Significant viral load. Medical search. Frequent questions

HIV status was self-reported, persons maintain HIV disease control, including maintaining and patients with unknown status or deemed eligible and ART continuity and adherence, achieving viral suppression, and consented for testing were tested at admission. (cdc.gov)
reaching this goal will require increasing promotion of various risk reduction strategies, including viral suppression, condom use, sexual HIV concordance, and PrEP use. (natap.org)
when accounting for a combination of sustained viral suppression and risk reduction strategies, only 11% of sexually active MSM with diagnosed HIV engaged in high-risk sex, thereby illustrating the importance of PrEP, condom use, and HIV treatment as HIV prevention strategies. (natap.org)
There were significant differences in condomless sex by race/ethnicity among persons who did not have sustained viral suppression (P (natap.org)
Among HIV-discordant partnerships, 67% included an HIV-positive person who did not have sustained viral suppression, 45% involved condomless sex, and 82% involved sex with an HIV-negative partner not known to be using PrEP or an HIV-unknown partner. (natap.org)
Among sexually active MSM, 36% did not have sustained viral suppression, 66% had condomless sex, 73% had sex with an HIV-negative or HIV-unknown partner, 64% had sex with an HIV-negative partner not known to be using PrEP or an HIV-unknown partner, and 11% engaged in high-risk sex (Fig. 1). (natap.org)
Among sexually active HIV-positive MSM (n = 4923), we described prevalence of high-risk sex, defined as: (1) not having sustained viral suppression, and (2) having condomless sex with an HIV-negative partner not known to be taking pre-exposure prophylaxis or an HIV-unknown partner. (natap.org)
Viral load suppression for those on ART increased from 50% in 2019 to 55% in 2020. (theglobalfund.org)
Improved access to viral load and drug resistance testing is not enough to improve viral suppression in children with HIV, researchers from Kenya and the United States reported at the Conference on Retroviruses and Opportunistic Infections (CROI 2022) this week. (aidsmap.com)
Dr Rena Patel of the University of Washington, Seattle, presenting results of the Opt4Kids study, noted that viral suppression rates remain lower among children than adults in lower-income settings. (aidsmap.com)
In HIV, optimal viral suppression is measured as the reduction of viral load (HIV RNA) to undetectable levels and is the goal of antiretroviral therapy. (aidsmap.com)
A pair of new studies suggests combining 2 new broadly neutralizing antibodies might be an effective way to achieve long-term HIV viral suppression without the use of antiretroviral therapy. (hcplive.com)
A pair of new papers is fueling hope that a combination of next generation broadly neutralizing antibodies might be able to achieve long-term viral suppression of HIV without the need for a daily antiretroviral pill. (hcplive.com)
In the second study, 9 patients who had been taking ART stopped that therapy and instead underwent a series of infusions of the bNAb combination in order to see if viral suppression could be maintained without the use of antiretroviral therapy. (hcplive.com)
The second study, "Combination therapy with anti-HIV-1 antibodies maintains viral suppression," was published in Nature on the same day. (hcplive.com)
Once the decision to initiate antiretroviral therapy has been made, treatment should be aggressive with the goal of maximal viral suppression. (cdc.gov)
Evaluating facility-based antiretroviral therapy programme effectiveness: a pilot study comparing viral load suppression and retention rates. (bvsalud.org)
In this pilot study , we compared commonly utilised performance metrics of 12- and 24-month retention with rates of viral load (VL) suppression at 15 health facilities in Uganda . (bvsalud.org)
Increased linkage to care and viral suppression among MSM with HIV infection can prevent transmission. (cdc.gov)
Linkage to care within 1 month and viral suppression within 6 months of diagnosis increased overall (2.9% and 6.8% per year, respectively) and among all racial/ethnic groups. (cdc.gov)
Annual percentages of linkage to care within 1 month and viral suppression within 6 months of diagnosis among all MSM increased (2.9% [95% CI = 2.4-3.5] and 6.8% [95% CI = 6.2-7.4] per year, respectively). (cdc.gov)
Viral suppression within 6 months of diagnosis was measured for MSM whose infection was diagnosed during the outcome year and who resided in any of the 33 jurisdictions at the time of diagnosis of HIV infection. (cdc.gov)

