Seven factor vii. Medical search. Frequent questions

Cite this: Higher Weight Loss on Tirzepatide Links to Seven Factors - Medscape - Oct 26, 2023. (medscape.com)
October 7, 2023. (timesofisrael.com)
Dig Dis Sci;68(7): 3158-3166, 2023 07. (bvsalud.org)

Therapeutic options for major bleeds include recombinant activated factor VIIa (rFVIIa), plasma-derived factor VII, fresh frozen plasma, and prothrombin complex concentrates. (medscape.com)
The discovery of vitamin K-dependent factors evolved slowly, after the initial identification of the role of prothrombin in blood clotting 100 years ago. (medscape.com)
In 1951, Alexander and colleagues identified factor VII as the key initiator of coagulation when they reported the first case of factor VII deficiency in a child and called it serum prothrombin conversion accelerator deficiency. (medscape.com)
Other vitamin K-dependent factors include prothrombin, factors IX and X, and proteins C and S. (medscape.com)
Familial multiple factor deficiency type III: Inherited combined deficiency of prothrombin and factors VII, IX, and X has been reported. (medscape.com)
Factor Xa along with factor Va converts prothrombin to thrombin. (medscape.com)

Once bound to tissue factor released from damaged tissues, it is converted to factor VIIa (or blood-coagulation factor VIIa, activated blood coagulation factor VII), which in turn activates factor IX and factor X. Using genetic recombination a recombinant factor VIIa (eptacog alfa) (trade names include NovoSeven) has been approved by the FDA for the control of bleeding in hemophilia. (wikipedia.org)
The complex of factor VIIa with TF catalyzes the conversion of factor IX and factor X into the active proteases, factor IXa and factor Xa, respectively. (wikipedia.org)
It is treated with recombinant factor VIIa (NovoSeven or AryoSeven). (wikipedia.org)
Gene therapy approaches for treating FVII deficiency are very promising () Recombinant factor VIIa, marketed under the trade names AryoSeven and NovoSeven, is used for people with hemophilia (with Factor VIII or IX deficiency) who have developed antibodies against replacement coagulation factor. (wikipedia.org)
When the vascular lumen is damaged, tissue factor is exposed and then binds to the small amounts of circulating factors VIIa and VII. (medscape.com)
This facilitates conversion of factor VII to factor VIIa. (medscape.com)
Factor VIIa bound to tissue factor in the presence of calcium and phospholipids facilitates the conversion of factor IX to factor IXa and factor X to factor Xa. (medscape.com)
Although this division is useful for understanding in vitro laboratory coagulation tests, no such division occurs in vivo because the tissue factor VIIa complex is a potent activator of factor IX and factor X. (medscape.com)
Factor VII is then converted to factor VIIa. (medscape.com)
Binding of human factor VII and VIIa to monocytes. (jci.org)
Human coagulation Factors VII and VIIa bind with equal affinity to monocytes stimulated with endotoxin. (jci.org)
Equilibrium binding studies performed at 0 degrees C using 125I-labeled Factor VII and VIIa showed the dissociation constant (Kd) to be congruent to 82 pM with congruent to 3,600 binding sites/monocyte. (jci.org)
Ca++ was required for Factor VII and VIIa interaction with monocytes (optimal CaC12 concentration greater than or equal to 2.5 mM) and binding was reversed by the addition of EDTA. (jci.org)
The rate of conversion of Factor X to Xa in mixtures containing Factor VIIa and monocytes was directly related to the quantity of Factor VIIa bound to the monocyte surface. (jci.org)
Competition experiments showed that Factor VII and VIIa bind to the same monocyte sites and further, that unlabeled Factor VII and VIIa have the same affinity for the binding sites as the 125I-labeled proteins. (jci.org)
The ability of factor VIIa to cleave other clotting factors depends on binding to its cofactor tissue factor (TF), which is expressed on the surface of endothelial cells and monocytes in response to injury or inflammation. (medscape.com)
With formation of the TF/VIIa complex, factor VIIa rapidly activates clotting factors VII, IX, and X, initiating the coagulation cascade. (medscape.com)
Five identified allelic polymorphisms also affect plasma levels of factor VII and factor VIIa, with variations of as much as 25-30% in levels of activity and antigen. (medscape.com)
Laurian Y. Treatment of bleeding in patients with platelet disorders: is there a place for recombinant factor VIIa? (medscape.com)

