• Calcinosis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia are early manifestations of the fulminant form of the disease. (oliviadiet.com)
  • CREST syndrome (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias-although not all are needed for the disorder to be called CREST) is an older term used to describe this subset of limited cutaneous systemic sclerosis. (medscape.com)
  • Pulmonary arterial hypertension (PAH) is commonly associated with the CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) syndrome. (wesstong.com)
  • This variant used to be called CREST based on the main symptoms of Calcinosis, Raynaud's, Esophageal Dysfunction, Sclerodactyly, and Telangiectasia. (marieperry.com)
  • INTRODUCTION - The term "calcinosis cutis" describes the deposition of insoluble calcium salts in the skin and subcutaneous tissue. (medilib.ir)
  • The treatment of calcinosis cutis is often challenging, and the subtype influences the approach to treatment. (medilib.ir)
  • The management of the various subtypes of calcinosis cutis will be reviewed here. (medilib.ir)
  • The diagnosis and evaluation of patients with calcinosis cutis is discussed separately. (medilib.ir)
  • See "Calcinosis cutis: Etiology and patient evaluation" . (medilib.ir)
  • DYSTROPHIC CALCINOSIS CUTIS - Dystrophic calcinosis cutis, the most common form of calcinosis cutis, results from local tissue injury. (medilib.ir)
  • Treatment principles - The treatment of dystrophic calcinosis cutis associated with autoimmune connective tissue disease is often difficult. (medilib.ir)
  • Do the signs and symptoms of calcinosis cutis warrant treatment? (medilib.ir)
  • Treatment of calcinosis - Treatment of calcinosis cutis associated with autoimmune connective tissue diseases involves careful consideration of the need for treatment and the selection of an appropriate treatment regimen. (medilib.ir)
  • Decision to treat - Consideration of the severity of the signs and symptoms of calcinosis cutis is important because the response to treatment is variable and unpredictable, and there is risk for treatment-related adverse effects. (medilib.ir)
  • Clinical follow-up without intervention to reduce calcium deposits is a reasonable option for calcinosis cutis that is asymptomatic, nonprogressive, unassociated with internal involvement, and of minimal concern to the patient. (medilib.ir)
  • Surgery - Surgical removal of calcinosis may be useful for patients with discrete, symptomatic areas of calcinosis cutis as the primary treatment or as an adjunct to medical therapy. (medilib.ir)
  • Although early reports documenting poor wound healing and sinus track formation led to the historical avoidance of surgical procedures for dystrophic calcinosis cutis, subsequent reports suggest that surgery can be effective for some patients. (medilib.ir)
  • Duration of therapy - Patients who respond to systemic pharmacologic therapies for calcinosis cutis are often maintained on continuous or intermittent treatment for months to years in an attempt to reduce risk for recurrence of disease. (medilib.ir)
  • Do not administer Ceftriaxone simultaneously with Calcium Gluconate Injection via Y-site in any age group.5.3 Tissue Necrosis and CalcinosisIntravenous administration of Calcium Gluconate Injection and local trauma may result in calcinosis cutis due to transient increase in local calcium concentration. (drugcentral.org)
  • Calcinosis cutis can occur with or without extravasation of Calcium Gluconate Injection, is characterized by abnormal dermal deposits of calcium salts, and clinically manifests as papules, plaques, or nodules that may be associated with erythema, sweling, or induration. (drugcentral.org)
  • Tissue necrosis, ulceration, and secondary infection are the most serious complications.If extravasation occurs or clinical manifestations of calcinosis cutis are noted, immediately discontinue intravenous administration at that site and treat as needed.5.4 Hypotension, Bradycardia, and Cardiac Arrhythmias with Rapid AdministrationRapid injection of Calcium Gluconate Injection may cause vasodilation, decreased blood pressure, bradycardia, cardiac arrhythmias, syncope and cardiac arrest. (drugcentral.org)
  • 4, 5.2)Tissue Necrosis and Calcinosis: Calcinosis cutis can occur with or without extravasation of Calcium Gluconate Injection. (drugcentral.org)
