• The researchers used a virus to identify which types of neurons the retinal ganglion cells made connections with once inside the superior colliculus. (medindia.net)
  • We talked about studying how these neurons project to the colliculus back in 2013, and we've since worked on numerous grant-funded projects together," Fox said. (medindia.net)
  • When a whisker touches an object, cells called neurons at the base of the whiskers produce electrical signals that are relayed to other neurons in an area of the brain called the barrel cortex. (elifesciences.org)
  • Here we describe, in the rat, a direct projection from a primary visual structure, the midbrain superior colliculus (SC), to the substantia nigra pars compacta (SNc) where direct synaptic contacts are made with both dopaminergic and non-dopaminergic neurons. (scite.ai)
  • One way to decode the phasic DA signal would be to determine the perceptual properties of sensory inputs to DA neurons. (scite.ai)
  • After local disinhibition of the superior colliculus in anesthetized rats, DA neurons became visually responsive, whereas disinhibition of the visual cortex was ineffective. (scite.ai)
  • The object value signals in the CDt and SNr are likely used for controlling saccadic eye movements, because many of the SNr neurons projected to the superior colliculus and electrical stimulation in the CDt induced saccades. (mit.edu)
  • The majority of fibers from the second-order neurons reach the contralateral cerebellum by passing through the superior cerebellar peduncle and medullary velum. (grouperfishingsecrets.com)
  • Where retinal ganglion cell axons meet lateral geniculate nucleus axons before synapsing onto neurons in the anterior pretectal area behind the superior colliculi. (articlesall.com)
  • The mouse superior colliculus has been studied extensively for more than 60 years. (medindia.net)
  • 2018). Retinotopic Separation of Nasal and Temporal Motion Selectivity in the Mouse Superior Colliculus. (cam.ac.uk)
  • In neuroanatomy, the superior colliculus (from Latin 'upper hill') is a structure lying on the roof of the mammalian midbrain. (wikipedia.org)
  • In mammals, the superior colliculus forms a major component of the midbrain. (wikipedia.org)
  • The superior colliculi are a structure of the dorsal midbrain and are part of the mesencephalic tectum. (wikipedia.org)
  • Rubrospinal tract The rubrospinal tract is a descending motor pathway that originates in the red nucleus, located on each side of the midbrain tegmentum at the level of superior colliculi. (grouperfishingsecrets.com)
  • Here, we investigated the pharmacology and signalling mechanisms underlying group I mGluR-mediated inhibition of neuronal excitability and synaptic transmission in the rat SC slice. (elsevierpure.com)
  • The frontal eye field (FEF) and superior colliculus (SC) contribute to saccadic eye movement generation, and much of the FEF's oculomotor influence may be mediated through the SC. (duke.edu)
  • The retina serves as a transducer for the conversion of light into neuronal signals. (justapedia.org)
  • These signals are transmitted by the optic nerve , from the retina upstream to central ganglia in the brain . (justapedia.org)
  • Signals from the retina also travel directly from the retina to the superior colliculus . (justapedia.org)
  • This tract originates in the superior colliculus, where it receives information from the retina and cortical visual association areas. (grouperfishingsecrets.com)
  • Acetylcholine (ACh) signaling plays a key role in the development of the retina. (org.es)
  • Trained monkeys performed a two-choice perceptual decision-making task in which they reported the perceived orientation of a dynamic Glass pattern, before and after unilateral, reversible, inactivation of a brainstem area-the superior colliculus (SC)-involved in preparing eye movements. (nature.com)
  • The Brainstem Auditory Evoked Response (BAEP) is a complex response to externalstimulation that represents the neural electrophysiological activity of the auditory system at the level of the brainstem, mapping the synapses of the auditory pathways from the cochlear nerve, cochlear nucleus, superior olivary brainstem complex to the inferior colliculus-midbrain 1,2 . (bvsalud.org)
  • The brachium of superior colliculus (or superior brachium) is a branch that extends laterally from the superior colliculus, and, passing to the thalamus between the pulvinar and the medial geniculate nuclei, is partly continued into an eminence called the lateral geniculate nucleus, and partly into the optic tract. (wikipedia.org)
  • The lateral geniculate nucleus sends signals to primary visual cortex , also called striate cortex. (justapedia.org)
  • citation needed] The superior colliculus is associated with a nearby structure called the parabigeminal nucleus, often referred to as its satellite. (wikipedia.org)
  • citation needed] The superior colliculus is a synaptic layered structure. (wikipedia.org)
  • Fox and his team examined how a specific subtype of optic nerve cells - ipsilateral retinal ganglion cells - finds its way to the superior colliculus during brain development. (medindia.net)
  • One protein, emitted by a type of excitatory neuron in the superior colliculus, lures the optic nerve cell closer like a molecular homing beacon. (medindia.net)