Norovirus has not only prolonged viral shedding and has the ability to survive in the environment but a minuscule infectious dose is required to produce infection in humans: less than 100 viral particles. (wikipedia.org)
A higher viral burden, titre, or viral load often correlates with the severity of an active viral infection. (wikipedia.org)
An undetectable viral load does not implicate a lack of infection. (wikipedia.org)
There was no significant infection history despite regular nursery attendance. (frontiersin.org)
HIV infection in the CNS can be detected and monitored by cerebrospinal fluid (CSF) viral load measurements. (medscape.com)
This underlying chronic infection leaves COPD patients particularly vulnerable to acute viral infections, which further destabilize host immunity to bacteria. (frontiersin.org)
AECOPD triggered by a bacterial and viral co-infection increases circulating levels of the systemic inflammatory marker, serum amyloid A (SAA). (frontiersin.org)
After starting a regimen of ALA, NAC, Milk Thistle and Selenium I no longer show any infection - and the "professionals" said testing would always show an infection, even if my viral load level was below 10 (it was over 1 millions when I started treatment). (earthclinic.com)
In the United States of America, the prevalence of the viral infection among 14-49-year-olds is 19%, and throughout the world, seropositivity rates are uniformly higher in women than in men and increase with age. (who.int)
The viral copies increased up to 13 days post-infection, following which they either stayed at similar levels (bursa and bone marrow) or increased (thymus and spleen) up to 28 days post-infection in this study, whereas only a limited number of chickens were reported to be chicken anaemia virus positive in the thymus and spleen and none in the bursa and caecal tonsil following infection with a vaccinal virus. (thepoultrysite.com)
Walker thinks that if we can somehow get the HIV-specific T-help back, CTLs capable of attacking and destroying HIV-infected cells will be effectively remobilized and HIV infection will be officially turned into a chronic, manageable viral infection - like herpes or, say, genital warts. (treatmentactiongroup.org)
CoV-2 infection in Burkina Faso and to use the initial cycle threshold (Ct) values of RT-PCR as a tool to monitor the dynamics of the viral load. (bvsalud.org)
Approximately 1 out of 7 tested miners had SARS-CoV-2 infection and the duration of their RT-PCR tests positivity independently correlated with the initial viral load measured by initial Ct values. (bvsalud.org)

The study demonstrated a significant reduction in viral load in vaccinated subjects (n=30) versus placebo (n=31), thus meeting the primary endpoint. (prnewswire.com)
As with antiretroviral therapy, while broadly neutralizing antibody (bNAb) therapy appears to result in a significant reduction in viral load, administration of a single antibody therapy tends to result in a short-lived benefit as the viral develops resistance. (hcplive.com)
The results of the interim analysis, published in the New England Journal of Medicine, October 28, 2020 indicated that patients who received the 2800-mg dose of LY-CoV555 had a significant reduction in viral load by a factor of 3.4 vs. placebo at day 11, the primary outcome. (reachmd.com)

HIV positive patients on long-term combination antiretroviral therapy may present with an undetectable viral load on most clinical assays since the concentration of virus particles is below the limit of detection (LOD). (wikipedia.org)
By 2010, the Joint United Nations Programme on HIV/AIDS (UNAIDS) set a target of a 90% reduction in HIV incidence, a 90% reduction in AIDS deaths by 2030, and 95% of people living with HIV and AIDS being aware of their status, on treatment, and having an undetectable viral load. (medscape.com)

All count, viral load, or type of antiretroviral therapy (ART) ( 6 ). (cdc.gov)
In this prospective cohort study of patients who had been on combined antiretroviral therapy treatment (cART) for at least 12 months in Bangui, only one HIV plasma viral load per patient was realized at the Institut Pasteur of Bangui, between April 4th and November 28th, 2017. (scirp.org)
We lack antiretroviral (ARV) treatments, and few patients know their viral load. (kbs-frb.be)
The Ugandan trial showed that performed equally well in measuring trends in viral load for patients on highly active antiretroviral therapy (HAART). (newscientist.com)
Biological and medical variables included handedness, viral load, CD4 count and use of antiretroviral medication. (bl.uk)
Viral load and CD4+ T cell testing should ideally be performed twice before initiating or changing an antiretroviral treatment regimen. (cdc.gov)