  • If extravasation occurs or clinical manifestations of calcinosis cutis are noted, immediately discontinue intravenous administration at that site and treat as needed. (drugcentral.org)
  • Calcinosis is dystrophic calcification of the soft tissue which can lead to painful and debilitating disease. (stanfordhealthcare.org)
  • The severity of these symptoms varies greatly among patients: Some having scleroderma of only a limited area of the skin (such as the fingers) and little involvement of the underlying tissue, while others have progressive skin involvement. (wikipedia.org)
  • Calcinosis (deposition of calcium in lumps under the skin) is also common in systemic scleroderma, and is often seen near the elbows, knees, or other joints. (wikipedia.org)
  • These esophageal symptoms reflect the severity of the acid reflux disease in scleroderma. (oliviadiet.com)
  • Scleroderma has a wide spectrum of clinical manifestations and severity, as well as a variable course. (cohencenters.com)
  • A narrative review of imaging in calcinosis associated with systemic sclerosis. (stanfordhealthcare.org)
  • Systemic sclerosis varies in severity and progression, ranging from generalized skin thickening with rapidly progressive and often fatal visceral involvement (diffuse systemic sclerosis) to isolated skin involvement (often just the fingers and face) and slow progression (often several decades) before visceral disease develops. (msdmanuals.com)
  • Dermatologists can assist in the management of these patients by facilitating early diagnosis, and treating cutaneous manifestations such as Raynaud's phenomenon, cutaneous calcinosis, and digital ulceration. (skintherapyletter.com)
  • Cutaneous calcinosis can be the source of both pain and disability in patients with localised SSc. (skintherapyletter.com)
  • The fingers, joints and wrists are affected by many injuries, such as the Raynaud's phenomenon, which leads to infections and ulcers, [8] and calcinosis due to calcium accumulation in soft tissues, and hardening of the skin in the extremities. (healthmeth.com)
  • Calcinosis are deposits of calcium that start on the inside of your body near the bone. (marieperry.com)
  • Depending on the type and severity, the lifestyle and tolerance factors change. (home-remedies-for-you.com)
  • Pulmonary hypertension treatment depends on the type and severity of disease. (wesstong.com)
  • The aim of this study was to characterize OA frequency, severity, and distribution and to trace interrelationships between these findings and the demographic, occupational, and medical data from elderly Jewish nonrheumatologic patients. (nih.gov)
  • This narrative review aims to describe the use of imaging for calcinosis in patients with SSc. (stanfordhealthcare.org)
  • Patients present with vasculitis and a severity spectrum of interstitial lung disease, and several patients have developed pulmonary hypertension. (grantome.com)
  • However the severity of interstitial lung disease is variable in patients with SAVI ranging from being absent to severe. (grantome.com)
  • We are characterizing genetic variants that modify the severity of the IFN dysregulation and are hypothesizing that these variants may determine the severity of the lung disease in SAVI patients. (grantome.com)
  • Pruritus or autoimmune itching can have different amounts of severity and may occur despite not having an autoimmune connective tissue disorder. (integrativetelemedicine.com)
  • Other: for optional IV injections - thrombophlebitis, renal calcinosis in preterm infants. (sdrugs.com)
  • The severity of the disease varies from very mild to life threatening. (healthmeth.com)
  • The mitral valve tenting area, a subclinical index of leaflet stiffening, has also been correlated with the cumulative dose of cabergoline and severity of valvular regurgitation. (ox.ac.uk)
  • Severity depends on the extent of organs affected with skin and nail involvement, called discoid lupus, being the least serious and inflammmation of the kidney, called lupus nephritis, being the worst. (glutenfreeworks.com)
  • Hand OA was prevalent in our elderly cohort, and its severity was influenced by inherent traits such as age, female gender, ethnicity, and handedness. (nih.gov)
  • Serum OPG could be a valuable biomarker in the evaluation of severity of calcified AS and serve as an additional indicator besides clinical presentation and echocardiography in the assessment of surgical treatment or aortic valve replacement. (kbco.hr)
