• and 4) a NAT for HCV RNA is recommended for perinatally exposed infants and children aged 7-17 months who previously have not been tested, and a hepatitis C virus antibody (anti-HCV) test followed by a reflex NAT for HCV RNA (when anti-HCV is reactive) is recommended for perinatally exposed children aged ≥18 months who previously have not been tested. (cdc.gov)
  • Studies have estimated that chronic HCV infection will develop in 5.8%-7.2% of all perinatally exposed (i.e., exposed during pregnancy or delivery) infants and children ( 13 , 14 ), and curative direct-acting antiviral (DAA) therapy can be administered beginning at age 3 years ( 15 , 16 ). (cdc.gov)
  • No association was observed between PCE exposure and MBW, and a weak association was observed between PCE exposure and SGA infants, overall. (cdc.gov)
  • Much stronger associations were observed between PCE exposure and both birth weight outcomes among the infants of mothers who were 35 years of age or older and among the infants of mothers who had histories of fetal deaths, especially mothers who had had two or more fetal deaths. (cdc.gov)
  • In male infants, the association between long-term TCE exposure and these study outcomes was much more pronounced. (cdc.gov)
  • A peripheral maternal blood smear was ni infants considered by their mothers to be made by finger prick. (who.int)
  • Creatine kinase (CK), lactate dehydrogenase (LDH), and amylase levels of preterm infants following long-term tocolysis in pregnant women are limited. (hindawi.com)
  • This study included 215 preterm infants born to women treated with and without ritodrine hydrochloride. (hindawi.com)
  • Although ritodrine hydrochloride crosses the placenta freely [ 6 ], the data concerning escape enzyme, such as CK, lactate dehydrogenase (LDH), and amylase levels of preterm infants following long-term ritodrine tocolysis in pregnant women are limited. (hindawi.com)
  • Therefore, the aim of this study is to determine if the tocolytic therapy affects CK, LDH, and amylase levels in the umbilical blood of preterm infants. (hindawi.com)
  • To examine the clinical significance of the relationship between ritodrine hydrochloride and escape enzymes in the preterm infants, we reviewed all patients who were delivered at less than 36 weeks of gestation with preterm birth in the Perinatal Center of Social Insurance Funabashi Central Hospital between July 1, 2005, and June 30, 2008. (hindawi.com)
  • We assessed 625 samples (from 117 mothers and 130 very preterm infants). (nature.com)
  • The last published guidance for enteral nutrition in preterm infants by the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) [ 8 ] recommends an intake of 110-135 kcal/kg/day with between 3.5 and 4.0 (for patients weighing 1000-1800 g) and 4.0-4.5 g/kg/day (if under 1000 g) of protein. (nature.com)
  • Breast milk (BM) is beneficial due to its content in a wide range of different antioxidants, particularly relevant for preterm infants, who are at higher risk of oxidative stress. (mdpi.com)
  • Background As a result of advances in perinatal care, more small preterm infants survive. (bmj.com)
  • Advances in perinatal care have markedly increased the prospects of survival for infants born extremely preterm (EP). (bmj.com)
  • Diaz-Gomez NM, Domenech E, Barroso F, Castells S, Cortabarria C, Jiménez A. The effect of zinc supplementation on linear growth, body composition and growth factors in preterm infants. (ijpediatrics.com)
  • There is some evidence for impaired growth and psychomotor neurodevelopment in infancy (birth to 2 years) after preeclampsia exposure [ 23 , 24 ], but much of the existing data are limited by their minimal adjustment for perinatal confounders, the variable use of assessment tools for growth and development, and their specific study cohorts of preterm or very low birthweight (VLBW) infants (Table 1 and 2 ). (biomedcentral.com)
  • We aimed to determine whether infants with intrauterine preeclampsia exposure, compared to infants born from normotensive pregnancies, have differing anthropometric growth outcomes and psychomotor developmental outcomes from birth to 2 years of age. (biomedcentral.com)
  • On the other hand, among the fewer than 45% of infants who were exposed and delivered at term, "minor short-term benefit may have been outweighed by significant longer-term risks," she wrote. (medpagetoday.com)
  • After accounting for gestational age and maternal antibiotics, the distribution of organisms in all samples and the corresponding metabolic pathway abundance were compared between infants exposed to postnatal antibiotics and antibiotics-naïve infants. (biomedcentral.com)
  • In antibiotic-naïve infants, gestational and postnatal age imparted similar trajectories on maturation of the microbial community and associated metabolic functional capacity, with postnatal age exerting greater contribution. (biomedcentral.com)
  • Our findings may provide a mechanistic explanation for the known associations between antibiotic use and adverse outcomes in preterm infants. (biomedcentral.com)
  • In order to increase insight into the ontogeny of the microbiome in preterm infants, especially as it relates to modifiable environmental conditions, such as antibiotic exposure, we assessed the microbiome in a prospective cohort of preterm infants, from birth till 3 weeks of age using shotgun metagenomic sequencing. (biomedcentral.com)
  • At the 2016 conference of the International Lactation Consultant Association, anthropologist Katie Hinde , PhD discussed how a preponderance of "breastfed-type" bifidos bacteria in a baby's gut, especially B. infantis , is associated with better health outcomes and development, including improved immune function and decreased incidence of necrotizing enterocolitis ( a serious intestinal disease) in preterm infants. (llli.org)
  • It has been reported that pregnant women whose occupations require standing or repetitive, strenuous, physical work (eg, lifting) have a tendency to deliver earlier and have small-for-gestational-age infants (6). (afpafitness.com)
  • Prematurity is defined by the gestational age at which infants are born. (msdmanuals.com)
  • Preterm infants, even late preterm infants who are the size of some full-term infants, have increased morbidity and mortality compared to full-term infants due to their prematurity. (msdmanuals.com)
  • Preterm infants tend to be smaller than term infants. (msdmanuals.com)
  • 1 Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina. (nih.gov)
  • Despite the overall finding of no association between PCE and birth weight outcomes, there were two clinically distinct subgroups in which PCE exposure was associated with birth weight outcomes-mothers 35 years of age or older and mothers with a history of fetal deaths. (cdc.gov)
  • Recently, the incidence of preterm birth has increased, despite rapid advances in maternal-fetal medicine. (hindawi.com)
