Show basement membrane. Medical search. Frequent questions

Anti-glomerular basement membrane (anti-GBM) disease is a classic autoimmune disorder characterized by the presence of circulating pathogenic autoantibodies directed against proteins in the glomerular and alveolar basement membranes. (medscape.com)
it is found only in a few specialized basement membranes, including the glomerular and alveolar basement membranes. (medscape.com)
This binding of antibodies can be visualized as the linear deposition of immunoglobulin along the glomerular basement membrane and, less commonly, the alveolar basement membranes, by direct immunofluorescent techniques. (medscape.com)
Anti-GBM nephritis is a classic autoimmune disease characterized by the presence of circulating pathogenic autoantibodies directed against proteins in the glomerular and alveolar basement membranes. (medscape.com)

In Goodpasture syndrome , glomerulonephritis is accompanied by pulmonary hemorrhage due to anti-GBM antibodies acting on the alveolar basement membrane. (medscape.com)
Coexistence of ANCAs (mostly myeloperoxidase [MPO-ANCAs]) with anti-GBM antibodies is thought to occur when the renal involvement in ANCA vasculitis leads to the exposure of antigens from the basement membrane and the formation of anti-GBM antibodies. (medscape.com)
Capillaries become inflamed as a result of damage to the basement membrane by antibodies to alpha 3 NC1 domain of type IV collagen. (wikipedia.org)
Immunohistochemical staining was performed using antibodies against the major components of basement membranes such as laminin, heparan sulfate proteoglycan (HSPG), Collagen IV and fibronectin. (thieme-connect.com)
Goodpasture disease is a term used to describe glomerulonephritis, with or without pulmonary hemorrhage, and the presence of circulating anti-glomerular basement membrane (anti-GBM) antibodies. (medscape.com)
The antiglomerular basement membrane antibodies were strongly positive. (medscape.com)
in which binding of anticonjunctival basement membrane antibodies results in conjunctival inflammation. (msdmanuals.com)

The FREM1 protein is one of a group of proteins, including proteins called FRAS1 and FREM2, that interact during embryonic development as components of basement membranes. (medlineplus.gov)

Direct immunofluorescence usually shows intercellular and basement membrane deposition of IgG and C3. (dermnetnz.org)
Immunofluorescence showed diffuse deposition of glomerular basement membrane immunoglobulin (Ig)M and complement component C3, with mesangial IgG, but negative for C4, fibrin and IgA. (who.int)
Diagnosis can be confirmed by conjunctival biopsy showing linear antibody deposition on the basement membrane. (msdmanuals.com)

Alport syndrome is a X-linked hereditary nephritis caused by mutations in type IV collagen, leading to a split lamina densa of the glomerular basement membrane. (wikipedia.org)
Basement membranes were stained with anti-type IV collagen. (nih.gov)
The principal component of basement membrane is type IV collagen, which acts as a support structure and is composed of building blocks that are linked end-to-end. (medscape.com)

The hematoxylin and eosin stained section showed epithelium and connective tissue. (ispub.com)
Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)
Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. (nih.gov)

In cholesteatoma epithelium, we found a fragmented basement membrane with small amounts of laminin and HSPG showing only occasional positively stained fragments while Collagen IV was almost completely absent. (thieme-connect.com)
The epithelium showed seep clefts which showed keratotic plugging (figure 1). (ispub.com)
The intestinal mucosal epithelium was variably hyperplastic, showing moderate to marked lymphoplasmacytic infiltration, to eroded or deeply ulcerated, showing associated granulocyte and macrophage infiltration. (cdc.gov)
The basement membranes are complex structures that support layers of endothelium and epithelium. (medscape.com)
The epithelium is surrounded by a mesh-like structure known as the basement membrane, a thin matrix that encloses, protects, and separates epithelial cells from the surrounding tissue. (futurity.org)
This electron micrograph shows the basal lamina as a thin gray moustache following parallel along the basal membrane of epithelial cells from human corneal epithelium. (cellimagelibrary.org)
In terminal bronchioles 1 d post exposure, silver was localized to surface epithelium but was more prominent in the basement membrane at 7 d. (cdc.gov)

