• We evaluated nucleic acid amplification testing (NAAT) for Zika virus on whole-blood specimens compared with NAAT on serum and urine specimens among asymptomatic pregnant women during the 2015-2016 Puerto Rico Zika outbreak. (cdc.gov)
  • Using NAAT, more infections were detected in serum and urine than in whole blood specimens. (cdc.gov)
  • Several reports suggest higher sensitivity of nucleic acid amplification testing (NAAT) on whole-blood and urine specimens compared with serum specimens ( 6 - 10 ). (cdc.gov)
  • Therefore, we compared ZIKV NAAT results in whole blood specimens to those in serum and urine specimens among asymptomatic pregnant women living in Puerto Rico during the 2015-2016 Zika outbreak. (cdc.gov)
  • From October 1 - November 4, 2016, ≈2-3 months after the peak of the Puerto Rico Zika outbreak ( 12 ), the Puerto Rico Department of Health recruited pregnant women during routine prenatal care visits at 7 clinical sites to provide serum, urine, and whole-blood specimens. (cdc.gov)
  • These samples are stored in a "biobank" for future research and analyses of environmental exposures and include maternal urine, blood, serum, placenta, cord blood and the newborn's meconium. (mmm.edu)
  • Methods: A total of 26 EDCs were assessed in prenatal urine and serum samples from first trimester in pregnancy from 737 mother-child pairs participating in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study. (lu.se)
  • Deutchman M, Eisinger S, Kelber M. First trimester pregnancy complications [slide 26], Advanced Life Support in Obstetrics Course Syllabus, 4 ed. (jabfm.org)
  • Gesta- safe methods of terminating second trimes- tional age was 15-23 weeks (2nd trimester ter pregnancy other than surgery, which pregnancy is defined as the period of preg- can result in serious complications such as nancy from the beginning of the 15th cervical laceration, uterine perforation and through the 28th completed week of gesta- bowel injury. (who.int)
  • Once the diagnosis of diabetes is established in a pregnant woman, continued testing for glycemic control and diabetic complications is indicated for the remainder of the pregnancy. (medscape.com)
  • Her research focuses on human uterus-embryo interaction for implantation, implantation failure in IVF, placental development and pregnancy complications, particularly preeclampsia. (monash.edu)
  • Her work also focuses on developing new strategies to diagnose and treat pregnancy complications, especially early onset preeclampsia. (monash.edu)
  • Studies suggest that low levels of pregnancy-associated plasma protein A (PAPP-A) in early pregnancy are related to certain complications. (healthline.com)
  • Aberrations in these changes are associated with pregnancy complications such as gestational diabetes (GDM) (Kivelä et al. (springer.com)
  • Maternal Age Risk factors for complications during pregnancy include Preexisting maternal disorders Physical and social characteristics (eg, age) Problems in previous pregnancies (eg, a previous history. (msdmanuals.com)
  • ACE gene in pregnancy complications: Insights into future vascular risk. (cdc.gov)
  • Searching for a common mechanism for placenta-mediated pregnancy complications and cardiovascular disease: role of lipoprotein(a). (cdc.gov)
  • Placenta-mediated pregnancy complications are not associated with fetal or paternal factor V Leiden mutation. (cdc.gov)
  • This makes proMBP a marker comparable in diagnostic efficiency to human chorionic gonadotrophin (hCG), and exceeding that of alpha-fetoprotein (AFP) and unconjugated oestriol (uE3), in the second trimester. (nih.gov)
  • A 20-year-old gravida 1 presented for a targeted anatomy ultrasound in the setting of an elevated maternal serum alpha fetoprotein (MSAFP) (7.14 MoM) obtained from routine prenatal screening. (contemporaryobgyn.net)
  • Our aim is to study the changes in trace element levels in Chinese pregnant women and their association with adverse pregnancy outcomes. (nih.gov)
  • Deficiency can lead to adverse pregnancy outcomes. (nih.gov)
  • Therefore, we should have a reasonable diet, replenish trace elements, therefore reducing the occurrence of adverse pregnancy outcomes. (nih.gov)
  • iNOS plays an important role in poor fetoplacental vascular perfusion and adverse pregnancy outcomes. (medscimonit.com)