  • It has also been known to cause complications like calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyl and telangiectadias. (home-remedies-for-you.com)
  • CREST stands for a combination of symptoms: Calcinosis Raynaud's phenomenon Esophageal dysfunction Sclerodactyly and Telangiectasia. (washington.edu)
  • In total, 945 (94%) patients met the 2013 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for SSc, with the remaining 64 (6%) meeting the 1980 ACR or CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) criteria. (stanfordhealthcare.org)
  • Signs and symptoms of Raynaud's depend on the frequency, duration and severity of the blood vessel spasms that underlie the disorder. (findmeacure.com)
  • Two forms of this disease exist-(1) progressive systemic sclerosis (PSS), characterized by diffuse scleroderma, and a more fulminant form with early involvement of internal organs or (2) CREST syndrome, characterized by calcinosis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia. (medscape.com)
  • A significant association was noted between longer disease duration and higher odds of pulmonary hypertension, telangiectasia, and calcinosis. (stanfordhealthcare.org)
  • Anticentromere antibodies were correlated to sex (female), limited SSc, calcinosis and telangiectasia. (unimore.it)
  • Calcinosis (painful or painless lumps or sheets under the skin) are a feature of late diagnosis or poorly controlled disease. (pmmonline.org)
  • calcinosis, or hard, white lumps caused by a buildup of calcium underneath the skin. (lupusnewstoday.com)
  • Elevated CXCL4 serum levels correlate with the severity of pulmonary fibrosis and progression of pulmonary hypertension. (medscape.com)
  • High-resolution computed tomography (HRCT) scanning is the best imaging test for assessing the extent and severity of pulmonary disease. (naqlafshk.com)
  • Clinical features in bilateral striopallidodentate calcinosis (BSPDC), popularly referred to as Fahr's disease (five autosomal dominant families and eight sporadic cases, n = 38), recruited through a registry, are reported. (nih.gov)
  • LD is an under-recognized sequela of JDM, and certain DM patients with a severe, prolonged clinical course and a high frequency of calcinosis appear to be at greater risk for the development of this complication. (lvhn.org)
  • The life expectancy of these affected individuals depends on the severity of signs and symptoms. (medlineplus.gov)
  • Signs and symptoms of PH1 vary in severity and may begin any time from infancy to early adulthood. (nih.gov)
  • The severity of esophageal involvement does not correlate necessarily with severity of involvement of other organs. (medscape.com)
  • A radiograph of the distal digits demonstrating calcinosis and distal phalanx reabsorption (acral osteolysis). (medscape.com)
  • Calcinosis, muscle atrophy, joint contractures, and facial rash were DM disease features found to be associated with LD. (lvhn.org)
  • Monitor for hyperphosphatemia and withhold, reduce the dose, or permanently discontinue based on duration and severity of hyperphosphatemia. (nih.gov)
  • 7 mg/dL, initiate phosphate lowering therapy and withhold, reduce the dose, or permanently discontinue PEMAZYRE based on duration and severity of hyperphosphatemia as recommended in the prescribing information. (pemazyre.com)
  • Some patients may benefit from surgical removal of focal areas of calcinosis, particularly those that are painful. (medscape.com)
  • Specific LD features such as acanthosis nigricans, hirsutism, fat redistribution, and steatosis/nonalcoholic steatohepatitis were frequent in patients with LD, in a gradient of frequency and severity among the 3 sub-phenotypes. (lvhn.org)
  • Signs of IMHA vary depending on the class of antibodies involved and the severity of hemolysis. (vin.com)
  • MDI severity correlated with physician-assessed global damage, serum creatinine, and muscle atrophy on magnetic resonance imaging, and in juveniles also with functional disability and weakness. (nih.gov)
  • The severity of this form depends on the organs affected and how much they are affected. (washington.edu)
  • This study supports further larger randomized controlled trials to ascertain the full benefit of this combination in ameliorating the severity of COVID-19. (nutrition-evidence.com)