• weakness
  • Charcot-Marie-Tooth (CMT) disease is one of the hereditary motor and sensory neuropathy (HMSN) disorders, a group of genetically based disorders characterized by progressive motor weakness, decreased nerve conduction velocities, and nerve root enlargement ( 1 ). (ajnr.org)
  • CMT disease represents type I HMSN, a heterogeneous group of disorders of autosomal dominant inheritance characterized by distal muscle weakness, hypoactive or absent tendon reflexes, significantly decreased motor nerve conduction velocities, and hypertrophic onion-bulb changes on nerve biopsy. (ajnr.org)
  • A gradually progressing autoimmune muscle weakness in arms and legs caused by inflammation of the myelin sheath covering peripheral nerve axons. (thefreedictionary.com)
  • Dancing Doberman disease progresses over a few years to rear leg weakness and muscle atrophy. (wikipedia.org)
  • Abducens
  • Moreover, while the abducens and the trochlear nerve each innervate one specific muscle, the oculomotor nerve has many functions including eyelid retraction and pupil constriction. (wikipedia.org)
  • This is an interaction between the abducens nerve and a branch of the oculomotor nerve. (wikipedia.org)
  • Voluntary activation of the abducens nerve (eye abduction) causes involuntary activation of the oculomotor nerve (eye adduction and eyelid elevation). (wikipedia.org)
  • On attempted abduction, the eye's unreactive pupil constricts Another interaction, yet different, is between eye abduction (abducens nerve) and pupil constriction (the oculomotor nerve). (wikipedia.org)
  • infection
  • Rapidly progressive disease, over a time course of a few months and sometimes weeks, is commoner in children and in the presence of active acute infection. (entkent.com)
  • Some causes are facial nerve trauma, neoplasms, sarcoidosis, a varicella zoster infection of the geniculate ganglion (Ramsay Hunt syndrome), and otitis media in children. (lww.com)
  • Protozoa infection like Acanthamoeba keratitis is characterized by severe pain and is associated with contact lens users swimming in pools. (wikipedia.org)
  • conduction
  • Dyck et al ( 7 ) classified hereditary motor and sensory neuropathies into two main groups based on the presence or absence of decreased nerve conduction velocities and neuronal hypertrophy. (ajnr.org)
  • In patients with severe injury, progress is followed with nerve conduction studies. (wikipedia.org)
  • If nerve conduction studies show a large (>90%) change in nerve conduction, the nerve should be decompressed. (wikipedia.org)
  • pain
  • It is a facial nerve disorder in which there is severe pain in the face and jaw. (businessofcinema.com)
  • Local anesthetic and steroids have been successfully used for diagnostic and or therapeutic nerve pain with great success. (clinicaltrials.gov)
  • All patients presenting to the Northwestern Pain Center who are eligible and scheduled to receive a ultrasound-guided trigeminal nerve block. (clinicaltrials.gov)
  • Disseminated disease occurs when the fungus has spread outside of the lungs and may include clinical signs such as lameness, pain, seizures, anterior uveitis, and localized swelling. (wikipedia.org)
  • One researcher (Tzikas) found in a study of Radiance on 90 patients that 59 percent felt when injected, moderate to severe pain which disappeared two to five minutes later. (wikipedia.org)
  • bone
  • The disease has eroded the bone above and behind the upper part of the eardrum, the attic. (entkent.com)
  • It is a cancer of plasma cells in the bone marrow, a rare disease. (businessofcinema.com)
  • A-C , Thin-section (1-mm) coronal and axial CT images of the skull base obtained with an edge-enhancing bone algorithm show enlargement (arrows) of the mastoid canals of cranial nerve VII ( A ), the foramina of ovale ( B ), and rotundum (C) bilaterally. (ajnr.org)
  • Paget's disease of bone (commonly known as Paget's disease or historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more bones. (wikipedia.org)
  • Paget's disease may affect any one or multiple bones of the body (most commonly pelvis, femur, and lumbar vertebrae, and skull), but never the entire skeleton, and does not spread from bone to bone. (wikipedia.org)
  • Advanced Paget's disease may lead to other medical conditions, including: Osteoarthritis may result from changes in bone shape that alter normal skeletal mechanics. (wikipedia.org)
  • There is a hereditary factor in the development of Paget's disease of bone. (wikipedia.org)
  • Two genes, SQSTM1 and RANK, and specific regions of chromosome 5 and 6 are associated with Paget's disease of bone. (wikipedia.org)
  • About 40-50% of people with the inherited version of Paget's disease have a mutation in the gene SQSTM1, which encodes a protein, called p62, that is involved in regulating the function of osteoclasts (bone cells). (wikipedia.org)
  • Paget's disease of bone is associated with mutations in RANK. (wikipedia.org)
  • Most commonly, facial paralysis follows temporal bone fractures, though the likelihood depends on the type of fracture. (wikipedia.org)
  • affects
  • As the disease often affects people differently, treatments of Paget's disease can vary. (wikipedia.org)
  • Paget's disease affects from 1.5 to 8.0 percent of the population, and is most common in those of British descent. (wikipedia.org)
  • When Paget's disease affects the facial bones, the teeth may become loose. (wikipedia.org)