  • Association of maternal serum PAPP-A levels in first trimester and adverse pregnancy outcomes: systematic review and retrospective cohort study. (bham.ac.uk)
  • Serum IGF-I was measured in maternal serum from week 14, every fourth week until week 30, and every second week until delivery. (diabetesjournals.org)
  • Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. (whiterose.ac.uk)
  • 2017 guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. (medscape.com)
  • The proform of eosinophil major basic protein (proMBP), the most abundant protein in the eosinophil specific granule, is synthesized by the placenta and secreted into the maternal circulation, where it is found complex-bound to pregnancy-associated plasma protein-A (PAPP-A) and other proteins. (nih.gov)
  • Placenta percreta-induced spontaneous uterine rupture in the first trimester is extremely rare and difficult to diagnose. (medsci.org)
  • Objective: The article will review the associations between Prediabetes (PD) and Polycystic Ovarian Syndrome (PCOS) and present factors that decrease the progression of PD into type 2 diabetes mellitus (T2DM).Metformin will also be examined for its role in ovulation induction, pregnancy and ameliorating the metabolic syndrome. (scirp.org)
  • The higher affinity of both TBG and TBPA for T4 partially explains the higher serum levels, slower metabolic clearance, and longer half-life of T4 compared to T3. (nih.gov)
  • The serum metabolic profile during pregnancy might be used to identify women at increased risk for type 2 diabetes. (springer.com)
  • It has previously been demonstrated, in a cohort of women with overweight, that the serum metabolic profile of women developing GDM differs from those who remain normoglycemic already in early pregnancy (Mokkala et al. (springer.com)
  • Our working hypothesis was that by undertaking comprehensive examination of metabolic profiles, in addition to traditional metabolic markers, it could be possible to elucidate the associations of circulating metabolites during pregnancy to postpartum metabolic disorders and thus to reveal potential targets for interventions. (springer.com)
  • With respect to the traditional metabolic markers, high third trimester glycated hemoglobin (HbA1c) levels at least 36 mmol/mol (5.4%) have been associated with an increased risk of diabetes mellitus in women with GDM from pregnancy up to five years postpartum (Claesson et al. (springer.com)
  • We wanted to investigate the associations of early and late pregnancy serum metabolic profiles to the prediabetes status at two years' postpartum in an at-risk cohort of women who had overweight before becoming pregnant. (springer.com)
  • During pregnancy, the metabolic processes in the liver undergo significant adaptations to accommodate the growing foetus. (randox.com)
  • Her research interests focus on fetal cardiovascular assessment as well as on cardiac dysfunction in patients with congenital heart disease and in fetuses undergoing surgical intervention, including in multiple gestation pregnancies complicated by twin-to-twin transfusion syndrome. (ucsf.edu)
  • Background In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. (whiterose.ac.uk)
  • Hypertensive disorders of pregnancy: observations on cardiovascular pathophysiology. (bham.ac.uk)
  • includes measurements of baseline renal function (eg, serum creatinine, blood urea nitrogen [BUN]), funduscopic examination, and directed cardiovascular evaluation (auscultation and sometimes ECG, echocardiography, or both). (msdmanuals.com)
  • To assess the association between circulating angiogenic and antiangiogenic factors in the second trimester and risk of preeclampsia in women with type 1 diabetes. (diabetesjournals.org)
  • Preeclampsia developed in 17% of pregnancies ( n = 94). (diabetesjournals.org)
  • These data suggest that angiogenic and antiangiogenic factors measured during the second trimester are predictive of preeclampsia in women with type 1 diabetes. (diabetesjournals.org)
  • Dr. Oduyebo is also involved with the US Zika Pregnancy Registry, and provides technical assistance to support state, tribal, local and territorial health departments collecting information about pregnancy and infant outcomes following laboratory evidence of confirmed or possible Zika virus infection during pregnancy. (cdc.gov)
