Severe lymphopenia. Medical search. Frequent questions

Adenosine deaminase (ADA) deficiency is a rare autosomal recessive disorder of purine metabolism that leads to severe combined immunodeficiency (SCID) by primarily affecting lymphocyte development and function. (researchgate.net)
Severe combined immunodeficiency (SCID) is a life-threatening syndrome of recurrent infections, diarrhea, dermatitis, and failure to thrive. (medscape.com)
Outcomes Following Treatment for Adenosine Deaminase Deficient Severe Combined Immunodeficiency: A Report from the PIDTC. (chop.edu)
Smith H, Scalchunes C, Cowan MJ, Puck J, Heimall J. Expectations and experience: Parent and patient perspectives regarding treatment for Severe Combined Immunodeficiency (SCID). (chop.edu)
Scholars@Duke publication: Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation. (duke.edu)
BACKGROUND: Severe combined immunodeficiency (SCID) comprises rare inherited disorders of immunity that require definitive treatment through hematopoietic cell transplantation (HCT) or gene therapy for survival. (duke.edu)
Surgical intervention is customarily not indicated for severe combined immunodeficiency (SCID) and also is not part of the primary treatment. (medscape.com)

An article in Science Immunology describes how acalabrutinib, a selective BTK inhibitor, was administered off-label to 19 patients hospitalized with severe COVID-19. (powerpak.com)

NK) cells (T-B-NK-SCID) and severe lymphopenia. (researchgate.net)
in severe combined immune deficiency (SCID). (researchgate.net)
Without intervention, SCID usually results in severe infection and death in children by age 2 years. (medscape.com)
Despite successes of allogeneic HCT, many SCID patients experience incomplete immune reconstitution, persistent T-cell lymphopenia, and poor long-term outcomes. (duke.edu)
OBJECTIVE: We hypothesized that CD4+ T-cell lymphopenia could be associated with a state of T-cell exhaustion in previously transplanted SCID patients. (duke.edu)

Clinical laboratory findings can include lymphopenia, thrombocytopenia, and elevated creatinine. (cdc.gov)
Mild-to-severe hemolytic anemia, lymphopenia, and thrombocytopenia are the typical findings in babesiosis. (medscape.com)
The most common side effects with this treatment were severe asthenia (23 cases), flu-like symptoms (22 cases), weight loss (21 cases) and neutropenia (22 cases), anemia and thrombocytopenia (20 of 26 cases). (scirp.org)

Factors associated with severe or critical disease included hematologic malignancy, lung cancer, peri-diagnosis lymphopenia, and baseline neutropenia. (ascopost.com)

The pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a public health emergency, and research on the development of various types of vaccines is rapidly progressing at an unprecedented development speed internationally. (nature.com)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of Coronaviridae family, emerged in 2019 and caused a public health emergency of international concern. (nature.com)
Introduction The global pandemic of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, in December 2019, and has since spread worldwide. (medrxiv.org)
One hundred years after the 1918 influenza pandemic, we now face another pandemic with the severe acute respiratory syndrome-novel coronavirus-2 (SARS-CoV-2). (thieme-connect.com)
More severe lower respiratory infections (LRIs) were associated with the recent zoonotic crossovers of the severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) identified in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) identified in 2012. (thieme-connect.com)
The cause of the disease named coronavirus disease 2019 (COVID-19) was a new virus strain called severe acute respiratory coronavirus 2 (SARS-CoV-2) (2). (who.int)
The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the scientific community to elucidate the pathogenesis of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-induced lung injury and develop effective therapeutics. (ersjournals.com)
Our review explores influenza A virus-induced acute respiratory distress syndrome (ARDS) as a paradigm for understanding coronavirus disease 2019 (COVID-19)-induced ARDS pathogenesis and ageing as a risk factor for severe disease. (ersjournals.com)
We argue that the impaired interferon-I and -III response of severe COVID-19 is reminiscent of severe acute respiratory syndrome-coronavirus (SARS-CoV) and influenza pathobiology, suggesting conserved virulence mechanisms among these viruses. (ersjournals.com)
The spread of a novel coronavirus (severe acute respiratory syndrome-coronavirus-2, or SARS-CoV-2) has challenged the capacity of healthcare systems and the public health policies of governments worldwide [ 1 ]. (ersjournals.com)
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. (imperial.ac.uk)
We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. (imperial.ac.uk)
Background Coronavirus disease 2019 (COVID-19) triggered by infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been widely pandemic all over the world. (researchsquare.com)
Since December 2019, a cluster of acute respiratory illness patients with unclear causes have been found in some hospitals in Wuhan City, Hubei Province, China [ 1 ].On February12, 2020, the International Committee on Taxonomy of Viruses has declared that the official classification of the new coronavirus is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (researchsquare.com)
Later, the International Committee on Taxonomy of Viruses (ICTV) officially named the virus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). (biomedcentral.com)
COVID-19 COVID-19 is an acute, sometimes severe, respiratory illness caused by the novel coronavirus SARS-CoV-2. (msdmanuals.com)
BACKGROUND: Evidence is accumulating of coronavirus disease 2019 (COVID-19) vaccine effectiveness among persons with prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. (cdc.gov)
COVID-19) was a new virus strain called severe acute very similar to other viral infections in terms of clinical respiratory coronavirus 2 (SARS-CoV-2) (2) . (who.int)