160 ng/mL) had slightly lower viral load reduction than the control group. (techarp.com)

Tracking viral load is used to monitor therapy during chronic viral infections, and in immunocompromised patients such as those recovering from bone marrow or solid organ transplantation. (wikipedia.org)
Susceptibility to viral infections including herpes viruses and polyoma JC virus is recognized ( 4 - 6 ). (frontiersin.org)
Pathological inflammation is worsened by chronic bacterial lung infections and susceptibility to recurrent acute exacerbations of COPD (AECOPD), typically caused by viral and/or bacterial respiratory pathogens. (frontiersin.org)
Millions of viral sexually transmitted infections also occur annually, attributable mainly to HIV, human herpesviruses, human papillomaviruses and hepatitis B virus. (who.int)
The burden is greatest in the developing world, but industrialized nations can also be expected to experience an increased burden of disease because of the prevalence of non-curable viral infections, trends in sexual behaviour and increased travel. (who.int)
Some regions of the US have seen significant declines in new HIV infections. (medscape.com)

Despite this significant progress, the 2021 OIG audit on Mozambique found that improvements are needed in the efficiency and effectiveness of the procurement and supply chain processes and systems, which continue to affect the availability of health commodities at health facilities. (theglobalfund.org)
But as the world learned in 2021, anti-virals and vaccines put pressure on viruses to evolve, so new treatments will always be needed. (ubs.com)

We established in this manuscript a novel SARS-CoV-2 animal model that gives high viral load of omicron, which is currently the variant of concern. (eurekalert.org)

No statistically significant differences were found between viral loads in adults and pediatric patients. (cdc.gov)
Consistent with this hypothesis, until Jan 15th, we did not find any statistically significant differences in the average Ct value between the groups. (medrxiv.org)
Smaller, non-statistically significant differences in viral load were observed in patients receiving the 700 mg and 7000 mg doses. (reachmd.com)

The biocentric generic human immunodeficiency virus (HIV) load test was used to quantify a ribonucleic acid (RNA) HIV-1. (scirp.org)
Reverse transcription polymerase chain reaction (RT-PCR) is a variation of PCR that can be used to quantify viral RNA. (wikipedia.org)
Two experiments on tissue distribution and shedding profiles of chicken anaemia virus in specific pathogen-free and commercial broiler chickens were conducted, one in specific-pathogen-free-layer chickens and the other in commercial broiler chickens, to detect and quantify the viral genome in various tissues and environmental samples. (thepoultrysite.com)

It is not to be confused with viral titre or viral titer, which depends on the assay. (wikipedia.org)
When an assay for measuring the infective virus particle is done (Plaque assay, Focus assay), viral titre often refers to the concentration of infectious viral particles, which is different from the total viral particles. (wikipedia.org)
Viral load is often expressed as viral particles, (virions) or infectious particles per mL depending on the type of assay. (wikipedia.org)
Viral load was determined by use of quantitative PCR assay in supernatants obtained from infected cultures at specified time points. (avma.org)
Plasma viral loads declined from 1 to 3 logs, and up to 4 logs in some animals when declines were measured with a more sensitive assay. (natap.org)

No virus was detectable in plasma from 49.2% of patients, while 42.4% had virological failure (viral load, ≥1000 copies/mL) according to WHO criteria. (scirp.org)
Study participants were randomised to receive point-of-care viral load testing every three months and drug resistance testing if they had a viral load above 1000, or to receive the standard of care, which consists of viral load testing every six months and resistance testing only in the case of second-line regimen failure. (aidsmap.com)
Eleven per cent of the study population had a viral load above 1000 and 13% had missing viral load data at enrolment. (aidsmap.com)

Causes of viral rebound can include drug resistance, poor adherence to an HIV treatment regimen or interrupting treatment. (aidsmap.com)

There were no significant effects of age, sex, disease severity, viral load or educational status on BMI changes. (who.int)

Higher fecal viral load of recombinant norovirus genotype GII.P16-GII.2 compared with pandemic GII.Pe-GII.4 and epidemic GII.P17-GII.17 among patients in Hong Kong, August 2012-June 2017. (cdc.gov)

