AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesTechnology, Industry, Agriculture
LipogenesisLipidsSterol Regulatory Element Binding Protein 1Fatty Acid SynthasesLiverFatty AcidsAdipose TissueLipid MetabolismAcetyl-CoA CarboxylaseLipolysisInsulinGlucoseFatty Acid Synthase, Type ITriglyceridesStarvationStearoyl-CoA DesaturaseFatty LiverSebaceous GlandsAdipocytesDietary CarbohydratesOrphan Nuclear ReceptorsAcetatesDietary FatsATP Citrate (pro-S)-LyaseRats, Inbred StrainsLiver GlycogenLactationGlucosephosphate DehydrogenaseMalate DehydrogenaseFructoseSebumAdipose Tissue, BrownFoodObesityKetone BodiesHepatocytesMammary Glands, AnimalFatty Acids, NonesterifiedHydrocarbons, FluorinatedAdipose Tissue, WhiteSterol Regulatory Element Binding Protein 2PyruvatesLipoproteins, VLDLAcetoacetatesInsulin ResistanceSterol Regulatory Element Binding ProteinsGluconeogenesisBody WeightCarbon IsotopesAcetyl Coenzyme APalmitatesCholesterolRNA, MessengerCCAAT-Enhancer-Binding ProteinsDietEnergy MetabolismFastingBlood GlucoseTranscription FactorsGene Expression RegulationHep G2 CellsRats, ZuckerBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsAdipogenesisMice, ObeseEpididymisLiver ExtractsReceptors, Cytoplasmic and Nuclear3T3-L1 CellsFormic Acid EstersCarbohydrate MetabolismMalonyl Coenzyme AGlycerolClenbuterolAcne VulgarisCitratesStearatesGlucagonMice, Inbred C57BLOxidation-ReductionOleic AcidsLactatesEatingPhosphogluconate DehydrogenasePalmitic AcidHypobetalipoproteinemia, Familial, Apolipoprotein BOleic AcidLipid MobilizationAurothioglucoseCells, CulturedGlycolysisIsocitrate DehydrogenaseDiet, High-FatOilsHypertriglyceridemiaPPAR gammaOrgan SizeSubcutaneous FatFatty Acids, MonounsaturatedCalorimetry, Indirect
Novo lipogenesisInduced adipocyteLipolysis and lipogenesisAdipose tissuesAffect lipogenesisHepatic lipogenesisPathwayAcetyl-CoA carboxyInhibitionLiverVitroMetabolicTissuesAdipogenesisGenesGlucose uptakePathwaysFatty acidsIncreasesAccumulationLarvaeRegulationRegulatesDyslipidemiaProteinInhibitorsMicePromotesInsulin resistanceDose-dependentMolecularCardiovascularEffectMitochondrial functionIntakeResultsAbsorptionCholesterolLevelsStudiesDisordersRole
Novo lipogenesis14
  • 2008). Elevated peripheral free fatty acids (FFA) and de novo lipogenesis predominantly contribute to the accumulation of lipids in the liver at NAFLD. (webmedcentral.com)
  • We examined cells from mouse models of MYC-, RAS-, and BCR-ABL-driven lymphoid malignancies and find a convergence on de novo lipogenesis. (biomedcentral.com)
  • In a panel of human cell lines, we demonstrate sensitivity to TOFA treatment as a metabolic liability due to the general convergence on de novo lipogenesis in lymphoid malignancies driven by MYC, RAS, or BCR-ABL. (biomedcentral.com)
  • These studies suggest that de novo lipogenesis may be a common survival strategy for many lymphoid malignancies and may be a clinically exploitable metabolic liability. (biomedcentral.com)
  • In Drosophila, all growth occurs during the larval stage when larvae constantly feed, and as a result their body mass increases approximately 200-fold within 4 d, largely due to de novo lipogenesis. (sdbonline.org)
  • The body is capable of synthesizing fatty acids (FAs) endogenously via de novo lipogenesis in the liver. (endocrine-abstracts.org)
  • However, lipidomics analysis and de novo lipogenesis functional assays show that free cholesterol (FC) levels are unchanged. (columbia.edu)
  • We review the potential primary role of skeletal muscle insulin resistance in the pathophysiology of the metabolic syndrome, showing that in lean, young, insulin-resistant individuals, impaired muscle glucose transport and glycogen synthesis redirect energy derived from carbohydrate into hepatic de novo lipogenesis, promoting the development of atherogenic dyslipidemia and NAFLD. (nih.gov)