  • Studies on preterm birth needs to occur in high burden countries and control for clinical characteristics (maternal, fetal, labor, and placental) that may have an impact on placental histopathological abnormalities. (ox.ac.uk)
  • 1 Thus, preterm birth and the necessary respiratory support may disturb fine-tuned programmed patterns of fetal lung development, potentially with long-lasting negative effects on lung function. (bmj.com)
  • Improving the outcome of multifetal pregnancies involves decreasing the rate of preterm births, providing an optimal intrauterine environment for fetal growth, optimizing neonatal care in the delivery room, and neonatal ICU if required. (medscape.com)
  • The increase in fetal and neonatal morbidity and mortality associated with multiple- gestation/birth pregnancies correlates with an increased risk of preterm delivery, low birth weight, and intrauterine growth retardation. (medscape.com)
  • Severe maternal zinc deficiency has been associated with poor fetal growth, spontaneous abortion and congenital malformations (i.e., anencephaly), whereas milder forms of zinc deficiency have been associated with low birth weight (LBW), intrauterine growth retardation, and preterm delivery. (ijpediatrics.com)
  • The most common definition used is fetal weight below the 10th percentile for gestational age. (medscape.com)
  • In most cases of fetal growth restriction, the transcerebellar diameter appears to be spared and can be used as an unbiased measure of gestational age. (medscape.com)
  • The most frequently studied vessel in Doppler velocimetry is the umbilical artery because of its accessibility and association with fetal outcome. (medscape.com)
  • If the estimated fetal weight is below the 10th percentile for gestational age, they suggest that further evaluation be considered, such as amniotic fluid assessment and Doppler blood flow studies of the umbilical artery. (medscape.com)
  • Prenatal maternal stress is associated with pregnancy complications, poor fetal development and poor birth outcomes. (bgu.ac.il)
  • The aim of this study was to evaluate whether fetal sex modifies the association between continuous exposure to life-threatening rocket attack alarms and adverse pregnancy outcomes. (bgu.ac.il)
  • Medically indicated preterm deliveries were associated with hypertension and fetal growth restriction. (biomedcentral.com)
  • However the association between preterm birth and other maternal and fetal complications of pregnancy is less consistent, due to social, ethnic and demographic differences amongst the populations studied [ 7 ]. (biomedcentral.com)
  • There is no significant association between PTD and either maternal or fetal TNF‑α −308 polymorphism and frequency ofGAmutation is not significantly increased in mothers and neonates delivered preterm. (ac.ir)
  • Immunological maladaptation in the maternal-fetal interface has accounted for the pathogenesis of adverse pregnancy outcomes, including PE, intrauterine growth restrictions, spontaneous preterm births, and congenital infections [ 1 ]. (biomedcentral.com)
  • The indications for delivery in preterm birth group included preterm labor and preterm premature rupture of the membranes without other maternal or fetal indications. (biomedcentral.com)
  • There was a significant interaction with fetal sex (p-for-interaction = 0.037): among women carrying male fetuses, high cortisol at baseline increased the risk of preterm delivery threefold (3.18 (1.51, 6.71)) while there was no association (1.17 (0.50, 2.74)) among women carrying female fetuses. (biomedcentral.com)
  • Subgroup analysis by fetal sex revealed that this association is evident primarily among women carrying male fetuses. (biomedcentral.com)
  • Future studies of cortisol and preterm delivery should include consideration of fetal sex as a potential effect modifier. (biomedcentral.com)
  • The relative risk of fetal exposure to maternal depression versus that of antidepressant medication remains poorly defined because of our reliance on a patchwork conglomeration of case series, pregnancy registries, and observational studies with inconsistent levels of control for potentially confounding exposures. (psychiatrictimes.com)
  • Many interventions have been performed in pregnant women at risk of preterm delivery, hoping to reach greater maturity of the fetal lungs, especially regarding the lungs development and adequate surfactant function. (researchsquare.com)
  • Maternal and fetal characteristics and the results of the systematic postmortem examination protocol were collected from medical records. (degruyter.com)
  • However, other reports have failed to confirm these associations suggesting that several factors or conditions have to be present for strenuous activities to affect fetal growth or outcome (7, 8). (afpafitness.com)
  • Gestational age is not the actual embryologic age of the fetus, but it is the universal standard among obstetricians and neonatologists for discussing fetal maturation. (msdmanuals.com)
  • No association was evident between post-traumatic stress symptomatology and pregnancy outcome. (cdc.gov)
  • In addition to abstracting maternal demographic and obstetric characteristics, two study investigators separately reviewed each of the images from the first transvaginal ultrasound after cerclage placement, masked to pregnancy outcomes. (nih.gov)
  • As a result of increasing rates of acute infections in reproductive-aged persons and subsequent chronic infections, overall rates of HCV infections during pregnancy have increased by 20% during 2016-2020 and up to tenfold during 2000-2019 ( 6 , 7 ). (cdc.gov)
  • In 2020, because of the changing epidemiology of HCV infections in the United States, CDC expanded previous risk-based testing recommendations to include universal screening for all adults aged ≥18 years at least once and for all pregnant persons during each pregnancy ( 12 ). (cdc.gov)
  • ABSTRACT To investigate the consequences of maternal malaria during late pregnancy, we conducted a preliminary study in the 2 hospitals in Al Hodeidah on 276 women who had uncomplicated vaginal deliveries. (who.int)
  • Data con- maternal (100/10 000 live births, 1991) and cerning personal and obstetric history, the infant (78.8/1000 live births, 1998) mortal- current pregnancy and pregnancy outcome ity rates have been recorded [ 8 ]. (who.int)
  • Gestational diabetes mellitus (GDM) is defined as glucose intolerance of variable degree with onset or first recognition during pregnancy. (medscape.com)
  • Gestational diabetes mellitus accounts for 90% of cases of diabetes mellitus in pregnancy, while preexisting type 2 diabetes accounts for 8% of such cases. (medscape.com)
  • The US Preventive Services Task Force (USPSTF) recommends screening for gestational diabetes mellitus after 24 weeks of pregnancy. (medscape.com)
