• myocardial
  • Several physiologically relevant hemodynamic parameters such as stroke volume, cardiac output, ejection fraction, myocardial contractility, etc. can be determined from these loops. (wikipedia.org)
  • The intra-aortic balloon pump (IABP) is a mechanical device that increases myocardial oxygen perfusion while at the same time increasing cardiac output. (wikipedia.org)
  • Increasing cardiac output increases coronary blood flow and therefore myocardial oxygen delivery. (wikipedia.org)
  • contraction
  • In normal conditions, blood flows through an open mitral valve during diastole with contraction of the left atrium, and the mitral valve closes during systole with contraction of the left ventricle. (wikipedia.org)
  • Catecholamines will increase the heart rate and increase the strength of ventricular contraction, directly increasing cardiac output. (wikipedia.org)
  • Preload is described as the stretching of a single cardiac myocyte immediately prior to contraction and is, therefore, related to the sarcomere length. (wikipedia.org)
  • The contraction of the ventricle begins just prior to AV valves closing and prior to the semilunar valves opening. (wikipedia.org)
  • Heart failure characteristically involves increased catecholamine activity on the heart, which is responsible for a number of deleterious effects, including increased oxygen demand, propagation of inflammatory mediators, and abnormal cardiac tissue remodeling, all of which decrease the efficiency of cardiac contraction and contribute to the low ejection fraction. (wikipedia.org)
  • dysfunction
  • Thirty-one patients (mean age 2.1 ± 4.2 years) with severe LV dilatation (mean indexed LVEDV 136 ± 48 ml/m 2 ) and LV dysfunction (mean LV-EF 23 ± 8%) were examined. (biomedcentral.com)
  • Valve failure or dysfunction can result in diminished heart functionality, though the particular consequences are dependent on the type and severity of valvular disease. (wikipedia.org)
  • Dysfunction of any of these portions of the mitral valve apparatus can cause regurgitation. (wikipedia.org)
  • 50mm and risk factors and connective tissue disease The goal of the operation is the improvement of life expectancy and treatment of heart failure as the consequence of dysfunction of the aortic valve. (wikipedia.org)
  • pericardial
  • The intramyocardial injection of cells or saline did not result in cardiac enzyme elevation, perforation, or pericardial effusion. (ahajournals.org)
  • The pericardial heart valve was invented by Marian Ionescu, a British surgeon working at the General Infirmary in Leeds, England. (wikipedia.org)
  • The experimental and in vitro testing of this novel device took place in 1970, and in March 1971, Ionescu began, for the first time, the implantation of the pericardial valve in all three cardiac positions in humans.Between 1971 and 1976 the valves had been made in Ionescu's own hospital laboratory. (wikipedia.org)
  • Based on these results, the Shiley Laboratory in Irvine, California, began to manufacture this valve and to distribute it worldwide under the name of the 'Ionescu - Shiley Pericardial Xenograft. (wikipedia.org)
  • These modifications had been progressively introduced and all of them were incorporated in the 'Ionescu - Shiley Low Profile Pericardial Xenograft' valve, which became available in 1983. (wikipedia.org)
  • Despite all these difficulties and impediments, a general view of the performance of the pericardial valve as close to reality as possible could be obtained. (wikipedia.org)
  • heart valves
  • Heart murmurs are heart sounds produced when blood flows across one of the heart valves that are loud enough to be heard with a stethoscope. (wikipedia.org)
  • Specifically, the sounds reflect the turbulence created when the heart valves snap shut. (wikipedia.org)
  • Normal heart sounds are associated with heart valves closing: The first heart sound, or S1, forms the "lub" of "lub-dub" and is composed of components M1 (mitral valve closure) and T1 (tricuspid valve closure). (wikipedia.org)
  • One should however keep in mind that any single investigator should resist the temptation to write a review of such a complex matter as tissue heart valves, and to cover the subject completely and fairly. (wikipedia.org)
  • patient's
  • An electrogram (EGM) signal and a corresponding pressure signal are obtained, where the EGM signal is representative of electrical functioning of the patient's heart during a plurality of cardiac cycles, and the corresponding pressure signal is representative of pressure within the left atrium the patient's heart during the cardiac cycles. (google.com)
  • degenerative
  • Because the results of valve repair done by experienced surgeons in experienced centers are so good and so advantageous over replacement, repair has become the standard of care for degenerative mitral valve disease. (maimonidesmed.org)
  • posterior
  • The anterior cusp covers approximately two-thirds of the valve (imagine a crescent moon within the circle, where the crescent represents the posterior cusp). (wikipedia.org)
  • tissue
  • Biological valve replacements (made from animal tissue or from human donors) are better tolerated, but are not as durable as artificial valves. (maimonidesmed.org)
  • Anatomically, the valves are part of the dense connective tissue of the heart known as the cardiac skeleton and are responsible for the regulation of blood flow through the heart and great vessels. (wikipedia.org)
  • It is flexible and shock absorbent, essential qualities for a tissue heart valve support. (wikipedia.org)