• Renal
  • In hyperacute and acute liver failure the clinical picture develops rapidly with progressive encephalopathy and multiorgan dysfunction such as hyperdynamic circulation, coagulopathy, acute renal and respiratory insufficiency, severe metabolic alterations and cerebral edema that can lead to brain death. (wikipedia.org)
  • severity
  • Bone marrow compensatory reaction: Erythroid hyperplasia with accelerated production of red cells, reflected by reticulocytosis, and slight macrocytosis in peripheral blood Expansion of bone marrow in infants and children with severe chronic hemolysis - changes in bone configuration visible on X-ray The balance between red cell destruction and marrow compensation determines the severity of anemias. (wikipedia.org)
  • Depending on its severity, it carries an estimated mortality risk of 11% Persons with upper GI hemorrhage often present with hematemesis, coffee ground vomiting, melena, or hematochezia (maroon coloured stool) if the hemorrhage is severe. (wikipedia.org)
  • acute
  • The typical initial presentations range from occult bleeding causing transfusion-dependent chronic iron-deficiency anemia to severe acute gastrointestinal bleeding. (wikipedia.org)
  • cirrhotic
  • Rat models have shown decreased ET-B receptor expression in pulmonary arteries of cirrhotic and portal hypertensive animals, leading to a predominant vasoconstricting response to endothelin-1. (wikipedia.org)
  • treatment
  • LTx is the only treatment that has shown an improvement in the prognosis and survival with most severe cases of ALF. (wikipedia.org)
  • commonly
  • It may be associated with other congenital defects, commonly with autosomal recessive polycystic kidney disease, the most severe form of PKD. (wikipedia.org)