• We aimed to identify novel prognostic biomarkers to help predict the prognosis of Asian GC patients. (e-crt.org)
  • Therefore, there is an urgent need to explore novel prognostic biomarkers to increase the accuracy of prognosis prediction and seize therapeutic opportunities for GC patients. (e-crt.org)
  • Class III β-tubulin (TUBB3), microtubule-associated protein tau (MAPT) and breast cancer 1 early onset (BRCA1) are the most widely studied predictive biomarkers for taxane treatment ( 8 - 10 ). (iiarjournals.org)
  • The present study established a docetaxel-resistant gastric cancer cell line and evaluated the alteration of mRNA expression levels globally by microarray, in an attempt to obtain novel predictive biomarkers for docetaxel chemotherapy. (iiarjournals.org)
  • Dickkopf1 (DKK1) and cytoskeleton-associated protein 4 (CKAP4) have been extensively studied as biomarkers in cancer patients. (bvsalud.org)
  • And the comparison between postoperative ePD-L1 and conventional serum biomarkers (carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9) and CA72-4) in prognostic of GC patients was made. (bmj.com)
  • Results The prognostic value of postoperative ePD-L1 is superior to that of preoperative ePD-L1 on GC patients after resection, and also superior to that of conventional serum biomarkers (CEA, CA19-9 and CA72-4). (bmj.com)
  • Therefore the identification of new biomarkers and treatments for highly invasive/metastatic prostate cancers is of a high priority. (almacgroup.com)
  • no validated serum biomarkers currently exist. (lu.se)
  • The serum biomarkers proposed to date have not yet demon- pendent test cohort (prevalidation). (lu.se)
  • The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
  • A nomogram containing clinical characteristics and the prognostic model was established to predict the prognosis of Asian GC patients. (e-crt.org)
  • However, most patients with GC will eventually metastasize or relapse and the prognosis is still unsatisfactory [ 3 ]. (e-crt.org)
  • Data regarding demographics, clinical features, treatment and prognosis of IgG4-RD patients complicating malignancies were collected and compared to those of age- and sex-matched controls. (nature.com)
  • It is also important to know the risk factors and prognosis for IgG4-RD patients harboring malignancies. (nature.com)
  • Evaluation of the epidemiological and prognosis significance of ESR2 rs3020450 polymorphism in ovarian cancer. (cancerindex.org)
  • To investigate the correlation between the polymorphism of estrogen receptor β gene (ESR2) rs3020450 and cancer susceptibility, and explore the epidemiological significance and the effect of ESR2 expression levels on the prognosis of ovarian cancer. (cancerindex.org)
  • OBJECTIVE: Gastric cancer is diagnosed at an advanced stage in most patients, and the prognosis is poor. (bvsalud.org)
  • however, the prognosis and treatment substantially differ among patients who present with (1) both primary tumors (BC and gastric) and (2) primary BC and metastases to stomach. (biomedcentral.com)
  • While IGC follows a stepwise neoplastic progression arising from a premalignant transformation of the normal gastric mucosa, DGC manifests without a defined premalignant stage and is associated with a very aggressive behavior and a poor prognosis [ 2 ]. (oncotarget.com)
  • Perioperative plasma extracellular vesicular programmed cell death ligand-1 (ePD-L1) has been demonstrated as a potential prognosis biomarker in many types of cancers. (bmj.com)
  • 3 Males and patients with later age of onset tend to have more severe disease and poorer prognosis. (lww.com)
  • While certain features (eg, positive resection margins and lymph node positivity) portend poorer prognosis, patients with ampullary cancer generally have better overall survival than patients with pancreatic cancer. (medscape.com)
  • The first step involves achievement of cure, because the risk of pelvic recurrence is high in patients with rectal cancer, and locally recurrent rectal cancer has a poor prognosis. (medscape.com)
  • The risk of distant recurrence in breast cancer patients is difficult to prognostic indices, such as the Nottingham Prognostic Index (6, 7), assess with current clinical and histopathological parameters, and have proven valuable in identifying patients with poor prognosis. (lu.se)
  • Among the many challenges in cancer diagnosis is the early distinction between metastatic cancer and a secondary tumor. (biomedcentral.com)
  • An example of this challenge is distinguishing gastric metastases originating from breast cancer from a gastric primary tumor. (biomedcentral.com)
  • The Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK) criteria were followed for patient selection, assay performance, and data analysis throughout the study. (biomedcentral.com)
  • Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor and is ranked the eighth leading cause of cancer worldwide. (nature.com)