  • In mammals, and especially primates, the massive expansion of the cerebral cortex reduces the superior colliculus to a much smaller fraction of the whole brain. (wikipedia.org)
  • 3. Pain modulation - The reticular formation is one means by which pain signals from the lower body reach the cerebral cortex. (powershow.com)
  • The superior colliculus is a layered structure, with a pattern that is similar to all mammals. (wikipedia.org)
  • Note on terminology: This article follows terminology established in the literature, using the term "superior colliculus" when discussing mammals and "optic tectum" when discussing either specific non-mammalian species or vertebrates in general. (wikipedia.org)
  • The approach taken in this article is to follow the literature by using the term "superior colliculus" when discussing mammals, and "optic tectum" when discussing either specific non-mammalian species or vertebrates in general. (absoluteastronomy.com)
  • Receives auditory information from superior olivary nucleus. (powershow.com)
  • They are overlapped by the pulvinar of the thalamus, and a medial geniculate nucleus of the thalamus is situated lateral to either superior colliculus. (wikipedia.org)
  • This article provides an overview of the general structures and signalling mechanisms, and of typical developmental functions along with cell biological principles. (silverchair.com)
  • Cone ERG responses together with visual evoked potentials and multi-unit activity in the superior colliculus were also absent. (nih.gov)
  • When the beacon molecule - called nephronectin - is absent, a visual layer of the superior colliculus doesn't form properly, and the mice have trouble hunting prey. (medindia.net)
  • In other species, the superior colliculus is involved in a wide range of responses, including whole-body turns in walking rats. (wikipedia.org)
  • The absence of post-receptoral ERG responses and the diminished photoreceptor calcium signals are consistent with a loss of Ca((2+)) channel function in photoreceptors. (nih.gov)
  • Depth-dependent somatovisual responses in human superior colliculus using 9.4T fMRI. (mpg.de)
  • As the primary source of visual afferents, the limited processing capacities of the colliculus may constrain the visual information content of phasic DA responses. (scite.ai)
  • In the majority of cases, Eph forward signalling causes cell repulsion away from the ephrin-expressing cell, although adhesive responses have been described. (silverchair.com)
  • Mechanistically, Eph/ephrin signalling controls local cytoskeletal dynamics and thereby allows cellular shape changes that underlie repulsive or migratory responses. (silverchair.com)
  • In particular, he studied the superior colliculus, a conserved brain area responsible for extracting ethologically relevant sensory information from the surroundings and guide orienting movements (de Malmazet, 2018 and 2023). (cam.ac.uk)
  • The illusion must therefore be triggered by a "lowest common denominator" signal common to all the conditions tested and their respective neural circuits. (mit.edu)
  • Daniel's current work entails understanding the inhibitory network underlying motor control and dissecting the parallel channels encoding prey capture, sensory and cognitive signals in the superior colliculus. (cam.ac.uk)
  • Since various bands of fibers (fibers of the fasciculus retroflexus, rootlets of the oculomotor nerve, and fibers of the superior cerebellar peduncle) pass through the red nucleus (3, 4) , it has been proposed that these myelinated fiber bundles constitute the lamellae (1) . (ajnr.org)
  • 1 Group I metabotropic glutamate receptors (mGluRs) are thought to be important modulators of neuronal function in the superior colliculus (SC). (elsevierpure.com)
  • we know that the SC plays a crucial role in converting sensory signals, particularly visual signals, into commands to orient toward those sensory signals. (alliedacademies.org)
  • Somatosensory refers to these sensory signals except the sensory signals from A. Bones and muscles. (grouperfishingsecrets.com)
  • Calcium imaging in Fluo-4 loaded retinal slices depolarized with KCl showed 90% less peak signal in the photoreceptor synapses of the Cacna1f mutant than in wild-type mice. (nih.gov)
  • They have recently expanded their research program to study how retinal outputs are integrated in the superior colliculus together with top-down modulatory inputs from the visual cortex in response to behaviorally relevant stimuli. (sfari.org)
  • Retinal origin of orientation but not direction selective maps in the superior colliculus. (cam.ac.uk)
  • Cajal noted the presence of pericellular nests in the cerebellum, hippocampus, and cortex and hypothesized that they amplify signals from the presynaptic cells to the enveloped cell body. (nih.gov)
  • From the hippocampus, signals are relayed via the fornix to the mammillary bodies and via the mammillothalamic tract to the anterior nucleus of the thalamus. (medscape.com)
  • Composition and topographic organization of signals sent from the frontal eye field to the superior colliculus. (duke.edu)
  • Although this signal is important for reinforcement learning, the information it conveys to forebrain target structures remains uncertain. (scite.ai)
