Severe disorders autoimmune aquaporin 4 aquaporin 4. Medical search. Frequent questions

Background The presence of antibodies to aquaporin-4 (AQP4) has been identified as a key characteristic of neuromyelitis optica spectrum disorder (NMOSD), an autoimmune inflammatory demyelinating central nervous system (CNS) disorder. (guthyjacksonfoundation.org)
The NMO is autoimmune in nature and antibodies to Aquaporin 4 (AQP4) are associated with the development of the disease. (unicamp.br)
This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases. (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
Background: Neuromyelitis optica (NMO) is an inflammatory autoimmune disorder of the central nervous system, hallmarked by pathogenic anti-aquaporin 4 antibodies. (thestemcellfoundation.com)
Detection of aquaporin-4 immunoglobulin G antibodies (AQP4-IgG), using a blood test that was developed by Mayo Clinic investigators, is highly specific for NMOSD and facilitates the diagnosis. (sciencedaily.com)
One of today's sessions placed the focus squarely on neuromyelitis optica (more recently expanded to be called neuromyelitis optica spectrum disorder, or NMOSD), a rare autoimmune disorder of the central nervous system (CNS) in which the spinal cord and/or optic nerves are attacked and damaged by specific antibodies. (mssociety.ca)
Only a few biomarkers are available in MS clinical practice, such as cerebrospinal fluid oligoclonal bands and immunoglobulin index, serum anti-aquaporin 4 antibodies, and serum anti-John Cunningham virus antibodies. (clinlabint.com)
Oligoclonal band and aquaporin-4 antibodies were not detected in the CSF and serum. (aurametrix.com)
Progression to wheelchair dependence was faster among patients with paraneoplastic compared with nonparaneoplastic autoimmune ataxia and among those with positivity for neuronal nuclear and cytoplasmic antibodies (NNC Abs + ) only (vs positivity for plasma membrane protein Abs [PMP Abs + ] only). (jamanetwork.com)

Neuro-ophthalmic manifestations frequently are encountered in persons with multiple sclerosis (MS) and other central nervous system (CNS) inflammatory disorders, including neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD). (medscape.com)
BACKGROUND AND OBJECTIVES: Neuromyelitis optica spectrum disorder (NMOSD) is a disabling autoimmune neurologic disease. (bvsalud.org)
Neuromyelitis optica spectrum disorder (NMOSD) is an immune-related demyelinating defect. (bvsalud.org)
The topics are in the areas of diagnosis and management of MS, NMOSD, MOGAD and related disorders. (pactrims.org)
Neuromyelitis optica spectrum disorder (NMOSD) is one of the autoimmune demyelinating disorders, which is thought to be triggered by viral infection. (aku.edu)
keywords = "Aquaporin 4 (AQP-4), Neuromyelitis optica spectrum disorder (NMOSD), Severe acute respiratory syndrome (SARS). (aku.edu)
2 3 4 5 6 ] However, a more recent population-based survey conducted in urban Mangalore has shown a prevalence of 8.3/100,000 for MS and 2.6/100,000 for neuromyelitis optic spectrum diseases (NMOSD). (lww.com)
7 ] NMOSD is likely to constitute approximately 20% of all demyelinating disorders in India. (lww.com)
UPLIZNA is the first and only anti-CD19 B-cell-depleting humanized monoclonal antibody approved by the U.S. Food and Drug Administration (FDA) and European Commission (EC) for the treatment of adult patients with anti-aquaporin-4 (AQP4) antibody positive NMOSD. (minstercommunitypost.com)
UPLIZNA is indicated for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive. (minstercommunitypost.com)
While far less common than MS, NMOSD can sometimes be confused with MS due to similar clinical features, although NMOSD attacks are often more severe than MS relapses. (mssociety.ca)
Uplizna (inebilizumab-cdon) has been approved in Japan for preventing relapses in people with neuromyelitis optica spectrum disorder (NMOSD), including those with neuromyelitis optica. (neuromyelitisnews.com)
This decision from the Japanese Ministry of Health, Labour and Welfare covers all NMOSD adults, with or without aquaporin-4 water channel autoantibodies (AQP4-IgG). (neuromyelitisnews.com)
MS. Aquaporin-4 antibody positive neuromyelitis optica spectrum disorder (AQP4-NMOSD). (themedicaldispatch.com)
With AQP4-NMOSD, large areas of inflammation occur during attacks, which often results in severe symptoms. (themedicaldispatch.com)