  • Women with prediabetes identified before pregnancy should be considered at extremely high risk for developing gestational diabetes mellitus during pregnancy. (medscape.com)
  • The strength of these associations is small compared with factors in the prior reproductive history and with medical and obstetric complications of the current pregnancy. (frc.org)
  • In 2013, the U.S. birth rate for teenagers aged 15-19 dropped 57% from its peak in 1991, paralleling a decline in the teen pregnancy rate. (cdc.gov)
  • The association between exposure to secondhand smoke (SHS) during pregnancy and a child's neurodevelopment has not been established yet. (biomedcentral.com)
  • We quantified urine cotinine concentrations in mothers once from 12th to 20th gestational weeks and excluded those whose urine cotinine levels exceeded 42.7 ng/ml to represent SHS exposure in early pregnancy. (biomedcentral.com)
  • Maternal exposure to SHS during pregnancy may result in delayed MDI in early childhood. (biomedcentral.com)
  • Smoking during pregnancy is a well-known risk factor for adverse birth outcomes such as spontaneous abortion [ 4 ], low birth weight, and preterm birth [ 5 ] that, in turn might affect children's development. (biomedcentral.com)
  • Could prior Pregnancy Termination increase Preterm Delivery Risk? (drtonybushati.com)
  • The association between prior surgical or medical pregnancy termination and PTD, low birth weight (LBW), and small for gestational age (SGA) were evaluated. (drtonybushati.com)
  • Determinants of maternal zinc status during pregnancy. (ijpediatrics.com)
  • Ross SM, Nel E, Naeye R. Differing effects of low and high bulk maternal dietary supplements during pregnancy. (ijpediatrics.com)
  • Adolescent pregnancy: associations among body weight, zinc nutriture, and pregnancy outcome. (ijpediatrics.com)
  • Three previous reviews on the association of vitamin D insufficiency in pregnancy with preterm birth (PTB) and stillbirth were limited in scope and deemed inconclusive. (vitamindwiki.com)
  • Our study found no evidence to support an association between antipsychotic medication use during pregnancy and an increased risk of neurodevelopmental disorders in children" such as ADHD or autism , Wang and colleagues write . (sciencealert.com)
  • The risk associated with treatment exposure appeared to be comparable in magnitude to the risk of key covariates, such as maternal smoking during pregnancy. (medpagetoday.com)
  • The antiretroviral coverage during pregnancy was 95.5%, with most (87.8%) wom- en reporting excellent or good adherence. (who.int)
  • This is a part of a prospective cohort study among pregnant women in Ibadan, Nigeria (Ibadan Pregnancy Cohort Study (IbPCS), which investigated the associations between maternal obesity, lifestyle characteristics and perinatal outcomes in Ibadan. (springer.com)
  • Alcohol during pregnancy has many detrimental effects, including adverse birth outcomes such as low birth weight, preterm birth, and small for age [ 5 , 6 ]. (springer.com)
  • 39 years), socioeconomic problems, smoking during pregnancy, hypertension, psychiatric disorders and uterine abnormalities were significantly associated with preterm deliveries. (biomedcentral.com)
  • when adjustments for these three factors were made the relationship between psychiatric disease and pregnancy outcome was no longer significant. (biomedcentral.com)
  • Our objective was to determine whether maternal salivary cortisol during pregnancy was associated with pregnancy duration and preterm delivery in Ghana. (biomedcentral.com)
  • We used adjusted linear regression models to examine the association between cortisol and pregnancy duration and Poisson regression models to determine the risk of preterm delivery among women with high cortisol at baseline or 28 wk. (biomedcentral.com)
  • Mean maternal cortisol increased throughout pregnancy, from 4.9 ± 2.7 nmol/L at baseline (16 wk) to 6.4 ± 3.2 nmol/L at 28 wk. (biomedcentral.com)
  • Higher maternal cortisol is associated with a shorter pregnancy duration and an increased risk of preterm delivery. (biomedcentral.com)
  • During pregnancy, the placenta produces corticotropin-releasing hormone (CRH), the majority of which enters the maternal bloodstream and stimulates production of cortisol, causing circulating free cortisol to increase, beginning around the 25th week of gestation. (biomedcentral.com)
  • Despite, or perhaps because of, heightened attention to the use of antidepressants during pregnancy over the past decade, the management of prenatal maternal depression has become increasingly controversial. (psychiatrictimes.com)
  • The maternal outcome was studied in terms of type of labour, outcome of pregnancy, mode of delivery, indication of cesarean section, and maternal mortality. (hindawi.com)
  • Information is shown for the items: Risk factors in this pregnancy, Obstetric procedures, Characteristics of Objectives --This is the first report to present maternal and infant labor and delivery, Method of delivery, Abnormal conditions of the health information exclusive to the 2003 revision of the U.S. Standard newborn, and Congenital anomalies of the newborn. (cdc.gov)
  • No significant differences were found for mean gestational age, mean birthweight, the frequency of preterm births, or incidence of low birth weight. (cdc.gov)
  • In the United Kingdom, South Asian mothers have a slightly higher rate of preterm birth compared to White British mothers and their babies are twice as likely to be born with a low birthweight (below 2500 g) [ 21 ]. (springer.com)
  • Compared with a paternal age of 25-28 years as a reference group, the odds ratio for low birthweight was approximately 1.1 at a paternal age of 20 and approximately 1.2 at a paternal age of 50. (wikipedia.org)
  • results showed hospitalizations for acute respiratory or febrile illnesses were associated with low birthweight but not small-for-gestational-age births. (cdc.gov)
  • The state of North Dakota scores lower than the nation overall in births to unmarried mothers, cesarean deliveries, preterm births and low birthweight. (cdc.gov)
  • Multivariable models for each gender separately, controlling for possible confounders, evaluated the risk associated with exposure for preterm births (PTB), low birthweight (LBW), small for gestational age and small head circumference (HC). (bgu.ac.il)
  • High paternal age has been suggested as a risk factor for type 1 diabetes, but research findings are inconsistent, and a clear association has not been established. (wikipedia.org)
  • If maternal diabetes is longstanding or associated with known microvascular disease, obtain a baseline maternal electrocardiogram (ECG) and echocardiogram. (medscape.com)
  • In the arena of periodontal medicines, the studies of past decades suggest a link between human periodontal afflictions and certain systemic disorders such as cardiovascular diseases, diabetes mellitus, respiratory disorders, preterm birth, autoimmune disorders, and cancer. (encyclopedia.pub)