  • In this context, there is a need for new predictive markers, beyond the tumor stage, to select what patients will benefit from an adjuvant treatment and to better tailor treatment schemes and schedules. (frontiersin.org)
  • The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • Previous studies have identified that UBE3A exhibits abnormal expression in numerous tumor cells, including prostate, cervical and breast cancer ( 6 , 7 ). (spandidos-publications.com)
  • In this respect, in contrast to predictors based for each serum protein was determined by comparing the samples upon tumor characteristics at the time of surgery, serum is a par- collected at the primary operation and then 3-6 mo later. (lu.se)
  • before resection of the primary tumor and then postoperatively every 6-12 mo, resulting in three to five samples per patient. (lu.se)
  • Due to the complex biological and molecular mechanisms underlying GC, traditional predict methods relying on clinical data such as serum examination, imaging examination, and pathologic information are limited. (e-crt.org)
  • Patients and methods Seven H. pylori -naïve, 21 patients with H. pylori -associated gastritis and seven with autoimmune gastritis were enrolled. (thieme-connect.com)
  • PATIENTS AND METHODS: Serum DKK1 and CKAP4 levels in 58 patients with gastric cancer and 41 healthy controls were examined using an ELISA kit in this prospective study. (bvsalud.org)
  • Subsequently, we carried out feature selection to identify the most relevant DEGs using LASSO and Penalized-SVM methods. (bvsalud.org)
  • Targeted proteomics analysis of the prioritized proteins in saliva, combined with machine-learning methods, highlights a peptide-based signature as the most powerful predictor to distinguish patients with and without lymph node metastasis. (nature.com)
  • Methods We evaluated the prognostic value of preoperative, postoperative and change in plasma ePD-L1, as well as plasma soluble PD-L1, in short-term survival of GC patients after surgery. (bmj.com)
  • Professor Black is a member of the Centre for Translational Cancer Research, and his research focuses on the development of methods for the analysis of genomic data, with a strong emphasis on cancer and other human diseases. (otago.ac.nz)
  • METHODS: Male colorectal cancer (CRC) screenees were recruited to undergo upper endoscopy, identifying newly diagnosed cases of Barrett's esophagus. (who.int)
  • Patients and Methods: A prospective evaluation of all boys undergoing operation for undescended testes at the Lagos University Teaching Hospital, Idi-Araba, Lagos, over a 12 month period was performed. (bvsalud.org)
  • The development dataset comprised 1186 patients from the Surveillance, Epidemiology, and End Results Program who were diagnosed with metastatic gastric adenocarcinoma in 2004-2011, while the validation dataset included 407 patients diagnosed in 2012-2015. (biomedcentral.com)
  • Gastric adenocarcinomas can be further categorized into an intestinal type and a diffuse type. (oncolink.org)
  • However, a substantial proportion of gastric adenocarcinomas are advanced or metastatic disease at the time of diagnosis. (biomedcentral.com)
  • We performed immunohistochemistry analysis of HNF4A, ER, PR and GCDFP-15 in 126 patients divided into three cohorts: primary breast cancer, primary gastric cancer and both types of tumors. (biomedcentral.com)
  • In the past, the general policy was that resection was selected for patients with resectable tumors, and transplantation was performed in patients who were not candidates for resection but were within in the scope of transplantation candidacy. (hormonessignaling.com)
  • Recently, however, it was proposed to also conduct selleck screening library transplantation in patients with resectable tumors as long as they are within the scope of transplantation candidacy. (hormonessignaling.com)
  • Overexpression of IGF-1 in serum and tissue alters the growth of normal cells and causes uncontrolled proliferation, inhibits differentiation and reduces apoptosis, resulting in the incidence and development of malignant tumors ( 10 ). (spandidos-publications.com)
  • A randomized clinical trial REGATTA which aimed to evaluate whether the addition of gastrectomy to chemotherapy improves survival for advanced gastric cancer patients with a single non-curable factor was terminated ahead of time due to the negative results from the interim analysis [ 2 ]. (biomedcentral.com)
  • Surgical resection remains the most effective treatment for early and some advanced forms of GC, and over the last decade, chemotherapy has been considered a standard therapeutic regimen for patients with advanced or metastatic GC [ 2 ]. (e-crt.org)
  • Chemotherapy is an indispensable element of treatment for gastric cancer patients, and fluoropyrimidines, platinum-containing agents, taxanes, alone or in combinations, are the most effective and commonly used chemotherapy regimens ( 1 ). (iiarjournals.org)