Since substitution or dose reductions of zidovudine should be considered in patients whose haemoglobin concentrations or neutrophil counts fall to clinically significant levels, it is recommended that separate preparations of lamivudine and (if appropriate) zidovudine be administered (see section 4.4). (who.int)
The addition of PH-797804 to ART permits a more significant recovery of CD4+ T-cell counts than ART alone when the virus damage of the immune system has been more severe and the combined regimen appears to counteract a later initiation of ART. (natap.org)
T-cell responses correlate directly with clinical symptoms, and were better predictors of HHV-6 disease than viral load or total CD3+ counts. (hhv-6foundation.org)
Dr. Sax, I commend you for speaking up on the lack of value of CD4 counts in stable patients, but doesn't such a significant shift call into question many of the fundamental tenants of the HIV-AIDS hypothesis. (jwatch.org)
Why are CD4 counts fluctuating widely if viral load is stable and HIV causes the decline in CD4 counts seen in AIDS? (jwatch.org)
Since it is no skin off of my teeth to order the test with a viral load as I did in years past, I have agreed to return to the more frequent testing only to keep our grant quality measures high, much like measuring how many patients with CD4 counts below 200 are on Bactrim, another questionable measure of quality. (jwatch.org)

It is a prodrug which inhibits cap-dependent endonuclease, an enzyme specific to influenza, resulting in inhibition of viral replication. (medscape.com)

Objective To evaluate viral loads at different stages of disease progression in patients infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first four months of the epidemic in Zhejiang province, China. (bmj.com)
The rate of virological failure among patients on cART is very high in the CAR, despite the availability of and access to monitoring of HIV plasma viral load in Bangui. (scirp.org)
In developed countries, patients with HIV are tested for viral load and CD4+ level four or five times a year. (newscientist.com)
Follow-up of patients with complete early virological response until the end of treatment showed a statistically significant decrease in HOMA-IR score. (who.int)
For some patients, yes, but for others it's hopeless - they simply can't understand that this test, which was the cornerstone of HIV monitoring for decades, now provides us with information that has no role in determining what we do therapeutically (provided the viral load remains suppressed). (jwatch.org)
The treatment was well-tolerated in all patients, and 4 of the patients saw viral load reductions averaging 2.05 log10 copies per milliliter. (hcplive.com)
According to the EUA, bamlanivimab is authorized for the treatment of mild to moderate COVID-19 in adults and pediatric patients who are 12 years of age and older weighing at least 40 kg, with positive results of direct SARS-CoV-2 viral testing, who are at high risk for progressing to severe COVID-19 and/or hospitalization. (reachmd.com)
There was a significant increase in overweight and obese patients. (who.int)
Le nombre de patients en surpoids ou obèses s'est fortement accru. (who.int)
Gender and viral load values were statistically significant when HIV-positive patients with and without oral lesions were compared. (bvsalud.org)

More than 30 bacterial, viral and parasitic pathogens are transmissible sexually. (who.int)

Traditionally, the vaccine was trivalent (ie, designed to provide protection against three viral subtypes, generally an A-H1, an A-H3, and a B). The first quadrivalent vaccines, which provide coverage against an additional influenza B subtype, were approved in 2012 and were made available for the 2013-2014 flu season. (medscape.com)
To overcome SARS-CoV-2 immune evasion, the relatively conserved, potentially immunogenic NSP4, NSP13, NSP14, membrane, and ORF3a viral proteins may serve as more suitable targets for molecular vaccines or therapeutics than the mutation-prone NSP6, spike, ORF8, or nucleocapsid protein. (bvsalud.org)
One of the key questions regarding COVID19 vaccines is whether they can reduce viral shedding. (medrxiv.org)
As we do not have access to the vaccine status of each test, our hypothesis was that if vaccines reduce viral load, we should see a difference in the Ct values between these two age groups in late January but not before. (medrxiv.org)

Influenza causes significant loss of workdays, human suffering, and mortality. (medscape.com)
The gold standard for diagnosing influenza A and B is a viral culture of nasopharyngeal samples or throat samples. (medscape.com)
Characterization of viral load, viability and persistence of influenza A virus in air and on surfaces of swine production facilities. (cdc.gov)

Many viral diseases remain significant challenges for society, especially in developing countries, and new treatments are still needed. (ubs.com)

