• An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
  • Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
  • Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
  • Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide. (stembook.org)
  • Chronic Graft-Versus-Host Disease, Non-Relapse Mortality and Disease Relapse in Older versus Younger Adults Undergoing Matched Allogeneic Peripheral Blood Hematopoietic Cell Transplantation: A CIBMTR Analysis. (stembook.org)
  • A short-chain fatty acid made by bacteria in the gut could play an important role in graft-versus-host disease (GVHD) after allogeneic bone marrow transplant in mice. (oncologynurseadvisor.com)
  • Kaminski E, Hows J, Man S, Brookes P, Mackinnon S, Hughes T, Avakian O, Goldman JM, Batchelor JR. Prediction of graft versus host disease by frequency analysis of cytotoxic T cells after unrelated donor bone marrow transplantation. (anthonynolan.org)
  • In a newly reported study, an experimental antibody treatment largely prevented gastrointestinal acute graft versus host disease (GI-aGVHD) in the intestines of mice and non-human primates (NHPs) given a bone marrow transplant-allogeneic hematopoietic cell transplant (allo-HCT)-but without causing broad immune suppression. (genengnews.com)
  • Gene therapy trials using retroviral vectors to treat X-linked severe combined immunodeficiency (X-SCID) represent the most successful application of gene therapy to date. (wikipedia.org)
  • The infant was placed in strict isolation, and a diagnosis of severe combined immunodeficiency (SCID) was made on September 15. (cdc.gov)
  • Severe combined immunodeficiency (SCID) is a life-threatening syndrome of recurrent infections, diarrhea, dermatitis, and failure to thrive. (medscape.com)
  • Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. (nih.gov)
  • Surgical intervention is customarily not indicated for severe combined immunodeficiency (SCID) and also is not part of the primary treatment. (medscape.com)
  • one chronic granulomatous disease, one ectodermal dysplasia/cytokines deficiency and 4-severe combined immunodeficiency were diagnosed to have disseminated BCGitis. (bmj.com)
  • Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
  • Title: Impact of Induction Therapy with VRD vs. VCD on Outcomes in Patients with Multiple Myeloma in Partial Response or Better Undergoing Upfront Autologous Stem Cell Transplantation. (stembook.org)
  • Association between the choice of the conditioning regimen and outcomes of allogeneic hematopoietic cell transplantation for myelofibrosis. (stembook.org)
  • Montpetit K, Palomo T, Glorieux FH, Fassier F, Rauch F. Multidisciplinary Treatment of Severe Osteogenesis Imperfecta: Functional Outcomes at Skeletal Maturity. (smw.ch)
  • MONDAY, April 11, 2022 (HealthDay News) -- Real-world evidence shows that patients with cancer have a higher risk for developing breakthrough COVID-19 infections and severe outcomes, according to a study published online March 14 in the Journal of Clinical Oncology . (healthday.com)
  • Real-world evidence shows that patients with cancer, especially hematologic malignancies, are at higher risk for developing breakthrough infections and severe outcomes," the authors write. (healthday.com)
  • Qianqian Song, Ph.D., from Indiana University in Indianapolis, and colleagues used data from the National COVID Cohort Collaborative to identify breakthrough infections (Dec. 1, 2020, through May 31, 2021) among more than 64,000 patients partially or fully vaccinated with mRNA COVID-19 vaccines and with no prior severe acute respiratory syndrome coronavirus 2 infection record. (healthday.com)
  • Transplantation proceedings 2021 0 0. (cdc.gov)
  • Without intervention, SCID usually results in severe infection and death in children by age 2 years. (medscape.com)
  • SCID is considered a pediatric emergency because survival depends on expeditious stem cell reconstitution, usually by bone marrow transplantation (BMT). (medscape.com)
  • Full hematopoietic engraftment was reported in one case after bone marrow transplantation without conditioning for a SCID patient. (nih.gov)
  • To examine whether T- and B-lymphocytes in Peyer's patches have an influence on M-cell generation, we studied the development of Peyer's patches and M-cells in severe combined immunodeficient (SCID) mice reconstituted with bone marrow cells from normal syngeneic mice. (nih.gov)
