• [ 5 ] Odds ratios for bleeding were 13 in homozygotes or double heterozygotes and 2.6 in heterozygotes. (medscape.com)
  • Genotype analysis divided the patients with cystic fibrosis into three groups: AF508 homozygotes, AF508 heterozygotes and others. (portlandpress.com)
  • RESULTS: MnSOD genotype distributions were 27% CC (wildtype homozygotes), 50% CT (heterozygotes) and 23% TT (variant homozygotes). (cdc.gov)
  • Among these patients, there were 54 wild-type homozygotes (AA), 53 heterozygotes (AG) and 21 mutant homozygotes (GG). (spandidos-publications.com)
  • Patients treated with this class of medications, including ADUHELM, who are ApoE ε4 homozygotes have a higher incidence of ARIA, including symptomatic and serious ARIA, compared to heterozygotes and noncarriers. (nih.gov)
  • Risk of ARIA, including symptomatic ARIA, was increased in apolipoprotein E ε4 homozygotes compared to heterozygotes and noncarriers. (nih.gov)
  • We found that after adjusting for other covariates, NSCLC patients who smoked and who respectively had CG, CT, and TC heterozygotes of HMGB1 rs2249825, rs1045411, and rs1360485, were at lower risk of developing mutant EGFR , compared to those patients with wild-type homozygotes. (jcancer.org)
  • Two previously undiagnosed C282Y homozygotes (1.6%), and 16 C282Y heterozygotes (12.5%), including four (3.1%) C282Y/H63D compound heterozygotes were identified. (ox.ac.uk)
  • This represents a significant overrepresentation of C282Y homozygotes (relative risk 3.4, p=0.037), but the number of heterozygotes was not significantly increased. (ox.ac.uk)
  • A slight, but non-statistically significant higher risk of cancer mortality was observed for the CT (HR=1.13, 95% CI: 0.86-1.49) and TT (HR=1.24, 95% CI: 0.90-1.70) genotypes compared to CC genotype (p-trend=0.19). (cdc.gov)
  • Analysis of specific genotypes also showed a significant effect. (nutraingredients-usa.com)
  • People with the so-called TT homozygote genotype with low folate status are reported to have higher homocysteine concentrations than the other genotypes, putting this subset at increased risk of CAD and cognitive decline. (nutraingredients-usa.com)
  • Moreover, significant inverse associations between the CG and CG + GG genotypes of HMGB1 rs2249825 and the EGFR hotspot mutation, an exon 19 in-frame deletion, were also observed among NSCLC patients. (jcancer.org)
  • The studies of the stability of the buffer and substrate showed that no statistically significant variation of cholinesterase activity when the buffer and the substrate were stored at room temperature (30 C) for 48 hours. (who.int)
  • The studies showed that there was no statistically significant correlation between Erythrocyte cholinesterase activity and Hemoglobin content. (who.int)
  • Studies of anthropometric measurements showed there was no statistically significant correlation between Erythrocyte cholineaterase activity and Height, and Erythrocyte cholinesterase activity and weight. (who.int)
  • Low-dose folic acid supplementation for eight weeks for the TT genotype people led to a significant 2.1 micromoles per litre reduction in homocysteine levels, and 1.4 micromoles per litre for people who carry the T-allele either hetero- or homozygously. (nutraingredients-usa.com)
  • Our findings of significant linkage of the alpha-adducin locus to essential hypertension and greater sensitivity to changes in sodium balance among patients with the mutant allele suggest that alpha-adducin is associated with a salt-sensitive form of essential hypertension. (nih.gov)
  • Within patients harboring mutant EGFR , HMGB1 rs1360485 C (TC + CC) allele carriers were at higher risk of developing poorly differentiated cancer types (odds ratio=5.493, 95% confidence interval: 1.130~26.696, p =0.019), compared to patients with TT homozygotes. (jcancer.org)
  • There was no significant difference in allele and genotype frequencies of +276G>T between type T2DM patients and controls. (who.int)
  • ALZ-801 has shown potential for robust efficacy in the highest-risk Alzheimer's population - patients with two copies of the apolipoprotein ε4 allele (APOE4/4 homozygotes), and favorable safety with no increased risk of brain vasogenic edema, seen in trials with plaque-clearing antibodies. (biospace.com)
  • There were no significant differences in fentanyl dose or adverse effects, including nausea, vomiting and dizziness, for the OPRM1 A118G polymorphism (P>0.05). (spandidos-publications.com)
  • Twenty one tests were carried out on mutant mice and three significant abnormalities were observed. (wikipedia.org)
  • The increase in frequency of the mutant gene though is balanced by the fact that mutant homozygotes have decreased fitness. (discovermagazine.com)
  • In particular, we find variants that are known to cause diseases with recessive inheritance with significant heterozygous phenotypic effects. (nature.com)
  • The researchers report that, while the low-dose folic acid supplements had no significant effect on homocysteine concentrations in the general study population, levels did significantly decrease in hyperhomocysteinemic subjects by 1.8 micromoles per litre. (nutraingredients-usa.com)
  • "The significant result of this study was that a low dose of folic acid supplementation (400 microg/d) could significantly decrease plasma homocysteine concentration in hyperhomocysteinemic patients with CAD but not in normohomocysteinemia patients," ​ wrote the researchers. (nutraingredients-usa.com)
  • These data were recapitulated in vivo, where G/G homozygotes had significantly higher resistin mRNA levels in human abdominal subcutaneous fat. (diabetesjournals.org)
  • The OPRM1 A118G polymorphism does not play a significant role in post-operative fentanyl analgesic dose or post-operative nausea, vomiting and dizziness in patients undergoing radical gastrectomy. (spandidos-publications.com)
  • The polymorphism has a significant effect on baseline arachidonic acid levels, and on the product-precursor relationship for the omega-6 LCPUFA biosynthesis pathway. (fatsoflife.com)