There was evidence of normoleukocytemia, with lymphopenia and eosinopenia, besides the occurrence of neutrophilia with deviation to the left. (usp.br)
In addition, we confirm what has been observed in other studies: disturbances in the immune system such as neutrophilia or lymphopenia, for example, are related to the severity of the disease in hospitalized patients, but are not specific to SARS-CoV-2. (eurekalert.org)
To date, there has been a small number of reports that severe depression is accompanied by disturbances in total white blood cell (i.e. leukocytosis) and leukocyte subset (i.e. neutrophilia, monocytosis, lymphopenia) counts. (nih.gov)

The main symptoms and signs of COVID-19 patients are with fever, dry cough, dyspnea, fatigue and lymphopenia. (researchsquare.com)

Patients were classified in Mild, Moderate, Severe & Critical categories of COVID cases. (medrxiv.org)
Results A total 204 (N) patients were clinically classified into different severity groups, as per MOHFW and qCSI(quick Covid Severity Index) guidelines, as Mild (34), Moderate (56), Severe (39) and Critical (75). (medrxiv.org)
Some people may have multiple, severe infections while others show mild symptoms to none at all. (medlineplus.gov)
Infection with SARS-Cov-2 is very similar to other viral infections in terms of clinical manifestations (7,11), and patients show a wide range of clinical symptoms from mild and asymptomatic to very severe including viral pneumonia, respiratory failure and even death (12). (who.int)
Twenty-three (51%) children were asymptomatic, 8 (17%) children had mild symptoms, 4 (8.8%) had moderate disease and 10 children were admitted with severe/critical disease requiring admission in critical care unit. (pediatriconcall.com)
The World manifestations (7,11) , and patients show a wide range of Health Organization (WHO) declared the outbreak a clinical symptoms from mild and asymptomatic to very public health emergency of international concern on 30 severe including viral pneumonia, respiratory failure and January 2020 (3) . (who.int)
And that can be mild illness, uncomplicated upper respiratory tract signs and symptoms to moderate, mild to moderate pneumonia without the need for supplemental oxygen to more moderate to severe pneumonia requiring supplemental oxygen and potentially other forms of oxygen delivery support. (cdc.gov)
So just as an overview, some-- one very large study of cases in China reported that the vast majority of patients with COVID-19 do in fact have mild to moderate illness, however, 19% had severe or critical illness. (cdc.gov)

However, two new coronaviruses, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), caused severe outbreaks around the world in 2003 and 2012, respectively (10). (who.int)
Clinical data indicate that severe COVID-19 most commonly manifests as viral pneumonia-induced acute respiratory distress syndrome (ARDS), a clinical entity mechanistically understood best in the context of influenza A virus-induced pneumonia. (ersjournals.com)
Of the severe/critical patients, septic shock with respiratory failure was seen in 4 (8.8%), Guillain Barre Syndrome (GBS) in 1 (2%), encephalitis in 2 (4%), Kawasaki disease (KD) in 1 (2%) and acute respiratory distress syndrome (ARDS) in 2 (4%) children. (pediatriconcall.com)

