• During embryonic development, various niche factors act on embryonic stem cells to alter gene expression, and induce their proliferation or differentiation for the development of the fetus. (wikipedia.org)
  • Within the human body, stem-cell niches maintain adult stem cells in a quiescent state, but after tissue injury, the surrounding micro-environment actively signals to stem cells to promote either self-renewal or differentiation to form new tissues. (wikipedia.org)
  • This is because for regenerative therapies, cell proliferation and differentiation must be controlled in flasks or plates, so that sufficient quantity of the proper cell type are produced prior to being introduced back into the patient for therapy. (wikipedia.org)
  • reported that GATA4 MK-1775 manufacturer localizes towards the coelomic epithelium of gonads also to the Sertoli and follicle cells before and after sex differentiation, [26] respectively. (ap26113.com)
  • hCG was insufficient to facilitate Leydig cell differentiation, restore steroidogenesis and improve sperm yield. (elifesciences.org)
  • The evidence that the culture of testicular fragments of 6.5-day-old mouse testes does not allow optimal differentiation of steroidogenic cells is compelling and should enable further optimizations in the future. (elifesciences.org)
  • It starts from spermatogonial stem cells (SSCs) in the seminiferous tubules with gradual differentiation toward spermatocytes, spermatids, and spermatozoa (1). (ijfs.ir)
  • An error during these developmental steps in females may lead to defective gonads, affecting the differentiation and/or function of the gonads and the development, differentiation, and maturity of the germ cells. (lidsen.com)
  • A stem cell commences as an undifferentiated cell that can either undergo self-renewal, whereby it generates daughter cells that remain as stem cells, or mature into a specific cell type via differentiation (Can/Hematol 2008). (papersowl.com)
  • European eel males treated with cold seawater (10 °C, T10) for 2 weeks showed an increase in the proliferation and differentiation of spermatogonial cells until the differentiated spermatogonial type A cell stage, and elevated testosterone and 11-ketotestosterone plasma levels. (biomedcentral.com)
  • In particular, our cold seawater treatment induces the synchronization and increased proliferation and differentiation of specific spermatogonial cells. (biomedcentral.com)
  • SOX9 has a role in sex determination and differentiation of Sertoli cells. (thermofisher.com)
  • In testes from mature mice, CUX1 was highly expressed only in round spermatids at stages IV-V of spermatogenesis, in both spermatids and Sertoli cells at stages VI-X of spermatogenesis, and only in Sertoli cells at stage XI of spermatogenesis. (dordt.edu)
  • Spermatogenesis requires both germ cells and testicular somatic cells, which are also involved in testicular development and male fertility. (chinagene.cn)
  • Sertoli cells are the only somatic cells in the seminiferous tubules and play very important roles in normal spermatogenesis. (chinagene.cn)
  • Abnormality of Sertoli cells in proliferation and adhesion may induce aberrant spermatogenesis and eventually cause infertility. (chinagene.cn)
  • Hai Y, Hou J, Liu Y, Liu Y, Yang H, Li Z, He Z . The roles and regulation of Sertoli cells in fate determinations of spermatogonial stem cells and spermatogenesis. (chinagene.cn)
  • Escott GM, da Rosa LA, Loss Eda S . Mechanisms of hormonal regulation of sertoli cell development and proliferation: a key process for spermatogenesis. (chinagene.cn)
  • Cell polarity, cell adhesion, and spermatogenesis: role of cytoskeletons. (chinagene.cn)
  • It is very clear from these reviews that GATA4 takes on an important part in gonadal somatic cells that get excited about spermatogenesis and oogenesis. (ap26113.com)
  • In vitro spermatogenesis could indeed be proposed to patients with testicular localization of residual tumor cells, for whom testicular tissue autografting is not indicated (about 30% of patients with acute leukemia). (elifesciences.org)
  • Human testisderived cells (hTCs) are suitable candidates for the initiation of in-vitro spermatogenesis for these types of patients. (ijfs.ir)
  • As of 2004, several studies have shown that embryonic stem cells may restore the spermatogenesis and functional sperms in mouse and human, known as in vitro gametogenesis (IVG) (2-4). (ijfs.ir)
  • These elements include somatic cells (such as Leydig cells, myoid cells, and Sertoli cells), extracellular matrix (ECM) components (including laminin, collagen type IV and collagen type I), as well as growth factors and hormones [including bFGF, glial cell-derived nerve factor, glial cellderived nerve factor (GDNF), and testosterone] that are capable of forming a complex microenvironment where spermatogenesis occurs (6). (ijfs.ir)