  • The data were controlled for infant characteristics such as birth year, admission to the neonatal ICU, and weight and gestational age, as well as maternal characteristics (delivery mode, smoking, gestational diabetes, and mental health disorders). (medpagetoday.com)
  • All singleton pregnant women with a gestational age of less than 34 weeks and at risk of preterm delivery, normal prenatal ultrasound screening results, and no significant medical and obstetrical conditions regarding the mother (such as cardiovascular disorders, diabetes mellitus, epilepsy, and asthma) were included in the study. (researchsquare.com)
  • Gestational diabetes mellitus (GDM) has become a major public health issue and one of the most discussed topics in contemporary obstetrics. (degruyter.com)
  • To assess the association between circulating angiogenic and antiangiogenic factors in the second trimester and risk of preeclampsia in women with type 1 diabetes. (diabetesjournals.org)
  • Maternal plasma concentrations of placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), and soluble endoglin (sEng) were available at 26 weeks of gestation in 540 women with type 1 diabetes enrolled in the Diabetes and Preeclampsia Intervention Trial. (diabetesjournals.org)
  • The American Diabetes Association has endorsed exercise as "a helpful adjunctive therapy" for gestational diabetes mellitus when euglycemia is not achieved by diet alone (3, 4). (afpafitness.com)
  • levels for both types of diabetes increased steadily with maternal states ( Table A ) represent 14 percent of all U.S. 2004 births. (cdc.gov)
  • Some studies have identified relationships between PFAS exposure and reproductive outcomes, although the evidence regarding the pathway and significance of associations is mixed. (biomedcentral.com)
  • A new paper in the Journal of the American Medical Association found that Nurse-Family Partnership (NFP), a prenatal and early child home visiting program, did not improve birth outcomes for low-income mothers in South Carolina. (scienceblog.com)
  • The randomized evaluation measured maternal and newborn health as a composite outcome indicating whether a participant experienced any of the following adverse birth outcomes: preterm birth, low birth weight, small for gestational age, or perinatal death. (scienceblog.com)
  • There was also no statistically significant effect on any individual component of the composite, or on nine other secondary outcomes. (scienceblog.com)
  • Previous studies indicated a range of risk factors associated with these poor outcomes, including maternal psychosocial and economic wellbeing. (springer.com)
  • The consequences of these poor perinatal outcomes present a significant public health issue, requiring an exploration into primary prevention. (springer.com)
  • The relevant evidence of laryngeal mask airway (LMA) on maternal and neonatal outcomes is still limited. (frontiersin.org)
  • We aimed to assess the maternal and neonatal outcomes when the LMA Supreme was used for cesarean section under general anesthesia. (frontiersin.org)
  • The primary outcome was adverse maternal and neonatal outcomes defined as maternal regurgitation, aspiration, hypoxemia, and low neonatal Apgar scores. (frontiersin.org)
  • The LMA Supreme was not associated with higher adverse maternal and neonatal outcomes when compared to an endotracheal tube for cesarean section under general anesthesia. (frontiersin.org)
  • We hypothesized that the LMA Supreme is not associated with higher adverse maternal and neonatal outcomes when compared to the tracheal tube. (frontiersin.org)
  • However, the association between IPI and maternal and neonatal outcomes in women whose first delivery was by cesarean delivery is unclear. (biomedcentral.com)
  • Our study results suggest that if pregnant women have a clinical need for antipsychotics, clinicians should not stop administering regular treatment because of a fear of birth outcomes with ADHD, ASD, preterm birth, and small for gestational age," write pharmaco-epidemiologist Zixuan Wang from the University College London and colleagues in their published paper . (sciencealert.com)
  • Melchiorre et al found that there is a significant relationship between first-trimester uterine artery Doppler resistance indices (RI) and the subsequent delivery of neonates who are small for gestational age (SGA) or have intrauterine growth restriction. (medscape.com)
  • Therefore, we compared the frequency of G308A transition in the promoter region of TNF‑α gene of women and neonates delivered preterm with the normal subjects. (ac.ir)
  • According to the gestational age, mothers and their neonates were allocated to the case (preterm, 64 subjects) and control (term, 71 subjects) groups. (ac.ir)
  • Butyrate-producing genera, including Clostridium and Blautia , were significantly more abundant in antibiotic-naïve neonates at 3 weeks postnatal age. (biomedcentral.com)
  • We also characterized the abundance of microbial genes that encode metabolic functions and identified metabolic pathways that are impacted by antibiotics exposure in our cohort of low gestational age neonates. (biomedcentral.com)
  • The present study aimed to evaluate the effect of 25 - hydroxyvitamin D [25(OH)D] administration in pregnant women at risk of preterm delivery on the incidence of RDS in their preterm neonates. (researchsquare.com)
  • Neonatal Respiratory Distress Syndrome (RDS) is a significant cause of mortality and morbidity in preterm neonates besides leading to a remarkable rise in NICU-hospitalization related costs. (researchsquare.com)
  • Pregnancies complicated by multiple births are associated with a higher rate of neonatal morbidity and mortality, paralleling the increased risk of preterm delivery, low birth weight, and other associated high-risk morbidities. (medscape.com)
  • [ 1 ] Maternal morbidity and mortality are also increased in pregnancies complicated by multiple gestations and multiple births. (medscape.com)
  • PTD is associated with significant morbidity and mortality of the newborn. (drtonybushati.com)
  • PTD is also a source of increased maternal morbidity and mortality. (drtonybushati.com)
  • This multisystem disorder affects millions of women worldwide and is recognized as an important direct cause of maternal and foetal morbidity and mortality [ 2 ]. (hindawi.com)
  • To assess the value of transvaginal ultrasound parameters after cerclage placement in estimating the risk of spontaneous preterm birth. (nih.gov)
  • and among spontaneous idiopathic preterm births, in whether there was preterm labour or premature rupture of the membranes. (frc.org)
  • Vitamin D insufficiency was not associated with risk of spontaneous abortion and stillbirth (RR of 1.04 [95% CI: 0.95,1.13] and 1.02 [95% CI: 0.96,1.09], respectively), as well as short gestational length (ES = -0.24, 95% CI: -0.69, 0.22), and low Apgar score . (vitamindwiki.com)