  • Our experiments demonstrate that the donor bone marrow cells in the host scid mice repopulate to form single (primary) follicles and aggregates of lymphoid nodules, the Peyer's patches. (nih.gov)
  • Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
  • The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
  • Innovative therapies, such as progenitor and mesenchymal stem cell transplantation, targeting the specific altered pathway rather than the symptoms, are in the process of development. (smw.ch)
  • BACKGROUND: Mesenchymal stromal cell (MSC) transplantation can improve the left ventricular ejection fraction (LVEF) after an acute myocardial infarction (AMI). (bvsalud.org)
  • COVID-19 is caused by the novel coronavirus, called severe acute respiratory syndrome coronavirus 2 or SARS- CoV-2, whereas flu is caused by any of the several different types and strains of influenza viruses. (bayhealth.org)
  • He has successfully taken research discoveries to the bedside and has been instrumental in establishing many of the clinicial HSCT procedures and current clinical trials including HSCT for severe autoimmune diseases and HIV. (edu.au)
  • Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT. (stembook.org)
  • Bone marrow transplantation can cure blood problems, but there can be severe complications. (theaat.org.uk)
  • Individuals with fanconi anaemia have an increased risk of developing a cancer of blood-forming cells in the bone marrow called acute myeloid leukaemia (AML). (theaat.org.uk)
  • This strategy stopped donor T cells from infiltrating and attacking the intestines, a major site of severe GVHD, but did not block the T cells' infection- and cancer-fighting capabilities. (genengnews.com)
  • A male 13-year-old patient with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia undergoing cancer treatment with methotrexate presented with severe oral mucositis. (bvsalud.org)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • The use of a treatment protocol consisting of a mucositis solution associated with low-level laser therapy effectively resolved a case of severe chemotherapy-induced oral mucositis. (bvsalud.org)
  • patients with severe chronic neutropenia. (drugs.com)
  • These reactions tend to occur more frequently in patients with severe hypogammaglobulinemia, particularly at the initiation of treatment, and in patients with intercurrent infections or bronchiectasis. (medscape.com)
  • Bone marrow studies are necessary to confirm the diagnosis. (rxmed.com)
  • The average age at time of diagnosis was 10½ - months (range: 3 to 30 months), one patient was diagnosed post-bone marrow transplantation. (bmj.com)
  • In human patients who receive bone marrow transplants, GVHD can cause severe gut damage from donor cells attacking host cells. (oncologynurseadvisor.com)
  • Bone marrow transplants can be important components for treating some types of leukemia and lymphoma. (oncologynurseadvisor.com)
  • [8] Subsequent reports showed that severe problems developed from fetal tissue transplants. (lozierinstitute.org)
  • Kaminski E, Hows J, Brookes P, Mackinnon S, Hughes T, Avakian O, Sharrock C, Goldman J, Batchelor JR. Alloreactive cytotoxic T-cell frequency analysis and HLA matching for bone marrow transplants from HLA matched unrelated donors. (anthonynolan.org)
  • The condition is among the leading causes of death and long-term adverse health consequences associated with bone marrow transplants. (genengnews.com)
  • provides an overview of the dynamic in vivo life of NK cells from their development in the bone marrow to their mature cellular responses in the periphery and their ultimate demise, with emphasis on mouse NK cells and viral infections. (scielo.br)
  • Infections following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. (stembook.org)
  • PID characterized by increased susceptibility to severe infections with distinctive susceptibility to various types of pathogens, like mycobacterium bovis in BCG (Bacille Calmette-Guérin) vaccine. (bmj.com)
  • In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 × 10 9 /l, and a history of severe or recurrent infections, long term administration of Neupogen is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events. (medicines.org.uk)
  • And even when a bone marrow transplant is curative for leukemia or lymphoma, GVHD-in which T cells in the donor graft attack the recipient's own tissues-can still be fatal. (genengnews.com)