Probable severe CMV infection and the interstitial pneumonia raised the possibility of HIV infection. (hawaii.edu)
Three patients had recurrent sinopulmonary infections, 3 had severe cytomegalovirus (CMV) disease, and 1 had Pneumocystis carinii pneumonia. (nih.gov)
Compared with patients with CVID, opportunistic infections, including severe CMV disease, P. carinii pneumonia, and mucocutaneous candidiasis, appear to be more common in patients with GS, and patients with GS may have a worse prognosis. (nih.gov)
Provide Pneumocystis pneumonia (PCP) prophylaxis during concomitant phase and continue in patients who develop lymphopenia until resolution to Grade 1 or less. (nih.gov)

Even though circulating lymphocytes only present ~2-5% of the total lymphocyte population in the body, a correlation of lymphopenia and treatment outcome, due to dose to circulating lymphocytes, has been demonstrated. (iomp.org)

S. Lactate Dehydrogenase & D-dimer was associated with severe covid-19 illness and early in-hospital death. (medrxiv.org)
Majority of patients presented with lymphopenia and elevated lactate dehydrogenase. (medrxiv.org)

PML occurs almost exclusively in patients with severe immune deficiency, most commonly among patients with acquired immune deficiency syndrome (AIDS), but people on chronic immunosuppressive medications including chemotherapy are also at increased risk of PML, such as patients with transplants, Hodgkin's lymphoma, multiple sclerosis, psoriasis, rheumatoid arthritis, and other autoimmune diseases. (wikipedia.org)
Using this approach, the laboratory has identified several new gene defects, including DOCK2 deficiency, TTC7A deficiency (responsible for combined immune deficiency and intestinal atresias), HOIP deficiency (a cause of immune deficiency and autoinflammatory disease), EXTL3 deficiency (associating severe T-cell immunodeficiency, skeletal dysplasia, and neurodevelopmental delay), PAX1 deficiency and SASH3 deficiency. (nih.gov)
By modeling human T-cell differentiation in an artificial thymic organoid system, our lab is interested in defining the stages at which T-cell development is blocked in patients with known and novel forms of severe combined immune deficiency. (nih.gov)

An absolute lymphocyte count lower than 2500/µL in an infant definitely warrants further workup, but any infant with severe infection or opportunistic infection should have the full initial workup. (medscape.com)
There is considerable variability in the incidence of infection and severe disease following exposure to SARS-CoV-2. (thieme-connect.com)
Moreover, we discuss the deleterious effect of interferon-γ activity in influenza infection and how this observation contrasts with findings in severe COVID-19. (ersjournals.com)
A severe disease phenotype has emerged in children that seems to be temporally associated with SARS-CoV-2 infection. (pediatriconcall.com)
Children with less severe manifestations of HTLV-III/LAV infection (AIDS-related complex, or ARC) or with asymptomatic infections are not now reported to CDC, and no seroprevalence studies have been conducted among children. (cdc.gov)

Screening for kappa receptor excision circles (KREC) (B cell lymphopenia in X-linked agammaglobulinemia (XLA)) followed in 2011 ( 6 ), and a combined assay is used in selected countries. (researchsquare.com)

Drugs used to treat types of leukemia and lymphoma are showing promise for controlling "cytokine storms" in patients with severe COVID-19. (powerpak.com)
Specifically, we argue that the hypercoagulable and hyperinflammatory state of severe COVID-19 is a consequence of the expanded tropism of SARS-CoV-2, which allows it to infect vascular endothelial cells, and that cytokine storm physiology contributes to a lesser degree. (ersjournals.com)

Furthermore, this system also allows to distinguish between hematopoietic cell autonomous and non-hematopoietic (mostly, thymus-intrinsic) causes of severe congenital T-cell lymphopenia. (nih.gov)

