Severe ossification heterotopic. Medical search. Frequent questions

Several terms have been used to describe the condition, including heterotopic ossification, ectopic ossification, and myositis ossificans. (medscape.com)
Heterotopic ossification (HO) is a dynamic, complex pathologic process that often occurs after severe polytrauma trauma, resulting in an abnormal mesenchymal stem cell differentiation leading to ectopic bone growth in soft-tissues including tendons, ligaments, and muscles. (nih.gov)
Ectopic bone formation leads inevitably to severe disability and early death. (freecme.com)
Heterotopic ossification (HO) is the formation of ectopic lamellar bone in atypical, extraskeletal tissues. (postgraduateorthopaedics.co.uk)
Brooker AF, Bowerman JW, Robinson RA, Riley LH Jr. Ectopic ossification following total hip replacement. (postgraduateorthopaedics.co.uk)
Serum levels of ALP and BAP appear to be promising biomarkers for monitoring the development of ectopic ossifications and efficacy of the therapy. (biomedcentral.com)

There are also rare genetic disorders causing heterotopic ossification such as fibrodysplasia ossificans progressiva (FOP), a condition that causes injured bodily tissues to be replaced by heterotopic bone. (wikipedia.org)
Fibrodysplasia ossificans progressiva (FOP) causes abnormal bone formation in muscles and soft tissues in episodic "flare-ups" that lead to heterotopic ossification (HO), or replacement of muscle with bone. (freecme.com)
Extensive heterotopic ossification on the back of a patient with fibrodysplasia ossificans progressiva. (medscape.com)
Fibrodysplasia ossificans progressiva is the most catastrophic disorder of heterotopic ossification in humans. (medscape.com)
Progressive postnatal heterotopic ossification in fibrodysplasia ossificans progressiva usually appears within the first decade of life as spontaneous or injury-induced exacerbations. (medscape.com)
As heterotopic bone accumulates in fibrodysplasia ossificans progressiva, range of motion is progressively lost, leading to near complete immobility. (medscape.com)
The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. (medscape.com)
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disease characterized by progressive ossification of tendons, ligaments, fascia, and skeletal muscle. (ispub.com)
Currently, there are no effective medical treatment options to prevent the formation of heterotopic bones in fibrodysplasia ossificans progressiva (FOP). (biomedcentral.com)
Fibrodysplasia ossificans progressiva (FOP) (OMIM: 135100) is a severely disabling heritable disorder of connective tissue characterized by congenital malformations of the great toes and progressive heterotopic ossification in various extraskeletal sites. (biomedcentral.com)
Fibrodysplasia ossificans progressiva (FOP) is a rare and disabling genetic condition characterized by congenital malformations of the great toes and progressive heterotopic ossification (HO) in specific anatomic patterns. (medscape.com)
Age- and joint-specific risk of initial heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. (medscape.com)

There is no evidence etidronate disodium affects mature heterotopic bone. (nih.gov)
Surgical removal of mature heterotopic bone is required in order to regain a functional range of movement although the surgeon must take care to avoid fractures and damage to adjacent neurovascular structures. (the-medical-dictionary.com)

The patient may experience deep venous thrombosis - also known as DVT, spasticity, heterotopic ossification - also named as HO, and contractures. (mossrehab.com)
Implantation of pumps for the continuous infusion of intrathecal baclofen for severe spasticity not amenable to targeted injections of botulinum toxin has shown promise in properly selected cases. (physiotherapy-treatment.com)

The specific cause and pathophysiology of heterotopic ossification (HO) remain uncertain, but the condition appears to involve the inappropriate differentiation of mesenchymal cells into osteoblastic stem cells in response to still-unidentified inducing agents. (medscape.com)