The main role of factor VII (FVII) is to initiate the process of coagulation in conjunction with tissue factor (TF/factor III). (wikipedia.org)
Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself. (wikipedia.org)
Greifswald Factor FVII Deficiency Study Group. (medlineplus.gov)
Inherited deficiency of factor VII (FVII), the crucial enzyme triggering blood coagulation, is the most common of the rare coagulation disorders transmitted in an autosomal recessive manner. (medscape.com)
The relationships between the Arterial and venous thrombosis, which clinical presentation and FVII levels and the clinically manifest as stroke, myocardial in- associated molecular genetic defects lack farction or pulmonary embolism are a ma- apparent consistency [ 7,10 ]. (who.int)
10976 in exon 8 in the catalytic region of ing factors that may increase cardiovascu- the FVII gene and an insertion of a decanu- lar disease. (who.int)
Upon contact with tissue ferences in FVII activity levels and in geno- factor exposed by vascular injury, FVII is type frequencies depend on the ethnic cleaved to its two-chain active form, which groups [ 15 ]. (who.int)
We studied FVII gene poly- then activates factors IX and X leading to morphisms in healthy Tunisians with the the generation of thrombin [ 2 ]. (who.int)
Inherited factor VII (FVII) deficiency is a rare autosomal recessive hemorrhagic disorder. (medscape.com)
Molecular analysis of factor VII deficiency in Italy: a frequent mutation(FVII Lazio) in a repeated intronic region. (medscape.com)
Polymorphisms of the factor VII gene and circulating FVII:C levels in relation to acute cerebrovascular disease and poststroke mortality. (medscape.com)

Factor VII deficiency is a rare bleeding disorder that varies in severity among affected individuals. (medlineplus.gov)

Coagulation factor VII (EC 3.4.21.21, formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade, and in humans is coded for by the gene F7. (wikipedia.org)
The inherited form of factor VII deficiency, known as congenital factor VII deficiency, is caused by mutations in the F7 gene, which provides instructions for making a protein called coagulation factor VII. (medlineplus.gov)
These mutations reduce the amount of coagulation factor VII in the bloodstream. (medlineplus.gov)
it does not appear to be related to the amount of coagulation factor VII in the bloodstream. (medlineplus.gov)
Coagulation factor VII mass and activity in young men with myocardial infarction at a young age. (medscape.com)

Factor VII shares a common domain architecture with factors IX and X. The gene for factor VII is located on chromosome 13 (13q34). (wikipedia.org)
Factor VII deficiency: clinical manifestation of 717 subjects from Europe and Latin America with mutations in the factor 7 gene. (medlineplus.gov)
Factor VII is coded by the gene on band 13q34, closely located to the gene for factor X ( F10 ). (medscape.com)
ABSTRACT Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant (FVIIc) levels that have been associated with cardiovascular risk. (who.int)
The Q353 allele of the factor VII gene polymorphism is associated with decreased factor VII and could be protective against cardiovascular disease. (who.int)
Recently several reports have cleotide (designated as 0/10 bp) in the pro- focused on the association between the moter region of the gene at position -323 factor VII of the cascade coagulation and [ 13,14 ]. (who.int)
More than 100 mutations, mostly missense mutations, have been identified in the factor VII gene located on chromosome 13. (medscape.com)
What exactly causes the gene mutations that lead to breast cancer is unclear, but diet, smoking, and other lifestyle factors play a role. (cedars-sinai.org)

Factor VII deficiency (congenital proconvertin deficiency) is rare and inherited recessively. (wikipedia.org)
The noninherited form of the disorder, called acquired factor VII deficiency, is less common than the congenital form. (medlineplus.gov)
Mariani G, Herrmann FH, Bernardi F, Schved JF, Auerswald G, Ingerslev J. Clinical manifestations, management, and molecular genetics in congenital factor VII deficiency: the International Registry on Congenital Factor VII Deficiency (IRF7). (medlineplus.gov)
Mandhyan R, Tiwari A, Cherian G. Congenital factor VII deficiency. (medscape.com)