  • A non-coding p73 polymorphism (denoted AT or GC) may be functionally significant. (tcd.ie)
  • Some patients show significant tumor regression while others may develop intrinsic or acquired resistance to chemical drugs, which highlights the need to tailor the treatment for individuals [ 3 ]. (hindawi.com)
  • Significant differences in PFS and OS were observed in RPA1 rs5030740, EXO1 rs1776148, and rs1047840. (hindawi.com)
  • There were no significant differences between rs6817105 genotype and the serum concentrations of miRNAs. (nature.com)
  • There were no significant differences in recurrence according to treatment groups. (medscape.com)
  • Interestingly, there were no significant differences between the groups in terms of type of therapy or in the sequence of therapies in terms of remission. (medscape.com)
  • In addition to the clinical predictors, findings from pretreatment resting-state functional MRI (fMRI) for 112 patients showed significant differences between those who did and those who did not achieve remission with CBT compared with antidepressant therapy, reported coauthor Boadie Dunlop, MD, of Emory University. (medscape.com)
  • A genetic disorder (discovered in 2003 and 2004) is caused by mutation in the transporter of thyroid hormone, MCT8, also known as SLC16A2, is believed to be account for a significant fraction of the undiagnosed neurological disorders (usually resulting in hypotonic/floppy infants with delayed milestones). (wikipedia.org)
  • No unique phenotype for genetic homozygotes has been reported. (medscape.com)
  • 2. There was no significant difference in age or body weight between patients with cystic fibrosis and control subjects. (portlandpress.com)
  • Results from studies in patients with cancer pain or post-operative pain suggest that the A118G SNP has significant associations with morphine or alfentanil requirements for analgesia ( 6 - 10 ). (spandidos-publications.com)
  • Nous avons génotypé les deux polymorphismes mononucléotidiques du gène ADIPOQ chez 140 patients atteints de DNID sans lien de parenté et 66 témoins non diabétiques en recourant à l'analyse du polymorphisme de longueur des fragments de restriction par réaction en chaîne de polymérase. (who.int)
  • Problems arise with interpretation in many new polymorphisms without significant clinical relevance. (intechopen.com)
  • The frequency of R103R homozygote in obese group was higher than in the control group, whereas Q223Q homozygote in obese group was lower than in the control group. (ajol.info)
  • There was a significant association between the 460 Trp mutation and hypertension (p = 0.0003). (nih.gov)
  • This was backed up by clinical observations, indicating that an individual homozygote of Ser268Pro would be completely M-ficolin deficient. (nih.gov)
  • [ 23 ] However, a significant correlation exists between the clinical presentation of keratosis follicularis (Darier disease) and the intensity of histologic features. (medscape.com)
  • There was no significant difference in the sex distributions in the two groups or the age at death of the cases compared to the age of examination of the controls. (bmj.com)
  • SNP rs2073618 of OPG gene was identified in all study groups without any significant distribution or association with the development of diabetic retinopathy. (jcpsp.pk)
  • Significant linkage was found for all three markers in the sibling-pair study. (nih.gov)
  • Plasma p-tau 181 change from baseline was significant at 13 and 26 weeks and reached -41% at 52 weeks (p=0.016). (biospace.com)
  • Our findings indicate that p73 AT/AT homozygotes appear to be protected against the development of oesophageal cancer. (tcd.ie)
  • Female homozygote mutants had decreased circulating glucose levels. (wikipedia.org)
  • In type 2 N, there is impaired binding of VWF to factor VIII and significant reduction in factor VIII levels (ie, to 1 to 5%) similar to that seen in hemophilia A. (msdmanuals.com)
  • Statistical analysis was performed using t-test to show the significant difference between the groups. (ajol.info)
  • There was no significant difference between the whole blood cholineaterase activity of childdren exposed to pesticides and children not exposed to pesticides. (who.int)
  • Approximately 10% of AT homozygotes develop cancer, mostly of the lymphoid system. (bmj.com)
  • Surprisingly, we found that there is a significant percentage of the embryos (∼60%) with labeled and nonlabeled cells randomly distributed and intermingled. (bioone.org)
  • Only the control group showed significant results for the probing depth according to the polymorphic region. (bvsalud.org)
  • No significant effects emerged when the data were adjusted for age, sex, or apoE ε4 carrier status. (bmj.com)
  • No significant drug effects were observed in the prefrontal cortex. (exeter.ac.uk)
  • Significant Biomarker Effects of Oral Anti-Amyloid Agent ALZ-801 (Valiltramiprosate) In Phase 2 Study In APOE4 Carriers With Early Alzheimer's Disease , on March 30, 2023, at 6:50 p.m. (biospace.com)
  • The new study, published in the journal Nutrition Research ​ (Vol. 26, pp. 460-466), reports that even a low-dose folic acid supplement (400 micrograms) could lead to significant reductions in hyperhomocysteinemic elderly people. (nutraingredients-usa.com)
  • The aims of this study were: (i) to determine the range of variability in resting metabolic rate in cystic fibrosis, (ii) to relate this to pulmonary function and body size, and (iii) to investigate the hypothesis that, in cystic fibrosis, genotype exerts a significant influence on energy requirements. (portlandpress.com)
  • 4. We conclude that there is a significant contribution to resting metabolic rate in cystic fibrosis associated with specific mutations that is not explained by declining pulmonary function. (portlandpress.com)
  • Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)