  • Pregnancy, delivery, and the puerperium are associated with increased rates of iron deficiency and anemia, which correlates with worse maternal and fetal outcomes and places pregnant women at increased risk of obstetric hemorrhage. (karger.com)
  • To determine whether the midtrimester serum lipid profile, as expressed by fluorescence polarization (FP) values is decreased in patients who subsequently develop pregnancy-induced hypertension (PIH). (tau.ac.il)
  • We examined the relation between plasma PCB concentrations measured during pregnancy and autistic behaviours in a subset of children aged 3-4 years old in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a pregnancy and birth cohort of 546 mother-infant pairs from Canada (enrolled: 2008-2011). (mdpi.com)
  • We assessed the associations of maternal serum PFAS concentrations measured during pregnancy with maternal (n = 185) and cord (n = 256) sera thyroid stimulating hormone (TSH), total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), and free triiodothyronine (FT3) using two mixture modeling approaches (Bayesian kernel machine regression (BKMR) and quantile g-computation) and multivariable linear regression. (nih.gov)
  • Background Concentrations of critical metabolites, hormones, and nutritional elements change significantly throughout pregnancy. (nist.gov)
  • 1) Serum copper levels was significantly higher after pregnancy than before, calcium and iron levels decreased, but zinc levels did not change significantly. (nih.gov)
  • Preventing unintended pregnancy in HIV-positive women can significantly reduce maternal-to-child HIV transmission as well as improve the woman's overall health. (hindawi.com)
  • The accuracy of serum free T4 measurement by the indirect analog immunoassays is influenced by pregnancy and also varies significantly by manufacturer. (medscape.com)
  • CONCLUSIONS: Cigarette and sheesha smoking significantly affect first-trimester markers of Down syndrome (fetal NT, free beta-hCG and PAPP-A). Correction for this effect in women who smoke might improve the effectiveness of first-trimester screening for Down syndrome in these women. (who.int)
  • ABSTRACT To assess the effectiveness of intravaginal misoprostol for second trimester uterine evacuation, we studied 70 women with singleton pregnancies complicated by fetal malformation or dead fetuses. (who.int)
  • This study determined the accuracy of first-trimester serum human chorionic gonadotrophin (hCG) for estimating gestational age (GA). We included 273 584 singleton live births that had a first-trimester ultrasound and measured serum hCG at 4-12 weeks gestation in Ontario from 2012 to 2018. (bvsalud.org)
  • Technological advances in imaging modali- had singleton pregnancies that were com- ties to detect fetal viability and genetically plicated by either fetal malformation ( n abnormal fetuses have created a need for = 32) or missed abortion ( n = 38). (who.int)
  • POPULATION: Women with a singleton pregnancy who were either nonsmokers (n = 1736) or cigarette smokers (n = 420) or sheesha smokers (n = 181). (who.int)
  • These include parathormone (PTH), vitamin D, hepatic and renal function (for conversion of vitamin D to active metabolites), and serum phosphate and magnesium levels. (medscape.com)
  • Fetal assessment with ultrasound after the first trimester reveals free-floating loops of bowel with a "cauliflower-like" appearance in the setting of a normal umbilical cord insertion (Figure 2). (contemporaryobgyn.net)
  • Stored serum samples of normotensive patients who had undergone midtrimester biochemical screening for Down's syndrome were used in this case-control study Forty patients who subsequently developed PIH comprised the study group and were divided into subgroups with proteinuric PIH (P-PIH, n = 18) and those with nonproteinuric PIH (NP-PIH, n = 22. (tau.ac.il)
  • Sixty randomly selected patients who remained normotensive throughout pregnancy comprised the control. (tau.ac.il)
  • Midtrimester serum FP values may have some predictive value for the development of P and NP-PIH. (tau.ac.il)
  • A Random Forests classifier based on serum metabolites and clinical variables in early pregnancy displayed an acceptable predictive power for the prediabetes status at postpartum (AUROC 0.668). (springer.com)
  • Blight, L.F., Judd, S.J. and White, G.H. (1989) Relative diagnostic value of serum non-SHBG-bound testosterone, free androgen index and free testosterone in the assessment of mild to moderate hirsutism. (scirp.org)