Myositis ossificans circumscripta without trauma - Also referred to as neurogenic HO, this is a localized soft-tissue ossification occurring after neurologic injury or burns. (medscape.com)
In traumatic heterotopic ossification (traumatic myositis ossificans), the patient may complain of a warm, tender, firm swelling in a muscle and decreased range of motion in the joint served by the muscle involved. (wikipedia.org)
Heterotopic ossification may occur for no known reason as in myositis ossificans progressiva or may follow a wide variety of surgical, occupational, and sports trauma (e.g., hip arthroplasty, spinal cord injury, head injury, burns, and severe thigh bruises). (nih.gov)
Myositis ossificans is a misnomer, although the term myositis ossificans circumscripta continues to be used to describe nonhereditary forms of heterotopic ossification. (medscape.com)
The term myositis ossificans is not used anymore because primary muscle inflammation is not a necessary precursor and ossification does not always occur in muscle tissue. (ruralneuropractice.com)
Neurogenic myositis ossificans is a disabling condition affecting the large joints of patients with severe post-traumatic impairment of the central nervous system. (the-medical-dictionary.com)
Neurogenic myositis ossificans is the formation of heterotopic bone in the periarticular soft tissues of patients who have sustained a severe injury to the brain or spinal cord. (the-medical-dictionary.com)

Heterotopic ossification (HO) is the abnormal growth of bone in soft connective tissues that occurs as a frequent complication in individuals with traumatic brain injury (TBI) and in rare genetic disorders. (mdpi.com)

Prophylactic radiation therapy for the prevention of heterotopic ossification has been employed since the 1970s. (wikipedia.org)
Etidronate disodium tablets, USP are indicated for the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury. (nih.gov)
Prevention of heterotopic ossification after spinal cord injury with indomethacin. (scireproject.com)
Banovac K, Williams JM, Patrick LD, Levi A. Prevention of heterotopic ossification after spinal cord injury with COX-2 selective inhibitor (rofecoxib). (scireproject.com)
Objectives and Rationale: This proposal is designed to address the Fiscal Year 2015 Peer Reviewed Orthopaedic Research Program Applied Research Award focus area of prevention of heterotopic ossification (HO) by providing a therapeutic strategy to prevent the development of post-traumatic HO as occurs in the upper extremity. (usuhs.edu)
This proposal has been developed to specifically address HO prevention and treatment in patients with severe trauma such as is seen with orthopaedic and blast-related injuries from improvised explosive devices and explosively formed projectiles that cause severe trauma to patients. (usuhs.edu)
At this time our preoperative concerns included: difficulty obtaining an airway, difficulty with ventilation, difficulty with positioning and prevention of trauma or ossification, difficulty and risk vs. benefit of IV and arterial access, unknown surgical conditions and potential for increased length of surgery and bleeding. (ispub.com)
We could not prove the efficacy of oral Pex administration in the prevention of heterotopic ossifications in FOP. (biomedcentral.com)

About every third patient who has total hip arthroplasty (joint replacement) or a severe fracture of the long bones of the lower leg will develop heterotopic ossification, but is uncommonly symptomatic. (wikipedia.org)
Between 50% and 90% of patients who developed heterotopic ossification following a previous hip arthroplasty will develop additional heterotopic ossification. (wikipedia.org)
Significant heterotopic ossification (HO) was found in 21 hips following total hip arthroplasty (THA) rated as class I (7), class II (5), class III (7) and class IV (2). (postgraduateorthopaedics.co.uk)

NHO often forms around the hip, knee and shoulder joints, causing severe pain and joint deformation which is associated with significant morbidity and reduced quality of life. (monash.edu)
Apart from neurological deficits, musculoskeletal involvement is also seen in very few cases in the form of heterotopic ossification around immobile joints. (ruralneuropractice.com)
X-ray films of multiple joints revealed heterotopic ossification over left shoulder, hip and knee joint with bony ankylosis of left hip and soft tissue contractures. (ruralneuropractice.com)

Enlargement of the complex and soft tissues and ossifications in other body sections follow these early symptoms. (a2zfitnessmart.com)
Classic celiac disease, characterized by mild to severe gastrointestinal symptoms, is less common than non-classic celiac disease, characterized by absence of gastrointestinal symptoms. (nih.gov)

