MethadoneNarcoticsOpiate Substitution TreatmentOpioid-Related DisordersHeroin DependenceAnalgesics, OpioidMethadyl AcetateBuprenorphineNeonatal Abstinence SyndromeHeroinSubstance Abuse DetectionPyrrolidinesMorphineDrug OverdoseNarcotic AntagonistsDose-Response Relationship, DrugSubstance Abuse, IntravenousSubstance Withdrawal SyndromeDextropropoxypheneSubstance-Related DisordersStreet DrugsCocaine-Related DisordersTreatment OutcomeOpiumDrug InteractionsStereoisomerismNaloxoneOxidoreductases, N-DemethylatingPainMeconiumTherapeutic CommunityCodeineReceptors, Opioid, muDirectly Observed TherapyNaltrexonePrisonersDouble-Blind MethodAdministration, OralTime FactorsPupilCytochrome P-450 CYP3AHydromorphoneDrug Administration Schedule