  • Assessment of thyroid function during first- trimester pregnancy: what is the rational upper limit of serum TSH during the first trimester in Chinese pregnant women? (thyroid.org)
  • Serum copper, zinc, calcium and iron levels were measured at pre-pregnancy, 1st trimester (7w-12w), 2nd trimester (24w-28w) and 3rd trimester (35w-40w). (nih.gov)
  • Nausea and vomiting of pregnancy (NVP) is a common condition that affects as many as 70% of pregnant women. (nature.com)
  • The women had visual acuity testing and fundus photography before pregnancy, once in each trimester, and 4 months after birth. (diabetesjournals.org)
  • Pregnancy is a prominent risk factor for the development and progression of retinopathy in women with type 1 diabetes. (diabetesjournals.org)
  • Among 142 consecutive pregnancies of which 18 were repeated pregnancies, 124 pregnancies in women with type 1 diabetes were included from the outpatient clinic at Skejby Hospital, Aarhus, Denmark. (diabetesjournals.org)
  • The women were scheduled for ophthalmologic examination, including visual acuity testing and fundus photography, before pregnancy, once in each trimester, and 4 months after birth, according to the principles defined in the Early Treatment for Diabetic Retinopathy Study ( 6 ). (diabetesjournals.org)
  • Women with prediabetes identified before pregnancy should be considered at extremely high risk for developing gestational diabetes mellitus during pregnancy. (medscape.com)
  • Methods Serum pools from non-pregnant women and women in each trimester were bottled into four levels. (nist.gov)
  • I'd like to welcome you to today's COCA call, Updated Interim Zika Clinical Guidance for Pregnant Women in Data on Contraceptive Use to Decrease Zika-Affected Pregnancy. (cdc.gov)
  • The consensus is not to offer antiviral therapy to HCV-infected pregnant women because it is based on ribavirin (pregnancy category X) because of its embryocidal and teratogenic effects in animal species. (wjgnet.com)
  • Methods The Baby VIP (Baby's Vascular health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. (whiterose.ac.uk)
  • 15 ug/L) was detected in 79 (23%) women in early pregnancy. (whiterose.ac.uk)
  • Marijuana use was assessed during pregnancy from women who later brought their newborns for study. (scienceblog.com)
  • If measured in pregnant women, assay method-specific and trimester-specific pregnancy reference ranges should be applied. (medscape.com)
  • In most regions, including the United States, women who are planning pregnancy or currently pregnant should supplement their diet with a daily oral supplement that contains 150 μg of iodine in the form of potassium iodide. (medscape.com)
  • Euthyroid, but TPO or Tg antibody positive, pregnant women should have measurement of serum TSH concentration performed at time of pregnancy confirmation, and every 4 wk through mid-pregnancy. (medscape.com)
  • Evaluation of serum TSH concentration is recommended for all women seeking care for infertility. (medscape.com)
  • Levothyroxine treatment is recommended for infertile women with overt hypothyroidism who desire pregnancy. (medscape.com)
  • Evaluation of the immune phenotype of women with recurrent pregnancy loss. (bham.ac.uk)
  • To investigate if early and late pregnancy serum metabolomic profiles differ in women who develop prediabetes by two years postpartum compared to those who remain normoglycemic. (springer.com)
  • An NMR metabolomics platform was used to measure 228 serum metabolite variables from women with pre-pregnancy overweight in early and late pregnancy. (springer.com)
  • The CHES portion that I intern for is the initial phase of this larger study in which biological specimens are collected across each trimester of pregnancy from all consenting pregnant women who visit NYU clinics. (mmm.edu)
  • METHODS: Fetal nuchal translucency thickness (fetal NT), maternal serum free beta-human chorionic gonadotrophin (free beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) were measured at 11 weeks 0 days to 13 weeks 6 days of gestation in all women. (who.int)
  • Women were grouped according to smoking status, confirmed by maternal serum cotinine measurements, and analyte levels between groups were compared. (who.int)
  • Vitamin D deficiency is common among women during pregnancy. (bvsalud.org)
