MetoprololBeta-blockiReductionInhibitorInhibitionShownSevereProstateActivityPotentialTargetBeta-adrenergicAntihypertensiveMorphologicalTranscriptionalProteinsMechanismProtectiveReproductiveClinicalIncreasePatientsFieldMiceNegative effectsTreatmentMaleHighEvidenceBlood pressureStudiesDevelopmentPositive
Metoprolol3
- Metoprolol tartrate is a selective beta 1 -adrenoreceptor blocking agent, available as 25 mg, 37.5 mg, 50 mg, 75 mg and 100 mg tablets for oral administration. (pillsync.com)
- This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol also inhibits beta 2 adrenoreceptors, chiefly located in the bronchial and vascular musculature. (pillsync.com)
- Clinical pharmacology studies have demonstrated the beta-blocking activity of metoprolol, as shown by (1) reduction in heart rate and cardiac output at rest and upon exercise, (2) reduction of systolic blood pressure upon exercise, (3) inhibition of isoproterenol-induced tachycardia, and (4) reduction of reflex orthostatic tachycardia. (pillsync.com)
Beta-blocki2
- Catecholamine-depleting drugs may have an additive effect when given with beta-blocking agents. (nih.gov)
- The mechanism of the antihypertensive effects of beta-blocking agents has not been fully elucidated. (pillsync.com)
Reduction2
- Considering we applied a nonspecific inhibitor, the resultant improvement in spermatogenesis may well be mediated by means of reduction of iNOS levels, and even further experiments are required to delineate the underlying mechanism. (hifsignaling.com)
- As spermatogenesis requires both testosterone and FSH, it is impaired by the reduction in FSH caused by trestolone and the reduction in LH and subsequent reduction in testosterone. (bmm-supplements.com)
Inhibitor1
- We also employed the CK2-specific inhibitor CX-4945 to validate the effect of CK2 activity on the polar body extrusion, spindle assembly, microtubule stability and DNA damage level in porcine oocytes. (biomedcentral.com)
Inhibition2
- The decreased expression and inhibition of nuclear transfer of GLI1 downregulated macrophage M1 polarization and osteoclast activation, the effect of which was achieved by modulation of DNA methyltransferases (DNMTs) via transcriptional regulation and protein interactions. (elifesciences.org)
- Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation. (theodora.com)
Shown1
- In vitro studies have shown that the effect of tadalafil is more potent on PDE5 than on other phosphodiesterases. (theodora.com)
Severe2
- Severe bradycardia, greater than first degree heart block, or sick sinus syndrome without a pacemaker. (nih.gov)
- These compounds can only bind to the androgen receptors in your muscles and bones to produce powerful local anabolic effects without making you experience severe side effects. (bmm-supplements.com)
Prostate2
- In tissue culture IN showed no vital cytotoxic action in the amount of cell lines at doses under M. In vivo day by day injection of IN in mice with established prostate cancer xenografts led to a significant reduce while in the tumor growth price in association with an enhanced CTL response. (hifsignaling.com)
- Most aim for bone tissues and muscles with little to no effects on the prostate and other body organs. (bmm-supplements.com)
Activity2
- P-eIF2α blocks its translation initiating activity and induces ATF4 phosphorylation (P-ATF4) leading to P-ATF4 nuclear translocation as a transcription factor to induce expression of GRP78, C/EBP homologous protein (CHOP), XBPu etc. (londonspring.org)
- GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
Potential1
- Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)
Target2
- Due to the fact TRII is usually a constitutively lively kinase and TGF signaling usually requires TRI ALK activation, ALK is the principle target for designing tiny molecule inhibitors that block TGF signaling. (hifsignaling.com)
- SARMs and androgenic hormones target the same receptors to produce similar effects on the liver, bones, and muscles. (bmm-supplements.com)
Beta-adrenergic3
- Pindolol, a synthetic beta-adrenergic receptor blocking agent with intrinsic sympathomimetic activity is 1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol. (nih.gov)
- Beta-blockade therapy is useful when it is necessary to suppress the effects of beta-adrenergic agonists in order to achieve therapeutic goals. (nih.gov)
- Nebivolol Tablets are a beta-adrenergic blocking agent indicated for the treatment of hypertension, to lower blood pressure. (nih.gov)
Antihypertensive2
- Pindolol has been shown in controlled, double-blind clinical studies to be an effective antihypertensive agent when used as monotherapy, or when added to therapy with thiazide-type diuretics. (nih.gov)
- The mechanism of the antihypertensive effects of beta-blocking agents has not been established, but several mechanisms have been postulated: 1) an effect on the central nervous system resulting in a reduced sympathetic outflow to the periphery, 2) competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic receptor sites, leading to decreased cardiac output, 3) an inhibition of renin release. (nih.gov)
Morphological1
- Negative developmental and morphological effects were detected in the experimental groups. (nature.com)
Transcriptional2
- tion and a conserved region (CR) which has variously been associated with positive and negative effects on transcriptional activity [5 - 9]. (123dok.net)
- Expression or transient expression of cell cycle arresting genes is described for "metabolic engineering", i.e. regulating expression of desirable proteins, and it is mentioned that a transcriptional "squelching" effect by the VP16 transactivator domain may be lethal for the host cell, even at moderate expression levels (Berger et al. (allindianpatents.com)
Proteins1