Investigations to determine the contribution by factor VII polymorphisms, other hemostatic proteins, and environmental factors have not yielded specific predictors of bleeding risk. (medscape.com)
Modulation of factor VII levels by intron 7 polymorphisms: population and in vitro studies. (medscape.com)
The significance of published polymorphisms in 14 cases of mild factor VII deficiency. (medscape.com)

Interferon Regulatory Factor-7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
An interferon regulatory factor that is induced by INTERFERONS as well as LMP-1 protein from EPSTEIN-BARR VIRUS. (umassmed.edu)
IRF-7 undergoes PHOSPHORYLATION prior to nuclear translocation and it activates GENETIC TRANSCRIPTION of multiple interferon GENES. (umassmed.edu)
This graph shows the total number of publications written about "Interferon Regulatory Factor-7" by people in this website by year, and whether "Interferon Regulatory Factor-7" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Interferon Regulatory Factor-7" by people in Profiles. (umassmed.edu)
Results: The novel finding was a dominant type I interferon signaling network with the transcription factor Irf7 as a central component maintained through 28 d. (cdc.gov)

health;26(7): 1-8, 2022. (bvsalud.org)

Genetic factors levels vary significantly in the general pop- contribute significantly to the development ulation and are influenced by environmental of these diseases. (who.int)
Factor VII plasma levels are influenced by both environmental and genetic factors. (medscape.com)
Genetic and environmental determinants of factor VII coagulant activity in ethnic groups at differing risk of coronary heart disease. (medscape.com)

In SQL Server 2017 consuming or providing JSON data is so efficient that you can implement effective microservices right from the database, argues Phil Factor. (sqlservercentral.com)

Factor VII, which was discovered around 1950, is vitamin K-dependent and produced in the liver. (wikipedia.org)
Acquired factor VII deficiency can also be caused by certain drugs such as medicines that prevent clotting, or by a deficiency of vitamin K. (medlineplus.gov)
Factor VII is a vitamin K-dependent serine protease glycoprotein (also known as stable factor or proconvertin) with a pivotal role in hemostasis and coagulation. (medscape.com)
Warfarin inhibits the activity of vitamin K epoxide reductase and prevents recycling of vitamin K back to the reduced form, thus interfering with the synthesis of factor VII and other vitamin K-dependent factors. (medscape.com)
Factor VII is one of the vitamin K-dependent coagulation factors synthesized in the liver. (medscape.com)
FACTOR VII is a Vitamin K dependent glycoprotein essential to the extrinsic pathway of coagulation. (umassmed.edu)
Plasma from 98 patients receiving long-term anticoagulant therapy was assayed with 'Thrombotest', a clotting test in whole blood introduced by Owren and in these plasmas the activity of each of the vitamin K-dependent factors was assayed with spectrophotometric methods. (karger.com)
Factor VII deficiency is associated with severe liver disease, vitamin K deficiency and broad spectrum antibiotic therapy, or may follow anticoagulant coumarin therapy. (drugfuture.com)
Levels of factor VII in this syndrome are lower than those in disorders with other vitamin K-dependent factors. (medscape.com)
Liver disease, vitamin K deficiency, and oral coagulant-induced conditions: These conditions can be differentiated from factor VII deficiency by measuring other vitamin K-dependent factor levels, which are also decreased. (medscape.com)

Analyses were based on 7 years of follow-up. (nih.gov)
Analyses of Variance (ANOVA) showed that the GAD-7 scores were significantly different between males and females, with females scoring higher than males. (bvsalud.org)

Roberts HR, Monroe DM, Hoffman M. Molecular biology and biochemistry of the coagulation factors and pathways of hemostasis. (medscape.com)

Correlations between the factor VII genotype, factor VII clotting activity and the clinical phenotype are not tight. (medscape.com)
Role of plasma lipoproteins and factor VII genotype. (medscape.com)

These factors are usually known as the broad determinants of health. (who.int)

Although individuals with the lowest factor VII levels are most likely to be symptomatic, patients with identical mutations may have marked differences in clinical bleeding, suggesting that other factors may contribute to the clinical manifestations of factor VII deficiency. (medscape.com)

Factor VII has been shown to interact with tissue factor and endothelial protein C receptor. (wikipedia.org)
The prognostic impact of insulin-like growth factor binding protein 7 (IGFBP7) in breast cancer is unclear. (lu.se)