Agrin, a protein linked to heparan sulfate basement membrane nephrin Renal corpuscle (glomerulus) showing glomular basement membrane. (wikipedia.org)

In 1948, Lauren V. Ackermann first described this neoplasm of the oral mucous membrane, which is now also know as Verrucous Carcinoma of Ackermann or Ackermann's tumor. (ispub.com)
Ocular mucous membrane pemphigoid is a chronic, bilateral, progressive scarring and shrinkage of the conjunctiva with opacification of the cornea. (msdmanuals.com)
Mucous membrane involvement is rare. (msdmanuals.com)
Mucous Membrane Pemphigoid Mucous membrane pemphigoid is the designation given to a heterogeneous group of rare chronic autoimmune disorders that tend to cause waxing and waning bullous lesions of the mucous membranes. (msdmanuals.com)
Oral mucous membrane involvement with ulceration and scarring is common, but skin involvement, characterized by scarring bullae and erythematous plaques, is uncommon. (msdmanuals.com)
Diagnosis of ocular mucous membrane pemphigoid is suspected clinically in patients with conjunctival scarring plus corneal changes, symblephara, or both. (msdmanuals.com)

The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus. (wikipedia.org)
Sarcolemma of skeletal muscle prepared by a quick-freeze deep-etch method also shows the basement membrane (lamina externa, labeled here as the basal lamina) associated with the muscle fiber. (cellimagelibrary.org)

Objective: 1) To analyze the γ2 chain expression of laminin 332 in the basement membrane of vessels of oral squamous cell carcinoma (OSCC), and the appearance of continuity, to identify possible vascular invasive procedures which are important events in the disease progression. (bvsalud.org)

The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. (wikipedia.org)
30 nm in diameter, establish direct membrane-to-membrane contact with endothelial cells in specialized areas of irregular endothelial basement membrane and enriched with vesicular activity. (elifesciences.org)

An analysis of the basement membrane, which can modulate epithelial proliferation, reveals a dysfunction of this layer between cholesteatoma and stroma. (thieme-connect.com)
Consistent with this hypothesis, developing granule cells from the rostral region of Gpr56 −/− cerebella at birth exhibit a specific defect in cell adhesion to extracellular matrix (ECM) molecules of the pial basement membrane (BM) but no defects in migration, proliferation, or process outgrowth. (jneurosci.org)
Renal biopsy revealed membranoproliferative glomerulonephritis, with lobulated glomerular tufts, endocapillary proliferation, thickened basement membrane, and glomerular hyaline thrombi suggestive of cryoglobulin deposits. (who.int)

Breast cancer cells can physically push their way out of their normal confines to become invasive tumors, new research shows. (futurity.org)

In contrast, fibronectin demonstrated an intensive staining especially in the stroma adjacent to the basement membrane. (thieme-connect.com)
Light microscopy shows irregular thickening and thinning of the epithelial layer, which offset the ridges and furrows in the underlying stroma and the focal absences of the epithelial basement membrane. (aao.org)

Because Radiofrequency (RF) energy has been shown to renew and restore spatial structural arrangement of collagen fibers, treatment of ED with RF could lead to anatomical and physiological changes at the penile tissue level and could lead to improvement in the erectile mechanism. (researchgate.net)
Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. (nih.gov)

The lead-binding proteins are postulated to facilitate the movement of lead across the mitochondrial membranes. (medscape.com)
The series of images in this group have particular historic and cell biologic importance for determining the role of the glomerular basement membrane in urinary filtration, especially the charge properties and size selectivity in retention of proteins in the circulation. (cellimagelibrary.org)
Absence of functional FREM1 protein interferes with its role in embryonic basement membrane development and may also affect the location, stability, or function of the FRAS1 and FREM2 proteins. (medlineplus.gov)