  • Personalised chemotherapy based on pharmacogenetics and pharmacogenomics has shown a promising predictive role to achieve superior outcomes in cancer treatment ( 4 - 7 ). (iiarjournals.org)
  • Introduction In patients with non-small cell lung cancer, surgical treatment with postoperative adjuvant chemotherapy is performed. (bmj.com)
  • 3 Although there have been no randomised controlled trials to compare surgery with radiation therapy or chemotherapy, observational studies have suggested that surgery is the most curative treatment for lung cancer. (bmj.com)
  • There is no standard first-line chemotherapy for advanced gastric cancer with severe peritoneal metastasis. (biomedcentral.com)
  • The standard first-line chemotherapy for patients with erb-b2 receptor tyrosine kinase 2 (ERBB2, also known as HER2)-negative advanced GC (AGC) in Japan is a combination therapy with fluoropyrimidine plus platinum (e.g. (biomedcentral.com)
  • Based on such backgrounds, no standard first-line chemotherapy has been established and an unmet need exists for prolongation the survival time in AGC patients with SPM. (biomedcentral.com)
  • On the other hand, adaptation of patients to chemotherapy should be carefully judged before treatment initiation because an aggressive disease course can immediately change the condition of patients into a non-adaptive state to chemotherapy. (biomedcentral.com)
  • By enabling accurate staging, diagnostic laparoscopy permits patient selection for curative resection or neoadjuvant chemotherapy while avoiding nontherapeutic laparotomy, which is associated with a delay in the initiation of chemotherapy. (medscape.com)
  • For more than two decades 5-FU-based adjuvant chemotherapy has been the standard of care for patients with stage III and selected stage II CRC. (frontiersin.org)
  • pediatric bl patients received standardized chemotherapy and supportive care. (liverpool.ac.uk)
  • The novel identification of chemotherapy-mediated selection for an angiogenic phenotype in EOC, through upregulation of the PDGFR-VEGF-A signalling pathway. (almacgroup.com)
  • Volatile aldehydes are enriched in esophageal adenocarcinoma (EAC) patients' breath and could improve early diagnosis, however the mechanisms of their production are unknown. (nature.com)
  • For esophageal squamous cancers, inactivating variants in ALDH2 convey predisposing risk 10 . (nature.com)
  • There is general agreement among the guidelines that patients with chronic GERD and multiple other risk factors associated with esophageal adenocarcinoma should undergo upper gastrointestinal endoscopy to screen for Barrett esophagus or esophageal adenocarcinoma. (medscape.com)
  • The 2019 ASGE guideline found insufficient evidence on the effectiveness of screening for Barrett esophagus, but suggested that if screening endoscopy is performed, it should be done in an at-risk population, defined as individuals with a family history of esophageal adenocarcinoma or Barrett esophagus (high risk) or patients with GERD plus at least 1 other risk factor (moderate risk). (medscape.com)
  • Instead, ACG guidelines advise that "it is reasonable to cease endoscopic surveillance in patients with an estimated survival of less than 5 years and those who are no longer fit for repeated endoscopy or cannot tolerate endoscopic, surgical, or oncological intervention for esophageal neoplasia. (medscape.com)
  • Serum levels of both proteins in the patients with gastric cancer were measured preoperatively, 10 and 30 days after surgery. (bvsalud.org)
  • This risk assessment was not dependent on the type of adju- decoding patterns of immunoregulatory serum proteins could re- vant therapy received by the patients. (lu.se)
  • In 2023, it is estimated that 26,500 Americans will be diagnosed with gastric cancer and 11,130 will die of it. (oncolink.org)
  • Review the evidence on the benefits and harms of screening for gastric cancer using barium-meal photofluorography, gastric endoscopy, or serum pepsinogen in this expert-reviewed summary. (oncolink.org)
  • Tytgat GN, Mathus-Vliegen EM, Offerhaus J: Value of endoscopy in the surveillance of high-risk groups for gastrointestinal cancer. (oncolink.org)
  • New diagnostic adjuncts are needed to triage patients with non-specific symptoms to receive an endoscopy, especially as the EAC incidence in Western countries has risen sharply in recent decades and is not projected to fall 4 . (nature.com)
  • As a conditional recommendation, the ASGE suggests performing surveillance endoscopy in patients with nondysplastic Barrett esophagus. (medscape.com)
  • Screening endoscopy is not recommended for women of any age or men younger than 50, regardless of other risk factors, because of the low incidence of cancer in these populations. (medscape.com)