We compared clinical outcomes among HIV-infected participants receiving ART who were randomized to viral load (VL) and CD4 cell count monitoring in comparison to CD4 cell count monitoring alone in Tororo, Uganda. (biomedcentral.com)
Participants with higher Ct values corresponding to lower viral loads had shorter viral clearance time than those of lower Ct values or higher viral loads. (bvsalud.org)

In multivariate analyses of log-transformed HIV-1 RNA levels, each log increment in the viral load was associated with a rate ratio of 2.45 for seroconversion (95 percent confidence interval, 1.85 to 3.26). (nih.gov)

Where available, anti-retroviral drugs can control HIV viral loads, effectively turning HIV into a manageable chronic condition. (ubs.com)

Chronic hepatitis B (CHB) is a viral disease, common across the world, and associated with several extraintestinal manifestations including vasculitis. (hindawi.com)
Cox's proportional hazard regressions to the two dependent variables of time to CD4 count below 200 x106L and time to ARC or AIDS diagnosis showed that biomedical variables were predominant in predicting disease progression but acceptance coping was a significant predictor of longer ARC or AIDS-free survival. (bl.uk)
The authors noted that a decreased viral load at day 11 did not appear to be a clinically meaningful end point since viral load went down in all groups, including placebo, a finding that was consistent with the natural course of the disease. (reachmd.com)

Main outcome measures Ribonucleic acid (RNA) viral load measured in respiratory, stool, serum, and urine samples. (bmj.com)
In practice, the viral load is estimated from the number of copies of ribonucleic acid (RNA) HIV-1 per milliliter of plasma, determined with commercial molecular technic used to evaluate the effectiveness of ART. (scirp.org)

The pathogeneses of bacterial and viral exacerbations are significant as clinical symptoms are more severe and there is a marked increase in neutrophilic inflammation and tissue damage. (frontiersin.org)

This happened in 2014-15, for example, with the introduction of new curative anti-viral therapies for hepatitis C (HCV). (ubs.com)

Anaemia at diagnosis was associated with a significant increase in BMI. (who.int)
Linkage to care was defined as one or more CD4 or viral load tests performed within 1 month of diagnosis. (cdc.gov)

The hypothesis of Opt4Kids was that point-of-care viral load testing and early referral for drug resistance testing would speed up clinical decision-making resulting in improved treatment outcomes among children with HIV. (aidsmap.com)

Viral load is measured using body fluids sputum and blood plasma. (wikipedia.org)
EDTA Plasma, from and EDTA blood sample is a good source of cell-free viral RNA for RNA-based viral load testing. (wikipedia.org)
EDTA blood can be stored at room temperature for 30 hours, and separated plasma for extended periods of time at -70 °C without significant decreases in viral load. (wikipedia.org)
High plasma levels of ivermectin can reduce SARS-CoV-2 viral load at a higher rate. (techarp.com)

C t values were determined by qRT-PCR and used as proxies for norovirus load. (cdc.gov)
A lower C t value indicates a higher norovirus load. (cdc.gov)
As an example of environmental specimens, the viral load of norovirus can be determined from run-off water on garden produce. (wikipedia.org)

Viral load monitoring for HIV is of particular interest in the treatment of people with HIV, as this is continually discussed in the context of management of HIV/AIDS. (wikipedia.org)

We then used demographic data and the daily vaccination rates to estimate the effect of vaccination on viral load reduction. (medrxiv.org)
Our estimate suggests that vaccination reduces the viral load by 1.6x to 20x in individuals who are positive for SARS-CoV-2. (medrxiv.org)

The viral load is the chief predictor of the risk of heterosexual transmission of HIV-1, and transmission is rare among persons with levels of less than 1500 copies of HIV-1 RNA per milliliter. (nih.gov)

0.05 indicated statistically significant trends, whereas p-values ≥0.05 indicated no significant change. (cdc.gov)

The prevalence of drug resistance is high among children with HIV, making it critical that children receive regimens that are active against drug-resistant virus and that clinicians have timely viral load information to enable a switch in treatment before high-level drug resistance emerges. (aidsmap.com)

Conclusions and Clinical Relevance -The difference in FHV-1 DNA load was unlikely to be biologically important. (avma.org)

Viral load dynamics. (bmj.com)