Indeed, granule cells from the rostral region of perinatal Gpr56 −/− cerebella show loss of adhesion to extracellular matrix molecules of the pial basement membrane. (jneurosci.org)

Goodpasture's syndrome is also known as anti-glomerular basement membrane disease. (wikipedia.org)

Nephrotic syndrome is a change in the structure of the glomerular filtration mechanism usually in the glomerular basement membrane. (wikipedia.org)
Image is low magnification vies of the basement membrane filtration slits, urinary space, and the glomerular filtration capillary lumen. (cellimagelibrary.org)
The images here clearly show the glomerular filtration barrier. (cellimagelibrary.org)

Expression of glomerular basement membrane (GBM) collagens is reduced in Lmx1b(-/-) mice, suggesting one basis for NPS nephropathy. (nih.gov)
ECM components (i.e., fibronectin or collagens) directly interact with membrane receptors (i.e., integrins), particularly, by influencing cell behavior. (springer.com)

Cell damage was assessed using MTT assays, and the lactate dehydrogenase (LDH) release rate and flow cytometry were used to detect the accumulation of reactive oxygen species (ROS) and mitochondrial membrane potential respectively. (sdbonline.org)
GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)

The glomerular basement membrane is a fusion of the endothelial cell and podocyte basal laminas, and is the main site of restriction of water flow. (wikipedia.org)
Glomerular basement membrane is secreted and maintained by podocyte cells. (wikipedia.org)

The syndrome was subsequently shown to be caused by an antibody response against antigens present in the alveolar and glomerular basement membranes. (medscape.com)

Anti-GBM disease is an autoimmune disorder characterized by autoantibodies directed against the glomerular/alveolar basement membrane. (medscape.com)

The tea extracts and components displayed various degrees of antibacterial activity that may involve damage to the bacterial cell membrane and the chelation of iron. (nature.com)
In an effort to elucidate the mechanism of bacterial killing by PBP 10, we compared its effects on artificial lipid bilayers and eukaryotic cell membranes with the actions of the mellitin, magainin II, and LL37 peptides. (upenn.edu)
The hemolytic activities of the PBP 10 and LL37 peptides significantly increase when RBCs are osmotically swollen in hypotonic solution, indicating that these antibacterial peptides may take advantage of the more extended form of bacterial membranes in exerting their killing activities. (upenn.edu)

The thickness and density of tenascin, lumican, and procollagen III in the reticular basement membrane (RBM) were quantified immunohistochemically by confocal microscopy. (jci.org)

Transmission electron microscopy shows subepithelial electron-dense, rod-shaped bodies, which are immunopositive for the TGFBI protein, keratoepithelin. (aao.org)

This low power image of a basal cell adenoma shows a trabecular pattern of growth characterized by ribbon-like areas. (webpathology.com)
The basal epithelial cell layer shows high reflectivity associated with small granular deposits without any shadows (Fig 7-6A), which would be typical of TBCD. (aao.org)
The deposits in the basal epithelial cell layer show reflectivity, with round edges and dark shadows not seen in RBCD (Fig 7-7A). (aao.org)
The basal surface of the cells break through the basement membrane and infiltrates and grows into the matrix. (researchsquare.com)

Biopsy reveals only a few seminiferous tubules, lined by hyalinized thickened basement membrane. (abchomeopathy.com)

Histone H3 and p53 in ALCs of patients with ARC were up-regulated in a grade-dependent manner, and the expression of CRYAA showed a positive association with histone H3, p53, and GLB1. (techscience.com)
Microscopic aspects were evaluated, including the expression of the molecule in the basement membrane of vessels and the appearance of continuity. (bvsalud.org)
Results: 15 cases (93.75%) showed vessels with γ2 chain expression. (bvsalud.org)

The glomerular basement membrane contains three layers: The glomerular membrane consists of mesangial cells, modified pericytes that in other parts of the body separate capillaries from each other. (wikipedia.org)