  • The onset of RCC is hidden, and 16% of patients have metastasized at first diagnosis with a 5-year survival of 9-12%[ 3 ]. (medsci.org)
  • Diagnostic laparoscopy is useful for making a definitive clinical diagnosis whenever there is a diagnostic dilemma even after routine diagnostic workup, including patients with nonspecific abdominal pain, hemodynamically stable patients who have sustained blunt or penetrating trauma with suspected intra-abdominal injuries, and critically ill intensive care unit (ICU) patients with suspected intra-abdominal sepsis or pathologies. (medscape.com)
  • Unfortunately, these approaches were often associated with prolonged hospital stays, higher numbers of radiologic imaging studies and laparotomies with negative findings, and patient dissatisfaction if the diagnosis could not be established. (medscape.com)
  • Regarding the utility of exploratory laparoscopy for patients with NSAP, a meta-analysis of four randomized control trials (N = 811) comparing exploratory laparoscopy with active observation concluded that early diagnostic laparoscopy was associated with a decreased number of patients discharged without a final diagnosis. (medscape.com)
  • The accurate diagnosis of primary gastric cancer compared to gastric metastasis from BC can be difficult. (biomedcentral.com)
  • The use of serum prostate-specific antigen (PSA) levels has been recognised as a huge step forward in the diagnosis and treatment of prostate cancer, however since its implementation as a biomarker it has become apparent that the numbers of deaths from prostate cancer has only decreased slightly. (almacgroup.com)
  • In Sweden, there has been a steady prostate-specific antigen (PSA) velocity for the diagnosis of pros- decrease in age-standardized breast cancer mortality in women up tate cancer (15). (lu.se)
  • Many patients are not candidates given the advanced stage of their cancer at diagnosis or their degree of liver disease and, ideally, could be cured by liver transplantation . (medscape.com)
  • Patients with advanced gastric cancer and severe peritoneal metastasis were included if they had massive ascites and/or inadequate oral intake requiring intravenous nutritional support. (biomedcentral.com)
  • Combination therapy with fluoropyrimidine and platinum might be more effective than monotherapy with fluoropyrimidine and was tolerable for patients with advanced gastric cancer and severe peritoneal metastasis. (biomedcentral.com)
  • Colorectal cancer (CRC) liver metastasis accounts for the majority of fatalities associated with CRC. (bvsalud.org)
  • Early detection of metastasis is crucial for improving patient outcomes but can be delayed due to a lack of symptoms. (bvsalud.org)
  • The gene expression profile of CRC patients with liver metastasis was obtained using the GSE41568 dataset, and the differentially expressed genes between primary and metastatic samples were screened. (bvsalud.org)
  • HNF4A alone could be a gold standard marker for distinguishing primary gastric cancer from breast metastasis, thus validating its potential clinical use, especially in populations with high genetic diversity. (biomedcentral.com)
  • This predict the likelihood of a later recurrence, i.e., an indicator that unique longitudinal sample material was collected from each pa- allows risk assessment for breast cancer metastasis, would be tient between 0 and 36 mo after the primary operation. (lu.se)
  • Despite the progress of available therapeutic agents, significant challenges remain regarding patient selection and optimal therapeutic combinations. (medsci.org)
  • This may provide a therapeutic rationale for immune-checkpoint targeted therapies in the context of DNA damage response deficiency in cancer. (almacgroup.com)
  • In Western countries, general resection is applicable only to Child-Pugh class A patients (only non-cirrhosis patients at some institutions). (hormonessignaling.com)
  • Conclusions The level of plasma postoperative ePD-L1 could be considered as a candidate prognostic biomarker of GC patients after resection. (bmj.com)
  • Surgical resection with pancreaticoduodenectomy (the Whipple procedure) remains the gold standard for treatment, although local excision is an option for patients who may be unable to tolerate this. (medscape.com)
  • Resection may benefit certain patients, albeit mostly transiently. (medscape.com)
  • Adenocarcinoma accounts for the majority of gastric cancer diagnoses, and patients with gastric adenocarcinoma often experience relatively short survival times. (biomedcentral.com)
  • Participants were also matched against the National Registry of Diseases Office for missed diagnoses of early gastric neoplasia (EGN). (bmj.com)
  • Based on fair evidence, screening with barium-meal photofluorography or serum pepsinogen would not result in a decrease in mortality from gastric cancer in areas with relatively low incidence of the disease, such as the United States. (oncolink.org)