  • Fatty acid synthesis (de novo lipogenesis, DNL) is elevated in liver in obesity and type 2 diabetes and is usually associated with insulin resistance. (grantome.com)
  • Aim 3 is to determine the cellular mechanisms by which ChREBP regulates de novo lipogenesis in adipocytes. (grantome.com)
  • Pathway enrichment analysis showed significant alterations of lipids (e.g., glycosphingolipids, linoleic acid, and de novo lipogenesis), and amino acids (e.g., aspartate and asparagine, tyrosine, arginine and proline) in association to PFASs exposure. (goranlab.com)
  • De novo lipogenesis (DNL) is a fatty acid synthesis process that requires several genes, including sterol regulatory element binding protein (SREBP), ATP-citrate lyase (ACLY), and acetyl-CoA carboxylase (ACC). (gov.scot)
  • High fructose intake increases de novo lipogenesis (DNL), which contributes to fat accumulation in the liver, he says. (integrativepractitioner.com)
  • The thyroid hormone receptor-beta pathway helps to maintain liver health through control of de novo lipogenesis, fatty acid oxidation, mitophagy and mitochondrial biogenesis, cholesterol metabolism, and anti-inflammatory and anti-fibrotic effects, Harrison said. (medscape.com)
Induced adipocyte1
  • This mouse also showed an ectopic lipid in﫿ammation indicates that HFD induced adipocyte death would distribution and insulin resistance. (deepdyve.com)
Lipolysis and lipogenesis3
  • We look at the enzyme processes that actually contribute to cutting fat levels called lipolysis and lipogenesis. (testosteronejunkie.com)
  • An experiment was conducted to evaluate the effects of dietary levels of chromium in the form of chromium picolinate on growth performance, nutrient utilizability, carcass composition, serum traits, and in vitro lipolysis and lipogenesis in adipose tissues of Arbor Acre broiler chicks. (eurekamag.com)
  • The in vitro lipolysis and lipogenesis in adipose tissues were significantly influenced by dietary addition of chromium (p lt 0.05). (eurekamag.com)
Adipose tissues3
  • Through the promotion of fatty acid oxidation and lipogenesis inhibition, leptin was found to control the release of stored glucose from adipose tissues. (wikipedia.org)
  • Although less fat stor- adqcKO pose lipid storage in adipocyte-speci﫿c Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
  • Background: Vitamin B12 (B12) deficiency is associated with obesity and was recently shown to trigger lipid accumulation in the adipose tissues and liver. (endocrine-abstracts.org)
Affect lipogenesis2
  • Another hormone that may affect lipogenesis through the SREBP-1 pathway is leptin. (wikipedia.org)
  • Background: Vitamin B12 (B12) deficiency results in disturbance of 1-carbon metabolites [methylmalonyl coenzyme A (MMA), homocysteine and S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM) and methionine] that collectively affect lipogenesis leading to risk of cardiovascular diseases. (endocrine-abstracts.org)
Hepatic lipogenesis2
Pathway3
  • Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)
  • Insulin is an anabolic hormone that promotes glucose uptake, glycogenesis, lipogenesis, and protein synthesis of skeletal muscle and fat tissue through the tyrosine kinase receptor pathway. (medscape.com)
  • [ 3 ] Increased use of the glycolytic pathway also increases lipogenesis, leading to hypercholesterolemia and hypertriglyceridemia , which can result in hepatic steatosis and pancreatitis. (medscape.com)
Acetyl-CoA carboxy2
  • 2007). Suppression of the genes, which are involved in lipogenesis (ATP-citrate lyase (ACL), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA-desaturase 1 or sterol regulatory element-binding protein 1(SREBP-1)), reduced proliferation and survival of hepatic carcinoma cells (Calvisi et al. (webmedcentral.com)