Abstract Neuromyelitis optica is an autoimmune disorder characterized by optic neuritis, transverse myelitis, and aquaporin-4 autoantibodies. (guthyjacksonfoundation.org)
Advances in defining clinical criteria and immunologic biomarkers of autoimmune diseases such as MS or autoimmune encephalitides coupled with conventional MRI studies and diffusion tensor imaging (DTI) have revealed overlapping diseases characterized by autoantibodies against neuronal or glial surface proteins (NMDA receptor, aquaporin 4, or myelin oligodendrocyte glycoprotein) 1 , 2 and may disclose in the future unclassified autoimmune disorders with yet unknown mechanisms. (neurology.org)
NMO's etiology is unknown but NMO is believed to be an autoimmune disease associated with autoantibodies to aquaporin-4. (collinsquest.org)
MOGAD is typically associated with acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), and transverse myelitis (TM) and is less commonly associated with cerebral cortical encephalitis, brainstem or cerebellar symptoms, and clinical presentations including the combination of several phenotypes and sometimes accompanies other autoantibodies such as anti- N -methy-D aspartate receptor (NMDAR) autoantibodies with symptoms of autoimmune encephalitis. (encyclopedia.pub)
In fact, MOG was initially identified as an immunodominant target for demyelinating autoantibodies in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) [ 2 ] [ 3 ] . (encyclopedia.pub)
Over the years, extensive studies conducted in patients with MS have investigated the presence of anti-MOG autoantibodies using Western blotting and enzyme-linked immunosorbent assays targeting recombinant mouse MOG, without clear relation and specificity with MS [ 4 ] . (encyclopedia.pub)

Genetic defects involving aquaporin genes have been associated with several human diseases including nephrogenic diabetes insipidus and neuromyelitis optica. (wikipedia.org)
Multiple reports on the co-existence of autoimmune diseases and myasthenia gravis (MG) have raised considerable concern. (bvsalud.org)
Therefore, we reviewed autoimmune diseases in MG to explore their clinical presentations and determine whether the presence of autoimmune diseases affects the disease severity and treatment strategies for MG. We reviewed all the major immune-mediated coexisting autoimmune conditions associated with MG. PubMed, Embase and Web of Science were searched for relevant studies from their inception to January 2023. (bvsalud.org)
Current systemic therapies are rarely curative for patients with severe life-threatening forms of autoimmune diseases (ADs). (thestemcellfoundation.com)
In the accompanying editorial comment, Dr. Finke 4 discusses the type of disease that these patients may have and indicates similar clinical-radiologic dissociations noted in other diseases. (neurology.org)
NMO DefinedNeuromyelitis optica (NMO) and NMO spectrum disorders are inflammatory demyelinating diseases of the central nervous system characterized mainly by attacks of uni- or bilateral optic neuritis (ON) and acute myelitis. (collinsquest.org)
There are many peer-reviewed papers covering the diagnosis of autoimmune diseases, and it is frequently difficult for healthcare professionals to keep up with the literature. (clinlabint.com)
Other manifestations of immunosuppression, such as the development of autoimmune diseases or malignancies, may also occur with some of these therapies. (medilib.ir)
Overview discussions of the use of these agents in rheumatic disorders and oncologic diseases are found separately. (medilib.ir)
Horizon is focused on the discovery, development, and commercialization of medicines that address critical needs for people impacted by rare autoimmune and severe inflammatory diseases. (wearesrna.org)
Primary Sjogren's syndrome (pSS) occurs in the absence of other autoimmune diseases and is characterized by keratoconjunctiva sicca (dry eyes) and xerostomia (dry mouth), collectively called the sicca syndrome. (rxharun.com)
In contrast, secondary Sjogren's syndrome presents along with other autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) [ rx] . (rxharun.com)
We continue to aggressively execute on a global expansion strategy with our other on-market and investigational medicines with the goal of bringing important treatments to those impacted by rare, autoimmune and severe inflammatory diseases," Walbert said. (neuromyelitisnews.com)
Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases. (bmj.com)
This applies to central nervous system (CNS) disorders of all causes, including inflammatory, neurodegenerative, traumatic and vascular diseases. (bmj.com)

Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders. (ox.ac.uk)
BACKGROUND: Patients with anti-aquaporin-4 antibody seropositive (AQP4-IgG+) neuromyelitis optica spectrum disorders (NMOSDs) frequently suffer from optic neuritis (ON) leading to severe retinal neuroaxonal damage. (ox.ac.uk)

An example is anti-NMDA receptor encephalitis, where patients with severe symptoms often have normal conventional MRI studies, but DTI reveals extensive white matter abnormalities with decreased fractional anisotropy. (neurology.org)
5 Further studies are needed to characterize this category of MRI-negative autoimmune encephalitis, which perhaps in the future may be defined by yet unknown immunologic biomarkers. (neurology.org)
Herein, we report a rare case of A-GFAP-A resembling infectious encephalitis with obvious autonomic nervous disorder, especially including abnormity in HRV and CRBP as clinical manifestation, to broaden the spectrum of autonomic dysfunction types in A-GFAP-A. (biomedcentral.com)

Disorders that affect myelin interrupt nerve transmission. (msdmanuals.com)
In neuromyelitis optica spectrum disorder, the immune system targets aquaporin 4, a protein that is present on astrocytes in the brain and particularly the spinal cord and optic nerves, or myelin oligodendrocyte glycoprotein (MOG), which is present on the myelin of oligodendrocytes in the same areas of the CNS and possibly other targets. (msdmanuals.com)
MOG antibody disease is an autoimmune disease in which the immune system is attacking the MOG protein, which is expressed on the myelin in your brain, optic nerves, and spinal cord. (wearesrna.org)
In patients with neuromyelitis optica (NMO), binding of NMO-IgG antibody to astrocytes results in uncontrolled complement activation and destruction of myelin-producing cells, leading to severe damage to the central nervous system and predominantly impacting the spinal cord and optic nerve. (physicianeditorial.com)
Myelin oligodendrocyte glycoprotein antibody associated disorder (MOGAD). (themedicaldispatch.com)

Autoimmune glial fibrillary acidic protein astrocytopathy (A-GFAP-A) is a newly discovered autoimmune nervous system disease involving the brain, spinal cord, meninges and optic nerve. (biomedcentral.com)
Autoimmune glial fibrillary acidic protein astrocytopathy is a form of monophasic or relapsing steroid-responsive meningoencephalomyelitis often accompanied by a hallmark radial periventricular brain MRI enhancement pattern and inflammatory cerebrospinal fluid with lymphocytic pleocytosis. (medlink.com)

Optic neuritis is an inflammatory injury of the optic nerve that causes vision loss, which is common in MS and other CNS inflammatory disorders. (medscape.com)
Keywords:Devic's syndrome;neuromyelitis optica;plasma exchange;apheresis;steroid-refractory;MRI Abstract Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease of the central nervous system with exacerbations involving the optic nerves, spinal cord, or both. (guthyjacksonfoundation.org)
Abstract: Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system (CNS) of putative autoimmune aetiology, which is characterized by severe attacks of myelitis and optic neuritis (ON). (unicamp.br)
In the past, NMO was considered to be a severe variant of multiple sclerosis (MS) because both can cause attacks of optic neuritis and myelitis. (collinsquest.org)
OCT at onset of ON is also potentially confounded by edema of the optic disc, which may lead to overestimates of baseline RNFL.4 Ganglion cell layer (GCL) thickness, another OCT measure, is not confounded by disc edema but declines in a similar time frame to RNFL and therefore may be more useful as a baseline measurement. (clevelandclinic.org)
In patients with NMO, chronic, uncontrolled complement activation results in severe damage to the central nervous system (CNS), predominantly impacting the optic nerve and spinal cord. (physicianeditorial.com)