  • While sperm production has classically been the focus of adult reproductive function, somatic cells are crucial for the maintenance of spermatogenesis and gamete production. (biomedcentral.com)
  • Sertoli cells not only regulate the inflow of external substances, but also produce several substances which are critical to the proper progression of spermatogenesis [ 4 ]. (biomedcentral.com)
  • Sertoli-Germ (Spermatid)-cell interactions affect spermatogenesis at the molecular, cellular and biochemical levels. (proteinlounge.com)
  • Moreover, RNA-seq results indicated that 46 differentially expressed genes (DEGs) involved in meiotic cell cycle, synaptonemal complex assembly and spermatogenesis were upregulated in the hemicastration group, while 197 DEGs were downregulated, which were related to arachidonic acid metabolism. (animbiosci.org)
  • C: Tumor either Stage IA or Stage IB, but with tumor on the surface of one or both ovaries, or with capsule ruptured, or with ascites containing malignant cells or with positive peritoneal washings. (medscape.com)
  • A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
  • These PanIN lesions are in turn associated with somatic alterations in canonical oncogenes and tumor suppressor genes. (proteinlounge.com)
  • This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)
  • Tumor formation generally start in cells in leydig cells in the testis that normally make male sex hormones. (planetayurveda.net)
  • Acosta AM, Al-Obaidy KI, Sholl LM, Dickson BC, Lindeman NI, Hirsch MS, Collins K , Fletcher CD, Idrees MT. Sarcomatoid Yolk Sac Tumor Harbors Somatic Mutations That Are Otherwise Rare in Testicular Germ Cell Tumors. (iu.edu)
  • Collins K , Segura S, Hwang M. Endocrine cell micronests in an ovarian mucinous borderline tumor: a potential diagnostic pitfall for microinvasion. (iu.edu)
  • Sex cord-stromal tumors are groups of tumors composed of granulosa cells, theca cells, Sertoli cells, Leydig cells, and fibroblasts of stromal origin, singly or in various combinations. (medscape.com)
  • Finally, elevation of serum AMH above normal male prepubertal levels may be indicative of rare cases of sex-cord stromal tumors or Sertoli cell-limited disturbance in the McCune Albright syndrome. (biomedcentral.com)
  • Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
  • Furthermore, the nuclei of 90C95% granulosa cells of porcine MK-1775 manufacturer primordial, unilaminar, multilaminar, and antral follicles of different sizes stain positive for GATA4 [25]. (ap26113.com)
  • Progesterone dose during synchronization treatment alters luteinizing hormone receptor and steroidogenic enzyme mRNA abundances in granulosa cells of Nellore heifers. (tamu.edu)
  • Granulosa cells produce androgens, which stimulates follicle maturation. (easynotecards.com)
  • On day 1 of the cycle, growing follicles have both FSH and LH receptors on granulosa cells. (easynotecards.com)
  • Follicle maturation is stimulated when FSH binds to theca cells and LH binds to granulosa cells. (easynotecards.com)
  • Conclusion】 The expression trends of ADAMTS 1, PI 3 K and A k t genes and proteins were consistent and showed a positive correlation in ovary and granulosa cells of Mongolian sheep,suggested that ADAMTS 1 gene played an important role in twin birth of Mongolian sheep mediated by PI3K/Akt signaling pathway. (chvm.net)
  • Pancreatic adenocarcinoma, the malignant neoplasm of the exocrine duct cells, accounts for more than ninety percent of all pancreatic tumors (Ref.1). (proteinlounge.com)
  • Gliomas are the most common intracranial malignant tumors in humans, and high-grade Gliomas in particular pose a unique challenge due to their propensity for proliferation and tissue invasion. (proteinlounge.com)
  • Most of the testicular cancers arise from germinal cell tumors and spread rapidly. (planetayurveda.net)
  • These germ cell tumors are divided into seminomas and nonseminomas. (planetayurveda.net)
  • The mixed cell tumors are treated as nonseminomas as they grow and multiply like nonseminomas. (planetayurveda.net)
  • These Cells are generally involved in 40% of testicular tumors. (planetayurveda.net)
  • It is thought that leiomyoma is the result of either transformation of normal uterine muscle cells into abnormal cells through somatic mutations , or through the growth of abnormal uterine muscle cells into tumors. (wikidoc.org)
  • During puberty, testosterone induces Sertoli cell maturation, and prevails over FSH on AMH regulation. (biomedcentral.com)