As an rFVIIa product, eptacog beta works in a complex with tissue factor to activate factor X to Xa, thereby bypassing FVIII and FIX. (wikipedia.org)

The activation of Factor X to Xa initiates the coagulation cascade's common pathway, leading to clot formation at the site of hemorrhage. (wikipedia.org)
Recombinant human factor VII while initially looking promising in intracerebral hemorrhage failed to show benefit following further study and this is no longer recommended. (wikipedia.org)
Management of acute hemorrhage primarily consists of factor VII replacement therapy to treat bleeding. (medscape.com)

Inherited factor VII deficiency: genetics and molecular pathology. (medscape.com)

Upon vessel injury, tissue factor is exposed to the blood and circulating factor VII. (wikipedia.org)
The epidermal growth factor domain has a calcium ion- binding site that to some degree mediates interaction with the tissue factor exposed at the site of vessel injury. (medscape.com)

Specific factor VII assays are required for diagnosis. (medscape.com)
Factor assays in family members are indicated to identify other affected individuals. (medscape.com)
For the clotting factors IX and VII, novel spectrophotometric methods were applied and the plasma activities thus measured were compared to results obtained with factor IX and VII clotting assays. (karger.com)
The chromogenic assays for the factors II, VII, IX and X provide the same information on the therapeutic state of the patients in respectively 86.7, 78.6, 81.6 and 89.8% of the cases. (karger.com)

Spectrophotometric methods were used to assay the clotting factors II, VII, IX and X in plasma of 33 subjectively healthy human donors and in plasma of 98 patients receiving long-term oral anticoagulant therapy. (karger.com)
7. ANALYTICAL METHODS contrast illumination, using a Walton-Beckett graticule. (cdc.gov)

Molecular biology and clinical manifestation of hereditary factor VIIdeficiency. (medscape.com)

I am thinking of something like a "Auto inherit" button for each row in the experimental factors tables on the experiment view page. (lu.se)

A systematic search of the databases PUBMED and EMBASE was performed to identify all studies reporting on possible risk factors for cholangitis following pancreatoduodenectomy . (bvsalud.org)

Association between coagulation factors VII and X with triglyceride rich lipoproteins. (bmj.com)

Starting project conversations with a clear understanding of the motivation behind it, whether it's driven by vanity, cost-saving goals, or other factors mean that there will be fewer obstacles and disagreements during the implementation phase. (red-gate.com)

These findings help inform which people with type 2 diabetes are most likely to achieve greater body weight reduction with improved cardiometabolic risk factors with tirzepatide," say the authors. (medscape.com)
At present, classification based on clinical history (age and type of presentation) rather than on factor VII activity levels has proved to be more useful in predicting future risk of bleeding. (medscape.com)
1,000 m from the epidemic focus were risk factors for posttransplant visceral leishmaniasis. (cdc.gov)
This large, urban outbreak provided us the opportunity to analyze the incidence and specific risk factors of VL among SOT recipients. (cdc.gov)
7 Common Breast Cancer Risk Factors: What's My Risk? (cedars-sinai.org)
Below are 7 of the most common risk factors for breast cancer, but there are others. (cedars-sinai.org)
Younger (6-7 years) versus older (11 years) age at baseline was a significant risk factor (adjusted hazard ratio (HR) = 6.6, 95% CI = 3.4, 12.7) for having high myopia within 7 years. (nih.gov)
More (SER from -2.26 to -4.50 D) vs. less (SER from -1.25 to -2.25 D) baseline myopia was also a significant risk factor for high myopia at 7 years (adjusted HR = 7.4, 95% CI = 4.4, 12.4). (nih.gov)
Gender, ethnicity, and treatment assignment were not associated with the risk of high myopia within 7 years. (nih.gov)
Risk Factors for Cholangitis After Pancreatoduodenectomy: A Systematic Review. (bvsalud.org)
The aim of this systematic review was to provide an overview of the literature identifying risk factors for postoperative cholangitis . (bvsalud.org)
Data on 26 potential risk factors concerning the patient , peri- and postoperative characteristics were analyzed. (bvsalud.org)
Multiple potential risk factors for postoperative cholangitis were identified, with large discrepancies between studies. (bvsalud.org)
Prospective research , with consensus on the definition, is required to determine the true relevance of these risk factors . (bvsalud.org)
This study aims to determine the risk factors associated with macrosomia. (bvsalud.org)
Antenatal risk factors are important in the prediction of macrosomia, but fetal and maternal outcome depends on labour management. (bvsalud.org)

