Significant double blind method. Medical search. Frequent questions

Methods Randomised double-blind, placebo-controlled clinical trial comparing a 12-week programme of using a GTN or placebo patch in combination with eccentric squats on a decline board. (bmj.com)
This double-blind clinical trial assessed the incidence of nausea and vomiting after cataract surgery with intravenous anaesthesia in 100 patients randomly assigned to preinduction placebo (saline), metoclopramide (10 mg), dexamethasone (8 mg) or the 2 drugs combined. (who.int)
Methods: Randomised, double-blind, HA-controlled clinical trial in 100 knee OA patients (98 randomised, 69 completing the study) in a high-specialisation tertiary care setting. (researchsquare.com)
Forty-two patients with RA were assigned into two groups in this randomized, double blind, placebo-controlled clinical trial. (weeksmd.com)
This randomized, double-blind, parallel, sham-controlled clinical trial, single-center, included 36 women with FM, aged from 30 to 65 years old, assigned 2:1 to receive a-tDCS ( n = 24) and s-tDCS ( n = 12). (frontiersin.org)
This was a double-blind, prospective, clinical trial. (qxmd.com)
In this double blind clinical trial, 80 patients with chronic moderate periodontitis and a healthy systemic status were chosen, and divided into two 40-subject groups. (bvsalud.org)
In a randomized, double-blind, placebo-controlled clinical trial over 8 weeks, 284 children on inhaled steroids were allocated to receive zinc supplements (50 mg/day) ( n = 144) or placebo ( n = 140). (who.int)

1 It causes significant morbidity in both elite and recreational athletes, particularly those participating in sports involving repeated jumping and landing. (bmj.com)
Key eligibility criteria included absence of significant co-morbidity and no previous SARS-CoV-2 infection or vaccination. (paceadvantage.com)
We plan to recruit thirty patients with mild to moderate Alzheimer's disease with no history of previous seizures or other significant co-morbidity. (biomedcentral.com)
Background: Congenital diaphragmatic hernia is an orphan disease with high neonatal mortality and significant morbidity. (eur.nl)
BACKGROUND: Tick-transmitted rickettsial diseases, such as ehrlichiosis and spotted fever rickettsiosis, are significant sources of morbidity and mortality in the southern United States. (cdc.gov)

A double-blind, parallel randomized controlled trial was conducted in 61 healthy older individuals aged 65-80 y. (neurosciencenews.com)

Twenty-five participants with DSM-IV trichotillomania participated in a 12-week, randomized, double-blind, placebo-controlled trial of flexible-dose olanzapine for trichotillomania. (psychiatrist.com)
Participants will be allocated to a double-blind placebo-controlled crossover trial that tests levetiracetam against placebo. (biomedcentral.com)
Participants, doctors and researchers collecting participant data will be blinded to treatment allocation. (druglib.com)
Study participants and research assistants were blinded. (biomedcentral.com)
METHODS: Twenty healthy participants performed TSB, both leg lift while side-lying (BLLS), torso lift on a 45 ∘ bench while side-lying (TLBS), and … pelvic lift on side-lying (PLS) in random order. (iospress.com)
Settings and Design: This hospital‑based randomized double‑blinded controlled trial was conducted among 56 study participants who were children below the age of 12 years, admitted as inpatients with fever and whose blood culture grew S. typhi. (who.int)
Materials and Methods: Study participants were equally allocated into intervention or control group by simple randomization. (who.int)
METHODS: Ticks submitted by study participants from April-September 2011 and 2012 were identified to species and life stage, and preliminarily screened for the genus Rickettsia by nested PCR targeting the 17-kDa protein gene. (cdc.gov)

