Signal transduction gene nuclear receptor subfamily 6 group a member 1. Medical search. Frequent questions

Further, emerging evidence suggests that nicotine can also regulate the expression of genes/proteins involved in various functions such as ERK1/2, CREB, and c-FOS [ 20 - 22 ], as well as the expression state of multiple biochemical pathways, for example, mitogen-activated protein kinase (MAPK), phosphatidylinositol phosphatase signaling, growth factor signaling, and ubiquitin-proteasome pathways [ 23 - 25 ]. (hindawi.com)
Pathways such as cytokine-cytokine receptor interaction, glycolysis/gluconeogenesis and apoptosis are closely related to sperm quality. (biomedcentral.com)
Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)
The mechanisms of radioresistance are still poorly understood, despite it has been suggested that miRNAs play an important role in cell signaling pathways. (frontiersin.org)
Indeed, it has been shown that miRNAs play an important role in gene expression, mainly when associated with the monitoring of several cell and metabolic pathways, being also an essential component of the gene silencing machinery in most eukaryotic organisms ( 4 , 8 ). (frontiersin.org)
When resources are scant, C. elegans larvae arrest as long-lived dauers under the control of insulin/IGF- and TGFβ-related signaling pathways. (biomedcentral.com)
How are signals from the TGFβ and insulin/IGF pathways integrated? (biomedcentral.com)
What gene expression programs do these pathways regulate, and how do they control complex downstream events? (biomedcentral.com)
Studies of these signaling pathways have led to some understanding of the basic role of these pathways in regulating dauer formation. (biomedcentral.com)
The results showed that immunity and metabolism-related pathways (neuroactive ligand-receptor interactions, cytokine-cytokine receptor interactions and NOD-like receptor signaling pathways) were significantly enriched at both 24h and 48h. (frontiersin.org)
Such novel pathways include induction of mitochondrial stress, inhibition of mitochondrial shuttles, alteration of intestinal microbiota, suppression of glucagon signaling, activation of autophagy, attenuation of inflammasome activation, induction of incretin receptors and reduction of terminal endoplasmic reticulum stress. (cyberleninka.org)
In addition, upregulation of AEG-1 expression can protect nigral dopaminergic neurons from injury caused by aberrant apoptotic signaling pathways ( 13 ). (spandidos-publications.com)
In response to environmental changes, signaling pathways rewire gene expression programs through transcription factors. (molcells.org)
Emerging evidence shows that key signal transduction pathways including TGFβ (transforming growth factor-β), ERK (extracellular signal-regulated kinase), and mTORC1 (mechanistic target of rapamycin complex 1) regulate downstream gene expression through m 6 A processing. (molcells.org)
In this review, we discuss the current understanding of the crosstalk between m 6 A and signaling pathways and its implication for biological systems. (molcells.org)
In this review, we will focus on how the signal transduction pathways, which play key roles in diverse physiological and pathological conditions, coordinate cellular processes through m 6 A. Given that m 6 A also controls signaling pathways through RNA modification or acting as a ligand, understanding the crosstalk between signal transduction networks and m 6 A RNA processing will provide us insights into the complex biological systems. (molcells.org)
They are key regulators of brassinosteroid signaling and are also involved in the cross-talk between auxin and brassinosteroid pathways. (biomedcentral.com)
In humans and animals, GSK-3/SGG are key regulators of a broad range of signaling pathways and their dysregulation responsible for a number of diseases or developmental abnormalities, both aspects abundantly documented in the literature. (biomedcentral.com)
SGG/GSK-3 are a master switch in the Wnt/Wingless(Wg) pathways and are involved in fundamental developmental processes in animals such as cell fate specification, pattern formation and body axis formation [ 2 , 6 , 7 ]. (biomedcentral.com)
Limb-girdle muscular dystrophy (LGMD) protein defects occur in several pathways involved in the biologic function of muscle and can be divided into groups based on cellular localization. (medscape.com)

Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. (mcw.edu)
The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
Proviral infection at the "site of the highest degree" was thought to be the mechanism of carcinogenesis, giving the first name to the gene found along this pathway as INT1. (chemdiv.com)
Currently, there are 273 genes in SZGR 2.0 (with evidence in schizophrenia) that are present at this pathway. (uth.edu)
Dong W , Yang H, Cheng M, Zhang X, Yin J, Zeng Z, Huang G. Dexmedetomidine alleviates pulmonary ischemia-reperfusion injury through modulating the miR-21-5p/Nr4a1 signaling pathway. (referencecitationanalysis.com)
Taken together, Dex treatment attenuated ischemia-reperfusion induced pulmonary injury through modulating the miR-21-5p/Nr4a1 signaling pathway. (referencecitationanalysis.com)
Many insulin/IGF pathway and other known dauer regulatory genes have changes in expression that suggest strong positive feedback by the TGFβ pathway. (biomedcentral.com)
However, our observation that the position of putative DAF-16 binding sites is correlated with the direction of regulation suggests a novel method of achieving gene-specific regulation from a single pathway. (biomedcentral.com)
this included the TNF‑α pathway, the NF‑κB pathway, the MAPK signaling pathway, the Notch signaling pathway and Axon guidance. (spandidos-publications.com)
Collectively, the present study provides insights into AEG‑1‑dependent gene regulation and signaling pathway transduction in neurons. (spandidos-publications.com)
Conversely, m 6 A can modulate the activity of signal transduction networks via m 6 A modification of signaling pathway genes or by acting as a ligand for receptors. (molcells.org)
Adding further complexity to this picture is the fact that both kinases and phosphatases can function in signaling networks where multiple kinases and phosphatases contribute to the outcome of a pathway. (rupress.org)
Each of these biological outcomes results from the interaction of this pathway with other signaling networks. (biomedcentral.com)

In the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1, group I, member 2 (NR1I2) is a protein that in humans is encoded by the NR1I2 (nuclear Receptor subfamily 1, group I, member 2) gene. (wikipedia.org)
The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
Upon performing GO analysis, we found that some DEGs correlated with an integral part of membrane, protein complex, cell surface, ATP binding, immune system process, signal transduction and metabolic process which are responsible for the epididymal injury. (biomedcentral.com)
Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)
Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
Recombinant full length protein corresponding to Human Retinoid X Receptor beta/RXRB. (abcam.com)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. (lookformedical.com)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
events have receptors stimulated with students( GAGs), unregulated chains docking of a inactive actin, all of an been protein respiration cell a considerable subunits. (evakoch.com)
Small non-protein-coding RNA molecules, composed of around 22 nucleotides, are commonly named as miRNAs ( 1 - 3 ). (frontiersin.org)
Briefly, miRNAs are expected to account for 1-5% of the human genome and to interfere with at least 30% of the protein-coding genes ( 4 , 5 ). (frontiersin.org)
Though researchers' attention and this Viewpoint focus on a few famous ion channels that are considered the usual suspects as MS mechanosensors, we also discuss some of the more unusual suspects, such as G-protein coupled receptors. (stanford.edu)
Also, this region may contain nuclear localization signals and protein-protein interaction sites. (indigobiosciences.com)
adaptor related protein complex 1 subuni. (gsea-msigdb.org)
amyloid beta precursor like protein 1 [S. (gsea-msigdb.org)
docking protein 1 [Source:HGNC Symbol;Ac. (gsea-msigdb.org)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
The FH1 domain is also a binding site for diverse SH3-domain containing proteins like Src-like non-receptor tyrosine kinases, WISH (WASP-interacting SH3 protein) and IRSp53 (insulin receptor substrate) in mammals, and Hof1p in yeast [ 6 ]. (biomedcentral.com)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
Dopamine acts in the striatum through the D 1 and D 2 subfamilies of G-protein-coupled receptors. (jneurosci.org)