  • We sought to describe the incidence and clinical characteristics of malignancies in patients with IgG4-RD. Based on these results, significant factors were evaluated to determine whether they were related to malignancy. (nature.com)
  • Objective To investigate the incidence of gastric cancer (GC) attributed to gastric intestinal metaplasia (IM), and validate the Operative Link on Gastric Intestinal Metaplasia (OLGIM) for targeted endoscopic surveillance in regions with low-intermediate incidence of GC. (bmj.com)
  • The age-adjusted EGN incidence rates for patients with and without IM were 133.9 and 12.5 per 100 000 person-years. (bmj.com)
  • The incidence and epidemiology, etiology, pathogenesis, and screening recommendations are common to both colon cancer and rectal cancer. (medscape.com)
  • Results: Only CXCR4 mRNA levels in gastric cancer tissues were correlated with docetaxel sensitivity (R 2 =0.23, p=0.019) and significantly higher in resistant specimens (p=0.038). (iiarjournals.org)
  • Increased expression of circSHKBP1(hsa_circ_0000936) was revealed in GC tissues and serum and was related to advanced TNM stage and poor survival. (biomedcentral.com)
  • Kaplan Meier plotters were used to evaluate overall survival (OS) and progression-free survival (PFS) in ovarian cancer patients and GEPIA for the differential expression of ESR2 levels in ovarian cancer and adjacent normal tissues. (cancerindex.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • In gastric cancer, the efficacy of docetaxel combined with cisplatin/fluorouracil remains unsatisfactory, with a clinical response rate of 37%, and some patients suffer form adverse effects without any benefit ( 3 ). (iiarjournals.org)
  • Ethics and dissemination The study protocol was approved by the Clinical Research Review Board of Saitama Medical University in September 2019 (No. 192002) and will be approved by each institutional review board of all participating institutions before patient enrolment. (bmj.com)
  • 4 5 However, surgery alone may not be a sufficient treatment because an observational study of 11 663 surgically treated patients with NSCLC showed that the 5-year overall survival (OS) rate in all patients was 69.6%, while the rates in patients with clinical stage IA, IB, IIA and IIB were 82.0%, 66.1%, 54.5% and 46.1%, respectively. (bmj.com)
  • In addition, the recurrence of symptoms that require intensive treatment is often encountered in clinical practice and poses a considerable concern for physicians and patients. (springer.com)
  • Therefore, defining biological signatures that allow assessing the prognostic outcomes for OSCC patients would be of great clinical significance. (nature.com)
  • Histopathological-based models may be used to stratify patients into low- and high-risk classes 9 and further identify patients at risk of aggressive early-stage OSCC, thus contributing to disease predictability in terms of clinical progression and treatment outcomes. (nature.com)
  • Find cutting edge cancer clinical trials near you using the new Victorian Cancer Trials Link. (cancervic.org.au)
  • There are clinical challenges related to adjuvant treatment in colorectal cancer (CRC) and novel molecular markers are needed for better risk stratification of patients. (frontiersin.org)
  • The integration of IFNG -rs1861494 in our previous clinical genetic multiparametric score of DFS improved the patients' risk stratification (Log-rank P = 0.0026 in the pooled population). (frontiersin.org)
  • Impact of clinical data veracity on cancer genomic research. (otago.ac.nz)
  • This clinical and pre-clinical data supports the use of anti-angiogenic agents in the first and second line setting in patients with innate and acquired resistance to platinum therapy, respectively. (almacgroup.com)
  • Conse- demonstrated that this protein signature provided an added value quently, using minute amounts of nonfractionated serum (14) and compared with conventional clinical parameters. (lu.se)
  • Current study aimed to develop and validate prognostic nomograms for patients with metastatic gastric adenocarcinoma treated with palliative gastrectomy. (biomedcentral.com)
  • Validation of the prognostic model was conducted using The Cancer Genome Atlas (TCGA) database. (e-crt.org)
  • The four-gene-related prognostic model and the nomogram based on it are reliable tools for predicting the overall survival of Asian GC patients. (e-crt.org)
  • 11 genes were commonly selected by LASSO and P-SVM algorithms, among which seven had prognostic value in colorectal cancer. (bvsalud.org)
  • Conclusions: miR-22 is associated with the survival outcome of leukemia patients suggesting that miR-22 may be a promising prognostic biomarker for this patient population, and the expression level of miR-22 in ALL patients down-regulated. (bvsalud.org)