  • A brown 13-year-old boy with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia presented with severe oral mucositis (Oral Assessment Guide / OAG)6, namely, ulcerated skin and mucosa in the upper and lower lips ( Figure 1 ), and complaints of pain and much discomfort, especially when talking and eating. (bvsalud.org)
  • We hypothesized that clinical risk factors could be identified within 2 weeks of onset of severe (stage 3 or 4) acute gut GVHD for identifying a patient population with a very poor outcome. (nature.com)
  • Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
  • This information should be considered in designing future studies of severe gut GVHD and in counseling patients about prognosis. (nature.com)
  • A new algorithm that uses a simple blood test performed 7 days after bone marrow transplant may predict serious, life-threatening graft-vs-host disease (GVHD), according to a study published online February 9 in the Journal of Clinical Investigation Insight . (medscape.com)
  • In experiments with mouse models of GVHD, the researchers showed that blocking a particular Notch activator known as DLL4 effectively prevented GVHD when administered within the first days after transplantation. (genengnews.com)
  • The team confirmed that the Notch pathway involvement in GVHD was conserved across species, and demonstrated in their animal models that just a single dose of the DLL4-blocking antibody given immediately before stem cell transplantation greatly increased survival and prevented signs of GVHD in the intestines, but without causing global immunosuppression. (genengnews.com)
  • Approximately 90% of people with fanconi anaemia have impaired bone marrow function that leads to a decrease in the production of all blood cells - aplastic anaemia . (theaat.org.uk)
  • Bone marrow suppression is dose related and may be severe, resulting in infection and/or bleeding. (nih.gov)
  • Bone marrow transplantation (BMT) or cord blood stem cell transplantation has been tried in a few patients, with variable outcome. (medscape.com)
  • All these therapies target the symptoms and have effects on the mechanical properties of bone due to modification of bone remodelling, therefore influencing skeletal outcome and orthopaedic surgery. (smw.ch)
  • Validation and refinement of the disease risk index for allogeneic stem cell transplantation: a study from the CIBMTR. (stembook.org)
  • Niemann-Pick disease is a group of autosomal recessive disorders caused by an accumulation of fat and cholesterol in cells of the liver, spleen, bone marrow, lungs, and, in some instances, brain. (nih.gov)
  • Other individuals have a multitude of the most severe symptoms of end-stage liver disease and a limited chance for survival. (medscape.com)
  • Over time, excessive storage of fats can cause permanent cellular and tissue damage, particularly in the brain, peripheral nervous system (the nerves from the spinal cord to the rest of the body), liver, spleen, and bone marrow. (nih.gov)
  • These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
  • The severe neurological impairment and retarded psychomotor development do not improve with time. (lu.se)
  • Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
  • A bone marrow transplant is a procedure that replaces a person's faulty bone marrow stem cells. (medlineplus.gov)
  • This destroys the faulty stem cells in your bone marrow. (medlineplus.gov)
  • In some cases, you can donate your own bone marrow stem cells in advance. (medlineplus.gov)
  • most of the neutrophils in the body are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). (medscape.com)
  • It is the prototype of the primary immunodeficiency diseases and is caused by numerous molecular defects that lead to severe compromise in the number and function of T cells, B cells, and occasionally natural killer (NK) cells. (medscape.com)
  • His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
  • A stem cell in the bone marrow becomes cancerous, and produces a large number of abnormal white cells, called granulocytes. (rxmed.com)
  • Successful Salvage Haploidentical Bone Marrow Transplantation in a Child With Hemophagocytic Lymphohistiocytosis, When the Previously Matched Unrelated Donor Tested Positive for SARS-CoV-2 on the Day of Stem Cells Collection. (cdc.gov)
  • This study aimed to report the resolution of a case of severe oral mucositis and demonstrate the intervention protocol used by the pediatric sector of the Hospital Napoleão Laureano (João Pessoa, PB) for treating these cases. (bvsalud.org)