PXR is a nuclear receptor whose primary function is to sense the presence of foreign toxic substances and in response up regulate the expression of proteins involved in the detoxification and clearance of these substances from the body. (wikipedia.org)
Domain commonly found in eukaryotic signalling proteins. (embl.de)
Comparative functional multiomics showed that blood proteins induce distinct receptor-mediated transcriptional programs in microglia and macrophages, such as redox, type I interferon and lymphocyte recruitment. (nature.com)
Our data provide an interactive resource for investigation of the immunology of blood proteins that could support therapeutic targeting of microglia activation by immune and vascular signals. (nature.com)
However, how microglia integrate extracellular signals at sites of cerebrovascular damage and the specificity of blood proteins controlling innate immune cell polarization in disease remain poorly understood. (nature.com)
We report a blood-induced microglia gene network and show that blood proteins elicit distinct receptor-mediated transcriptional changes and signaling programs in innate immune cells. (nature.com)
To discover the molecular programs controlling microglial and macrophage polarization by blood proteins, we developed an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline consisting of deep sequencing of blood-induced transcriptomes, functional single-cell and oxidative stress transcriptomics, global phosphoproteomics and integration with innate immune signatures from AD and MS models (Extended Data Fig. 1 ). (nature.com)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
How do three dozen insulin-like proteins regulate one tyrosine kinase receptor to control complex events in dauer, metabolism and aging? (biomedcentral.com)
These proteins are intracellular transcription factors that directly regulate gene expression in response to lipophilic molecules. (indigobiosciences.com)
m 6 A recruits effector proteins that determine the fate of mRNAs through changes in splicing, cellular localization, stability, and translation efficiency. (molcells.org)
The m 6 A-modified RNAs then recruit m 6 A-binding proteins (readers) that guide these RNAs for RNA biogenesis processes such as pre-mRNA splicing, nuclear export, stabilization, degradation, and translation. (molcells.org)
Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. (biomedcentral.com)
In vitro, the FH2 domain competes with barbed-end capping proteins and is necessary and sufficient to nucleate actin polymerization, but the FH1 domain, which interacts with profilin-actin, funnels actin to the nucleation vicinity and confers full activity to the molecule [ 1 ]. (biomedcentral.com)

HO-1 and their products exert beneficial effects through the protection against oxidative injury, regulation of apoptosis, modulation of inflammation as well as contribution to angiogenesis. (springer.com)
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Furthermore, a functional analysis of differentially expressed genes revealed enriched gene ontology terms involved in the regulation of circadian rhythm, histone modification, meiotic nuclear division, and others. (biomedcentral.com)
Finally, we also see strong regulation of many novel hedgehog- and patched-related genes, hormone biosynthetic genes, cell cycle genes, and other regulatory genes. (biomedcentral.com)
Up and down regulation of insulin-like ligands and novel genes with similarity to the extracellular domain of insulin/IGF receptors suggests opposing roles for several members of these large gene families. (biomedcentral.com)
We see evidence of TGFβ-mediated regulation of several other classes of regulatory genes, and we discuss possible functions of these genes in dauer formation. (biomedcentral.com)
DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
Epigenetic modification of the transcribed RNA can be another layer of gene expression regulation. (molcells.org)

Overexpression of this gene is associated with tumor cell proliferation and metastasis. (cancerindex.org)
The methylation specific polymerase chain reaction in conjunction with sequencing verification was used to establish the methylation patterns of the 14 genes in the liver tissues of four healthy liver donors, as well as tumor and the paired non-cancerous tissues of 30 HCC patients. (wjgnet.com)
Both glutathione S-transferase pi ( GSTpi ) (80%, 24/30 in tumor and 56.7%, 17/30 in the paired non-cancerous tissues) and cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) ( CFTR ) (77%, 23/30 in tumor and 50%, 15/30 in the paired non-cancerous tissues) genes were prevalently hypermethylated in HCC as well as their neighboring non-cancerous tissues. (wjgnet.com)
The first miRNA was discovered in 1993 by Lee, Freinbaum and Ambros ( 6 , 7 ), and since then an increasing load of literature data have pointed that they can act as both tumor suppressors and oncogenes ( 1 - 3 ). (frontiersin.org)
Human derived T lymphocytes engineered to express chimeric antigen receptors, which are expanded in vitro culture and then infused into patients exerting robust cytotoxicity after tumor antigen recognition and subsequent activation. (biomedcentral.com)
Astrocyte elevated gene‑1 (AEG‑1) is a key regulatory factor of progression in multiple types of tumor and neurodegenerative disease development. (spandidos-publications.com)
As an oncogene, AEG-1 has been found to facilitate tumor growth, metastasis, angiogenesis and drug resistance ( 5 , 6 ). (spandidos-publications.com)

Early classification of these receptors was based on ligands, DNA binding properties or other functional characterization. (indigobiosciences.com)

The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. (biomedcentral.com)
Some of the induced genes, such as CREM, CHOP, and MAP kinase phosphatase-1, may be components of a homeostatic response to excessive stimulation. (jneurosci.org)

Like other type II nuclear receptors, when activated, it forms a heterodimer with the retinoid X receptor, and binds to hormone response elements on DNA which elicits expression of gene products. (wikipedia.org)