The sophisticated American consumer has grown accustomed to the gold-standard for drug and health products-the prospective randomized, double-blind, placebo-controlled trial (RCT). (paceadvantage.com)
Balmforth et al, conducted a prospective double-blind, placebo-controlled trial of a xylitol based nasal spray in the prevention of SARS-CoV-2 infection in exposed healthcare workers in two hospitals in Uttar Pradesh, India. (paceadvantage.com)
We conducted a prospective, single-center, double-blind randomized controlled trial in elderly patients aged ≥ 65 years with ASA I-II. (dovepress.com)
Methods A prospective, randomised, 6-month, 3-arm, double-blind, double-dummy, placebo and celecoxib (200 mg/day)-controlled trial assessing changes in pain on a Visual Analogue Scale (VAS) and in the Lequesne Index (LI) as coprimary endpoints. (bmj.com)
In this multicenter, randomized, prospective, double-blinded study with crossover, 17 patients were divided into two groups, with eight initially receiving RFNA treatment and nine initially receiving sham treatment. (japmaonline.org)

The goal of this study was to investigate the efficacy of this self-described cognitive enhancing nootropic on cognitive functioning in a group of healthy adults by utilizing a randomized, double blind, placebo-controlled design. (nih.gov)
The study is titled 'Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial' and was published in the Journal of Clinical Viroloy (October, 2022. (paceadvantage.com)
This 9-week, multicenter, randomized, double-blind, placebo-controlled, flexible-dose study evaluated the film-coated tablet formulation of modafinil, which was titrated to an optimal dose on the basis of efficacy and tolerability (range: 170-425 mg once daily). (erowid.org)
Multivariate linear regression (MLR), artificial neural network (ANNs) and regression tree (RT) statistical analysis methods were evaluated to determine their efficacy to predict body fat, lean and bone. (preprints.org)
In contrast to the existing literature on the beneficial use of local intraoperative epidural steroids in conventional lumbar discectomy, the present study did not demonstrate such significant efficacy for the use of local epidural steroids in instrumented posterolateral lumbar spinal fusion. (thejns.org)
Finally, influenza vaccines are effective in no more than 80% of vaccinated children, with significant reduction of efficacy when mismatch between circulating vital strains and strains included in the vaccine occurs [ 7 ]. (biomedcentral.com)
The efficacy of 1% metronidazole gel in facial seborrheic dermatitis: a double blind study. (qxmd.com)

patients, parents, and study staff other than a statistician were blinded. (nih.gov)
Conclusion The results suggest that simultaneous transcranial direct current stimulation (anodic and cathodic) is a method that can improve the rehabilitation of patients with anomic and Broca's aphasia after stroke, and that language strategies should be considered in the analysis of naming task responses. (scielo.br)
Cette étude clinique en double aveugle évaluait l'incidence des nausées et des vomissements après une chirurgie de la cataracte avec anesthésie par voie intraveineuse chez 100 patients auxquels un placebo (eau saline), du métoclopramide (10 mg), de la dexaméthasone (8 mg) ou les deux médicaments associés avaient été administrés de manière randomisée avant l'opération. (who.int)
L'association du métoclopramide et de la dexaméthasone a considérablement réduit les nausées et vomissements, non seulement en salle de réveil mais également dans les 24 heures qui suivent, et est recommandée pour les groupes à haut risque, notamment pour les patients opérés en ambulatoire. (who.int)
Results: KSS total score and KSS pain item: significant improvement in both groups, with significantly more pain improvement in patients treated with PNHA (2-point reduction) than HA (1-point reduction). (researchsquare.com)
Both groups experienced significant long-term reductions in WOMAC total scores: significantly stronger in PNHA-treated patients after 24 months with a steady difference of 16% favouring PNHA in WOMAC pain subscore. (researchsquare.com)
Conclusions: The outcomes of the 2-year study confirmed that a short cycle of intra-articular treatment (3 weekly double-blind injections) with polynucleotides (long-acting viscosupplementation properties, pro-trophic activity on chondrocytes, pain-relieving properties) in fixed combination with high molecular weight hyaluronic acid is more effective in improving knee function and pain in knee OA patients than HA alone. (researchsquare.com)
Methods Patients were divided into two groups. (scielo.br)
Methods In this exploratory, phase 2, randomised, double-blind, parallel-group study, patients received tofacitinib 10 mg twice daily + MTX, tofacitinib 10 mg twice daily + placebo (tofacitinib monotherapy), or MTX + placebo (MTX monotherapy), for 1 year. (whiterose.ac.uk)
41 patients with COPD participated in a randomised, double blind, double dummy, three way crossover study with 2 week washout periods between treatments. (bmj.com)
In this randomized, double-blind, placebo-controlled trial, patients were randomly divided into two groups (treatment and control). (thejns.org)
Patients and methods. (bvsalud.org)
METHODS Studies published up to the 16th of January 2023, including patients with traumatic hemorrhage comparing WB ± BCT and BCT were included in meta-analysis. (transfusionevidencelibrary.com)
Early prophylaxis in surgical patients with low-molecular-weight heparin (LMWH) has been associated with significant reductions in postoperative venous thrombosis. (medscape.com)