  • Recombinant human/mouse/rat BMP-2 (355-BM) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. (novusbio.com)
  • BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair (6, 7). (novusbio.com)
  • The dendritic cells of elite controllers also appear to produce higher levels of a DNA-sensing protein called cGAS that recognizes the presence of HIV and induces rapid expression of type 1 interferons. (regenerativemedicine.net)
  • Postnatal testis development, Sertoli cell proliferation and number of different spermatogonial types in C57BL/6J mice made transiently hypo- and hyperthyroidic during the neonatal period. (chinagene.cn)
  • Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)
  • We also molecularly defined the development of Sertoli, Leydig and peritubular myoid cells during the perinatal period, allowing us to identify candidate signaling pathways acting between somatic and germ cells in a stage-specific manner during the perinatal period. (biologists.com)
  • Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
  • We have gained crucial insights into molecular factors and pathways of the cells generating either the supporting gonadal cells or germ cells of both sexes. (lidsen.com)
  • Several factors are important to regulate stem-cell characteristics within the niche: cell-cell interactions between stem cells, as well as interactions between stem cells and neighbouring differentiated cells, interactions between stem cells and adhesion molecules, extracellular matrix components, the oxygen tension, growth factors, cytokines, and the physicochemical nature of the environment including the pH, ionic strength (e.g. (wikipedia.org)
  • Transformed glial cells share the common attributes of the invasion process, including cell adhesion to ECM (Extracellular Matrix) components, cell locomotion, and the ability to remodel extracellular space. (proteinlounge.com)
  • citation needed] A Nature Insight review defines niche as follows: "Stem-cell populations are established in 'niches' - specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. (wikipedia.org)
  • It constitutes a basic unit of tissue physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms. (wikipedia.org)
  • In conclusion, this study reports the failure of adult Leydig cell development and altered steroid production and signaling in tissue cultures. (elifesciences.org)
  • The organotypic culture procedure, which preserves testicular tissue architecture, microenvironment and cell interactions, has been used successfully to obtain spermatozoa from fresh or frozen/thawed mouse prepubertal testicular tissues ( 3 - 6 ). (elifesciences.org)
  • By means of scaffolds, cells, and growth factors, tissue engineering has provided enormous hope and interest in academia, industry, and the public to cure various disorders (7). (ijfs.ir)
  • 8) indicates that tissue engineering might be helpful for the transplantation of germ cells by improving the cellular environment using scaffolds to enhance graft outcomes for prepubertal boys exposed to gonadotoxic treatments. (ijfs.ir)
  • The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of Gliomas and contributes to the failure of current therapeutic modalities (surgery, radiation and chemotherapy). (proteinlounge.com)
  • In contrast, adult stem cells can only give rise to differentiated somatic cells of the particular tissue from which these cells originated (Can/Hematol 2008). (papersowl.com)
  • Until recently, it was believed that they were tissue-specific…however, this concept has been challenged… (multipotent cells) can differentiate in vitro and in vivo into various cell types not only from the tissue of origin" (Can/Hematol 2008). (papersowl.com)
  • Testicular cancer is a condition in which the unusual cell grows out of control in the tissue of one or both of the testes. (planetayurveda.net)
  • Depending on the molecules and testis age, highly deleterious effects of phytocannabinoid exposure were observed on testis tissue after 14 days, including Sertoli and germ cell death. (biomedcentral.com)
  • Rubella virus tropism and single-cell responses in human primary tissue and microglia-containing organoids. (antibodiesinc.com)
  • An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
  • Testosterone is essential for male fertility, mediating its biological effects through the androgen receptor (AR) present in somatic Leydig, peritubular, and Sertoli cells. (biomedcentral.com)
  • Adult stem cells remain in an undifferentiated state throughout adult life. (wikipedia.org)
  • It is believed that correct culturing conditions of adult stem cells needs to be improved so that adult stem cells can maintain their stemness over time. (wikipedia.org)