This study uses an established animal model for heterotopic ossification due to traumatic blast-related amputation. (health.mil)
Relative to immediate amputation groups, the groups with simulated tourniquets had more heterotopic bone, a heightened and prolonged systemic inflammatory response, and increased evidence of injury to the kidneys, liver, and lungs. (health.mil)
Tourniquet use following blast-associated complex lower limb injury and traumatic amputation promotes end organ dysfunction and amplified heterotopic ossification formation. (health.mil)

Patients with traumatic neurological injuries, severe neurologic disorders or severe burns who develop heterotopic ossification experience limitation of motion in the areas affected. (wikipedia.org)
Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue following a neurological condition, of which the most common are brain and spinal cord injuries. (monash.edu)
Arduini M, Mancini F, Farsetti P, Piperno A, Ippolito E. A new classification of peri-articular heterotopic ossification of the hip associated with neurological injury: 3D CT scan assessment and intra-operative findings. (scireproject.com)
Brady D, Shultz S, McDonald S, O'Brien T. Neurological heterotopic ossification: Current understanding and future directions. (scireproject.com)

3) Spontaneous flare-ups present as large, painful swellings resulting in heterotopic ossification. (ispub.com)
The efficacy of Pex for preventing heterotopic ossifications was evaluated by the presence of flare-ups, measurements of serum bone markers, and changes in the total bone volume calculated by the three-dimensional computed tomography (3D-CT) images. (biomedcentral.com)

Heterotopic ossification (HO) is the abnormal bone formation within skeletal soft tissues. (ruralneuropractice.com)
HO is the pathologic formation of extra-skeletal bone within soft tissues that occurs in patients with severe trauma. (usuhs.edu)

citation needed] Heterotopic ossification often develops in patients with traumatic brain or spinal cord injuries, other severe neurologic disorders or severe burns, most commonly around the hips. (wikipedia.org)

They help detect heterotopic ossification, typical significant toe deformities, and other related abnormalities. (a2zfitnessmart.com)
Hai reported that no significant difference in segmental range of motion was found in patients with either Class I (20%) or Class II (25.7%) ossification and those with none. (spinalnewsinternational.com)
During a follow-up visit with the hand specialist two months later, he noted a significant loss in range of motion and more heterotopic bone. (tmlt.org)

2018. MPP1/p55 gene deletion in a hemophilia A patient with ectrodactyly and severe developmental defects. (tufts.edu)
2018. Q204D does Nnot result in heterotopic ossification. (tufts.edu)

Characteristically exhibiting in the big toe at birth, it causes the formation of heterotopic bone throughout the body over the course of the sufferer's life, causing chronic pain and eventually leading to the immobilisation and fusion of most of the skeleton by abnormal growths of bone. (wikipedia.org)

Heterotopic ossification refers to a condition when a bony material grows on/around the artificial disc after the surgery. (socalbrainspine.com)

Individuals with FOP will frequently have ossification of their temporomandibular joint (TMJ) resulting in jaw immobility. (ispub.com)

The clinical evaluation was performed according to the Harris hip score, pain, and for the radiological evaluation of the presence of periprosthetic osteolysis, loosening of prosthesis, and heterotopic ossification. (dsmc.or.kr)

citation needed] Heterotopic ossification of varying severity can be caused by surgery or trauma to the hips and legs. (wikipedia.org)
Recently, we observed that NGF (Nerve growth factor)-responsive TrkA (Tropomyosin receptor kinase A)-expressing nerves invade sites of soft-tissue trauma, and this is a necessary feature for heterotopic bone formation at sites of injury. (nih.gov)
Here, we assayed the effects of the partial TrkA agonist Gambogic amide (GA) in peritendinous heterotopic bone after extremity trauma. (nih.gov)
In summary, these studies further link injury site hyper-innervation with increased vascular ingrowth and ultimately heterotopic bone after trauma. (nih.gov)
In the future, modulation of TrkA signaling may represent a potent means to prevent the trauma-induced heterotopic bone formation and improve tissue regeneration. (nih.gov)
In cases of severe trauma or insult to the central nervous system (CNS), 10-20% of patients develop HO, and the condition has been observed in 20% of patients with severe brain injury. (medscape.com)
Ossification can occur either spontaneously or as a result of tissue trauma beginning in childhood. (ispub.com)
Also, trauma from needle placement can lead to further progression of their disease and lead to additional painful ossification. (ispub.com)