  • 53% of preterm deliveries were spontaneous, and were strongly associated with episodes of threatened preterm labour. (biomedcentral.com)
  • Preterm premature rupture of the membranes, vaginal bleeding, anaemia and oligohydramnios were significantly increased in both spontaneous and indicated preterm deliveries compared to term controls. (biomedcentral.com)
  • To compare single nucleotide polymorphisms (SNPs) in the 3′-untranslated region (3′UTR) of human leukocyte antigen (HLA)-G in placentas between spontaneous preterm birth and preeclampsia pregnancies. (biomedcentral.com)
  • Placental samples matched for gestational age were obtained from 20 cases of spontaneous preterm births and 19 cases of preeclampsia. (biomedcentral.com)
  • Therefore, the aim of the present study was to compare SNPs in the 3′UTR of the HLA-G between pregnancies complicated with spontaneous preterm births and those with preeclampsia in gestational age matched placentas. (biomedcentral.com)
  • We collected placental samples from 20 cases with spontaneous preterm births and 19 cases of preeclampsia. (biomedcentral.com)
  • For gestational age matching, cases of spontaneous preterm birth were selected with a similar gestational age at delivery for each case of preeclampsia. (biomedcentral.com)
  • Preterm labor was defined as demonstrated progressive dilation of the cervix with uterine contractions before 36 weeks of gestation. (hindawi.com)
  • Gestational age was estimated based on menstrual dates and an ultrasound examination performed before 20 weeks of gestation. (hindawi.com)
  • 37 weeks of gestation) is a significant clinical and public health problem. (johnshopkins.edu)
  • Multiple-gestation pregnancies are associated with a significantly higher maternal complication rate than are singleton gestations. (medscape.com)
  • Preterm delivery (PTD) is defined as a delivery before the 37th week of gestation. (drtonybushati.com)
  • This study has been undertaken to confirm the association between maternal serum zinc concentration and birth weight and period of gestation in setting like India. (ijpediatrics.com)
  • The transcerebellar diameter in millimeters is equal to gestational age in weeks to 22 weeks of gestation. (medscape.com)
  • Analysis of preterm deliveries below 35 weeks' gestation in a tertiary referral hospital in the UK. (biomedcentral.com)
  • 274 deliveries between 23-35 weeks' gestation (preterm group), were compared to 559 randomly selected control deliveries at term (37-42 weeks) using standard statistical procedures. (biomedcentral.com)
  • However, the mechanisms that lead to preterm birth, defined as birth before 37 completed weeks of gestation, remain poorly understood and the actual cause of preterm birth is unestablished in most cases [ 2 ]. (biomedcentral.com)
  • An infant born before 37 weeks gestation is considered preterm. (msdmanuals.com)
  • Birth prior to 37 weeks gestation is considered preterm. (msdmanuals.com)
  • PubMed/Medline, Scopus, Web of Science and Embase were searched using the keywords related to preterm birth, placental histopathology and infection. (ox.ac.uk)
  • Together, the findings suggest "unmeasured familiar confounding did not explain these associations," and that corticosteroids "may not pose a risk for mental and behavioral disorders independent of complications and illnesses related to preterm birth," Räikkönen and colleagues wrote. (medpagetoday.com)
  • Subjects were included preterm labor, premature rupture of membranes (PROM), and cervical insufficiency. (hindawi.com)
  • More than 50% of preterm births are potentially preventable, but remain associated with risk factors such as increased uterine contractility, preterm premature rupture of the membranes and uterine bleeding whose aetiology is unknown. (biomedcentral.com)
  • A realization in recent years of its association with severe diseases such as carditis, low birth weight babies, and preeclampsia has instigated dedicated research in this area. (encyclopedia.pub)
  • It is additionally unknown whether any impacts of preeclampsia are independent of confounders including shared genetic factors that predispose to both preeclampsia and childhood morbidity, perinatal factors including small for gestational age or preterm birth and their sequelae, and postnatal environmental factors such childhood nutrition. (biomedcentral.com)
  • Recently, associations between preeclampsia and SNPs in the 3′ untranslated region (3′UTR) of HLA-G have been observed [ 13 ]. (biomedcentral.com)
  • However, these studies only compared placentas from cases of preeclampsia and normal full term pregnancies without consideration of gestational age at delivery. (biomedcentral.com)
  • To investigate association between maternofoetal complications and the amount of proteinuria measured by spot urine protein creatinine ratio in patients with preeclampsia. (hindawi.com)
  • Preeclampsia is a major health problem in maternal health with the prevalence ranging from 1.8% to 16.7% in developing countries [ 1 ]. (hindawi.com)
  • A couple of studies have also been done to find out association between the amount of proteinuria and maternofoetal outcome in patients with preeclampsia but the results have been variable [ 9 - 11 ]. (hindawi.com)
  • This study was carried out in patients with preeclampsia to estimate the prevalence of maternal and foetal morbidity and to investigate the association between the amount of proteinuria measured by spot UPCR and maternofoetal outcome. (hindawi.com)
  • In the present study, preeclampsia was diagnosed in patients who had resting blood pressure equal to or more than 140/90 mmHg at two different occasions at least 4 hours apart with significant proteinuria detected in urine samples (defined as more than or equal to 300 mg/24 hrs or spot UPCR 0.3 gm/gm in random urine sample). (hindawi.com)
  • Of the mothers aged 35 years and older, the number of women studied was relatively small. (cdc.gov)
  • Regarding ND, 70.71% of the children had achieved the motor milestones for their age, 98.99% of mothers breastfed, 37.38% of them had exclusive breastfed (EBF) for six months. (bvsalud.org)
  • We explored the association between prenatal exposure to SHS and neurodevelopment at 24 months of age considering genetic polymorphism and breastfeeding in 720 mothers and their offspring enrolled in the Korean multicenter birth cohort study (Mothers and Children Environmental Health, MOCEH). (biomedcentral.com)
  • No association was evident in children whose mothers had cotinine levels ≤1.90 ng/ml. (biomedcentral.com)
  • It also protects mothers against breast and ovarian cancer, osteoporosis and postpartum bleeding while promoting maternal-child bonding [ 2 ]. (biomedcentral.com)
  • Both lean and obese mothers were more common in the preterm group. (biomedcentral.com)