No significant difference was found in baseline demographic, clinical, and surgical characteristics between the two groups. (thejns.org)

The NMS-Nab Study is as a mono-centric phase II, randomized, placebo-controlled, double-blind, parallel-group, enriched enrollment withdrawal study. (springer.com)

Results No statistically significant difference was observed between the pre-intervention assessment and the post-training auditory processing re-evaluation of the placebo, but statistically significant difference was found between the pre- and post-auditory training conditions. (scielo.br)
Results: A statistically significant difference was found for masticatory efficiency between groups G1 and G2 (pd"0.05) and between G1 and G3 (pd"0.05), and there was no statistically significant difference between G2 and G3 (pe"0.05). (bvsalud.org)

A total of 63-treatment naïve individuals between 18 and 35 years of age completed the randomized, double-blind, placebo controlled trial. (nih.gov)
In total, eleven healthy young humans participated in a repeated crossover randomized controlled double-blind n-of-1 trial. (frontiersin.org)
METHODS/DESIGN: PRECISE is a prospectively registered, double-blind, randomised placebo-controlled trial of pregabalin compared to placebo, in addition to usual care. (druglib.com)
In this 2-group, parallel, double-blind, randomized controlled trial, 74 women aged 20-65 years and Fitzpatrick skin phototypes I or II were recruited from the general community in Quebec City, for randomization to either HFC (n = 33) or low-flavanol chocolate (LFC) (n = 41). (biomedcentral.com)
A randomised, double blind, placebo controlled trial of 50 preterm infants of gestational age ⩽32 weeks needing assisted ventilation. (bmj.com)
Method: This was a randomized, double-blind, placebo-controlled trial in 600 healthy adults. (edu.au)
METHODS: Double-blinded, placebo-controlled randomized trial. (bvsalud.org)
METHODS This study is a secondary analysis of the TRACT trial data restricted to those who received an immediate transfusion (using whole blood or red cell concentrates). (transfusionevidencelibrary.com)
It involved a randomised, double blind, placebo-controlled trial of 61 healthy men and women aged 65 to 80, who drank a beverage made with 26 grams of freeze-dried wild blueberry powder (equivalent to about 178 grams of whole berries) whilst the other group drank a matching placebo. (neurosciencenews.com)
Wild Blueberry (Poly)phenols can Improve Vascular Function And Cognitive Performance In Healthy Older Males And Females: A Double-Blind Randomized Controlled Trial " by Ana Rodriguez-Mateos et al. (neurosciencenews.com)
As part of a double blind randomized-controlled field trial of the effectiveness of permethrin-treated clothing in preventing tick bites, we identified tick species removed from the skin of outdoor workers in North Carolina and tested the ticks for Rickettsiales pathogens. (cdc.gov)
The intervention group (n = 40) and control group (n = 38) took the probiotics or placebo daily for 6 months in a double-blinded randomised trial. (lu.se)

On day 11 a significant reduction in serum creatinine was observed, compared with day 5, with no difference between the two groups. (bmj.com)
CS and celecoxib showed a greater significant reduction in pain and LI than placebo. (bmj.com)
SUMMARY: In the present study, treatment with Nigella sativa produced a significant reduction of NO and MDA levels.The results were consistent with outcomes provided by previous studies indicating TQ may reduce nitrite production, a parameter for NO synthesis, and decrease both gene expression and protein synthesis levels of iNOS (Umar et al. (weeksmd.com)

0.05 as significant. (uwi.edu)
0.05 (vs MTX monotherapy) were considered significant. (whiterose.ac.uk)
P value less than 0.05 was considered statistically significant. (bvsalud.org)