Genomic and cDNA sequence alignments as well as chromosome localization using nullisomic-tetrasomic lines provided strong evidence for three expressed gene copies located on homoeolog chromosomes for TaSK1 as well as for TaSK2 . (biomedcentral.com)

Further, clustering of these genes resulted in six clusters with themes in synaptic transmission, signal transduction, metabolic process, and apoptosis, which provided an intuitional view on the major molecular functions of the genes. (hindawi.com)

GeneChip-based transcriptomic analyses revealed that vulnerable neurons had higher expression of genes related to stress and immune response, and lower expression of energy generation and signal transduction genes in comparison with resistant neurons. (biomedcentral.com)
However, none of these studies except for the one on dopaminergic neurons focused on a specific form of stress, or on genes or bio-functions that might contribute to the etiology of SNV. (biomedcentral.com)
Since OS-sensitive neurons might be the ones that degenerate early during the aging process or in certain neurodegenerative diseases [ 1 ], study of the molecular mechanisms of SNV to OS may offer insights into both aging-associated and disease-initiated neurodegeneration, as well as provide leads to the protection of vulnerable neurons. (biomedcentral.com)
In a subsequent study, we examined how neurons in CA1 and CA3 responded differentially to OS increases in terms of the neuronal gene expression patterns and we identified genes whose expression distinguished the responses of CA1 from those of CA3 neurons [ 21 ]. (biomedcentral.com)
The first neurons of the retina are the rod and cone photoreceptors, which convert changes in photon flux into electrical signals that are the basis of vision. (bvsalud.org)
Food availability, competition for available food resources (population density, as measured by the concentration of a constitutively secreted pheromone), and temperature are assessed by identified chemosensory and thermosensory neurons, and signals are transduced from these neurons to affect the physiology and structure of most cell types in the body. (biomedcentral.com)
The aim of the present study was to clarify the function and related mechanism of AEG‑1 in neurons. (spandidos-publications.com)
AEG-1 has differential regulatory effects on astrocytes (AST) and neurons. (spandidos-publications.com)
By contrast, in neurons, downregulation of AEG-1 expression has been shown to reduce the viability of motor neurons in models of amyotrophic lateral sclerosis (ALS), both in vivo and in vitro ( 12 ). (spandidos-publications.com)

PXR belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. (wikipedia.org)
Unlike receptors found on the cell surface, members of the nuclear hormone receptor (NR) superfamily are restricted to metazoan organisms such as nematodes, insects, and vertebrates. (indigobiosciences.com)

In addition, the regulatory relationship between miR-21-5p and orphan nuclear receptor 4A1 (Nr4a1) was revealed by several assays, including the dual-luciferase reporter assay, real-time quantitative polymerase chain reaction (RT-qPCR) and western blot. (referencecitationanalysis.com)
However, the vast majority of known receptors do not have an identifiable physiologically relevant ligand, and are deemed orphan receptors. (indigobiosciences.com)

We propose that FXR activation by increased bile acid flux is a signal of decreased functional capacity of the liver. (nih.gov)

Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
AEG-1 has been shown to localize to the cell membrane, cytoplasm, endoplasmic reticulum, nucleolus and nucleus in cancer cells ( 2 ). (spandidos-publications.com)
The MACOM complex does not have catalytic activity, but it is necessary for efficient m 6 A methylation by recruiting RNA substrates and stabilizing the MAC-MACOM complex in the nucleus and nuclear speckles. (molcells.org)

FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth. (nih.gov)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Hence, it is a valuable source to identify the expression of all genes with a specific time and space in the cell. (biomedcentral.com)
Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. (affbiotech.com)
Transcriptomes from the tissues of the brain-pituitary-gonad (BPG) axis of T10 samples revealed a differential gene expression profile compared to the other experimental groups, with clustering in a principal component analysis and in heat maps of all differentially expressed genes. (biomedcentral.com)
We have identified genes that show different levels of expression in a comparison of wild-type L2 or L3 larvae (non-dauer) to TGFβ mutants at similar developmental stages undergoing dauer formation. (biomedcentral.com)
In addition, many insulin-like ligand and novel genes with similarity to the extracellular domain of insulin/IGF receptors have altered expression. (biomedcentral.com)
The expression of immunity and metabolism-related genes (BS2A1, PIWIL2 and Fads1) significantly decreased at all-time points compared to the control group. (frontiersin.org)
Understand Nuclear Receptors through our introduction to this family of intracellular transcription factors that regulate gene expression. (indigobiosciences.com)
AEG‑1 is associated with glutamate excitotoxicity due to its reported function of repressing excitatory amino acid transporter 2 expression in astrocytes. (spandidos-publications.com)
Results from RNA sequencing revealed that AEG‑1 modulated neuronal morphology and development by regulating the expression of numerous genes, such as ubiquitin C, C‑X‑C motif chemokine ligand 1, MMP9, Notch1, neuropilin 1 and ephrin type‑A receptor 4. (spandidos-publications.com)
Downregulation in cellular ion homeostasis, including ion channel function and neurotransmitter release, were observed after knocking out AEG‑1 expression. (spandidos-publications.com)
Silencing AEG-1 expression has also been shown to suppress AST migration and proliferation to wounded areas ( 11 ). (spandidos-publications.com)
Real-time PCR was used to study the expression pattern of formin genes. (biomedcentral.com)
Expression of forC, D, I and J increased during transition to multi-cellular stages, while the rest of genes displayed less marked developmental variations. (biomedcentral.com)
these effects are thought to involve alterations in gene expression. (jneurosci.org)
Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)
The induced mRNAs include both novel and previously described genes, with diverse time courses of expression. (jneurosci.org)
these gene expression changes may be responsible for the alterations in striatal physiology. (jneurosci.org)
One example is dynorphin gene expression, which is progressively induced in dorsal striatum by cocaine. (jneurosci.org)

Innate immune cells integrate environmental signals to rapidly activate target genes and perform specialized cellular functions 5 . (nature.com)

Despite factors in codon, all apoptotic dwarfism genes person three employed cells( CRs) and each is with RAS and MEK synapses, although with pulmonary cyclins. (evakoch.com)

PXR is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. (wikipedia.org)
Blood induced widespread microglial transcriptional changes, including changes involving oxidative stress and neurodegenerative genes. (nature.com)

Indeed, cells tightly regulate m 6 A modification using specialized enzymes, m 6 A writers and erasers. (molcells.org)

The results demonstrate the pattern of photoreceptor apoptosis between rd1 mice and the control group. (bvsalud.org)

In contrast to some previously described early genes, most of the novel genes are not induced in cortex by apomorphine, indicating specificity of induction. (jneurosci.org)

In summary, by analyzing the overall characteristics of the nicotine addiction related genes, this study provided valuable information for understanding the molecular mechanisms underlying nicotine addiction. (hindawi.com)
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. (cancerindex.org)
1). According to results of a bioinformatics analysis, Gene Ontology (GO) function is divided into three categories: cellular component, molecular function and biological process. (biomedcentral.com)
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)

Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. (cancerindex.org)
Although causative gene mutations have been well characterized for LGMD, no specific treatment is available for any of the LGMD syndromes yet. (medscape.com)
For example, mutations in TTN gene may present with a wide range of phenotypes ranging from congenital myopathy to late-onset distal myopathy. (medscape.com)
The intra- and intertumor heterogeneity of cell types and gene mutations as well as the complexity of the microenvironment contribute to limiting the efficacy of the current therapeutic options for high grade glioma. (mdpi.com)
Overlap exists with Congenital Muscular Dystrophy (CMD) as several gene mutations can cause both a LGMD and CMD phenotype. (medscape.com)
These diseases are discussed here in part because mutations in 2 genes can present with either an LGMD or a myofibrillar myopathy phenotype. (medscape.com)

Creation of T helper 2 (Th2) cytokines [IL-4, -5, and -13 (6)] regulates these occasions because they're crucial for the change to IgE creation by differentiating B cells and promote the influx of eosinophils and additional inflammatory cells that donate to airway pathology. (enmd-2076.com)
In addition, AEG-1 as a key modulator regulates aberrant cellular processes within the central nervous system (CNS), where it is involved in neurological diseases such as Huntington's chorea, migraine and HIV-induced neurological disorders ( 7-9 ). (spandidos-publications.com)

cytochrome P450 family 27 subfamily A me. (gsea-msigdb.org)

C-C motif chemokine receptor like 2 [Sou. (gsea-msigdb.org)
C-X-C motif chemokine receptor 5 [Source. (gsea-msigdb.org)

Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma. (wjgnet.com)
To establish the DNA methylation patterns of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma (HCC). (wjgnet.com)
N 6 -adenosine methylation (m 6 A) is one of the most common modifications on mRNA. (molcells.org)
N 6 -methyladenosine (m 6 A) is a methylation modification of adenosine on RNA. (molcells.org)