  • Present study was designed to establish a causal connection between changes in the cell-cell junction protein expression at the blood-testis barrier and alterations in the adult rat testis histology following an anti-androgen flutamide exposure. (biomedcentral.com)
  • GATA4 can be an integral regulator of Sertoli cell function in adult mice [21]. (ap26113.com)
  • Despite a conserved density of Leydig cells after 30 days of culture (D30), transcript levels of adult Leydig cell and steroidogenic markers were decreased. (elifesciences.org)
  • In the last four decades, transgenic and knockout mouse models have helped to understand the mechanisms of mammalian sex determination, germ cell development, and adult gonad functions. (lidsen.com)
  • That is to say, one type of stem cell may be capable of differentiating into all adult cell types, while another may only be capable of maturing into one specific somatic cell type. (papersowl.com)
  • On a macro scale, the two classifications of stem cells are embryonic and adult stem cells. (papersowl.com)
  • To delve further into the specifics, embryonic and adult stem cells fall into potency categories reflecting their ability to differentiate: totipotent, pluripotent, multipotent, and unipotent. (papersowl.com)
  • Using these definitions, embryonic stem cells can be classified as totipotent or pluripotent at different developmental stages and locations, whereas adult stem cells can be categorized as pluripotent, multipotent, or unipotent (Figure 1). (papersowl.com)
  • In the early 1980s, scientists began to exploit two major classes of stem cells: embryonic and non-embryonic, or adult stem cells. (papersowl.com)
  • However, the crowning achievement arose in 2006 when researchers at Kyoto University discovered the necessary means to reprogram differentiated adult cells to possess embryonic stem cell-like functionality, as if reversing time itself. (papersowl.com)
  • Theca cells produce estrogen, which is converted to the androgens that stimulate follicle maturation. (easynotecards.com)
  • The proliferation/viability of the cells was assessed using the MTT assay, along with H&E histological staining method. (ijfs.ir)
  • Following our previous animal studies performed on mice (9, 10), the aim of this study was to evaluate the viability and proliferation of the cells derived from human TESE samples, which were cultivated on a novel threedimensional (3D) nano-scaffold containing human serum albumin (HSA)/tri calcium phosphate nanoparticles (TCP NPs), as examined by MTT and H&E histological staining assays. (ijfs.ir)
  • Ex vivo exposure of first trimester testes to CBD, THC, or CBD/THC [ratio 1:1] at 10 −7 to 10 −5 M altered testosterone secretion by Leydig cells, AMH secretion by Sertoli cells, and impacted testicular cell proliferation and viability as early as 72 h post-exposure. (biomedcentral.com)
  • Transcript levels of the androgen receptor (AR)-regulated gene Rhox5 were decreased at the end of the culture period, suggesting that testosterone production by Leydig cells and/or AR transcriptional activity was impaired in organotypic cultures ( 8 ). (elifesciences.org)
  • By the 10th week, Leydig cells develop from the mesenchymal cells of the genital ridge and secrete testosterone, initially under the influence of placental chorionic gonadotropin and later by the pituitary gonadotrophins. (your-doctor.net)
  • Genomic instability creates a permissive state in which a potential cancer cell is allowed to acquire enough mutations to become a cancer cell. (proteinlounge.com)
  • Functional impact and targetability of PI3KCA, GNAS, and PTEN mutations in a spindle cell rhabdomyosarcoma with MYOD1 L122R mutation. (iu.edu)
  • Recently, various studies have demonstrated that miRNA are involved in the regulation of Sertoli cell proliferation and adhesion. (chinagene.cn)
  • Regulation of spermatogonial stem cell self-renewal and spermatocyte meiosis by Sertoli cell signaling. (chinagene.cn)
  • It has a transcriptional regulation in melanin production in cells. (thermofisher.com)
  • Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate cell fate. (wikipedia.org)
  • The word 'niche' can be in reference to the in vivo or in vitro stem-cell microenvironment. (wikipedia.org)
  • Human embryonic stem cells are often grown in fibroblastic growth factor-2 containing, fetal bovine serum supplemented media. (wikipedia.org)
  • They are grown on a feeder layer of cells, which is believed to be supportive in maintaining the pluripotent characteristics of embryonic stem cells. (wikipedia.org)
  • Embryonic stem cells have the unique ability to exist in an undifferentiated state indefinitely while also being pluripotent. (papersowl.com)