  • To provide a quality assurance material to underpin clinical health assays and calibration of secondary standards, Standard Reference Material (SRM) 1949, Frozen Human Prenatal Serum, was developed. (nist.gov)
  • Dr. Oduyebo is also a subject matter expert, and provides clinical consultation to healthcare providers and state, tribal, local and territorial health departments through the CDC Zika Pregnancy Hotline. (cdc.gov)
  • We discuss a patient, who presented to our high risk clinic, with a clinical history of solid pseudopapillary tumor of the pancreas, predating her pregnancy. (hindawi.com)
  • Similar associations were not detected for metabolites in late pregnancy. (springer.com)
  • In non-pregnant populations, certain distinct serum metabolites, such as the levels of branched-chain amino acids (BCAAs), as well as those of phenylalanine, glutamate and several lipids, have been associated with an elevated risk of type 2 diabetes (Long et al. (springer.com)
  • In children, hypocalcemia is defined as a total serum calcium concentration less than 2.1 mmol/L (8.5 mg/dL). (medscape.com)
  • In term infants, hypocalcemia is defined as total serum calcium concentration less than 2 mmol/L (8 mg/dL) or ionized fraction of less than 1.1 mmol/L (4.4 mg/dL). (medscape.com)
  • In preterm infants, hypocalcemia is defined as total serum calcium concentration less than 1.75 mmol/L (7 mg/dL) is defined as hypocalcemia in infants weighing less than 1500 g birthweight. (medscape.com)
  • In lieu of measuring free T4, total T4 measurement (with a pregnancy-adjusted reference range) is a highly reliable means of estimating hormone concentration during the last part of pregnancy. (medscape.com)
  • Lack of trace elements during pregnancy is detrimental to maternal and fetal health. (nih.gov)
  • The levels of angiogenic and anti-angiogenic molecule concentrations in pregnancy based disorders in the maternal and fetal circulation. (bham.ac.uk)
  • Posttraumatic stress symptoms following pregnancy complicated by hyperemesis gravidarum. (nature.com)
  • One of the 3rd trimester symptoms is back pain, and a sacroiliac Serola Sacroiliac SPD Belt can work wonders as it is designed to compress and support the sacroiliac joints. (inhealth.ie)
  • Unlike during pregnancy, elevated PTHrP and low estradiol result in temporary demineralization of maternal skeleton to meet the calcium needs of the breastfeeding infant. (medscape.com)
  • We measured serum testosterone, estradiol, dehydroepiandrosterone sulfate (DHEA-S), inhibin B, and sex hormone-binding globulin (SHBG) at age 8-13, and assessed Tanner stages for sexual maturation (breast, pubic hair development, and menarche status), at two time points (8-13, 14-18 years). (cdc.gov)
  • Many drugs and physiologic conditions affect the binding of thyroid hormones to serum proteins (see PRECAUTIONS, Drug Interactions and Drug-Laboratory Test Interactions). (nih.gov)
  • Previous studies have found associations between PFAS and thyroid hormones in maternal and cord sera, but the results are inconsistent. (nih.gov)
  • In addition, we recommend laparoscopy for the investigation of acute abdomen with unclear diagnosis in the first trimester of pregnancy. (medsci.org)
  • A positive screen, advanced maternal age, family history, previous history of a pregnancy with a chromosomal abnormality, and other high-risk pregnancy were associated with the greatest odds of electing laboratory-delivered genetic counseling. (preprints.org)
  • All of these methods are highly effective at preventing pregnancy, with the typical-use failure rate ranging from 0.1% (LNG-IUS) to 8% (POPs, COCs, ring) [ 3 ]. (hindawi.com)
  • There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV. (whiterose.ac.uk)
  • OBJECTIVE: To investigate the influence of cigarette or sheesha smoking on first-trimester markers of Down syndrome. (who.int)
  • The underlying mechanism(s) relating smoking to the changes in first-trimester markers require further studies. (who.int)
  • Gestational diabetes mellitus (GDM) is defined as glucose intolerance of variable degree with onset or first recognition during pregnancy. (medscape.com)
  • From the onset of presenting with her pregnancy, her care was managed with input from maternal fetal medicine, endocrinology, and general surgery. (hindawi.com)