Furthermore it is impossible to predict who will develop severe, erosive disease or who will respond to treatment thus patients are subjected to several rounds of "exploratory" treatments until the right treatment is identified. (dcu.ie)
However, under the "wrong" environmental circumstances, polyfunctional T-cells(poly-T) can drive autoimmune-disease pathogenesis. (dcu.ie)
Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)
Another form of NMO, in which an individual only has a single, severe attack extending over a month or two, is most likely a distinct disease that affects men and women with equal frequency. (collinsquest.org)
4,6 Loss of vision, paralysis, loss of sensation, bladder and bowel dysfunction, nerve pain and respiratory failure can all be manifestations of the disease. (minstercommunitypost.com)
New diagnostic criteria have been introduced for neuromyelitis optica, now called neuromyelitis optica spectrum disorder, which is an inflammatory disease of the central nervous system that is sometimes mistaken for multiple sclerosis. (sciencedaily.com)
It is an autoimmune disease characterised by chronic inflammation, demyelination, gliosis (plaques or scarring) and neuronal loss with relapsing or progressive course. (vjim.org)
Psoriasis is a chronic inflammatory autoimmune skin disease, characterized by the formation of erythematous scaly plaques on the skin and joints. (clinlabint.com)
Behçet's disease (BD) is a chronic inflammatory and multisystemic autoimmune disease of unknown etiology. (clinlabint.com)
His research focuses on what provokes relapses and remissions in multiple sclerosis (MS), and on the quest for antigen specific therapy in autoimmune disease. (neuroimmune.org)
00:01:10] Alexion, AstraZeneca Rare Disease is a global biopharmaceutical company focused on serving patients with severe and rare disorders through the innovation, development, and commercialization of life-transforming therapeutic products. (wearesrna.org)
In this article, the disease-related and treatment-related neurological complications of renal disorders will be reviewed. (neurologyindia.com)
Sjögren's syndrome is a chronic inflammatory autoimmune disease of unknown origin, attacking, in particular, the tear and salivary glands. (rxharun.com)
With more severe disease the foci may become confluent. (rxharun.com)
1-3 This devastating disease is characterized by severe weakness, paralysis, respiratory failure, loss of bowel and bladder function, blindness and premature death. (physicianeditorial.com)
4-6 Patients with NMO have a life-long exposure to the uncontrolled terminal complement activation due to chronic autoimmune attack, and most patients experience an unpredictable, relapsing course of disease with cumulative disability, as each attack adds to the neurologic disability. (physicianeditorial.com)
5,7,8 Fifty percent of relapsing NMO patients have been reported to sustain permanent severe disability, including paralysis and blindness, within five years of disease onset. (physicianeditorial.com)
Since it is feasible to measure NfL concentration in the blood, it may be a promising biomarker for monitoring the disease course in CNS disorders and, ideally, for evaluating patients' response to treatments. (bmj.com)

Epilepsy is a common chronic neurological disorder characterised by spontaneous seizures which can severely impact quality of life. (dcu.ie)
Multiple sclerosis (MS) is a chronic autoimmune disorder that affects the central nervous system, leading to a wide range of neurological symptoms. (aurametrix.com)
Soliris is a first-in-class terminal complement inhibitor and is currently approved in the United States, European Union, Japan and other countries for the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), two debilitating, ultra-rare and life-threatening disorders caused by chronic uncontrolled complement activation. (physicianeditorial.com)

Multiple Sclerosis (MS) is a CNS disorder that is characterized by both inflammatory and neurodegenerative mechanisms of brain and spinal cord injury. (medscape.com)
Neuromyelitis optica following thymectomy with severe spinal cord atrophy after frequent relapses for 30 years]. (guthyjacksonfoundation.org)
Neuromyelitis optica spectrum disorder is a demyelinating disorder that predominantly affects the eyes and spinal cord but can affect other structures in the central nervous system (CNS) that contain aquaporin 4. (msdmanuals.com)
Myelopathy can be the result of primary intrinsic disorders of the spinal cord or from secondary conditions, which result in extrinsic compression of the spinal cord. (bvsalud.org)