This electron micrograph shows a cross section through an axon, its myelin wrap, and the associated myelin-producing Schwann cell from the the cochlear nerve of the cat. (cellimagelibrary.org)

The autoantibodies bind to their reactive epitopes in the basement membranes and activate the complement cascade, resulting in tissue injury. (medscape.com)

It is likely that a basement membrane defect allows cyst formation in multiple organs, presumably including the seminal vesicles. (unboundmedicine.com)

Trypan blue has also been used to improve contrast during cataract extraction in eyes with corneal opacities 6 and to stain internal limiting membrane and epiretinal membrane during vitreoretinal surgery. (bmj.com)

The features of Manitoba oculotrichoanal syndrome may result from the failure of neighboring embryonic tissues to fuse properly due to impairment of the basement membranes' anchoring function. (medlineplus.gov)

Serum protein electrophoresis only showed hypoalbuminaemia, and bone marrow and splenic aspirates showed no abnormal cell clones. (who.int)

Researches on DH have shown that it is not just a bullous skin disease, but a cutaneous-intestinal disorder caused by hypersensitivity to gluten. (scielo.br)

Thus, human endocrine cells are not in direct contact with the vascular BM components but with the invaginated peri-islet membrane. (nature.com)

Microscopically, the tumor showed cribriform and tubular structures, with lightly basophilic material in the lumen. (hindawi.com)
The FREM1 gene provides instructions for making a protein that is involved in the formation and organization of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. (medlineplus.gov)

At higher magnification, the tumor cells showed minimal cytological atypia, scant cytoplasm, fine chromatin, small inconspicuous nucleoli, and rare mitotic figures (Figure 2 ). (hindawi.com)

Previous research had shown that epithelial cancers use chemical tricks to invade nearby tissue. (futurity.org)
These two micrographs show the outer cell surface of the epithelial cell border in intestine (upper) and stomach (lower) tissue. (cellimagelibrary.org)
The 20nm citrate particles showed the greatest effect, increasing lung macrophages even 21 d after exposure, and resulted in the greatest silver retention in lung tissue. (cdc.gov)

Pterygium excision combined with autologous conjunctival flap transposition, pterygium excision combined with amniotic membrane transplantation, pterygium excision combined with autologous limbal stem cell transplantation and so on [12] . (researchsquare.com)

This finding suggests that asymmetrical distribution of phospholipids in the external membranes of eukaryotic cells may represent an important factor in determining the specificity of antibacterial peptides for targeting bacteria rather than eukaryotic cells. (upenn.edu)
Showing how cells can physically invade the basement membrane suggests new therapeutic strategies for blocking invasion," he says. (futurity.org)

PBP 10, an antibacterial, cell membrane-permeant rhodamine B-conjugated peptide derived from the polyphosphoinositide binding site of gelsolin, interacts selectively with both lipopolysaccharides (LPS) and lipoteichoic acid (LTA), the distinct components of gram-negative and gram-positive bacteria, respectively. (upenn.edu)

This staining pattern resembles the initial rear-rangement of the epithelial basement membrane in human skin wounds and provides evidence for a lost contact inhibition on the provisional fibronectin-layer as a reason for the hyperproliferative nature of cholesteatoma lesions. (thieme-connect.com)
[ 1 ] In this modified classification, numeric AHA lesions types I to IV are replaced by descriptive terminology to include adaptive intimal thickening, intimal xanthoma, pathologic intimal thickening (PIT), and fibroatheroma, as shown in the table below. (medscape.com)
In OSCC defined as being "Well Differentiated," 85.71% of lesions presented with loss of vessel continuity of the basement membrane, whereas in OSCC defined as being "Moderately Differentiated," 100% of presented vessels with this aspect. (bvsalud.org)

The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. (medlineplus.gov)

