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  • varices
  • Esophageal varices result from collateral portal blood flow through vessels in the stomach and esophagus (a process called portacaval anastomosis). (wikipedia.org)
  • Renal
  • In hyperacute and acute liver failure the clinical picture develops rapidly with progressive encephalopathy and multiorgan dysfunction such as hyperdynamic circulation, coagulopathy, acute renal and respiratory insufficiency, severe metabolic alterations and cerebral edema that can lead to brain death. (wikipedia.org)
  • consequence
  • Diastolic dysfunction is an early consequence of hypertension-related heart disease and is exacerbated by left ventricular hypertrophy and ischemia. (wikipedia.org)
  • Hypertension-related cognitive impairment and dementia may be a consequence of a single infarct due to occlusion of a "strategic" larger vessel or multiple lacunar infarcts due to occlusive small vessel disease resulting in subcortical white matter ischemia. (wikipedia.org)
  • cirrhotic
  • other, less frequent causes are therefore grouped as non-cirrhotic portal hypertension. (wikipedia.org)
  • Rat models have shown decreased ET-B receptor expression in pulmonary arteries of cirrhotic and portal hypertensive animals, leading to a predominant vasoconstricting response to endothelin-1. (wikipedia.org)
  • severity
  • Bone marrow compensatory reaction: Erythroid hyperplasia with accelerated production of red cells, reflected by reticulocytosis, and slight macrocytosis in peripheral blood Expansion of bone marrow in infants and children with severe chronic hemolysis - changes in bone configuration visible on X-ray The balance between red cell destruction and marrow compensation determines the severity of anemias. (wikipedia.org)
  • Depending on its severity, it carries an estimated mortality risk of 11% Persons with upper GI hemorrhage often present with hematemesis, coffee ground vomiting, melena, or hematochezia (maroon coloured stool) if the hemorrhage is severe. (wikipedia.org)
  • The physical examination performed by the physician concentrates on the following things: Vital signs, in order to determine the severity of bleeding and the timing of intervention Abdominal and rectal examination, in order to determine possible causes of hemorrhage Assessment for portal hypertension and stigmata of chronic liver disease in order to determine if the bleeding is from a variceal source. (wikipedia.org)
  • chronic
  • GAVE is associated with a number of conditions, including portal hypertension, chronic kidney failure, and collagen vascular diseases. (wikipedia.org)
  • The typical initial presentations range from occult bleeding causing transfusion-dependent chronic iron-deficiency anemia to severe acute gastrointestinal bleeding. (wikipedia.org)
  • survival
  • LTx is the only treatment that has shown an improvement in the prognosis and survival with most severe cases of ALF. (wikipedia.org)
  • pressure
  • Assessment of portal pressure showed a significant increase in BDL-placebo mice compared to sham-placebo mice. (springer.com)
  • In contrast, BDL-emricasan mice had significantly lower levels of portal pressure compared to BDL-placebo mice. (springer.com)
  • commonly
  • It may be associated with other congenital defects, commonly with autosomal recessive polycystic kidney disease, the most severe form of PKD. (wikipedia.org)