There was no significant difference in patient-reported outcomes including VAS scores for back and leg pain as well as the Oswestry Disability Index at 4 and 12 weeks postoperatively. (thejns.org)

Although a majority of women taking a therapeutic dose of ulipristal acetate have anovulation, a non hormonal contraceptive method is recommended during treatment. (medicines.org.uk)
Significant improvements were observed with modafinil treatment on the ADHD-RS-IV School Version at week 1, with improvements maintained throughout the study. (erowid.org)
Treatment differences in RAMRIQ synovitis were statistically significant at month 3, consistent with DCE MRI findings. (whiterose.ac.uk)
WB groups received significant higher PLT:RBC (p = 0.030) during early treatment and significant higher PLT:RBC and Plasma:RBC ratios during 24-hours of treatment (p = 0.031 and p = 0.007). (transfusionevidencelibrary.com)
This study provides additional evidence in support of this treatment, with statistically significant data that demonstrate the success of this technique. (japmaonline.org)
[ 10 ] The 2016 updates for the 10th edition of the ACCP guidelines did not contain significant changes with regard to VTE prophylaxis (as distinct from treatment) in orthopedic surgery. (medscape.com)
There were no significant differences in IgE levels before and after treatment. (who.int)
To minimize or prevent a surge in the prevalence of blindness from these two causes, appropriate methods of screening and medical treatment need to be further assessed and incorporated as priorities into national health-care strategies. (who.int)
A simple randomization method will be used dental assistant who is not participating in the study will have a list of random numbers and will determine the side of the light cure treatment, Blinding description: A dental assistant who does not participate in the study will have a list of random numbers and will determine the side of the light cure treatment .and Will register as a code. (who.int)
Inclusion criteria: Children between 2-4 years without significant systemic disease (ASA I and II) who are unable to cooperate in routine dental treatment. (who.int)

No significant differences in side effects were found (p ¼ ns). (unl.edu)

Results No significant results were observed for sequences 1 and 2 in the Snodgrass test. (scielo.br)
The Boston test results indicated significant difference related to mean time for correct responses with strategy. (scielo.br)
Results also indicated significant time-by-group interaction in delayed verbal recall for the Alpha BRAIN® group. (nih.gov)
Given there were some significant results, and the potential for confounding factors, this topic warrants further investigation into melatonin as a behavioral aide. (maddiesfund.org)
Several double blind clinical trials have demonstrated that supplementing the diet with 10 to 12 grams of EPA results in significant improvement. (awakeningspirit.com)
While some studies have reported statistically significant results, they often lack replicability and fall short of meeting the stringent criteria required for scientific validation. (cashinsure.com)

We performed a randomized, double-blind, placebo-controlled, crossover study to identify the effects of melatonin on sleep and seizure control in children with epilepsy. (nih.gov)

Dans un essai clinique randomisé d'une durée de 8 semaines, en double aveugle et contrôlé contre placebo, 284 enfants sous corticostéroïdes inhalés ont été répartis entre un groupe recevant une supplémentation en zinc (50 mg/jour) (n = 144) et un groupe sous placebo (n = 140). (who.int)

Nutritional photoprotection with flavanol-rich chocolate is a promising area for research, but double-blind clinical trials are required to confirm experimental findings. (biomedcentral.com)

Patient satisfaction showed no difference between GTN and placebo groups (p=0.25) after 24 weeks, but did show a significant difference over time (p=0.01). (bmj.com)

No significant adverse events were reported. (biomedcentral.com)
No clinically significant adverse events in either group. (researchsquare.com)

Methods Retrospective observational descriptive study during one year. (scielo.br)
Nous avons réalisé une étude transversale descriptive sur un groupe de malades vus en consultation à l'unité de Gastro-entérologie de l'hôpital du district de la commune IV de Bamako. (bvsalud.org)
The data were assessed using descriptive statistics and analytical test methods (Mann-U-Whitney and Chi-square). (bvsalud.org)