Diabetic glomerulosclerosis is a thickening of the basement membrane, which can become up to 4-5 times thicker than normal. (wikipedia.org)
5. Our findings support the hypothesis that structural abnormalities, which are characterized by an early reduction in capillary size and later thickening of basement membrane, form an important mechanism for the impaired hyperaemic response in diabetic patients. (portlandpress.com)

The work reveals a previously unknown mechanism cancerous cells use to break through the basement membrane, allowing the tumor to become invasive, says lead author Ovijit Chaudhuri, assistant professor of mechanical engineering at Stanford University. (futurity.org)

Additionally, we found that LL37 hemolytic activity was much higher when RBCs were induced to expose phosphatidylserine to the external leaflet of their plasma membranes. (upenn.edu)
This image shows the heterogeneity in the content of lysosomes (Lys) near the plasma membrane between two hepatocytes and near the bile canaliculus (not visible in this field). (cellimagelibrary.org)

β-Cells depend on the islet basement membrane (BM). (nature.com)
The peri-islet membrane, which encapsulates the islets, separates the endocrine cells from the exocrine pancreas and serves as a barrier from immune cell infiltration to the islets. (nature.com)
The results demonstrated that myoepithelial cells are relatively rare in the majority of pleomorphic adenomas and that many of the cells which have been classically described as myoepithelial in routine histological preparations do not clearly show this type of differentiation. (nih.gov)
Confocal micrograph showing nerve cells growing along fibers (purple) made from a specially modified silk that is similar to that made by spiders and silkworms. (cellimagelibrary.org)
Schwann cells, whose nuclei are shown i. (cellimagelibrary.org)
Electron micrograph of a nerve from the mesentery of a rat shows groups of unmyelinated axons wrapped by deeply invaginating Schwann cells in cross section. (cellimagelibrary.org)
The cells of verrucous carcinoma do not show dysplastic features and mitosis is also absent. (ispub.com)
PC12 cells will show neurite formation within 2 days when they are grown on a thin layer of this ECM gel. (sigmaaldrich.com)
A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
The researchers made their discovery by embedding breast cancer cells in a gelatin-like biogel that mimics the basement membrane-with one major exception. (futurity.org)
The images show that cancer cells used their invadopodia like stiff arms to tear tiny holes in the biogel, Wisdom says. (futurity.org)
We have shown that AUF1 induces EMT and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation. (nature.com)
Basement membranes help anchor layers of cells lining the surfaces and cavities of the body (epithelial cells) to other embryonic tissues, including those that give rise to connective tissues such as skin and cartilage. (medlineplus.gov)

Transmission electron micrograph of a bone marrow orthochromatic erythroblast from guinea pig showing terminal differentiation in erythrocyte formation. (cellimagelibrary.org)

The dye has been shown to stain basement membrane of lens capsule. (bmj.com)

This study reveals that pore formation is unlikely to be involved in PBP 10-mediated membrane destabilization. (upenn.edu)

The intervening areas between the basaloid cell islands show eosinophilic basement membrane-like material. (webpathology.com)
While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)

The autopsy showed consolidated lung from extensive bleeding, which led to asphyxiation. (medscape.com)

In the past, numerous studies investigating WAT inflammation have shown that the release of pro-inflammatory cytokines, such as TNFα, IL-6 or gp130 cytokines, are implicated in insulin-resistance [ 9 , 10 ]. (springer.com)

Here, we show that pericytes produce multiple components of the mouse pancreatic and islet interstitial and BM matrices. (nature.com)

Laboratory assessment revealed the following: haemoglobin (Hb) 7.4 g/dL (74 g/L), creatinine 2 mg/dL (177 μM/L) and albumin 2.1 g/dL (21 g/L). Urine analysis showed 3+ albumin, granular casts, no ova and urine protein/creatinine ratio of 3.5 g/g. (who.int)
21 g/L). Urine analysis showed 3+ which is endemic in the subtropics, albumin, granular casts, no ova and affecting almost 200 million people urine protein/creatinine ratio of 3.5 worldwide. (who.int)

Anatomy66

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Alveolar basement membranes4

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