  • A single-blinded randomized controlled clinical trial was conducted on pregnant mothers with a gestational age of less than 34 weeks at risk of preterm delivery. (researchsquare.com)
  • But a significant portion comes from mothers' milk, when maternal gut bacteria migrate to the mammary glands and are ingested by the baby. (llli.org)
  • The preterm labour and low birth weight rates were 21.2% and 15.9%, respectively. (who.int)
  • Significant breakthroughs in the management of preterm birth are likely to come from research into the mechanisms of human parturition and the pathophysiology of preterm labour using multidisciplinary clinical and laboratory approaches. (biomedcentral.com)
  • Preterm birth remains a major cause of perinatal mortality and morbidity and efforts to predict and prevent its occurrence are difficult because of our lack of understanding of the biochemical mechanism of labour and the multiplicity of medical and socioeconomic factors associated with preterm delivery [ 1 ]. (biomedcentral.com)
  • Log binomial regression was used to estimate the relative risk of preterm birth for all significant obstetric and ultrasound characteristics. (nih.gov)
  • 6.3 nmol/L) had an increased relative risk of preterm delivery (RR (95% CI): 1.96 (1.13, 3.40)), but the association between high cortisol at 28 wk. (biomedcentral.com)
  • Nurses tailored activities to clients' strengths, risks, and preferences using motivational interviews, educational tools, health assessments, and goal-setting related to prenatal health, child health and development, and maternal life course. (scienceblog.com)
  • The data were collected among low- income households as part of an evaluation of the government's Oportunidades poverty reduction program.4 Using information about prenatal care procedures received from 3,553 women of reproductive age, we predicted the average proce- dures received by clinical setting and individual characteristics in multivariate analyses. (who.int)
  • Although effects of prenatal exposure to SHS on early neurodevelopment vary among studies, they remain significant issues. (biomedcentral.com)
  • and (3) the impact of untreated maternal prenatal depression on the well-being of offspring. (psychiatrictimes.com)
  • In the analyses of PCE exposure, a slight but statistically significant difference in MBW was observed between the exposed and comparison groups. (cdc.gov)
  • In a retrospective cohort study of VSD data from 45,356 children aged 6-23 months during 1991-2003, IIV3 was not associated with statistically significant increases in any clinically important medically attended events other than gastritis/duodenitis during the 2 weeks after vaccination compared with control time periods before and after vaccination ( 391 ). (cdc.gov)
  • We found a statistically significant association between low surrounding greenness and term low birth weight. (edu.au)
  • the results were statistically significant. (ijpediatrics.com)
  • Statistically significant association was found between the frequencies of various complications in mother and newborn and spot UPCR. (hindawi.com)
  • An array of: definitions of preterm birth subgroups, histological classification systems, histopathologic abnormalities and diagnostic methods to identify infections were reported in this systematic review. (ox.ac.uk)
  • As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)
  • Methods Two population-based cohorts born at gestational age ≤28 weeks or with birth weight ≤1000 g performed lung function tests at 10 and 18 and at 18 and 25 years of age, respectively, together with matched term-born controls. (bmj.com)
  • Information on the impact of maternal, gestational or neonatal characteristics on milk macronutrient composition could help identify mother-infant pairs at higher risk of extrauterine growth restriction and move towards a more individualized nutritional support [ 24 ]. (nature.com)
  • In this context, we aimed to measure macronutrient content of very preterm milk and to identify changes associated with time and maternal, gestational and neonatal characteristics. (nature.com)
  • NCHS has just released a new report that presents preliminary data on births and birth rates and selected maternal and infant health characteristics for the United States in 2014. (cdc.gov)
  • 0.001), but not among children born preterm (HR 1.00, 95% CI 0.92-1.09, P =0.97), they added. (medpagetoday.com)
  • Recent epidemiological research activities have focused on the ways in which risk factors such as physical workload, drugs and alcohol, lack of social support and infection might be mediating factors between sociodemographic status and preterm birth. (frc.org)
  • In a recent case-control study of antenatal and intrapartum risk factors for cerebral palsy in very preterm babies we found associations between chorioamnionitis, prolonged rupture of membranes, and maternal infection and an increased risk of cerebral palsy. (bmj.com)
  • Infection is known to play a significant role in preterm birth. (ox.ac.uk)
  • The aim of this systematic review is to explore the association between placental histopathological abnormality and preterm birth in the presence of confirmed infection. (ox.ac.uk)
  • Despite this, histopathological chorioamnionitis, and funisitis (when examined) were commonly observed in preterm birth complicated by confirmed bacterial or viral, but not parasitic, infection. (ox.ac.uk)
  • In high income countries, there has been minimal decline in the rate of preterm birth in the last few decades [ 29 ]. (springer.com)
  • Longitudinal development was compared for groups born at term and preterm, split by a history of absence (n=20), mild (n=38) or moderate/severe (n=25) neonatal bronchopulmonary dysplasia (BPD). (bmj.com)
  • The aim of this statement is to discuss the current knowledge of prevention of VKDB with respect to the term and preterm infant and address parental concerns regarding vitamin K administration. (aap.org)
  • Transvaginal ultrasound parameters were compared between women with preterm birth and those without preterm birth using chi-square, Fisher's exact, and Wilcoxon's rank-sum tests, as appropriate. (nih.gov)
  • Increased concentrations of tumor necrosis factor alpha (TNF‑α) in blood and amniotic fluid are observed in women with preterm delivery (PTD) and TNF‑α mutations at −308 position are associated with higher expression of this gene. (ac.ir)
  • The beta-adrenergic agent ritodrine hydrochloride is commonly used for the treatment of preterm labor in Japan. (hindawi.com)
  • Commitment to using standardised terminology and classification of histopathological abnormalities associated with infections is needed to identify causality and potential treatment of preterm birth. (ox.ac.uk)
  • Mental developmental index (MDI) and psychomotor developmental index (PDI) values were measured using the Korean version of the Bayley Scales of Infant Development II (K-BSID-II) at 24 months of age. (biomedcentral.com)