In 2017, with the support of the International Federation of Red Cross and Red Crescent Societies, the Institute Pasteur of Bangui (IPB) proposed the measurement of HIV viral load and other biological tests for the monitoring of people living with HIV (PLWH) were taken in charge. (scirp.org)
Changes in cell viability were monitored by continuous measurement of electrical impedance of cultured cells and by observation of viral cytopathic effects. (avma.org)

Dual antiviral therapy improved the clinical condition and reduced the viral load. (frontiersin.org)
Observational study suggests that an early one-week treatment at the first sign of viral reactivation may achieve clinical benefits and avoid antiviral toxicity. (hhv-6foundation.org)

Viral load, also known as viral burden, is a numerical expression of the quantity of virus in a given volume of fluid, including biological and environmental specimens. (wikipedia.org)

an experimental way of measuring the level of HIV in the blood, which costs just a fifth of the standard viral load test, and another to monitor the number of CD4+T cells - key immune system cells. (newscientist.com)
As secondary endpoints, we evaluated effects of treatment on viral loads, reservoirs, and immune system preservation. (natap.org)
Administered alone, it had no significant effect on immune activation. (natap.org)
Combining demographic, immune and viral parameters, the best predictive models for mortality comprised IFNB1 or age, viral ORF7a and ACE2 receptor transcripts. (nature.com)

And the viral load test showed "significant promise" for effectively monitoring HIV treatment, says CDC-Uganda researcher Robert Downing. (newscientist.com)

Chi-squared test was used to analyse viral load according to sex and age. (scirp.org)
citation needed] There are many different molecular based test methods for quantifying the viral load using NATs. (wikipedia.org)
The experimental viral load test measures the blood level of reverse transcriptase, an enzyme unique to retroviruses, instead of directly assessing the level of viral RNA. (newscientist.com)
Viral load was determined by using the COBAS TaqMan HBV test. (nursingcenter.com)
200 copies/mL or a viral load test interpretation value of undetected. (cdc.gov)

However, the team said that the viral load in these environmental samples was not very high (10 3.9 -10 2.6 per mg). (thepoultrysite.com)

The results from 187 carefully perused genome clones showed significantly higher mean percent mutations in the spike, ORF8, nucleocapsid, and NSP6 than in other viral proteins. (bvsalud.org)
160 ng/mL) showed significantly higher viral decay rate . (techarp.com)

The WHO 2003 guidelines for the use of ART initially did not recommend viral load (VL) testing as a necessary component of treatment programs. (biomedcentral.com)
The effect of treatment varied in individual hamsters infected with omicron, and viral load reduction was significant in males but not females. (eurekalert.org)

El CoV-2 causante del síndrome respiratorio agudo grave (SARS-CoV-2) apareció a finales de diciembre de 2019 en Wuhan, China, y en marzo de 2020 la COVID-19 fue declarada pandemia. (bvsalud.org)

Viral load and heterosexual transmission of human immunodeficiency virus type 1. (nih.gov)
We examined the influence of viral load in relation to other risk factors for the heterosexual transmission of human immunodeficiency virus type 1 (HIV-1). (nih.gov)
All hamsters treated with molnupiravir survived, showing reduction in lung virus load from one order of magnitude for delta to four orders of magnitude for gamma. (eurekalert.org)
The most significant finding of the study was the detection of the virus in chicken dust and litter. (thepoultrysite.com)

The present study quantified gene/protein mutations in 13 major SARS-CoV-2 variants of concern/interest, and analyzed viral protein antigenicity using bioinformatics. (bvsalud.org)

Rhesus macaques were infected with a chimeric SIV-HIV (SHIV 89.6P). This viral strain in this animal induces rapid CD4 depletion within weeks. (natap.org)

Anatomy10

Organisms21

Diseases31

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Psychiatry and Psychology5

Phenomena and Processes25

Disciplines and Occupations1

Technology, Industry, Agriculture1

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Named Groups2

Health Care18

Geographicals7

Suppression22

Infection13

Reduction in viral load3

Undetectable2

Antiretroviral6

Lower viral load1

Infections6

20212

High viral1

Statistically significant differences3

Quantify3

Assay5

10003

Adherence1

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Counts6

Replication1

Patients10

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Participants2

Multivariate1

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Bacterial1

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20201

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