  • Marking a vast leap in reproductive therapy, it became possible to isolate these human embryonic stem cells for reproductive purposes, such as in vitro fertilization. (papersowl.com)
  • E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)
  • CUX1 expression was continuous in Sertoli cells from prepubertal testes but became cyclic when spermatids appeared. (dordt.edu)
  • Moreover, CUX1 was not expressed in proliferating cells in testes from either wild-type or transgenic mice. (dordt.edu)
  • also recognized in the cells of neonatal testes and total testicular cells, and that the manifestation of GATA4 was decreased in used older feeder cells. (ap26113.com)
  • Furthermore, GATA4 manifestation was more powerful in FFCs than in OFCs, and it had been recognized in Sertoli cells of neonatal pig testes. (ap26113.com)
  • Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
  • After 10 weeks, exercised and non-exercised males were sampled to determine plasma 11-ketotestosterone levels, testicular mRNA expression levels of genes involved in steroidogenesis and gametogenesis by qPCR, as well as the relative abundance of germ cells representing the different spermatogenic stages by histological examination. (biomedcentral.com)
  • The methodology included inducing differentiated somatic cells with the primary genes responsible for embryonic stem cell potency. (papersowl.com)
  • We determined the expression of components of the ECS in the human fetal testis from 6 to 17 developmental weeks and assessed the direct effects of phytocannabinoids Δ9-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the testis morphology and cell functions ex vivo. (biomedcentral.com)
  • Therefore, 3D HSA/TCP NPs scaffolds could be used for the reconstitu- tion of the artificial human somatic testicular niche for future applications in regenerative medicine for male infertility. (ijfs.ir)
  • The review will also provide theoretical basis for the pathogenesis of infertility associated with Sertoli cells. (chinagene.cn)
  • In accord, no difference in the apoptosis and proliferation level was found between control and treated groups. (biomedcentral.com)
  • Conclusion】 The PERP 1 gene had the function of promoting granulosa cell apoptosis,and regulating its expression was of great significance for follicular development. (chvm.net)
  • Pediatric cancer treatments such as chemotherapy have recognized toxicity on germline stem cells, which could lead to infertility at adulthood ( 1 , 2 ). (elifesciences.org)
  • Using single-cell RNA sequencing (RNAseq), we studied the development of ProSG, their SG descendants and testicular somatic cells during the perinatal period in mice. (biologists.com)
  • The stem cells and niche may induce each other during development and reciprocally signal to maintain each other during adulthood. (wikipedia.org)
  • Though the concept of stem cell niche was prevailing in vertebrates, the first characterization of stem cell niche in vivo was worked out in Drosophila germinal development. (wikipedia.org)
  • These total outcomes claim that GATA4-positive cells MK-1775 manufacturer support GDC development in two-dimensional tradition which, during tradition with GDCs, the GATA4-expressing FFCs most likely are likely involved similar compared to that of somatic cells in the testessupporting germ cell development and proliferation. (ap26113.com)
  • A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
  • Overall, the presence of stem cells is essential for proper human development and function as they contribute to the growth, maintenance, and repair of numerous physiological systems (Kara et al. (papersowl.com)
  • During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium. (thermofisher.com)
  • During the 6th week, cells of the genital ridge invade the mesenchyme to form primitive sex cords, consisting of cortical and medullary regions that will eventually invest the germ cells and support their development. (your-doctor.net)
  • It has been reported that Nanog, Oct4, and Sox2, often used as stem cell markers, function cooperatively in the regulatory network of self-renewal and pluripotency [16]. (ap26113.com)
  • Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. (wikipedia.org)
  • Mammalian sperm cells present highly specific lipidic composition, high content of polyunsaturated fatty acids, plasmalogenes and sphingomyelins. (scialert.net)
  • It is an essential structural component of mammalian cell membranes. (absoluteastronomy.com)
  • This acts to stimulate proliferation of cells in the medulla and degeneration of cells in the cortical regions of the primitive sex cords. (your-doctor.net)
