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HLA-DQ AntigensLocus CoeruleusSerotypingAllelesCeliac DiseaseMajor Histocompatibility ComplexHLA AntigensHistocompatibility Antigens Class IIHistocompatibility Antigens Class IMolecular Sequence DataGenotypeHistocompatibility AntigensBase SequenceHLA-DR AntigensAmino Acid SequencePolymorphism, GeneticGenes, MHC Class IGenes, MHC Class IIPolymerase Chain ReactionGene FrequencyMinor Histocompatibility AntigensGenetic LociChromosome MappingMutationHLA-DRB1 ChainsPhenotypeGenetic Predisposition to DiseaseHistocompatibilityH-2 AntigensHLA-B AntigensT-LymphocytesGenetic VariationHaplotypesHistocompatibility TestingHeterozygoteQuantitative Trait LociGenetic LinkageMice, Inbred C57BLPolymorphism, Single NucleotideHLA-DQ beta-ChainsHLA-D AntigensCrosses, GeneticEpitopesMinor Histocompatibility LociCell LineGenetic MarkersMacromolecular SubstancesPeptidesAntigen PresentationSpecies SpecificityCloning, MolecularAntibodies, MonoclonalDNASequence Analysis, DNAApolipoprotein E4T-Lymphocytes, CytotoxicPeptide FragmentsHLA-A AntigensProtein BindingMice, Inbred StrainsHomozygoteMice, Inbred BALB CReceptors, Antigen, T-CellLymphocyte ActivationPolymorphism, Restriction Fragment Lengthbeta 2-MicroglobulinLinkage DisequilibriumMicrosatellite RepeatsRecombinant Proteinsalpha 1-AntitrypsinReceptors, Antigen, T-Cell, alpha-betaCells, CulturedDNA PrimersModels, GeneticPedigreeBinding SitesTransfectionRNA, MessengerFlow CytometryImmunoglobulin alpha-ChainsHLA-DP AntigensGenesGene Expression RegulationMice, TransgenicB-LymphocytesInterferon-gammaCytotoxicity, ImmunologicMice, CongenicHLA-DR3 AntigenHistocompatibility Antigen H-2DCase-Control StudiesKineticsProtein ConformationHLA-C AntigensCD4-Positive T-LymphocytesGene ExpressionClone CellsRecombination, GeneticSequence Homology, Amino AcidPhylogeny
IsoformsHumansAspectsExonRiskCellClass
Isoforms3
  • A person often produces two α-chain and two β-chain variants and thus 4 isoforms of DQ. (wikipedia.org)
  • The DQ loci are in close genetic linkage to HLA-DR, and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. Different isoforms of DQ can bind to and present different antigens to T-cells. (wikipedia.org)
  • Using long-read sequencing, we identified 16 Mamu-E isoforms and all Mamu-E splicing junctions were detected among HLA-E isoforms in humans. (bvsalud.org)
Humans1
  • However, it is unclear how accurately the RM model reflects HLA-E immunobiology in humans. (bvsalud.org)
Aspects1
  • Serotyping is capable of identifying most aspects of DQ isoform structure and function, however sequence specific PCR is now the preferred method of determining HLA-DQA1 and HLA-DQB1 alleles, as serotyping cannot resolve, often, the critical contribution of the DQ α-chain. (wikipedia.org)
Exon1
  • Among four groups of Mamu-E alleles: three ~5% divergent full-length allele groups (G1, G2, G2_LTR) and a fourth monomorphic group (G3) with a deletion encompassing the canonical Mamu-E exon 6, the presence of G2_LTR alleles was significantly (p = 0.02) associated with the lack of RhCMV/SIV vaccine protection. (bvsalud.org)
Risk2
  • Carriers of risk serotypes such as DQ8 have a higher proportion of circulating T-cell receptors that may bind insulin, the primary autoantigen in type 1 diabetes. (wikipedia.org)
  • Association between the HLA-DQA1 rs1391371 risk allele and chronic rhinosinusitis. (nih.gov)
Cell5
  • HLA-DQ (DQ) is a cell surface receptor protein found on antigen-presenting cells. (wikipedia.org)
  • DQ mediates autoimmunity by skewing the T-cell receptor (TCR) repertoire during thymic selection. (wikipedia.org)
  • HLA DQ functions as a cell surface receptor for foreign or self antigens. (wikipedia.org)
  • Others result in changes in regions that are removed when the proteins is processed to the cell surface, still others result in change in the non-functional regions of the protein, and some changes result in a change of function of the DQ isoform that is produced. (wikipedia.org)
  • High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD). (nih.gov)
Class2
  • HLA-DQA1 belongs to the HLA class II alpha chain paralogues. (nih.gov)
  • The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. (nih.gov)