  • Using cell lines derived from conditional MYC, RAS, and BCR-ABL transgenic murine models, we demonstrate shared responses to inhibition of lipogenesis by the acetyl-coA carboxylase inhibitor 5-(tetradecloxy)-2-furic acid (TOFA), and other lipogenesis inhibitors. (biomedcentral.com)
Inhibition3
  • The inhibition of lipogenesis occurs through the down regulation of fatty acid and triglyceride gene expression. (wikipedia.org)
  • Inhibition of lipogenesis leads to cell death both in vitro and in vivo and does not induce cell death of normal splenocytes. (biomedcentral.com)
  • Using in vitro cell lines derived in from conditional MYC, RAS, and BCR-ABL transgenic murine models and oncogene-driven human cell lines, we determined gene regulation, metabolic profiles, and sensitivity to inhibition of lipogenesis in lymphoid malignancies. (biomedcentral.com)
Liver8
  • [ 20 ] This is in agreement with human studies showing that low circulating SHBG was not associated with elevated insulin levels [ 21 ] but was associated with obesity and dyslipidemia, conditions that are strongly associated with fatty liver in humans. (medscape.com)
  • T4 in both experiments in vivo and in vitro increased lipogenesis in liver cells of young rats, while old hepatocytes were resistant to the hormone action. (webmedcentral.com)
  • The data obtained have demonstrated for the first time that the age-dependent lipogenesis dysregulation depends on redox state changes in liver. (webmedcentral.com)
  • Caffeine, the main component of coffee, has showed its protective effect on non-alcoholic fatty liver disease (NAFLD) in many studies. (biomedcentral.com)
  • The findings which appear in the February 2013 issue of Experimental Biology and Medicine used a laboratory animal model of NAFLD to show that isocaloric replacement of a mixture of MCT abundant saturated fats for of dietary polyunsaturated fats prevented liver fat build-up. (iisr.org)
  • Research shows that carbs (and not fat) produce more fat in your stubborn belly and liver. (iisr.org)
  • Sugar turns on fat production in your liver, producing an internal process called lipogenesis, which is your body's normal action to sugar. (iisr.org)
  • Fructose, the most harmful sugar that heads straight to your liver, actually ramps up lipogenesis. (iisr.org)
Vitro1
  • GLP-1 and incretin mimetics, such as exenatide, have been shown to attenuate hepatocyte steatosis in vivo and in vitro, but the specific underlying mechanism is unclear. (diabetesjournals.org)
Metabolic5
  • In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat. (wikipedia.org)
  • The review describes the metabolic pathways enabling lipogenesis from volatile fatty acids, and focuses on strategies to enhance lipid accumulation in oleaginous microorganisms by tuning the ratios of volatile fatty acids generated via anaerobic fermentation. (diva-portal.org)
  • We explore the potential role of MYC in mediating lipogenesis by 13 C glucose tracing and untargeted metabolic profiling. (biomedcentral.com)
  • We performed metabolic tracing studies to confirm the influence of c-MYC and TOFA on lipogenesis. (biomedcentral.com)
  • Studies on overfeeding shows that metabolic rate typically increases about 6-8% for up to 24 hours after feeding. (leangains.com)
Tissues2
  • Despite the identification of several therapeutic targets, many glycolysis inhibitors show toxicity in normal tissues and/or limited therapeutic response [ 10 ]. (biomedcentral.com)
  • The characterization of this protein in vivo has shown that it widely expressed in different tissues and circulates in the blood, its levels rise after food intake in humans and stimulates insulin secretion and sensitivity and inhibits platelet aggregation. (yale.edu)
Adipogenesis2
  • Hypernova is a new topical fat loss product that works by blocking the key enzymes and pathways that are involved in lipogenesis/adipogenesis. (predatornutrition.com)