  • Thus, the identification of complementary biological signatures that assist in the prognostic prediction of patients with OSCC is needed. (nature.com)
  • Background The satisfactory prognostic indicator of gastric cancer (GC) patients after surgery is still lacking. (bmj.com)
  • The levels of postoperative ePD-L1 and ePD-L1 change are independent prognostic factors for overall survival and recurrence free survival of GC patients. (bmj.com)
  • The risk of developing distant strated enough prognostic accuracy in breast cancer (10). (lu.se)
  • For the first time, we evaluated by digital PCR the expression of CDH1 and CDH1a transcripts in cancer and normal tissue samples from 32 patients with intestinal-type gastric cancer. (oncotarget.com)
  • On the whole, the decrease of CDH1 transcript, corresponding to the canonical protein, and the presence of CDH1a , corresponding to an alternative isoform, are likely to perturb E-cadherin-mediated signaling and cell-cell adhesion, thus contributing to intestinal-type gastric carcinogenesis. (oncotarget.com)
  • It was found that the expression of the MMP3 gene decreases in stage IV of colorectal cancer compared to other stages (P value (bvsalud.org)
  • Giles, G. G. Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype . (cancervic.org.au)
  • colorectal cancer occurs in the colon or rectum. (medscape.com)
  • A multidisciplinary approach that includes colorectal surgery, medical oncology, and radiation oncology is required for optimal treatment of patients with rectal cancer. (medscape.com)
  • Human gastric cancer cell lines BGC-823 and SGC-7901, oesophageal cancer cell line CaEs-17, hepatocellular carcinoma cell lines SMMC-7721, QGY-7701 and HepG2, pancreatic cancer cell line Panc-1 and colon cancer cell lines LoVo and Ls174T were obtained from the Shanghai Institute of Cell Biology (Shanghai, China). (iiarjournals.org)
  • Renal cell carcinoma is one of the most common cancers in the urinary system, causing over 140,000 deaths worldwide each year[ 1 ]. (medsci.org)
  • Darmstadt, Germany and New York, US, May 14, 2019 - Merck KGaA, Darmstadt, Germany, which operates its biopharmaceutical business as EMD Serono in the US and Canada, and Pfizer Inc. (NYSE: PFE) today announced that the US Food and Drug Administration (FDA) has approved BAVENCIO® (avelumab) in combination with INLYTA® (axitinib) for the first-line treatment of patients with advanced renal cell carcinoma (RCC). (pfizer.com)
  • epstein-barr virus (ebv) is a human γ-herpesvirus associated with cancer, including burkitt lymphoma, nasopharyngeal, and gastric carcinoma. (liverpool.ac.uk)
  • whole-body (18)f-fdg pet/ct for m staging in the patient with newly diagnosed nasopharyngeal carcinoma: who needs? (liverpool.ac.uk)
  • although whole-body fluorine-18 fluorodeoxyglucose ((18)f-fdg) positron emission tomography (pet)/computed tomography (ct) ((18)f-fdg pet/ct) is commonly used for m staging of newly diagnosed nasopharyngeal carcinoma (npc), some patients may not benefit from this procedure. (liverpool.ac.uk)
  • Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. (medscape.com)
  • In this study, we investigate the effects of the perioperative administration of flurbiprofen axetil on postoperative recurrence in patients with non-small cell lung cancer. (bmj.com)
  • This is the first study to evaluate the effect of the perioperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) on postoperative recurrence in non-small cell lung cancer. (bmj.com)
  • Although the survival rates of patients with relapsing polychondritis (RP) have increased remarkably, the high recurrence rate remains a significant concern for physicians and patients. (springer.com)
  • Patients were classified into recurrence and non-recurrence groups. (springer.com)
  • The median time before the initial recurrence was significantly longer in patients who received combination therapy with prednisolone and immunosuppressants or biologics (400 vs. 70 days, p =0.0015). (springer.com)
  • Tracheal involvement, pre-treatment C-reactive protein level, and initial prednisolone monotherapy were risk factors for recurrence in patients with RP. (springer.com)
  • Thus, the present study aimed to retrospectively analyse the records of 34 patients with RP to determine the risk factors associated with RP recurrence. (springer.com)
  • Even though there has been a progress achieved in the development of more effective therapies against cancer, over the past years, recurrence of tumour growth and metastatic spread in the long-term is a common event. (oaepublish.com)
  • SEE NAMCS PATIENT DATASET NAMES FOR DSN ABSTRACT General Information This material provides documentation for users of the Micro-Data tapes of the National Ambulatory Medical Care Survey (NAMCS) conducted by the National Center for Health Statistics. (cdc.gov)