MATERIALS AND METHODS: Natural and semi-natural mouthrinses included in this study were herbal mix mouthrinse, cranberry mouthrinse, chlorhexidine digluconate mouthrinse, cranberry extract mixed with chlorhexidine digluconate mouthrinse, chlorhexidine digluconate mouthrinse with alcohol (positive control), and distilled water (negative control). (cranberryinstitute.org)

Methods: This study was a secondary analysis of the observational, longitudinal Health and Early Life Microbiota (HELMi) cohort data, collected among healthy, term infants and their families during 2016 and 2019 in the capital region of Finland. (helsinki.fi)

Our study failed to demonstrate a statistically-significant protective effect of HFC vs. LFC consumption on skin sensitivity to UV radiation as measured by MED. (biomedcentral.com)

The Global Initiative for the Elimination of Avoidable Blindness, known as Vision 2020 - the Right to Sight, was launched in 1999 as a partnership between WHO and the International Agency for the Prevention of Blindness to eliminate causes of avoidable blindness by the year 2020 and to halt and reverse the projected doubling of avoidable visual impairment in the world between 1990 and 2020. (who.int)
Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: A list of random numbers will be created using the WWW.randomizer.org site. (who.int)

fourteen men participated in this double-blind, placebo-controlled, crossover intervention study. (biomedcentral.com)

The aim of this study was to assess level of awareness, acceptability, previous utilization and willingness to utilize epidural analgesia in labour following health education.Subjects/Methods: This cross-sectional study was carried out in the antenatal clinic of UTH, Osogbo. (bvsalud.org)

A review of surveys conducted to date reveals considerable variation in both the choice and use of survey methods and in the assumptions made in the analysis and interpretation of findings. (who.int)
Conclusion: The findings suggest a modest yet significant impact of the probiotics on the faecal metabolome, primarily influencing proteolytic processes in the gut. (lu.se)

There was no significant difference between the percentages of subjects with at least one AE in the Tafenoquine Group (91.0%) versus Placebo (89.9%, p = 0.65). (edu.au)

Measurements of air infiltration rates for 23 leather and plastic hoses representing 11 types commonly available in Beirut, Lebanon were made, revealing that while leather hoses allowed significant outside air infiltration during a puff constituting up to 31% of the puff volume, plastic hoses were found to be air-tight, indicating that the smoke reaching the waterpipe user can be considerably more concentrated when delivered via a plastic hose. (who.int)
Inspiratory capacity measurements also showed significant benefits for triple therapy over individual components on day 14. (bmj.com)

The 'gold standard' method to assess humoral antibody responses fol owing vaccination is the neutralization assay. (who.int)

Fibromyalgia (FM) comprises widespread chronic pain and concurs with significant emotional distress associated with functional disability for daily activities. (frontiersin.org)

Method We recruited 162 women aged between 30 and 74 years to be submitted to abdominal hysterectomy. (scielo.br)

While this condition may cause significant suffering for the individual, the lack of evidence supporting effective treatments for sciatica makes clinical management difficult. (druglib.com)
Farmers are continually looking for new reliable, objective and non-invasive methods for evaluation of ewe condition. (preprints.org)
With ageing populations, their contribution to blindness globally is likely to grow, owing to unsuccessful attempts to control this blinding eye condition in low- and middle-income countries. (who.int)

To do this, we administered MDMA-HCl (100 mg p.o.) and, separately, placebo (ascorbic acid) in a randomized, double-blind, repeated-measures design with twenty-five healthy volunteers undergoing fMRI scanning. (researchgate.net)
METHODS: A double blind, counterbalanced crossover design was employed. (emfacts.com)

Initial studies of the use of modafinil to treat ADHD showed significant improvements in the core symptoms of the disorder, namely inattention, hyperactivity, and impulsivity. (erowid.org)
The case group showed significant improvements in clinical symptoms such as cough, wheezing and dyspnoea and in all spirometry parameters (FVC, FEV1 and FEV1/FVC). (who.int)