Astrocytes and oligodendrocytes are damaged by autoimmune-mediated inflammation as well as demyelination. (msdmanuals.com)
As part of her ongoing research program, Dr. Severance focuses on the major gateway of the immune system, the gastrointestinal mucosa, where inflammation, food hypersensitivities, barrier defects and immune dysregulation can cause downstream brain dysfunction in people with psychiatric disorders. (neuroimmune.org)

Affected individuals may experience problems with how they see the world (afferent visual pathway symptoms) and/or how smoothly and synchronously their eyes move together (efferent visual pathway disorders). (medscape.com)
Because patients with MS and other CNS inflammatory disorders who have visual symptoms often seek ophthalmic attention, eye care experts play a vital role in the localization and diagnosis of these conditions. (medscape.com)
Symptoms of neuromyelitis optica spectrum disorder include visual loss, muscle spasms, paraparesis or quadriparesis, and incontinence. (msdmanuals.com)
1, 4, 7, 8 A clinician should further narrow the diagnosis based on the timing of symptoms and associated features (Below). (clevelandclinic.org)
Neuro-ophthalmic manifestations are frequently encountered in multiple sclerosis (MS). Affected individuals may experience problems with how they see the world (afferent visual pathway symptoms) and/or how their eyes move together (efferent visual pathway disorders). (medscape.com)
This explains the severe symptoms that come and go in some people, and why some folks hurt so badly and others don't. (joyfullivingservices.com)

MS is an inflammatory and neurodegenerative disorder of the central nervous system (CNS) that causes progressive neurological disability over time. (medscape.com)
Multiple sclerosis (MS) is a demyelinating disorder with central nervous system (CNS) involvement, leading to varied presentations. (vjim.org)
Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system. (clinlabint.com)
Psychiatric researchers are looking beyond the central nervous system (CNS) for novel ways that the body's peripheral cellular and molecular pathways might be harnessed into effective treatments of brain disorders. (neuroimmune.org)
Neurological complications occur in almost all patients with severe CKD, potentially affecting all levels of the nervous system, from the central nervous system (CNS) through to the peripheral nervous system (PNS). (neurologyindia.com)

Aquaporins, also called water channels, are channel proteins from a larger family of major intrinsic proteins that form pores in the membrane of biological cells, mainly facilitating transport of water between cells. (wikipedia.org)
Also known as water channels, aquaporins are integral membrane pore proteins. (wikipedia.org)

However, because water is a polar molecule this process of simple diffusion is relatively slow, and in tissues with high water permeability the majority of water passes through aquaporin. (wikipedia.org)
Original Article Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly Andrea Rossi1,2, Julien Ratelade1,2, Marios C. Papadopoulos3, Jeffrey L. (guthyjacksonfoundation.org)

It was not until 1992 that the first aquaporin, 'aquaporin-1' (originally known as CHIP 28), was reported by Peter Agre, of Johns Hopkins University. (wikipedia.org)

CHESHIRE, Conn. November 25, 2014 -(BUSINESS WIRE)-Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN) today announced that Soliris ® (eculizumab) has been granted orphan drug designation (ODD) by Japan's Ministry of Health, Labour and Welfare (MHLW) for the treatment of patients with neuromyelitis optica (NMO), a life-threatening, ultra-rare neurologic disorder. (physicianeditorial.com)

The authors named this disorder "normal-appearing imaging-associated, neuroimmunologically justified, autoimmune encephalomyelitis. (neurology.org)

4% of total incidence of MS. The clinical course is rapid and often fatal. (vjim.org)
Sporadic mainly occurs by hyperglycemia, which causes osmotic diuresis, inverting the gradient across the renal tubule, diabetes insipidus family is linked to the X chromosome, specifically there alteration in Xq28, and its most severe clinical presentation it occurs during lactation [5,9,10]. (crimsonpublishers.com)