  • Therefore, the aim of this study was to evaluate the capacity of a concise panel of known BC markers together with GCDFP-15 and HNF4A to accurately distinguish primary gastric adenocarcinoma from metastases to stomach in the Brazilian population. (biomedcentral.com)
  • Evidence from case-control and cohort studies from East Asia are generally consistent with a substantial reduction in gastric cancer mortality associated with endoscopic screening. (oncolink.org)
  • Gastric cancer (GC) has substantial biological differences between Asian and non-Asian populations, which makes it difficult to have a unified predictive measure for all people. (e-crt.org)
  • A previous systematic review and meta-analysis of 14 studies comprising 3003 patients with incurable advanced gastric cancer revealed that palliative gastrectomy significantly improved overall survival [ 9 ]. (biomedcentral.com)
  • Results Fifteen of 21 (71 %) H. pylori -associated gastritis patients exhibited medium-to-large atrophic mucosa at the corpus lesser curvature. (thieme-connect.com)
  • For stomach (gastric) cancer, there is no standard or routine screening test for the general U.S. population. (oncolink.org)
  • One in particular, CDH1a , proved to be expressed in gastric cancer cell lines, while being absent in the normal stomach. (oncotarget.com)
  • [ 2 ] Nevertheless, extended survival was seen in a few patients and included a 3-year-old girl who received a multivisceral transplant (stomach, duodenum, pancreas, small bowel, colon and liver). (medscape.com)
  • Most patients with Hodgkin lymphoma present with painless cervical adenopathy. (msdmanuals.com)
  • Histoculture drug response assay (HDRA) was used to examine docetaxel sensitivity, while qRT-PCR was used to measure the mRNA levels of the genes in 25 surgically dissected gastric cancer specimens. (iiarjournals.org)
  • The patients were subdivided into groups based on pathological TNM staging and histological grades. (bvsalud.org)
  • Gastric cancer (GC) is a heterogeneous disease, with two major histological subtypes, "intestinal" (IGC) and "diffuse" (DGC) [ 1 ], that vary in terms of both clinic-pathological profiles and molecular pathogenesis [ 2 ]. (oncotarget.com)
  • Accuracy of screening for gastric cancer using serum pepsinogen concentrations. (oncolink.org)
  • In the stratified analysis by cancer types, significantly decreased risk was found in ovarian cancer (AG vs GG: OR = 0.73, 95%CI: 0.53-0.97, P = 0.03). (cancerindex.org)
  • Firstly, the overexpression of miRNA‑375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • However, biological functions and the underlying molecular mechanism of circRNAs in gastric cancer (GC) remain obscure. (biomedcentral.com)
  • Based on meta-analysis the association between ESR2 rs3020450 polymorphism and cancer susceptibility was estimated and a case-control design was used to verify this result in ovarian cancer. (cancerindex.org)
  • Based on meta-analysis and case-control pooled results, ARP and PARP were evaluated respectively in allele (21.95% and7.97%), heterozygote (36.99% and 12.11%) and dominant model (36.84% and 12.97%) of rs3020450 polymorphism in ovarian cancer. (cancerindex.org)
  • It results in the arrested growth of tumour cells at G 2 -M phase in a variety of tumours, including non-small cell lung cancer (NSCLC), hormone-refractory prostate cancer, advanced gastric cancer and breast cancer ( 2 ). (iiarjournals.org)
  • Breast cancer (BC) represents the major cause of cancer-related death among women. (biomedcentral.com)
  • A a predisposing variant for early onset breast cancer? (cancervic.org.au)
  • Johnatty SE, Spurdle AB, Beesley J, Chen X, Hopper JL, Duffy DL, Chenevix-Trench G. Progesterone receptor polymorphisms and risk of breast cancer: Results from two Australian breast cancer studies . (cancervic.org.au)
  • Is MSH2 a breast cancer susceptibility gene? (cancervic.org.au)
  • However, a simple way to screened 240 sera from 64 patients with primary breast cancer. (lu.se)
  • The samples were collected from breast cancer patients rent procedures. (lu.se)
  • Survival from breast cancer has improved during the past dec- markerserumlevelshavebeenusedpreviously,e.g.,incalculating ades in the Western world. (lu.se)
  • Advanced cancer is still considered an incurable disease because of its metastatic spread to distal organs and progressive gain of chemoresistance. (oaepublish.com)
  • This retrospective study involved patients at six Japanese academic hospitals between 2010 and 2016. (biomedcentral.com)
  • Nanotechnology-based drug delivery systems are able to incorporate drugs or gene products with active anti-cancer activity but poor solubility, low bioavailability, or inadequate toxicological profile. (oaepublish.com)
  • No impact of repeated endoscopic screens on gastric cancer mortality in a prospectively followed Chinese population at high risk. (oncolink.org)