Data analysis will be blinded and by intention-to-treat. (druglib.com)
There was no significant difference in terms of demographic data and lesions severity score. (qxmd.com)
Objective data were collected through the masticatory efficiency test performed by the colorimetric method with the beads, in which capsules of a synthetic material enclosing fuchsine-containing granules were used. (bvsalud.org)
More precise and comparable data about the risk of poliomyelitis could be obtained in future surveys by incorporating a standard case definition, by using house- to- house case- finding methods in representative community- based samples, by analyzing and presenting rates in more clearly defined ways, and by selecting stable populations for study. (who.int)
METHODS: The study analyzed data from the Adolescent Behaviors and Experiences Survey, conducted in January-June 2021. (cdc.gov)
Although the reasons for this are often limited .2 The unexpected nature of disasters also means complex, a significant contributing factor is that disaster planning that data collection on emergency medical responses is only as good as the assumptions on which it is based. (cdc.gov)

CONCLUSIONS: Thirty minutes of mobile phone exposure has no significant short-term effect on saccade performances. (emfacts.com)

No significant effect of CB supplementation was observed either on blood glutathione levels, nor on capillary blood analysis. (biomedcentral.com)
A dose-specific examination revealed a significant effect of ghrelin 3 mcg/kg versus placebo in increasing alcohol craving (p .05) with a large effect size (d ¼ .94). (unl.edu)
By contrast, no significant ghrelin effect was found in increasing either urge to drink juice or food craving (p ¼ ns). (unl.edu)
No significant effect of mobile phone use was demonstrated on the performance of various saccade tasks, suggesting that the cortical processing for saccades and attention is not affected by exposure to EMF emitted by a mobile phone. (emfacts.com)
The timing and duration of pharmacologic prophylaxis have also been determined to exert a significant effect the development of DVT. (medscape.com)

At 6 weeks postpartum, a significant difference was observed between the EPDS scores of both groups (p = 0.0001). (scielo.br)

Twelve weeks after iontophoresis, the colorimeter of the treated site showed a significant decrease in the L value (from 4.60 to 2.78, p = 0.002), compared to that of the control site (from 4.45 to 3.87, p = 0.142). (karger.com)

Of the studied population subgroups, a significant interaction was found in physical activity subgroups in men (P = 0.005), the inverse association between added sugar intake and overall diet quality being stronger among active men compared with moderately active and inactive men. (helsinki.fi)

Blindness and severe visual impairment have a significant impact on the socioeconomic development of individuals and societies. (who.int)

Methods Eighteen children aged 8-10 years, of both genders, participated in this study. (scielo.br)
There were significant relationships between the shape of the anterior-posterior curvatures and body composition in school-children. (preprints.org)
Methods: We examine the impact of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 supplementation on the faecal metabolome in genetically predisposed children having tissue transglutaminase autoantibodies, i.e., coeliac disease autoimmunity. (lu.se)

More than 82% of all blind persons are 50 years of age or older. (who.int)
Blindness in childhood, with the expectation of many years of life in that state, is a significant problem and requires further attention. (who.int)

IN follow-up sessions, the evaluator will be blinded about which side belongs to which group. (who.int)

Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)

According to the most recent (2002) estimates of the global burden of visual impairment, more than 161 million people were visually impaired, of whom 124 million people had low vision and 37 million were blind.1 As visual impairment due to refractive errors is not included in these figures, the actual magnitude of visual impairment globally is likely to be considerably greater. (who.int)
Method of measurement: visual and tactile assessment. (who.int)

Anatomy1

Organisms4

Diseases40

Chemicals and Drugs130

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Psychiatry and Psychology4

Phenomena and Processes18

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture6

Humanities1

Information Science1

Named Groups3

Health Care19

Clinical trial8

Morbidity5

Randomized controlled trial wa1

Participants8

Prospective5

Efficacy7

Patients14

Baseline1

Parallel group1

Statistically significant difference was found2

Trial12

Reduction3

0.053

Outcomes1

Treatment10

Differences1

Results6

Crossover study1

Aveugle1

Trials1

0.011

Adverse events2

Descriptive3

MATERIALS AND MET1

Observational1

Demonstrate1

Prevention2

Intervention1

Epidural analgesia1

Findings2

Subjects1

Measurements2

Assess1

Chronic1

Women aged1

Condition3

Design2

Improvements2

Data6

Conclusions1

Effect5

Groups1

Control1

Interaction1

Severe1

Children3

Years2

Side1

Research1

Visual2