  • Four in five neonatal deaths of preterm births occur in low and middle income countries and placental histopathology examination can help clarify the pathogenesis. (ox.ac.uk)
  • The majority of preterm births occur in settings associated with risk factors for sepsis. (biomedcentral.com)
  • The increased maternal cortisol concentration further stimulates additional production of placental CRH, creating a positive feedback loop that leads to higher and higher CRH and cortisol concentrations until birth finally occurs. (biomedcentral.com)
  • Studies span different gestational ages, analyze single or pooled samples and use a variety of techniques to determine macronutrient content. (nature.com)
  • Of 1529 articles, only 23 studies (13 bacterial, 6 viral and 4 parasitic) were included, and they used 7 different gestational age windows, and 20 different histopathological classification systems, precluding data pooling. (ox.ac.uk)
  • Mechanism-based insights into the disease pathogenesis and association are highly relevant and shall be useful in avoiding any systemic complications. (encyclopedia.pub)
  • The frequency of various maternal and foetal complications was between 14-53% and 22-92%, respectively. (hindawi.com)
  • Maternofoetal complications and outcome correlate with maternal spot UPCR. (hindawi.com)
  • Secular trends in the prevalence of preterm birth and international comparisons of the rates of preterm birth are difficult to interpret because of differences, both formal and informal, in the registration of extremely preterm births. (frc.org)
  • The classic social associations of preterm birth--low socioeconomic status, extremes of maternal age, primiparity, being unmarried--apply to extremely preterm and moderately preterm births as well as to the mildly preterm group. (frc.org)
  • Does the development of lung function from childhood to adulthood after extremely preterm birth differ from that of peers born at term? (bmj.com)
  • This is the first controlled and population-based report on the longitudinal development of lung function from childhood to adulthood after extremely preterm birth, and the data underline the risk of early onset of COPD in subsets of this population. (bmj.com)
  • Previous studies have found associations between particulate air pollution and IUGR as well as preterm births. (cdc.gov)
  • Our observation of an apparent association between maternal exposure to the WTC disaster and IUGR suggests that this event had a detrimental impact on exposed pregnancies. (cdc.gov)
  • With this definition, IUGR and "small for gestational age" are synonymous terms. (medscape.com)
  • No association was observed between any exposure group and preterm delivery. (cdc.gov)
  • This study investigates the relationship between maternal smoking and metabolic gene polymorphisms of CYP1A1 MspI and GSTT1 with preterm delivery (PTD) as a whole and preterm subgroups. (johnshopkins.edu)
  • We aimed to investigate the association between IPI after cesarean delivery and the risk of maternal and neonatal adverse events. (biomedcentral.com)
  • Women (aged ≥ 18 years) whose first delivery was cesarean delivery with 2 consecutive singleton pregnancies from the National Vital Statistics System (NVSS) database between 2017 and 2019 were included in this retrospective cohort study. (biomedcentral.com)
  • 1,2] The severity depends on the gestational age at delivery and includes respiratory difficulty, intraventricular hemorrhage, retinopathy, increased risk for infections, and delayed motor-neurodevelopment in the neonatal period. (drtonybushati.com)
  • The maternal and cord blood levels of zinc are correlated well with the birth weight and the gestational age at delivery. (ijpediatrics.com)
  • it is important to repeat surveillance and identify possible changes in clinical and socioeconomic factors associated with preterm delivery. (biomedcentral.com)
  • The aim of this study was to identify current risk factors associated with preterm delivery and highlight areas for further research. (biomedcentral.com)
  • There was no significant difference in gestational age at delivery or birth weight between two groups. (biomedcentral.com)
  • and 6.6% had a preterm delivery. (biomedcentral.com)
  • and preterm delivery was not significant. (biomedcentral.com)
  • According to this study, a single dose of 50,000 units of intramuscular 25(OH) D in pregnant women at risk of preterm delivery can reduce the incidence of RDS in the newborn. (researchsquare.com)
  • This clinical trial aimed to evaluate the consequences of a single-course of antenatal intramuscular injection of 25(OH) D for pregnant women at risk of preterm delivery on the incidence and severity of neonatal respiratory distress syndrome. (researchsquare.com)
  • More accurately, the gestational age is the difference between 14 days before the date of conception and the date of delivery. (msdmanuals.com)
  • A subsequent VSD study of 66,283 children aged 24-59 months noted diagnoses of fever, gastrointestinal tract symptoms, and gastrointestinal disorders to be significantly associated with IIV3 ( 392 ). (cdc.gov)
  • Taken together, maternal smoking significantly increased the risk of PTD among women with high-risk CYP1A1 and GSTT1 genotypes. (johnshopkins.edu)
  • Results The preterm-born cohorts, particularly those with neonatal BPD, had significantly lower forced expiratory volume in 1 s and mid-expiratory flow than those born at term at all assessments (z scores in the range −0.40 to −1.84). (bmj.com)
  • Conclusions Airway obstruction was present from mid-childhood to adulthood after extreme preterm birth, most evident after neonatal BPD. (bmj.com)
  • In addition to measuring cervical length, utilization of postcerclage transvaginal ultrasound to evaluate the location of the cerclage within the cervix, the curvature of the cervical canal, and the presence of funneling and sludge may help identify women who are at the highest risk for preterm birth. (nih.gov)
  • A number of risk factors have been identified for small for gestational age and preterm birth. (springer.com)
  • This paper finds an association between maternal financial strain and risk of preterm birth that is as high as that for smoking. (springer.com)
  • Conditions proposed to show correlation with paternal age include the following: Advanced paternal age may be associated with a higher risk for certain single-gene disorders caused by mutations of the FGFR2, FGFR3 and RET genes. (wikipedia.org)
  • Several studies have reported that advanced paternal age is associated with an increased risk of miscarriage. (wikipedia.org)
  • A second study also found a risk of schizophrenia in both fathers above age 50 and fathers below age 25. (wikipedia.org)