  • see this term) is a rare hematological disorder, seen almost exclusively in males, characterized by moderate to severe thrombocytopenia with hemorrhages with or without the presence of mild to severe anemia. (orpha.net)
  • Anemia is often present but can range from mild to severe. (orpha.net)
  • People with COVID-19 have had a wide range of symptoms reported, ranging from very mild to severe. (bayhealth.org)
  • The symptoms of hepatic encephalopathy may range from mild to severe and may be observed in as many as 70% of patients with cirrhosis. (medscape.com)
  • Neurologic symptoms consist of hypotonia, absence of coordinated voluntary movements and severe retarded psychomotor development. (lu.se)
  • Tartrate-resistant acid phosphatase 5b was 245 mU/dl and bone-specific alkaline phosphatase level was 6.1 μ g/l, clarifying the existence of SSBT [ 7 ]. (hindawi.com)
  • This study evaluates the use of five different asthma medicines to treat adults and adolescents with severe asthma. (nih.gov)
  • Allogeneic Transplantation to Treat Therapy Related MDS and AML in Adults. (stembook.org)
  • Different factors contribute to residual anemia during eculizumab treatment: underlying bone marrow dysfunction, residual intravascular hemolysis and the emergence of C3-mediated extravascular hemolysis. (frontiersin.org)
  • Those with severe hydrops fetalis (see this term) related anemia will need an in utero transfusion and transfusions can be required after birth for those with severe anemia. (orpha.net)
  • Medical treatment consists of bone-remodelling drug therapy. (smw.ch)
  • Bisphosphonates are widely used in the treatment of moderate to severe osteogenesis imperfecta, from infancy to adulthood. (smw.ch)
  • Eight patients (16 %) did not respond to treatment, and one died shortly after transplantation. (springermedizin.at)
  • Together, both IST and stem cell transplantation are reasonable treatment options for patients with AA. (springermedizin.at)
  • Sequential hepatic and bone marrow transplantation should be considered as a suitable treatment for the most severe cases of EPP with hepatic involvement. (orpha.net)
  • Except for cases in which bone marrow transplantation can be used successfully, treatment is not curative. (rxmed.com)
  • Mild thalassemia may not require treatment, but severe thalassemia may require bone marrow transplantation. (msdmanuals.com)
  • This article reports the resolution of a case of severe oral mucositis and the treatment protocol that promoted complete remission of the lesions. (bvsalud.org)
  • In face of the patient's condition, the option was to begin the treatment protocol for severe oral mucositis lesions used frequently by the pediatrics sector of the Hospital Napoleão Laureano (João Pessoa-PB). (bvsalud.org)
  • In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
  • The Equal Employment Opportunity Commission (EEOC) has updated its guidance on COVID-19 and the Americans with Disabilities Act (ADA), clarifying how to accommodate individuals who are at high risk for severe illness from the coronavirus. (shrm.org)
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
  • Allogeneic hematopoietic cell transplantation (allo-HCT) has lifesaving potential for patients with hematological malignancies and bone marrow disorders, the authors wrote. (genengnews.com)
  • Among aGVHD manifestations, gastrointestinal involvement (GI-aGVHD) is most challenging, with nearly all cases of severe aGVHD prominently involving the gastrointestinal (GI) tract," the team noted. (genengnews.com)
  • Gordon-Smith EC, Fairhead SM, Chipping PM, Hows J, James DC, Dodi A, Batchelor JR. Bone-marrow transplantation for severe aplastic anaemia using histocompatible unrelated volunteer donors. (anthonynolan.org)
  • Bone marrow failure syndrome (BMFS) is a group of disorders that may manifest as single cytopenia (eg, erythroid, myeloid, or megakaryocytic) or as pancytopenia. (medscape.com)
  • Type A, the most severe form, begins in early infancy. (nih.gov)
  • It presents in infancy or in neonates (in severe cases) with patients bruising easily along with further manifestations of thrombocytopenia including epistaxis, petechiae, ecchymoses, or splenomegaly. (orpha.net)
  • This study aimed to compare the effects of single versus double transplantation of Wharton's jelly MSCs (WJ-MSCs) on LVEF post-AMI. (bvsalud.org)