  • In their paper published, the research team reports finding that dendritic cells of elite controllers are better able to detect the presence of HIV paradoxically through a greater susceptibility to HIV infection which enables them to stimulate the generation of T cells specifically targeting the virus. (regenerativemedicine.net)
  • We identified both gene and protein markers for three temporally distinct ProSG cell subsets, including a migratory cell population with a transcriptome distinct from the previously defined T1- and T2-ProSG stages. (biologists.com)
  • These Are the less developed cancers with cells that appear like embryos in their early stages. (planetayurveda.net)
  • They invest the primordial germ cells to form ovarian follicles, which differentiate into oogonia and then primary oocytes that remain in this phase until puberty. (your-doctor.net)
  • This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
  • Endometrial Cells Acutely Exposed to Phthalates In Vitro Do Not Phenocopy Endometriosis. (ivi-rmainnovation.com)
  • The niche saves stem cells from depletion, while protecting the host from over-exuberant stem-cell proliferation. (wikipedia.org)
  • The simple location of stem cells is not sufficient to define a niche. (wikipedia.org)
  • citation needed] By continuous intravital imaging in mice, researchers were able to explore the structure of the stem cell niche and to obtain the fate of individual stem cells (SCs) and their progeny over time in vivo. (wikipedia.org)
  • In particular in intestinal crypt, two distinct groups of SCs have been identified: the "border stem cells" located in the upper part of the niche at the interface with transit amplifying cells (TAs), and "central stem cells" located at the crypt base. (wikipedia.org)
  • This bi-compartmental structure of stem cell niche has been mathematically modeled to obtain the optimal architecture that leads to the maximum delay in double-hit mutant production. (wikipedia.org)
  • It takes on an intrinsic role in the introduction of MK-1775 manufacturer testicular steroidogenic cells [22]. (ap26113.com)
  • The zygote and the cells within the initial zygotic divisions are considered totipotent (Kara et al. (papersowl.com)
  • At this location, the spermatogonia seem to go on to the next stage after increasing the number by repeating 6 to 7 somatic cell divisions. (gozasso.com)
  • Asynchronous Expression of the Homeodomain Protein CUX1 in Sertoli Cel" by Melissa R. Kroll, Engela S. Viss et al. (dordt.edu)
  • Whole cell extracts (30 µg lysate) of HeLa (Lane 1), SH-SY5Y (Lane 2), A549 (Lane 3), A-431 (Lane 4) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). (thermofisher.com)
  • The dendritic cells of elite controllers, however, were found to contain higher levels of HIV DNA, probably because of limited expression of a protein called SAMDH1 that usually blocks reverse transcription in several types of immune cells. (regenerativemedicine.net)
  • Moreover, in parallel, several groups have demonstrated the pluripotency of germ-line stem cells (GSCs) following SSCs culture in rodents, though, there is a debate about pluripotency of GSCs in primates and humans (5). (ijfs.ir)
  • Specific stem cell types possess unique potencies, or abilities to self-renew. (papersowl.com)
  • The subcultured GDCs in each passage experienced germ and stem cell characteristics, and circulation cytometric analyses exposed that ~60% of these cells were GFRPGP 9.5GFR-1NANOGwere used as shown in our earlier study [8]. (ap26113.com)
  • Based on these reports, it seems that germ and stem cell markers are expressed in cultured germ cells of domestic animals. (ap26113.com)
  • In this study, cells of the colonies at each passage were found to be positive for GFR em /em -1 and PGP 9.5, as well as for stem cell markers, in RT-PCR, immunocytochemistry, MK-1775 manufacturer and flow cytometry analyses. (ap26113.com)
  • These results suggest that the GDCs stably maintain germ and stem cell characteristics during subculture. (ap26113.com)
  • Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
  • A pluripotent stem cell has the potential to form all cells of the embryo, but cannot form a placenta. (papersowl.com)
  • Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced Neurons. (antibodiesinc.com)
  • As shown by examination of semi-thin and ultrathin sections, cell surface occupied by the basal ES connecting neighboring Sertoli cells and the number of gap and tight junctions coexisting with the basal ES were apparently reduced in flutamide-treated rats. (biomedcentral.com)
  • Oxygen is required to support life, but its metabolites such as Reactive Oxygen Species (ROS) can modify cell functions, endanger cell survival, or both. (scialert.net)