  • We prospectively analyzed the IgG4-RD patients recruited in Peking Union Medical College Hospital from January 2011 to August 2018 and identified patients diagnosed with IgG4-RD complicating malignancies. (nature.com)
  • We consecutively collected data on patients with IgG4-RD and malignancies who were prospectively enrolled in the IgG4-RD cohort in PUMCH from January 2011 and June 2018. (nature.com)
  • In Europe, 4.2 million new cases were diagnosed and almost 2 million deaths were caused by cancer in 2018 [ 1 ] . (oaepublish.com)
  • Gastric cancer is the fourth most common cause of cancer mortality in the world. (oncolink.org)
  • Complement component 1 Q subcomponent binding protein (C1QBP) plays a vital role in the progression and metabolism of cancer. (medsci.org)
  • 17% of the patients show greater genomic instability and present with targetable immune biology -that can be identified with the combination of the DDRD and PCM assays. (almacgroup.com)
  • Our survival nomograms for patients with metastatic gastric adenocarcinoma undergoing palliative gastrectomy can assist surgeons in treatment decision-making and prognostication. (biomedcentral.com)
  • Sedation treatment acquired and opposed events patients within the emergency division. (ehd.org)
  • These limitations of conventional cancer therapies prompted the use of nanomedicine, the medical application of nanotechnology, to provide more effective and safer cancer treatment. (oaepublish.com)
  • Cancer resistance can either exist before treatment (intrinsic) or can be generated after therapy (acquired) [ 4 ] . (oaepublish.com)
  • Closer understanding of the mechanisms involved in drug resistance is needed in order to achieve better outcomes in cancer treatment. (oaepublish.com)
  • Cancer cells are masters in finding a way to resist the treatment designed to kill them. (oaepublish.com)
  • These findings could improve the discrimination of patients who would benefit from adjuvant treatment. (frontiersin.org)
  • This result supported that FLs monotherapy is the preferred treatment for a patient with stage II disease, even if the routine administration of adjuvant therapy is not recommended in these patients. (frontiersin.org)
  • It is currently viewed as one of the most promising forms of cancer treatment with 12 cancer immunotherapies approved in recent years. (technologynetworks.com)
  • Conclusions IEE findings of the gastric corpus differed between H. pylori -associated and autoimmune gastritis, suggesting different pathogenesis of the two diseases. (thieme-connect.com)
  • In addition, patients with atypical CAP may present with more subtle pulmonary findings, nonlobar infiltrates on radiography, and various extrapulmonary manifestations (eg, diarrhea, otalgia). (medscape.com)
  • Les modèles paramétriques de survie n'ont pas été utilisés précédemment pour évaluer la survie après un diagnostic d'infection à VIH/sida en Australie. (who.int)
  • This is the first FDA approval for an anti-PD-L1 therapy as part of a combination regimen for patients with advanced RCC. (pfizer.com)
  • specifically one in six men are diagnosed with prostate cancer in their lifetime. (almacgroup.com)
  • To further these goals we developed a specific array platform, this array was based upon extensive sequencing of prostate tumour samples and contains approximately 90,000 probesets, many of which are specific to prostate cancer. (almacgroup.com)
  • Adding oxaliplatin (OXA) to therapy based on FLs (5-FU and capecitabine) further improves the disease-free (DFS) and OS rates in patients with stage III disease. (frontiersin.org)
  • and Levels of Evidence for Cancer Screening and Prevention Studies are also available. (oncolink.org)
  • Cervical cancer prevention in countries with the highest HIV prevalence: a review of policies. (who.int)
  • Sections on the prevention of bacterial pneumonia in mechanically ventilated and/or critically ill patients, care of respiratory-therapy devices, prevention of cross-contamination, and prevention of viral lower respiratory tract infections (e.g., respiratory syncytial virus {RSV} and influenza infections) have been expanded and updated. (cdc.gov)
  • All of the studies are observational and subject to selection bias on the basis of the individual who chooses to be screened. (oncolink.org)
  • This scenario is especially prevalent in pregnant women and obese patients, in whom availability of or access to imaging studies is limited by the gestational age or the patient's size. (medscape.com)
  • Whereas in the past, HCC generally presented at an advanced stage with right-upper-quadrant pain, weight loss, and signs of decompensated liver disease, it is now increasingly recognized at a much earlier stage as a consequence of the routine screening of patients with known cirrhosis , using cross-sectional imaging studies and serum alpha-fetoprotein (AFP) measurements. (medscape.com)