Glycogen synthase kinase 3 (GSK-3) / SHAGGY kinase (SGG) are multifunctional non receptor serine/threonine kinases. (biomedcentral.com)

Pathogenic activation of microglia contributes to oxidative stress, inflammation and neurodegeneration in both Alzheimer's disease (AD) and multiple sclerosis (MS) 6 . (nature.com)

Furthermore, kinases and phosphatases may work together to modulate the strength of a signal. (rupress.org)

To our knowledge, studies investigating the differentially expressed genes of host and T. gondii by transcriptome sequencing of the male reproductive system are limited. (biomedcentral.com)
This thermoception may have caused the observed effects through epigenetic mechanisms, since all analysed tissues further revealed differentially expressed genes involved in histone modification. (biomedcentral.com)

Unlike in adults, most genes with putative DAF-16 binding sites are upregulated during dauer entry, suggesting that DAF-16 has different activity in dauer versus adult metabolism and aging. (biomedcentral.com)

desert hedgehog signaling molecule [Sour. (gsea-msigdb.org)
Astrocyte elevated gene-1 (AEG-1), which is also known as metadherin and lysine-rich carcinoembryonic antigen-related cell adhesion molecule 1 co-isolated, was first observed to be upregulated in brain astrocytes from patients with HIV-induced Alzheimer's disease ( 1 ). (spandidos-publications.com)

Aberrant m 6 A modifications by overactivation or suppression of these enzymes lead to human diseases such as cancer, diabetes, and neurological disorders. (molcells.org)

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. (affbiotech.com)

ethanolamine kinase 1 [Source:HGNC Symbo. (gsea-msigdb.org)
The inhibition of mitochondrial complex activity by metformin might be a mechanism of metformin-induced AMPK activation9, as intracellular ATP levels are decreased by the inhibition of mitochondrial complex activity and AMP levels are increased by the action of adenylate kinase converting two molecules of adenosine diphosphate (ADP) to ATP and AMP (Figure 1). (cyberleninka.org)

We have identified a large group of regulated genes with putative binding sites for the FOXO transcription factor, DAF-16. (biomedcentral.com)

Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 4 h. (gsea-msigdb.org)

Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
oxLDL can interfere with the transduction of the signals responsible for triggering the activation of endothelial nitric oxide synthase (eNOS), causing reduced vasodilation and endothelial dysfunction, which are the main characteristics of preeclampsia. (biomedcentral.com)
The N terminus of the NR, sometimes called the modulator, hypervariable or A/B domain, has transactivation activity, termed activation function 1 (AF-1). (indigobiosciences.com)
Furthermore, AEG-1 can promote AST activation and hyperplasia induced by brain injury in a mouse model of reactive astrogliosis ( 11 ). (spandidos-publications.com)

In AST, AEG-1 causes glutamatergic excitotoxicity by downregulating the activity of the excitatory amino acid transporter 2 (EAAT2) promoter, leading to neuronal cell death in glioma-induced neurodegenerative disease ( 10 ). (spandidos-publications.com)

Notably, LGMD subtypes are phenotypically highly variable, limb-girdle weakness may not be the predominant presentation, and mutation in genes assigned to LGMD subtypes may cause allelic conditions with a different phenotype. (medscape.com)
GR versus RXR) and among receptor subtypes (RXRα versus RXRβ). (indigobiosciences.com)

ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
1. ß-catenin: structure and functions. (chemdiv.com)
An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)
FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling. (cancerindex.org)

Anatomy11

Organisms5

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes41

Information Science4

Pathways21

Pathway14

Protein25

Proteins15

Regulation8

Tumor7

Ligands1

Phosphatase2

Retinoid X recept1

Chromosome1

Synaptic1

Neurons9

Superfamily2

Orphan2

Decreased functional1

Nucleus3

Expression20

Target genes1

Apoptotic1

Transcriptional2

Regulate1

Apoptosis1

Specificity1

Molecular4

Mutations6

Regulates2

Cytochrome1

Motif chemokine2

Methylation4

Serine1

Oxidative stress1

Kinases1

Differentially2

Metabolism1

Molecule2

Aberrant1

Binds1

Kinase2

Transcription factor1

Dendritic cells1

Activation4

Neurodegenerative1

Subtypes2

Catenin7