  • In rodents, this brain region integrates multi-sensory inputs - visual cues, sounds, touch information, and smells - and delivers output signals to a variety of motor control centers in the brain, coordinating the animal's movements in response to its environment. (medindia.net)
  • Depth-Dependence of Visual Signals in the Human Superior Colliculus at 9.4T: Comparison with 3T. (mpg.de)
  • Depth-Dependence of Visual Signals in the Human Superior Colliculus at 9.4T. In Magnetic Resonance Materials in Physics, Biology and Medicine, 28 (Supplement 1), pp. (mpg.de)
  • The experiments show that the electrical signals in the barrel cortex encode information about motion as well as the distance between the mouse and the wall. (elifesciences.org)
  • The experiments suggest that the barrel cortex processes signals received from several whiskers to build an overall picture of the locations and shapes of objects. (elifesciences.org)
  • Gaze-related signals in frontal cortex are often used as an experimental model for visual working memory. (eneuro.org)
  • Receives signals from lateral reticular formation. (powershow.com)
  • Fitting signal detection theory and sequential sampling models to the data showed that SC inactivation produced a decrease in the relative evidence for contralateral decisions, as if adding a constant offset to a time-varying evidence signal for the ipsilateral choice. (nature.com)
  • Meanwhile, ipsilateral parasympathetic nerves send signals back down towards. (articlesall.com)
  • Although the superior colliculus composes a relatively small portion of the brain's volume in mice, it's a processing powerhouse - in part, because it's formed by precise cellular layers that organize and refine signaling patterns. (medindia.net)
  • Eph-ephrin signalling can be bi-directional and controls actin cytoskeleton dynamics, thereby leading to changes in cellular shape. (silverchair.com)
  • However, it is not clear how information is encoded in these electrical signals, in part, because it is technically challenging to collect data about neuron activity and behavior while the mice move around. (elifesciences.org)
  • Nestled deep in the middle of the vertebrate brain is a multi-sensory integration and movement control center called the superior colliculus. (medindia.net)
  • Is audio-visual integration subserved by the superior colliculus in humans? (unimib.it)
  • In primates, the superior colliculus has been studied mainly with respect to its role in directing eye movements. (wikipedia.org)
  • Even in primates, however, the superior colliculus is also involved in generating spatially directed head turns, arm-reaching movements, and shifts in attention that do not involve any overt movements. (wikipedia.org)
  • The signal intensity of the lamellae was consistently higher than that of other parts of the red nucleus on all images. (ajnr.org)
  • The nerve fibers in these pathways act in the spinal cord to block the transmission of some pain signals to the brain. (powershow.com)
  • I particularly love cell and molecular neurobiology, with emphasis on neuroimmune and neuroendocrine signaling during homeostasis and pathology. (duke.edu)
  • Following his PhD, he decided to understand further the motor aspects of the superior colliculus and joined the laboratory of Marco Tripodi in February 2019 at the MRC Laboratory of Molecular Biology in Cambridge. (cam.ac.uk)
  • A central structure in the brain involved in visual processing and eye movement control is the superior colliculus (SC). (alliedacademies.org)
  • These growing cells eventually branch off to shape thousands of intricate connections in precise brain regions, including the superior colliculus. (medindia.net)
  • Eph and ephrin proteins interact with a number of other ligand/receptor systems to influence how cells translate environmental signals to orchestrate morphogenetic events. (silverchair.com)
  • Specifically, it is suggested that chronostasis is triggered by a low-level signal arising in response to efferent signals generated in the superior colliculus. (mit.edu)
  • Further, changes in subjective sleepiness (the difference between the SC and SD sessions) were correlated with both changes in amygdala activity and functional connectivity between the amygdala and superior colliculus in response to subliminal fearful faces.Conclusion: Sleepiness induced functional decline in the brain areas involved in conscious visual cognition of facial expressions, but also enhanced subliminal emotional processing via superior colliculus as represented by activity in the amygdala. (elsevierpure.com)
  • Thus, our data suggest that the oculomotor SNr assists saccade adaptation by strengthening the error signal. (eneuro.org)
  • 2004). However, during development, cholinergic signaling does occur between SACs (Zheng et al. (org.es)
  • These results demonstrate that FEF activity undergoes a series of sensory-memory-motor transformations, including a dynamically evolving spatial memory signal and an imperfect memory-to-motor transformation. (eneuro.org)
  • These findings suggest that improvements of both sensorimotor processing and finger motor control by piano practice would contribute to superior synchronization stability. (biomedcentral.com)
  • Somatovisual processing in the deep layers of the human superior colliculus. (mpg.de)