho without ovariectomies. (cdc.gov)
  • For the intact animals, ody weights in the three vitamin E supplemented groups respectively did not differ significantly from the normal rat chow group throughout the ten-month study period. (medicaljournal-ias.org)
  • While the ΔSCO1712 mutant showed a significant decrease (4.6 mg/L) and the ΔphoU mutant showed no significant improvement (12.1 mg/L) in aborycin production, the ΔwblA, ΔorrA and ΔgntR mutations significantly improved the aborycin titers to approximately 23.6 mg/L, 56.3 mg/L and 48.2 mg/L, respectively, which were among the highest heterologous yields for lasso peptides in both Escherichia coli systems and Streptomyces systems. (bvsalud.org)
  • OVX-induced decrease in BMD was significantly reversed in Asthiposhak-treated animals. (ijpsr.com)
  • Various manifestations nantly male, cohorts to investigate potential tion, was made between the two by assuming of Pb toxicity have been uncovered through sex hormone-driven differences in the long- that only hysterectomies with ovariectomies epidemiologic investigations [World Health term skeletal accumulation of lead. (cdc.gov)
  • Treatment with TNF- and IL-1 increased enzyme actions in both spleen- and bone tissue marrowCderived osteoclasts Forskolin cell signaling significantly. (cancer-ecosystem.com)
  • Asthiposhak treatment significantly prevented an OVX-induced increase in body weight. (ijpsr.com)
  • The calcium content in bone ash was significantly increased on Asthiposhak treatment indicating remineralization of bones. (ijpsr.com)
  • BACKGROUND AND PURPOSE: Ovariectomy accelerates age-related skin changes as adequate oestrogen levels are required to control structural integrity and functional capacity of skin. (unime.it)
  • Results -Dogs that weighed less and dogs with lymphoma were significantly more likely to become septic, compared with larger dogs or dogs with solid tumors. (avma.org)
  • premenopausal women is significantly lower. (cdc.gov)
  • Haemoglobin level, postoperative fever, symptoms of dyspareunia and frequency of sexual intercourse were not significantly different between the 2 groups of women. (who.int)
  • High body weight, undergoing bilateral mastectomy, and postoperative antimicrobial administration were associated with significantly increased odds of complications. (avma.org)
  • After 60 days of ovariectomy, animals were treated with Asthiposhak for the next 45 days. (ijpsr.com)