- Considering the fact that the majority of these chaperone families are cell stress responders or heat shock proteins (HSPs), chaperones have important roles in raising the cellular resistance against environmental stressors, although the HSPs are known to be involved in regulating spermatogenesis ( 8 , 9 ). (ijfs.ir)
Mechanism2
- One of the genes regulated through this mechanism en-codes the B-Myb transcription factor, which has been shown to be critically required for early embryonal de-velopment in the mouse. (123dok.net)
- Surprisingly, it has now been found that it is possible to employ a positive feedback mechanism both to enhance the effect of an insect promoter, as well as to control its expression. (allindianpatents.com)
Protective2
- In this study, by employing metformin as a comparative group, we evaluated the protective effects of ICA on male reproductive damages caused by DM and explored the possible mechanisms. (biomedcentral.com)
- In contrast, Mir155 -KO mice showed a high bone mass phenotype and protective effect against inflammation-induced bone loss. (elifesciences.org)
Reproductive2
Clinical2
- However, in certain clinical situations, (e.g., cardiac failure, heart block, bronchospasm), the preservation of an adequate sympathetic tone may be necessary to maintain vital functions. (nih.gov)
- In order to accelerate contraceptive development, we screened the comprehensive collection of 12,000 molecules that make up the ReFRAME repurposing library, comprising nearly all the small molecules that have been approved or have undergone clinical development, or have significant preclinical profiling. (elifesciences.org)
Increase1
- Even a slight increase in temperature could lead to rapid disrupts in spermatogenesis due to inducing protein denaturation ( 8 ). (ijfs.ir)
Patients3
- At present, it is prudent to consider any IC antiarrhythmic to have a significant risk of provoking proarrhythmic events in patients with structural heart disease. (nih.gov)
- Given the lack of any evidence that these drugs improve survival, antiarrhythmic agents should generally be avoided in patients with non-life-threatening ventricular arrhythmias, even if the patients are experiencing unpleasant, but not life-threatening, symptoms or signs. (nih.gov)
- Consider reducing the dose in patients with hepatic impairment, significant widening of the QRS complex, or second- or third-degree AV block. (nih.gov)
Field1
- Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)
Mice1
- Consistent with this expression pattern, male mice lacking A-Myb are infer-tile because of a block in spermatogenesis, and A-myb null females have underdeveloped breast tissue after pregnancy [19]. (123dok.net)
Negative effects1
- These results demonstrated that ingesting low-level radiocesium contaminants in Fukushima (but not natural radiopotassium) imposed biologically negative effects on the cabbage white butterfly, as in the pale grass blue butterfly, at both cellular and organismal levels. (nature.com)
Treatment1
- Prostatic carcinoma is known to be androgen-sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen, e.g., castration. (sdrugs.com)
Male2
- Hence, a male contraceptive could work in a number of different ways - it could completely halt spermatogenesis, block an essential function of the spermatozoon (such a motility) or perturb a cellular process that results in a non-productive interaction with the oocyte (such as prematurely triggering the acrosome reaction, and/or by blocking exocytosis or inhibiting receptor binding). (elifesciences.org)
- The options for delivery of a contraceptive are wide ranging, but our primary aim is to develop a relatively fast-acting safe drug, self-administered by the male, that specifically and effectively irreversibly blocks the sperm's ability to get to the egg and/or fertilise it. (elifesciences.org)
High1
- Adverse biological effects of naturally high background radiation have been documented 5 , but presently, radiation-based technologies are widespread in society, which leads to the relatively high possibility of radiation exposure, whether intentional or accidental, for anyone. (nature.com)
Evidence2
- Although a beta-antagonist with ISA such as pindolol does not eliminate sympathetic tone entirely, there is no controlled evidence that it is safer than other beta-blockers in such conditions as heart failure, heart block, or bronchospasm or is less likely to cause those conditions. (nih.gov)
- Their fundamental work shows compelling evidence that miR155 is overexpressed in inflammatory diseases therefore, the use of anti-miR155 could produce anti-inflammatory effects. (elifesciences.org)
Blood pressure1
- The effect on blood pressure is not orthostatic, i.e., pindolol was equally effective in reducing the supine and standing blood pressure. (nih.gov)
Studies3
- In single-dose studies of the effects of beta-blockers on FEV 1 , pindolol was indistinguishable from other non-cardioselective agents in its reduction of FEV 1 , and its reduction in the effectiveness of an exogenous beta-agonist. (nih.gov)
- In contrast, some studies have reported no detectable effects. (nature.com)
- In animal studies, Flutamide demonstrates potent antiandrogenic effects. (sdrugs.com)
Development1
- Here, we evaluated the effects of ingesting cabbage leaves grown with contaminated soils from Fukushima on the development and hemocytes of the cabbage white butterfly, Pieris rapae . (nature.com)
Positive2
- Promoters active in insects can be enhanced by positive feedback mechanisms and associated with repressible lethal effects. (allindianpatents.com)
- Experiments with a monocistronic positive feedback configuration in transgenic animals also showed no detrimental effects (Shockett et al, 1995). (allindianpatents.com)