Joint symptoms are usually bilateral and symmetric and can be severe and debilitating. (cdc.gov)

These results suggest that targeting excessive host inflammation with a BTK inhibitor is a therapeutic strategy in severe COVID-19 and has led to a confirmatory international prospective randomized controlled clinical trial. (powerpak.com)
We also consider important differences between COVID-19 and influenza, mainly the protean clinical presentation and associated lymphopenia of COVID-19, the contrasting role of interferon-γ in mediating the host immune response to these viruses, and the tropism for vascular endothelial cells of SARS-CoV-2, commenting on the potential limitations of influenza as a model for COVID-19. (ersjournals.com)

DiGeorge syndrome is another example in which lymphocyte counts may be higher than 2000/µL with no T-cell function, or, conversely, normal T-cell function may be observed in spite of lymphopenia. (medscape.com)

INDIANAPOLIS, July 16, 2021 /PRNewswire/ - Eli Lilly and Company (NYSE: LLY) and Incyte (NASDAQ:INCY) announced today that the U.S. Food and Drug Administration (FDA) will not meet the Prescription Drug User Fee Act (PDUFA) action date for the supplemental new drug application (sNDA) for baricitinib for the treatment of adults with moderate to severe atopic dermatitis (AD). (nationaleczema.org)
It is also approved in over 40 countries for the treatment of adults with moderate to severe AD who are candidates for systemic therapy and approved in Japan for the treatment of certain hospitalized patients with COVID-19. (nationaleczema.org)
for moderate to severe infections we propose a tried‑and‑true treatment: the combination of arginine and ascorbate, administered orally or intravenously. (spandidos-publications.com)
A morphological analysis of moderate-to-severe multiorgan lymphopenia was designated in every affected instances. (woofahs.com)
No data are available in patients with moderate or severe hepatic impairment, therefore the use of [HA740 trade name] is not recommended unless the benefits are considered to outweigh the risks. (who.int)

It is the prototype of the primary immunodeficiency diseases and is caused by numerous molecular defects that lead to severe compromise in the number and function of T cells, B cells, and occasionally natural killer (NK) cells. (medscape.com)
The progression of deficits can lead to severe disability or death. (fda.gov)

It also highlights those at increased risk for severe disease and prevention measures to mitigate additional spread of the virus and potential importation into unaffected areas, including the United States. (cdc.gov)
Respiratory rate & Heart Rate on admission are correlated with severe and stormy disease. (medrxiv.org)
Severe lymphopenia has been associated with poor overall survival, occurrence of distant metastases, and disease recurrence. (iomp.org)
COVID-19 in Newborns and Infants-Low Risk of Severe Disease: Silver Lining or Dark Cloud? (thieme-connect.com)
Data from China and the United States suggest a low prevalence of neonates, infants, and children, with those affected not suffering from severe disease. (thieme-connect.com)
I hope that our study will lead to the development of biomarkers that will help us stratify patients based on their risk of developing a severe form of the disease. (eurekalert.org)
400 IU/ml was associated with more severe disease. (spandidos-publications.com)

GS should be ruled out in patients with thymoma or CVID who develop severe, especially opportunistic, infections. (nih.gov)

However, 60 days after treatment was discontinued, the horse again developed a stiff neck and rapidly progressive neurologic deficits, including severe ataxia and vestibular deficits. (avma.org)
Following the cut-off date for the presented data, one participant, who had severe lymphopenia at study entry, discontinued treatment due to a serious adverse event (AE) of lymphoproliferative disorder. (novartis.com)

however, high plasma fibrinogen concentration and relative lymphopenia were identified and the horse was seropositive for antibodies against Borrelia burgdorferi . (avma.org)

Immunologic testing revealed severe B-cell lymphopenia and a low serum IgM concentration consistent with common variable immunodeficiency. (avma.org)
We also explore the potential aetiologies of the lymphopenia associated with severe COVID-19: the virus' expanded tropism, elevated serum cytokines (particularly interleukin-6 and tumour necrosis factor-α), and excessive lymphocyte recruitment to the lungs. (ersjournals.com)