  • Pseudorabies is an infectious disease that primarily affects swine, but can also cause a fatal disease in dogs with signs similar to rabies. (wikipedia.org)
  • Blastomycosis* is a fungal disease caused by Blastomyces dermatitidis that affects both dogs and humans. (wikipedia.org)
  • Histoplasmosis* is a fungal disease caused by Histoplasma capsulatum that affects both dogs and humans. (wikipedia.org)
  • The disease in dogs usually affects the lungs and small intestine. (wikipedia.org)
  • Coccidioidomycosis* is a fungal disease caused by Coccidioides immitis or Coccidioides posadasii that affects a variety of species, including dogs. (wikipedia.org)
  • Sporotrichosis is a fungal disease caused by Sporothrix schenckii that affects both dogs and humans. (wikipedia.org)
  • Devil facial tumour disease (DFTD) is an aggressive non-viral clonally transmissible cancer which affects Tasmanian devils, a marsupial native to Australia. (wikipedia.org)
  • Dancing Doberman disease primarily affects the gastrocnemius muscle in Dobermans. (wikipedia.org)
  • Nearsightedness, which affects some sufferers of the disease, can be treated by corrective lenses. (wikipedia.org)
  • forehead
  • While not a defining feature, most sufferers of GAPO syndrome have coarse facial features, and abnormal structure of the middle portion of their faces, typically coupled with a large forehead. (wikipedia.org)
  • disorder
  • Case reports describing the imaging appearance of nerve hypertrophy in this disorder can be found from the mid-1970s with myelography, in the mid-1980s with CT, and to the current time with MR ( 2 - 5 ). (ajnr.org)
  • GAPO syndrome is a rare, autosomal recessive disorder that causes severe growth retardation, and has been observed fewer than 30 times before 2011. (wikipedia.org)
  • hemifacial
  • Hemifacial spasm (HFS) is a rare neuromuscular disease characterized by irregular, involuntary muscle contractions (spasms) on one side (hemi-) of the face (-facial). (wikipedia.org)
  • Clarifying the role of genetic susceptibility in hemifacial spasm may help to better understand the pathogenesis of this disease. (wikipedia.org)
  • Trochlear
  • In this case voluntary activation of the trochlear nerve (eye depression + eye abduction) is involuntarily activating a branch of the oculomotor nerve responsible for eyelid retraction. (wikipedia.org)
  • syndrome
  • LD is also a tick-transmitted disease and characteristically produces a different syndrome with a typical rash. (psychiatryadvisor.com)
  • Reactivation of latent virus within the dorsal root ganglion of the facial nerve is associated with vesicles affecting the ear canal, and termed Ramsay Hunt syndrome type II. (wikipedia.org)
  • Unfortunately, optic atrophy as a result of degradation of the optic nerve (common with GAPO syndrome) cannot be corrected. (wikipedia.org)
  • ulcers
  • Corneal ulcers are extremely painful due to nerve exposure, and can cause tearing, squinting, and vision loss of the eye. (wikipedia.org)
  • Corneal ulcers are a common human eye disease. (wikipedia.org)
  • Deep ulcers extend into or through the stroma and can result in severe scarring and corneal perforation. (wikipedia.org)
  • Immune-mediated eye disease can cause ulcers at the border of the cornea and sclera. (wikipedia.org)
  • Corneal ulcers are one of the most common eye diseases in dogs. (wikipedia.org)
  • Non-ambulant patients may develop pressure ulcers, severe constipation, urinary incontinence, and (rarely) reflux nephropathy in the advanced stages of the disease. (wikipedia.org)
  • brain
  • This study involves the treatment of cognitive impairment secondary to moderate to severe brain injury using central thalamic deep brain stimulation. (stanford.edu)
  • Sound vibrations are turned into electrical signals and sent to the brain in the nerve of hearing. (entkent.com)
  • Although the most frequent cause is a blood vessel pressing on the facial nerve at the spot where it leaves the patient's brain stem, sometimes there is no known cause. (wikipedia.org)
  • Mild
  • Mild to moderate glabella rhytids and Periocular rhytids by a measurement of 3 or more upon evaluation using the Rao-Goldman 5-point Facial Wrinkle Scale. (clinicaltrials.gov)
  • Mild or early cases of Pagets are asymptomatic, and so most people are diagnosed with Paget's disease incidentally during medical evaluation for another problem. (wikipedia.org)
  • Numbness and paresthesia may accompany or precede loss of motor function, which varies from mild to severe. (thefreedictionary.com)
  • Canine coronavirus is a gastrointestinal disease that is usually asymptomatic or with mild clinical signs. (wikipedia.org)
  • depends on the cause
  • Treatment depends on the cause, but is largely conservative with facial retraining or mime therapy, if needed, while Botox and surgery are used as last resort. (wikipedia.org)
  • involves
  • Field monitoring involves trapping devils within a defined area to check for the presence of the disease and determine the number of affected animals. (wikipedia.org)
  • The third theory or "Kindling theory" involves increased excitability of the facial nerve nucleus due to feedback from a damaged facial nerve. (wikipedia.org)
  • brainstem
  • A brainstem lesion could also cause impaired functioning of multiple cranial nerves, but this condition would likely also be accompanied by distal motor impairment. (wikipedia.org)