Acetabular fractures are severe injuries with an uncertain final functional outcome. (eexot-journal.com)

Early edema of connective tissue proceeds to tissue with foci of calcification and then to maturation of calcification and ossification. (medscape.com)

Excision should be considered for patients in whom shoulder motion is severely limited by extensive heterotopic bone, especially if dynamic electromyography studies reveal volitional capacity for the various shoulder muscles. (medscape.com)

A known local response is "heterotopic ossification," defined as the formation of bone tissue in damaged soft tissue and muscle. (health.mil)

Characteristically, the GISTs showed severe hyalinization with calcification and partial heterotopic ossification, which may have caused the patient's severe dysphagia. (elsevierpure.com)

citation needed] Another rare genetic disorder causing heterotopic ossification is progressive osseous heteroplasia (POH), is a condition characterized by cutaneous or subcutaneous ossification. (wikipedia.org)
MIM#135100), is characterized by progressive heterotopic ossification (HO) that leads to severe disability. (jefferson.edu)
At present, there is no definitive pharmacotherapy to prevent progressive heterotopic ossifications in FOP. (biomedcentral.com)

Heterotopic ossification (HO) is the process by which bone tissue forms outside of the skeleton in muscles and soft tissue. (wikipedia.org)

Because of severe deformities, the first step was to position the patient. (the-medical-dictionary.com)

Early diagnosis is critical for genetic counselling, limiting anxiety, and preventing severe pains. (a2zfitnessmart.com)

Clinical trials have demonstrated the efficacy of etidronate disodium in heterotopic ossification following total hip replacement or due to spinal cord injury. (nih.gov)
This is thought to be the mechanism by which etidronate disodium prevents or retards heterotopic ossification. (nih.gov)
Intravenous disodium etidronate therapy in spinal cord injury patients with heterotopic ossification. (scireproject.com)
Banovac K, The effect of etidronate on late development of heterotopic ossification after spinal cord injury. (scireproject.com)
If you are taking etidronate to treat Paget's disease of bone or to prevent or treat heterotopic ossification, it may take some time for your condition to improve. (medlineplus.gov)

It is a disabling complication which may cause severe limitation of joint mobility or ankylosis, and vascular or neural compromise. (the-medical-dictionary.com)

Resection of heterotopic ossification in patients with spinal cord injuries. (scireproject.com)
Blast-associated traumatic amputations are life-threatening, complex injuries that often result in severe bleeding. (health.mil)
While minor brain injuries are associated with mild effects that usually resolve on their own, severe brain injuries can have a lasting impact on your life. (halelawfirm.com)
Amputations frequently result from severe injuries to limbs or situations where efforts to save a limb fail. (mazininjurylawyers.com)

As a result of forming bone outside of the normal skeleton, HO leaves patients with severe chronic pain, open wounds, and limited range of motion. (usuhs.edu)

The plaintiff's orthopedic expert stated that based on reasonable medical probability, the delay and the subsequent treatment resulted in contracture of the surrounding soft tissues, loss of cartilage, joint incongruity, and misalignment causing severe limitation of motion. (tmlt.org)

Egan K P, Duque G, Keenan MA, Pignolo R J. Circulating osteogentic precursor cells in non-hereditary heterotopic ossification. (scireproject.com)