  • The T allele presents a dose-dependent effect on increased lipogenesis and mitochondrial function, and on the expression of genes involved in adipogenesis, lipid catabolism, lipogenesis, and lipolysis. (lu.se)
Genes3
  • by regulating lipogenesis-related genes (Ahmadian et al. (deepdyve.com)
  • Moreover, caffeine treatment was associated with upregulation of lipid β-oxidation gene ACO and downregulation of lipogenesis-associated genes (SREBP1, ACC1, CD36 and UCP2), ER stress-associated genes (PERK, IRE1, ATF6 and BIP), the inflammatory cytokine genes (IL-1beta and TNF-alpha) and autophagy associated genes (ATG12 and Beclin-1). (biomedcentral.com)
  • We induced hepatoteatosis in zebrafish by overfeeding regimen and demonstrated caffeine have a role in suppression of hepatosteatosis by downregulation of genes associated with lipogenesis, ER stress, inflammatory response and enhancement of lipid oxidation, indicating zebrafish model may be used to identify putative pharmacological targets and to test novel drugs for human NAFLD treatment. (biomedcentral.com)
Glucose uptake1
Pathways3
  • Insulin stimulates lipogenesis primarily by activating two enzymatic pathways. (wikipedia.org)
  • This proof-of-concept analysis shows that higher PFAS exposure was associated with dysregulation of several lipid and amino acid pathways and longitudinal alterations in glucose homeostasis in Hispanic youth. (goranlab.com)
  • [ 11 ] PIs have also been shown to activate endoplasmic reticulum stress pathways by depleting the calcium in adipocytes. (medscape.com)
Fatty acids3
  • Lipogenesis encompasses both fatty acid and triglyceride synthesis, with the latter being the process by which fatty acids are esterified to glycerol before being packaged into very-low-density lipoprotein (VLDL). (wikipedia.org)
  • Lipogenesis is the biosynthesis (also known as anabolism) which involves a multi-step, enzyme-catalyzed process of fatty acids and triglyceride combination from glucose for instance. (testosteronejunkie.com)
  • Lipid droplet area significantly increased in Nile red staining analysis after 24h of exposure to 2.5μg/L BDE-47 in T. japonicus, while DNL was down-regulated in response to 500μM salicylate (a lipogenesis inhibitor), indicating that BDE-47 exposure is closely associated with an increase in fatty acids in this copepod. (gov.scot)
Increases3
Accumulation3
  • Among them, AS and HY showed excellent fat-accumulation inhibitory activity. (medsci.org)
  • Elevated lipogenesis and subsequent lipid accumulation were demonstrated in several animal models of obesity and insulin-independent diabetes mellitus (Levadovwski et al. (webmedcentral.com)
  • We have previously shown that a combination of glucosyl hesperidin (G-hesperidin) plus caffeine reduces accumulation of body fat, whereas G-hesperidin or caffeine alone shows little effect on high-fat diet-induced obesity in mice. (ironmagazine.com)
Larvae1
  • During this transition, feeding is inhibited, and after pupariation, feeding is impossible, thus the larval-pupal transition marks when energy metabolism is switched from energy storage by lipogenesis in larvae to energy utilization by lipolysis in pupae (Xie, 2015). (sdbonline.org)
Regulation2
Regulates1
  • We also show that MTIF3 regulates mitochondrial respiration and endogenous fatty acid oxidation in adipocytes, probably as a consequence of MTIF3 affecting mitochondrial oxidative phosphorylation complex assembly. (lu.se)
Dyslipidemia2
  • Our studies in mice have shown that this upregulation results in mTOR activation, lipogenesis and development of NASH and dyslipidemia. (yale.edu)
  • In humans, studies have shown that low B12 is associated with dyslipidemia (higher triglycerides and low HDL). (endocrine-abstracts.org)
Protein1
  • Chicks fed diets containing 200 or 400 ppb chromium showed the highest protein content and the lowest fat content in their carcass. (eurekamag.com)
Inhibitors2