The choice of treatment for patients with factor VII deficiency depends on the site and severity of bleeding and the baseline factor VII activity. (medscape.com)
Item parameter analysis showed items 5 and 7 presented the highest severity thresholds for the generalized anxiety latent trait, whereas item 1 presented the lowest ones. (bvsalud.org)
Additionally, a range of uncertainty factors were considered for deriving OELs that correspond to each band, including interspecies extrapolation, human variability, and severity of effects. (cdc.gov)

[ 1 , 2 ] Clinical bleeding can widely vary and does not always correlate with the level of factor VII coagulant activity measured in plasma. (medscape.com)

The prognostic impact of IGFBP7high depends on host factors and treatment. (lu.se)

Among the 3188 people with type 2 diabetes who were adherent to their tirzepatide (Mounjaro, Lilly) regimen in four pivotal trials of the agent, a quarter achieved at least a 15% cut from their baseline body weight after 40-42 weeks of treatment, and researchers found seven baseline variables that were significantly linked with a higher incidence of this level of weight loss. (medscape.com)
Multivariate analysis of baseline covariates showed that these seven factors were significantly linked with ≥15% weight loss: higher tirzepatide dose, being female, being of White or Asian race, being of younger age, undergoing treatment with metformin , having better glycemic control (based on lower A1c and lower fasting serum glucose), and having lower non-high-density lipoprotein cholesterol level. (medscape.com)
Children who developed high myopia during 7 years of follow-up were younger and had more myopia at baseline. (nih.gov)

In contrast to factor VII deficiency, the activated partial thromboplastin time (aPTT) is also prolonged. (medscape.com)

During a visceral leishmaniasis outbreak in an area of Madrid, Spain, the incidence of disease among solid organ transplant recipients was 10.3% (7/68). (cdc.gov)
Fibrinolytic activity, clotting factors, and long-term incidence ofischaemic heart disease in the Northwick Park Heart Study. (medscape.com)
For example, the reported incidence of factor VII deficiency in Iran is 3 times higher than that in the United Kingdom or Italy. (medscape.com)

Phil Factor reflects on the occasional benefits of document loss, whether accidental or less so. (sqlservercentral.com)

Saints-Bengals Line at 6.5 to 7: Cold Weather a Factor? (gambling911.com)
With the Saints-Bengal line at either 6.5 or 7 in favor of New Orleans, sports bettors might want to strongly consider the "cold" factor for this game. (gambling911.com)
The Saints are 10-3 Against The Spread in their last 13 road games vs. a team with a losing home record but are also 1-7 ATS vs. a team with a losing record. (gambling911.com)
The Saints are 1-7 ATS vs. a team with a losing record. (gambling911.com)
The Jacksonville Jaguars are in the Big Easy tonight for a Week 7 showdown against the New Orleans Saints. (bigcatcountry.com)
However, with the team being on a short week, and with Trevor Lawrence nursing a knee injury , Jacksonville's Week 7 road contest against the New Orleans Saints on Thursday Night Football is shaping up to be a true test of the team's mental fortitude . (bigcatcountry.com)

Tissue factor is found on the outside of blood vessels - normally not exposed to the bloodstream. (wikipedia.org)

Factor VII is synthesized in the liver and secreted as a single-chain glycoprotein of 48 kd. (medscape.com)

Diseases7

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes5

20233

Prothrombin6

VIIa19

FVII11

Bleeding disorder1

Coagulation fac5

Gene8

Congenital4

Polymorphisms3

Interferon6

20221

Genetic3

20171

Vitamin10

Analyses2

Biochemistry1

Genotype2

Determinants1

Mutations1

Protein2

RFVIIa1

Hemorrhage3

Genetics1

Vessel injury2

Assays4

Methods2

Clinical manifestation1

Page1

Search1

Lipoproteins1

Implementation1

Risk16

Severity3

Coagulant activity1

Prognostic1

Baseline3

Contrast1

Incidence3

Occasional1

Saints6

Bloodstream1

Synthesized in the liver1