Background information in the articles points out that patients with severe COVID-19 have a hyperinflammatory immune response suggestive of macrophage activation, adding that BTK regulates macrophage signaling and activation. (powerpak.com)

One myocardial infarction, one breast cancer, and three severe skin reactions occurred without long-term sequelae. (lu.se)

Ex vivo analysis revealed significantly elevated BTK activity, as evidenced by autophosphorylation, and increased IL-6 production in blood monocytes from patients with severe COVID-19 compared with blood monocytes from healthy volunteers," the authors write. (powerpak.com)

Joint pains are usually bilateral, symmetric, and often severe and debilitating [8-9]. (cdc.gov)

Atypical or severe manifestations can be seen in 22% of children and require intensive monitoring. (pediatriconcall.com)

The primary hypothesis was that cytotoxic chemotherapy administered within 35 days of COVID-19 diagnosis would be associated with an increased risk of severe or critical COVID-19. (ascopost.com)
Among 309 patients in the COVID-19 cohort, 147 patients (47.6%) were admitted to the hospital, 31 (10.0%) died, and 120 (38.8%) developed severe or critical COVID-19 (primary endpoint). (ascopost.com)
On univariate analysis, no increased risk of severe or critical COVID-19 was observed among the 102 patients (33.0%) who received cytotoxic chemotherapy within 35 days of COVID-19 diagnosis (hazard ratio [HR] = 1.10, 95% confidence interval [CI] = 0.73-1.60, P = .74). (ascopost.com)
No increased risk of severe or critical COVID-19 was observed among the relatively small group of patients (n = 18) who received immunotherapy alone within 35 days of diagnosis (HR = 1.80, 95% CI = 0.89-3.50, P = .11). (ascopost.com)
Lung cancer (n = 29) was associated with an increased risk for severe or critical COVID-19 (HR = 2.00, 95% CI = 1.20-3.30, P = .01). (ascopost.com)
Receipt of cytotoxic chemotherapy within 35 days of COVID-19 diagnosis was not associated with severe or critical COVID-19. (ascopost.com)

Fatal and severe hepatotoxicity have been reported. (nih.gov)

In addition, the inversion of the leukocyte pattern, which changed from predominantly lymphocytic to neutrophilic, was observed, while the animals remained under severe anemia. (usp.br)

Individuals with this condition often have low numbers of white blood cells (lymphopenia), particularly B cells and T cells . (medlineplus.gov)

Similar to influenza, advanced age has emerged as the leading host risk factor for developing severe COVID-19. (ersjournals.com)
Observation: the elderly is at risk for severe forms of COVID-19, therefore, the evidence in this age group is very relevant. (who.int)

Most radiation therapy patients develop radiation-induced lymphopenia. (iomp.org)

Severe life-threatening illnesses in the form of ARDS, GBS, KD and other multisystem involvement are seen in these patients. (pediatriconcall.com)

Severe COVID-19 illness is seen more in patients more than 50 years of age. (medrxiv.org)
Conclusion Advanced age, male gender, IHD, Respiratory Rate & Heart Rate on admission were associated with severe covid-19 illness. (medrxiv.org)

She said the patient had been taking the drug for four and a half years, and for three and a half years had experienced severe prolonged lymphopenia, a lowering of the white blood cell count. (bostonglobe.com)

Organisms1

Diseases2

Chemicals and Drugs2

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes1

Combined immunodeficiency7

Hospitalized with severe COVID-191

SCID5

Thrombocytopenia3

Neutropenia1

Coronavirus18

Neutrophilia3

Dyspnea1

Mild8

Acute3

Pneumonia4

Lymphocytes1

Lactate Dehydrogenase2

Deficiency3

Infection5

Agammaglobulinemia1

Cytokine2

Congenital1

Symptoms1

Clinical2

Syndrome1

Moderate5

Lead to severe2

Disease7

Infections1

Treatment2

Antibodies1

Serum2

Hyperinflammatory1

Reactions1

Patients with severe1

Usually bilateral1

Manifestations1

Critical6

Fatal1

Anemia1

Cells1

Risk2

Develop1

ARDS1

Illness2

White1