  • The US Preventive Services Task Force (USPSTF) recommends screening for gestational diabetes mellitus after 24 weeks of pregnancy. (medscape.com)
  • The test is usually done between 15 and 20 weeks of pregnancy. (medlineplus.gov)
  • The ionized calcium level varies based on the level of serum albumin, blood pH, serum phosphate, magnesium, and bicarbonate levels, the administration of transfused blood containing citrate and free fatty acid content in total parenteral nutrition. (medscape.com)
  • Gestational diabetes mellitus accounts for 90% of cases of diabetes mellitus in pregnancy, while preexisting type 2 diabetes accounts for 8% of such cases. (medscape.com)
  • Maternal serum perfluoroalkyl substance mixtures and thyroid hormone concentrations in maternal and cord sera: The HOME Study. (nih.gov)
  • Zika virus (ZIKV) infection during pregnancy can cause severe brain and eye malformations and is associated with neurodevelopmental abnormalities in affected infants ( 1 ). (cdc.gov)
  • In addition, ZIKV detection might be transient during pregnancy, and absence of a positive test does not indicate lack of infection ( 11 ). (cdc.gov)
  • The World Health Organization (WHO) reports that approximately 90% of children living with HIV acquired the infection perinatally-during pregnancy, birth, or breastfeeding [ 1 ]. (hindawi.com)
  • pregnancy termination with autopsy. (bvsalud.org)
  • The research on and implementation of fetal surgery for prenatally diagnosed myelomeningocele has added a significant treatment option to the previous options (postnatal repair or pregnancy termination), but this new option carries an increased risk of maternal morbidity. (bvsalud.org)
  • Elevated serum concentrations of small HDL particles in early pregnancy associate with prediabetes and insulin resistance at two years postpartum. (springer.com)
  • it was reported that fasting serum levels of BCAAs valine, leucine and isoleucine, acylcarnitine C2 and 3-hydroxybutyrate measured at 28 weeks of gestation were associated with prediabetes or type 2 diabetes 10 to 14 years later. (springer.com)
  • MAIN OUTCOME MEASURES: Fetal NT, maternal serum free beta-hCG, PAPP-A and cotinine measurements. (who.int)
  • Newborn serum beta hCG concentrations are approximately 1/400th of the corresponding maternal serum concentrations, resulting in neonate beta hCG levels of 10-50 IU/L at birth. (medscape.com)
  • Trace elements is closely associated with fetal growth and development during pregnancy. (nih.gov)
  • Though extensive prospective cohort studies are required, miR-223 and miR-23a should be considered the most promising to develop a successful NIPT tool because they were found to be upregulated earliest, during the first trimester. (preprints.org)
  • She had normal weight gain during her pregnancy and had normal laboratory values, including fasting glucose levels ranging from 72 to 91 mg/dL and a normal 1-hour glucose tolerance test. (hindawi.com)
  • We examined whether a simple measurement of the IGF system (serum total IGF-I) correlated with progression of diabetic retinopathy in pregnancy in type 1 diabetes. (diabetesjournals.org)
  • Updated diagnostic criteria for partial and complete hydatidiform moles in early pregnancy. (jabfm.org)
  • As such, they should receive early (first-trimester) diabetic screening. (medscape.com)
  • If you are early in your pregnancy, you may need avoid urinating (peeing) before the test to make sure that you have a full bladder. (medlineplus.gov)
  • She is also studying novel ways to use machine learning to improve prenatal detection of heart disease as early as the first trimester. (ucsf.edu)
  • Objective This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV). (whiterose.ac.uk)
  • This study is the first to detect central nervous system effects of marijuana in human newborns and it identifies a vulnerable gestational period for the impact of marijuana on fetal brain development that is earlier than anticipated - as early as the end of the first trimester. (scienceblog.com)
  • Dr. Oduyebo is an OB-GYN, and works on the Pregnancy & Birth Defects Task Force for the CDC's Zika Response. (cdc.gov)
  • Dr. Berry-Bibee is a practicing OB-GYN and a guest researcher at the CDC, currently serving on CDC's Zika Virus Emergency Response on the Pregnancy and Birth Defects Task Force Contraception Access Team. (cdc.gov)