  • Paternal age may be associated with an increased risk of breast cancer, but the association is weak and there are confounding effects. (wikipedia.org)
  • This association was stronger in women (16% lower risk) than in men (8% lower risk). (health.gov)
  • In addition, consistent observational evidence indicates that regular consumption of coffee is associated with reduced risk of cancer of the liver and endometrium, and slightly inverse or null associations are observed for other cancer sites. (health.gov)
  • The following abstracts represent six studies which demonstrate the strongest and most significant risk association between IA and later preterm birth. (frc.org)
  • To identify neonatal risk factors for cerebral palsy among very preterm babies and in particular the associations independent of the coexistence of antenatal and intrapartum factors. (bmj.com)
  • Preterm birth is associated with a clear increase in risk of cerebral palsy. (bmj.com)
  • Previously, we reported that maternal smoking and metabolic gene polymorphisms of CYP1A1 MspI and GSTT1 synergistically increase the risk of low birth weight. (johnshopkins.edu)
  • An increase in distance to a city parks was associated with an increase in risk of preterm birth and decrease of gestational age. (edu.au)
  • When gestational age at termination was evaluated, those with an induced termination prior to week 14 were not at increased risk for PTD when compared with controls. (drtonybushati.com)
  • Gestational exposure to antipsychotic drugs is [also] unlikely to pose a significant risk of preterm birth and small for gestational age in children. (sciencealert.com)
  • Medication aside, underlying maternal psychiatric disorders may well be associated with the risk of ADHD and ASD in children, the Hong Kong study found. (sciencealert.com)
  • In both univariable and multivariable analyses exposure status was a significant risk factor in female fetuses only: PTB (adj. (bgu.ac.il)
  • It is unknown whether salivary cortisol is a risk factor for preterm birth in Ghana. (biomedcentral.com)
  • Some studies consider periodontitis as an independent risk factor for preterm birth, growth restriction, low birth-weight and pre-eclampsia. (intechopen.com)
  • At the risk of generalizing these data beyond their context, by any reckoning, the magnitude of recordable injury and illness percentages in these warehouses are quite significant and considerably higher than the aggregate data for the industry as a whole for all job classifications. (iloencyclopaedia.org)
  • Gestational Age Gestational age and growth parameters help identify the risk of neonatal pathology. (msdmanuals.com)
  • A modest association was observed between long-term TCE exposure and decreased MBW and increased SGA births, overall. (cdc.gov)
  • No association was observed between short-term exposure to TCE and MBW or SGA births. (cdc.gov)
  • Given the lack of an association between PCE exposure and birth weight in the overall study population, and given the large number of persons in the study, it is unlikely that maternal exposure to the unique combination of contaminants in the Tarawa Terrace water system had much of an effect on birth weight except in some small subgroups. (cdc.gov)
  • In addition, a variety of exposure categories were examined and at most a very weak association was observed among the births in which exposure occurred for the longest duration. (cdc.gov)
  • Levels of significant exposure for each route and duration are presented in tables and illustrated in figures. (cdc.gov)
  • The significance of the exposure levels shown in the Levels of Significant Exposure (LSE) tables and figures may differ depending on the user's perspective. (cdc.gov)
  • Alcohol consumption and tobacco exposure are not uncommon and have been an ongoing but neglected threat to maternal and child health in Nigeria. (springer.com)
  • Sources of uncertainty remained, not only for the subgroups in which elevations were found, but also because some potentially important confounders (e.g., maternal smoking, alcohol consumption, and height) were not controlled for in the analysis. (cdc.gov)
  • There are several reasons to question the meaning of the associations observed in these two subgroups. (cdc.gov)
  • Primary outcome is impairment-free survival at 18-22 months corrected age. (stanford.edu)
  • In this study we have carried out a detailed comparison of preterm and term deliveries in a relatively homogeneous obstetric population attending a tertiary referral maternity hospital, to highlight areas where further research or intervention is needed in order to prevent preterm birth and improve perinatal outcome. (biomedcentral.com)
  • To identify changes in macronutrient content of very preterm human milk associated with perinatal factors. (nature.com)
  • Gestational Age, Mode of Birth and Breastmilk Feeding All Influence Acute Early Childhood Gastroenteritis: A Record-Linkage Cohort Study. (llli.org)
  • who verified breastfeeding less than six months and the association between a gestational age of less than 32 weeks and greater chances of breastfeeding interruption 7 . (bvsalud.org)
  • PIH was diagnosed where there was systolic blood pressure higher than 140 mm Hg and/or diastolic blood pressure higher than 90 mm Hg after 20 gestational weeks. (hindawi.com)
  • Contrary to expectation, maternal distress in Pakistani women was negatively associated with SGA (OR 0.65: CI 0.48-0.88). (springer.com)
  • We hypothesize that BM antioxidants are adapted to gestational age and are negatively influenced by maternal age. (mdpi.com)
  • We hypothesized that ritodrine hydrochloride would affect the preterm fetuses, thereby adversely affecting escape enzyme levels. (hindawi.com)
  • The findings support the hypothesis that male and female fetuses respond differentially to chronic maternal stress. (bgu.ac.il)
  • The prevalence of PTSD is estimated to be 5-10% worldwide, and it is associated with significant distress and disability. (preprints.org)
  • Motivated by the state's high preterm birth rate, the South Carolina Department of Health and Human Services (SC DHHS) led an innovative expansion of NFP home visiting services between 2016 and 2020 to scale services statewide and learn about the program's impacts. (scienceblog.com)
  • A 2016 review concluded that the mechanism behind the reported associations was still not clear, with evidence both for selection of individuals liable to psychiatric illness into late fatherhood and evidence for causative mutations. (wikipedia.org)
  • An observational study assessed post-vaccination fever frequency in 314 children aged 24-59 months receiving IIV during the 2013-14 influenza season. (cdc.gov)
  • Birthrates of dizygotic twins vary by race (10-40 per 1000 births in blacks, 7-10 per 1000 births in whites, and approximately 3 per 1000 births in Asians) and maternal age (ie, the frequency has risen with increasing maternal age ≤40 years). (medscape.com)