  • In this study, we show that allosteric inhibitors of mutant IDH1 (mIDH1) are potent wtIDH1 inhibitors under conditions present in the TME. (nature.com)
  • 2010). Blocking of lipogenesis with siRNA or FAS-specific inhibitors cerulenin and C75 attenuates the cell senescence. (webmedcentral.com)
Mice2
  • Using a light-at-night (LAN) paradigm in mice, we showed that LAN induced depressive-like behaviors without disturbing the circadian rhythm. (researchgate.net)
  • On the HF-MCD diet, the Hif-p4h-2 gt/gt mice showed more browning of the WAT and increased thermogenesis. (springer.com)
Promotes1
Insulin resistance1
  • Conclusion The results of the present study showed that cranberry supplementation had a positive effect on some lipid profiles, insulin resistance, and hepatic steatosis in patients with NAFLD. (cranberryinstitute.org)
Dose-dependent1
  • Although total replacement of MCT oil for veggie oils in cooking is not feasible as a result of its low cigarette smoking point, the studies showed that the protective results of MCT were dose-dependent. (iisr.org)
Molecular1
  • The pharmacological targets and molecular mechanisms related to risperidone-induced lipogenesis (RIL) remain to be elucidated. (frontiersin.org)
Cardiovascular1
  • Several studies have shown a link between stress and cardiovascular disease. (scitechnol.com)
Effect4
  • We utilize preclinical murine models and transgenic primary model of T-ALL to determine the effect of lipogenesis blockade across BCR-ABL-, RAS-, and c-MYC-driven lymphoid malignancies. (biomedcentral.com)
  • Animal studies have shown that glucosylhesperidin reinforces the slimming effect of caffeine. (ironmagazine.com)
  • Korean research has shown that hesperedin, the basic flavonoid in hesperidin, may also have a muscle strengthening effect. (ironmagazine.com)
  • However, docosahexaenoic acid and arachidonic acid were down-regulated at days 1 and 4, showing an antagonistic effect. (gov.scot)
Mitochondrial function1
  • A growing body of evidence shows that mitochondrial function and antioxidant defense are also crucial under low nutrient conditions. (nature.com)
Intake1
  • Our results showed that intake of a combination of 500-mg G-hesperidin and 75-mg caffeine for 12 weeks significantly reduced abdominal fat (especially subcutaneous fat), body weight […] in subjects with a moderately high BMI", the researchers wrote. (ironmagazine.com)
Results1
  • The results showed that the 1.0 % CNCs-15 % TEVO emulsion had optimal stability and smaller particle size. (bvsalud.org)
Absorption2
  • Insulin is released by the pancreas when blood sugar levels rise, and it has many effects that broadly promote the absorption and storage of sugars, including lipogenesis. (wikipedia.org)
  • Additionally, the natural ingredients like licorice root and juniper berries in GlucoTrust diabetic formula have been shown to reduce glucose absorption in the intestines, helping to keep blood glucose levels under control and lower blood sugar levels. (newsdirect.com)
Cholesterol1
  • In TM6SF2 KO iPSCs, we further show a reduction in the activities of Acyl-Coenzyme A: Cholesterol Acyltransferase 1 (ACAT1) and Phosphatidylserine Synthase 1 (PSS1), two enzymes that display optimal function when specifically localized to cholesterol enriched ER lipid raft-like domains. (columbia.edu)
Levels1
  • Meanwhile, prolonged oral metformin therapy in T2DM decreases vitamin B12(B12) in patients and evidence shows that low B12 dysregulates lipid levels. (endocrine-abstracts.org)
Studies1
  • Accepted December 19, studies have shown that SUMO-speci﫿c protease 2 (Senp2)is involved in myogenesis (Qi et al. (deepdyve.com)
Disorders1
  • Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
Role1
  • We were the first group to show the role of Wnt signaling in atherosclerosis and the first to establish a genetic link between exocrine and endocrine pancreas in pathogenesis of diabetes. (yale.edu)