Because of the limitations of plain radiography in the imaging of heterotopic ossification (HO)-this modality may not show evidence of HO until 4-5 weeks after injury-radionuclide bone scanning is the preferred diagnostic test for earlier detection of the condition. (medscape.com)
Another finding, often misinterpreted as early heterotopic bone formation, is an increased (early) uptake around the knees or the ankles in a patient with a very recent spinal cord injury. (wikipedia.org)
Nine weeks after injury, this culminated in higher overall levels of heterotopic bone among GA-treated animals. (nih.gov)
Heterotopic ossification due to spinal cord injury typically develops radiographically 1 to 4 months after injury. (nih.gov)
Banovac K, Gonzalez F, Evaluation and management of heterotopic ossification in patients with spinal cord injury. (scireproject.com)
Treatment of heterotopic ossification after spinal cord injury. (scireproject.com)
Risk factors for heterotopic ossification in patients with spinal cord injury: A case-control study of 264 patients. (scireproject.com)
Durovic A, Miljkovic D, Brdareski Z, Plavsic A, Jevtic M. Pulse low intensity electromagnetic field as prophylaxis of heterotopic ossification in patients with traumatic spinal cord injury. (scireproject.com)
Emami Razavi S, Aryan A, Kazemi S, Rostamian A, Jahangiri A, Ghajarzadeh M. Prevalence of hip ossification and related clinical factors in cases with spinal cord injury. (scireproject.com)
Heterotopic ossification following hip replacement or spinal cord injury. (scireproject.com)
Diphosphonate treatment for heterotopic ossification in spinal cord injury patients. (scireproject.com)
Genet F, Jourdan C, Lautridou C, Chehensse C, Minooee K, Denormandie P, Schnitzler A. The Impact of Preoperative Hip Heterotopic Ossification Extent on Recurrence in Patients with Head and Spinal Cord Injury: A Case Control Study. (scireproject.com)
While there is no definable cause for heterotopic ossification after a brain injury, it remains a troubling complication. (halelawfirm.com)
His initial impression was a "severe stiffness problem" almost six months after the injury. (tmlt.org)

This radiograph clearly demonstrates fairly extensive heterotopic ossification at the bilateral hip regions. (medscape.com)
Very few reports have been published in the literature for association of heterotopic ossification with tubercular meningitis with such extensive joint involvement which compels us to report this clinical association of tubercular meningitis. (ruralneuropractice.com)

Cost of inpatient rehabilitation for children with moderate to severe traumatic. (annals.edu.sg)

By the drug repositioning strategy, we confirmed that perhexiline maleate (Pex) potentially ameliorates heterotopic ossification in model cells and mice. (biomedcentral.com)

A comparison of heterotopic ossification treatment within the traumatic brain and spinal cord injured population: An evidence based systematic review. (scireproject.com)

Pulmonary function tests were consistent with severe restrictive lung disease. (ispub.com)

In heterotopic ossification, the swelling tends to be more proximal and localized, with little or no foot/ankle edema, whereas in thrombophlebitis the swelling is usually more uniform throughout the leg. (wikipedia.org)
Dartnell J , Gough M, Paterson M, Norman-Taylor F . Proximal femoral resection without the use of post-operative traction in children with severe cerebral palsy: a review of 77 cases. (nuffieldhealth.com)
Dartnell J , Paterson M, Magill N, Norman-Taylor F . Proximal femoral resection for the painful dislocated hip in cerebral palsy: does indomethacin make a difference to heterotopic ossification? (nuffieldhealth.com)
He diagnosed the problem as "heterotopic bone and incongruity of the proximal radial ulnar joint with relative sparing of the interosseous membrane. (tmlt.org)

May take 6 weeks for ossification to be evident on plain radiographs. (postgraduateorthopaedics.co.uk)

Anatomy90

Organisms10

Diseases64

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes24

Disciplines and Occupations1

Health Care2

Geographicals1

Ectopic6

Fibrodysplasia ossificans12

Mature heterotopic bone2

Spasticity2

Pathophysiology1

Myositis7

Traumatic Brain1

Prevention8

Arthroplasty3

Joints3

Symptoms2

Amputation3

Neurological4

Flare-ups2

Skeletal2

Burns1

Significant3

20182

Abnormal1

Bony1

Individuals with FOP1

Prosthesis1

Trauma8

Fractures1

Calcification and ossification1

Severely limited1

Formation of bone1

Characteristically1

Progressive3

Bone tissue1

Deformities1

Genetic1

Etidronate5

Vascular1

Injuries4

Patients with severe1

Limitation1

Precursor1

Injury14

Extensive2

Rehabilitation1

Mice1

Evidence1

Restrictive lung di1

Proximal4

Plain radiographs1