Autoimmune GFAP astrocytopathy manifests as a meningoencephalomyelitis (or limited form thereof) with dramatic steroid-responsiveness. (medlink.com)
Autoimmune GFAP astrocytopathy presentation is subacute (over days to a few weeks). (medlink.com)

Since the publication of the original McDonald criteria[3] and subsequent iterations,[4, 5] radiological endpoints have become central in the diagnosis of MS. (medscape.com)

Severe acute respiratory syndrome (SARS). (aku.edu)
The pattern of RNFL thinning most specific to MS is temporal.3 RNFL can appear normal in the acute setting but starts to decline within 4 weeks of ON. (clevelandclinic.org)
A 17-year-old girl presented with acute severe holocranial headache for 3 weeks, and loss of vision for 12 days. (ruralneuropractice.com)

The use of biologics to modulate the immune system has become a major therapeutic approach in the setting of inflammatory disorders. (medilib.ir)

Importantly, this results in severe debilitating trauma for the patients. (dcu.ie)

aHUS is a debilitating, ultra-rare and life-threatening genetic disorder characterized by complement-mediated TMA. (physicianeditorial.com)

A 52-year-old male with, known case of systemic hypertension with hypothyroidism, presented with urinary retention for 10 days, and progressive weakness of both lower limbs for 4−5 days. (vjim.org)
Systemic lupus erythematosus (SLE) is a complex connective tissue disorder that involves multiple organs. (bmj.com)

Water moves through cells in an organized way, most rapidly in tissues that have aquaporin water channels. (wikipedia.org)

The functional status and medical fragility of the patient - Studies have shown that hospitalized patients, those with poor functional status or comorbid conditions, and older adults are more likely to develop immune complications when treated with glucocorticoids, and this is likely to be the case for other immunosuppressant drugs [ 4 ]. (medilib.ir)

After novel coronavirus pandemic that emerged from Wuhan, China in December 2019, several cases of inflammatory and immune-mediated disorders have been reported, thought to be triggered by SARS-CoV-2 infection. (aku.edu)
First, does cross-reactivity play a role in the multi-system disorders associated with SARS-CoV-2 infection? (frontiersin.org)
Third, are there any concerns for autoimmune development with either infection or vaccination with SARS-CoV-2? (frontiersin.org)
Historically, complement disorders have been attributed to immunodeficiency associated with severe or frequent infection. (clinlabint.com)

The cell membranes of a variety of different bacteria, fungi, animal and plant cells contain aquaporins through which water can flow more rapidly into and out of the cell than by diffusing through the phospholipid bilayer. (wikipedia.org)
Because aquaporins are usually always open and are prevalent in just about every cell type, this leads to a misconception that water readily passes through the cell membrane down its concentration gradient. (wikipedia.org)
Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. (wikipedia.org)
Of particular interest is the water channel aquaporin-4 (AQP4) which mislocalises in epilepsy. (dcu.ie)
INTRODUCTION - The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a disorder of impaired water excretion caused by the inability to suppress the secretion of antidiuretic hormone (ADH) [ 1 ]. (medilib.ir)

Indeed, astrocytic end feet, express the most AQP-4 channels in the entire CNS, playing a key role in brain activation and deactivation ( Mader and Brimberg, 2019 ). (raypeatforum.com)

Patients with visual disturbances in the setting of suspected or established multiple sclerosis (MS) or other CNS inflammatory disorder should be cautioned to avoid activities that present a safety risk to themselves or others. (medscape.com)
Acceptability of digital health application to empower persons with multiple sclerosis with moderate to severe disability: single-arm prospective pilot study. (inims.de)

In this case report, we will be discussing one such rare presentation of a rapidly progressive demyelinating disorder. (vjim.org)

Anatomy1

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Diseases4

Chemicals and Drugs14

Psychiatry and Psychology5

Phenomena and Processes8

Information Science2

Antibodies10

NMOSD15

Autoantibodies6

Diseases15

Neuromyelitis optica spectrum disorders2

Encephalitis3

Myelin5

Glial2

Optic6

Disease18

Chronic3

Spinal cord4

Inflammation2

Symptoms6

Central nervou5

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Infection4

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